Incidental Mutation 'R6920:Vmn2r9'
| ID |
539567 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r9
|
| Ensembl Gene |
ENSMUSG00000091624 |
| Gene Name |
vomeronasal 2, receptor 9 |
| Synonyms |
EG435864 |
| MMRRC Submission |
045040-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.113)
|
| Stock # |
R6920 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
108990813-109000376 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 108996912 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 119
(Y119F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129520
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170419]
|
| AlphaFold |
K7N6Z8 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170419
AA Change: Y119F
PolyPhen 2
Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: Y119F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
412 |
8.1e-29 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
2.3e-16 |
PFAM |
|
Pfam:7tm_3
|
592 |
829 |
3.4e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.1%
- 20x: 97.2%
|
| Validation Efficiency |
100% (65/65) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
T |
3: 137,773,811 (GRCm39) |
Y1000F |
probably damaging |
Het |
| 1700018B08Rik |
A |
G |
8: 122,262,160 (GRCm39) |
|
probably null |
Het |
| Aadat |
T |
C |
8: 60,982,467 (GRCm39) |
F245L |
probably damaging |
Het |
| Adcy10 |
T |
G |
1: 165,403,227 (GRCm39) |
L1575W |
probably damaging |
Het |
| Anks4b |
A |
T |
7: 119,782,231 (GRCm39) |
T421S |
probably damaging |
Het |
| Anpep |
A |
T |
7: 79,475,097 (GRCm39) |
I155N |
probably damaging |
Het |
| Arnt |
T |
C |
3: 95,397,932 (GRCm39) |
F572L |
probably damaging |
Het |
| Brip1 |
G |
A |
11: 86,039,362 (GRCm39) |
Q391* |
probably null |
Het |
| Brpf3 |
C |
A |
17: 29,042,970 (GRCm39) |
H1004N |
probably benign |
Het |
| Cand2 |
T |
A |
6: 115,768,250 (GRCm39) |
V465D |
possibly damaging |
Het |
| Card10 |
G |
T |
15: 78,686,609 (GRCm39) |
Y69* |
probably null |
Het |
| Catsperd |
A |
T |
17: 56,962,175 (GRCm39) |
K450* |
probably null |
Het |
| Ccdc137 |
T |
C |
11: 120,351,009 (GRCm39) |
L137P |
probably damaging |
Het |
| Cic |
T |
C |
7: 24,990,107 (GRCm39) |
S1905P |
probably damaging |
Het |
| Csmd3 |
C |
T |
15: 47,507,601 (GRCm39) |
G2971S |
probably damaging |
Het |
| Dmxl2 |
A |
G |
9: 54,379,496 (GRCm39) |
Y183H |
probably damaging |
Het |
| Drosha |
T |
C |
15: 12,834,396 (GRCm39) |
Y167H |
unknown |
Het |
| E330034G19Rik |
A |
G |
14: 24,358,310 (GRCm39) |
K214R |
unknown |
Het |
| Fam180a |
T |
G |
6: 35,290,765 (GRCm39) |
I73L |
possibly damaging |
Het |
| Fbxo28 |
G |
T |
1: 182,168,986 (GRCm39) |
H51N |
probably benign |
Het |
| Gm12728 |
T |
G |
4: 105,647,533 (GRCm39) |
|
probably null |
Het |
| Gm973 |
T |
C |
1: 59,591,620 (GRCm39) |
C335R |
possibly damaging |
Het |
| Gpx8 |
A |
G |
13: 113,179,770 (GRCm39) |
V177A |
probably damaging |
Het |
| Hdlbp |
A |
G |
1: 93,340,083 (GRCm39) |
|
probably null |
Het |
| Htt |
T |
G |
5: 35,034,444 (GRCm39) |
Y1972D |
probably null |
Het |
| Igkv6-14 |
T |
C |
6: 70,412,116 (GRCm39) |
Y56C |
possibly damaging |
Het |
| Kcnma1 |
A |
G |
14: 23,576,602 (GRCm39) |
|
probably null |
Het |
| Klc1 |
T |
C |
12: 111,754,019 (GRCm39) |
S105P |
probably damaging |
Het |
| Klhl20 |
T |
C |
1: 160,921,266 (GRCm39) |
D63G |
possibly damaging |
Het |
| Lamc3 |
A |
G |
2: 31,798,701 (GRCm39) |
D469G |
probably damaging |
Het |
| Lrit1 |
G |
C |
14: 36,782,052 (GRCm39) |
V242L |
probably damaging |
Het |
| Mboat4 |
G |
A |
8: 34,591,865 (GRCm39) |
R434H |
probably benign |
Het |
| Mttp |
T |
C |
3: 137,821,043 (GRCm39) |
K270E |
possibly damaging |
Het |
| Muc5ac |
G |
A |
7: 141,347,035 (GRCm39) |
C337Y |
possibly damaging |
Het |
| Nars1 |
A |
G |
18: 64,634,471 (GRCm39) |
V484A |
probably damaging |
Het |
| Noxa1 |
G |
T |
2: 24,981,844 (GRCm39) |
|
probably null |
Het |
| Or14c45 |
A |
G |
7: 86,176,522 (GRCm39) |
T186A |
probably benign |
Het |
| Or7g18 |
T |
A |
9: 18,786,821 (GRCm39) |
L63H |
probably damaging |
Het |
| Osbpl7 |
G |
A |
11: 96,941,584 (GRCm39) |
G36S |
probably damaging |
Het |
| P4htm |
C |
T |
9: 108,460,812 (GRCm39) |
G220D |
probably benign |
Het |
| Pcdhga7 |
A |
G |
18: 37,848,199 (GRCm39) |
I69V |
probably benign |
Het |
| Pla2g4e |
C |
T |
2: 120,015,795 (GRCm39) |
E250K |
possibly damaging |
Het |
| Plcd4 |
A |
G |
1: 74,604,994 (GRCm39) |
|
probably benign |
Het |
| Ppfia3 |
C |
A |
7: 45,008,231 (GRCm39) |
G213V |
possibly damaging |
Het |
| Ppp1r1a |
A |
G |
15: 103,441,513 (GRCm39) |
S67P |
probably damaging |
Het |
| Prss43 |
T |
C |
9: 110,657,680 (GRCm39) |
F193S |
probably benign |
Het |
| Rfx1 |
A |
G |
8: 84,822,117 (GRCm39) |
Y872C |
probably damaging |
Het |
| Rhot1 |
T |
A |
11: 80,132,921 (GRCm39) |
N218K |
probably benign |
Het |
| Sall1 |
A |
G |
8: 89,757,021 (GRCm39) |
F1028L |
probably damaging |
Het |
| Siglec1 |
G |
A |
2: 130,919,997 (GRCm39) |
Q845* |
probably null |
Het |
| Slc38a9 |
C |
T |
13: 112,838,060 (GRCm39) |
T275I |
possibly damaging |
Het |
| Slc39a4 |
A |
T |
15: 76,497,470 (GRCm39) |
S481T |
probably damaging |
Het |
| Ssr1 |
A |
T |
13: 38,169,998 (GRCm39) |
N191K |
probably damaging |
Het |
| Tenm4 |
A |
T |
7: 96,544,757 (GRCm39) |
S2258C |
probably damaging |
Het |
| Tm7sf3 |
T |
G |
6: 146,507,645 (GRCm39) |
R472S |
possibly damaging |
Het |
| Tmprss11a |
G |
A |
5: 86,576,494 (GRCm39) |
T119M |
probably benign |
Het |
| Traip |
C |
T |
9: 107,838,240 (GRCm39) |
R142* |
probably null |
Het |
| Utrn |
T |
C |
10: 12,626,214 (GRCm39) |
N100D |
probably damaging |
Het |
| Vmn1r74 |
T |
C |
7: 11,581,575 (GRCm39) |
S292P |
probably benign |
Het |
| Vmn2r71 |
A |
T |
7: 85,273,108 (GRCm39) |
I641F |
probably damaging |
Het |
| Vmn2r98 |
A |
G |
17: 19,285,510 (GRCm39) |
N110S |
probably damaging |
Het |
| Vwce |
A |
G |
19: 10,642,057 (GRCm39) |
T928A |
probably benign |
Het |
| Zfp608 |
T |
A |
18: 55,121,337 (GRCm39) |
K83N |
probably damaging |
Het |
| Zfp808 |
A |
G |
13: 62,320,982 (GRCm39) |
H737R |
probably benign |
Het |
| Zswim4 |
T |
C |
8: 84,940,714 (GRCm39) |
N795S |
probably benign |
Het |
|
| Other mutations in Vmn2r9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00920:Vmn2r9
|
APN |
5 |
108,995,890 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL00972:Vmn2r9
|
APN |
5 |
108,996,903 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01102:Vmn2r9
|
APN |
5 |
108,990,811 (GRCm39) |
splice site |
probably null |
|
|
IGL01892:Vmn2r9
|
APN |
5 |
108,995,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02086:Vmn2r9
|
APN |
5 |
108,995,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02118:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02119:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02120:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02121:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02123:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02131:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02132:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02171:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02185:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02186:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02346:Vmn2r9
|
APN |
5 |
108,990,850 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02508:Vmn2r9
|
APN |
5 |
108,996,067 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02815:Vmn2r9
|
APN |
5 |
108,990,856 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL03077:Vmn2r9
|
APN |
5 |
108,996,173 (GRCm39) |
splice site |
probably benign |
|
|
IGL03269:Vmn2r9
|
APN |
5 |
108,995,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03293:Vmn2r9
|
APN |
5 |
108,995,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r9
|
UTSW |
5 |
108,990,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0328:Vmn2r9
|
UTSW |
5 |
108,995,405 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0382:Vmn2r9
|
UTSW |
5 |
108,995,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Vmn2r9
|
UTSW |
5 |
108,996,154 (GRCm39) |
nonsense |
probably null |
|
|
R0975:Vmn2r9
|
UTSW |
5 |
108,991,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Vmn2r9
|
UTSW |
5 |
108,995,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Vmn2r9
|
UTSW |
5 |
108,996,850 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1469:Vmn2r9
|
UTSW |
5 |
108,991,694 (GRCm39) |
missense |
probably benign |
|
|
R1469:Vmn2r9
|
UTSW |
5 |
108,991,694 (GRCm39) |
missense |
probably benign |
|
|
R1704:Vmn2r9
|
UTSW |
5 |
108,994,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Vmn2r9
|
UTSW |
5 |
108,995,388 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1991:Vmn2r9
|
UTSW |
5 |
108,994,305 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2410:Vmn2r9
|
UTSW |
5 |
108,996,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3419:Vmn2r9
|
UTSW |
5 |
108,994,299 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3852:Vmn2r9
|
UTSW |
5 |
108,995,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3873:Vmn2r9
|
UTSW |
5 |
108,995,701 (GRCm39) |
missense |
probably benign |
0.14 |
|
R3905:Vmn2r9
|
UTSW |
5 |
108,995,785 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3908:Vmn2r9
|
UTSW |
5 |
108,995,785 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3921:Vmn2r9
|
UTSW |
5 |
108,996,921 (GRCm39) |
missense |
probably benign |
|
|
R4156:Vmn2r9
|
UTSW |
5 |
108,995,743 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R4477:Vmn2r9
|
UTSW |
5 |
108,994,143 (GRCm39) |
missense |
probably benign |
|
|
R4478:Vmn2r9
|
UTSW |
5 |
108,994,143 (GRCm39) |
missense |
probably benign |
|
|
R4544:Vmn2r9
|
UTSW |
5 |
108,995,551 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4546:Vmn2r9
|
UTSW |
5 |
108,995,551 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4627:Vmn2r9
|
UTSW |
5 |
108,995,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Vmn2r9
|
UTSW |
5 |
108,994,351 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5361:Vmn2r9
|
UTSW |
5 |
108,995,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5587:Vmn2r9
|
UTSW |
5 |
108,995,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6054:Vmn2r9
|
UTSW |
5 |
108,996,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6106:Vmn2r9
|
UTSW |
5 |
108,992,902 (GRCm39) |
missense |
probably benign |
|
|
R6125:Vmn2r9
|
UTSW |
5 |
108,990,836 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6137:Vmn2r9
|
UTSW |
5 |
108,996,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7579:Vmn2r9
|
UTSW |
5 |
108,992,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8683:Vmn2r9
|
UTSW |
5 |
108,996,873 (GRCm39) |
missense |
probably benign |
|
|
R8964:Vmn2r9
|
UTSW |
5 |
108,996,031 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9022:Vmn2r9
|
UTSW |
5 |
108,992,923 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9118:Vmn2r9
|
UTSW |
5 |
108,990,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9125:Vmn2r9
|
UTSW |
5 |
108,996,047 (GRCm39) |
missense |
|
|
|
R9240:Vmn2r9
|
UTSW |
5 |
108,996,099 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9327:Vmn2r9
|
UTSW |
5 |
108,996,841 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9412:Vmn2r9
|
UTSW |
5 |
108,991,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9499:Vmn2r9
|
UTSW |
5 |
108,995,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Vmn2r9
|
UTSW |
5 |
108,995,908 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9790:Vmn2r9
|
UTSW |
5 |
108,995,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9791:Vmn2r9
|
UTSW |
5 |
108,995,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATTGCTTGCAGGCACATGTAAATG -3'
(R):5'- GAGGCTTATTCCAATACAGTTAGACAG -3'
Sequencing Primer
(F):5'- GAGGTCCTAAGTTCAATTCCCAGG -3'
(R):5'- AACATCTCCCTTAATCATCATTATGC -3'
|
| Posted On |
2018-11-06 |
Incidental Mutation