Incidental Mutation 'R6920:Or7g18'
ID 539587
Institutional Source Beutler Lab
Gene Symbol Or7g18
Ensembl Gene ENSMUSG00000062868
Gene Name olfactory receptor family 7 subfamily G member 18
Synonyms GA_x6K02T2PVTD-12618399-12619337, Olfr830, MOR152-1
MMRRC Submission 045040-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # R6920 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 18786256-18787572 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 18786821 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Histidine at position 63 (L63H)
Ref Sequence ENSEMBL: ENSMUSP00000148394 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078861] [ENSMUST00000212723]
AlphaFold Q8VFJ5
Predicted Effect probably damaging
Transcript: ENSMUST00000078861
AA Change: L66H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077903
Gene: ENSMUSG00000062868
AA Change: L66H

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.8e-51 PFAM
Pfam:7tm_1 44 293 1.6e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212723
AA Change: L63H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 97.2%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A T 3: 137,773,811 (GRCm39) Y1000F probably damaging Het
1700018B08Rik A G 8: 122,262,160 (GRCm39) probably null Het
Aadat T C 8: 60,982,467 (GRCm39) F245L probably damaging Het
Adcy10 T G 1: 165,403,227 (GRCm39) L1575W probably damaging Het
Anks4b A T 7: 119,782,231 (GRCm39) T421S probably damaging Het
Anpep A T 7: 79,475,097 (GRCm39) I155N probably damaging Het
Arnt T C 3: 95,397,932 (GRCm39) F572L probably damaging Het
Brip1 G A 11: 86,039,362 (GRCm39) Q391* probably null Het
Brpf3 C A 17: 29,042,970 (GRCm39) H1004N probably benign Het
Cand2 T A 6: 115,768,250 (GRCm39) V465D possibly damaging Het
Card10 G T 15: 78,686,609 (GRCm39) Y69* probably null Het
Catsperd A T 17: 56,962,175 (GRCm39) K450* probably null Het
Ccdc137 T C 11: 120,351,009 (GRCm39) L137P probably damaging Het
Cic T C 7: 24,990,107 (GRCm39) S1905P probably damaging Het
Csmd3 C T 15: 47,507,601 (GRCm39) G2971S probably damaging Het
Dmxl2 A G 9: 54,379,496 (GRCm39) Y183H probably damaging Het
Drosha T C 15: 12,834,396 (GRCm39) Y167H unknown Het
E330034G19Rik A G 14: 24,358,310 (GRCm39) K214R unknown Het
Fam180a T G 6: 35,290,765 (GRCm39) I73L possibly damaging Het
Fbxo28 G T 1: 182,168,986 (GRCm39) H51N probably benign Het
Gm12728 T G 4: 105,647,533 (GRCm39) probably null Het
Gm973 T C 1: 59,591,620 (GRCm39) C335R possibly damaging Het
Gpx8 A G 13: 113,179,770 (GRCm39) V177A probably damaging Het
Hdlbp A G 1: 93,340,083 (GRCm39) probably null Het
Htt T G 5: 35,034,444 (GRCm39) Y1972D probably null Het
Igkv6-14 T C 6: 70,412,116 (GRCm39) Y56C possibly damaging Het
Kcnma1 A G 14: 23,576,602 (GRCm39) probably null Het
Klc1 T C 12: 111,754,019 (GRCm39) S105P probably damaging Het
Klhl20 T C 1: 160,921,266 (GRCm39) D63G possibly damaging Het
Lamc3 A G 2: 31,798,701 (GRCm39) D469G probably damaging Het
Lrit1 G C 14: 36,782,052 (GRCm39) V242L probably damaging Het
Mboat4 G A 8: 34,591,865 (GRCm39) R434H probably benign Het
Mttp T C 3: 137,821,043 (GRCm39) K270E possibly damaging Het
Muc5ac G A 7: 141,347,035 (GRCm39) C337Y possibly damaging Het
Nars1 A G 18: 64,634,471 (GRCm39) V484A probably damaging Het
Noxa1 G T 2: 24,981,844 (GRCm39) probably null Het
Or14c45 A G 7: 86,176,522 (GRCm39) T186A probably benign Het
Osbpl7 G A 11: 96,941,584 (GRCm39) G36S probably damaging Het
P4htm C T 9: 108,460,812 (GRCm39) G220D probably benign Het
Pcdhga7 A G 18: 37,848,199 (GRCm39) I69V probably benign Het
Pla2g4e C T 2: 120,015,795 (GRCm39) E250K possibly damaging Het
Plcd4 A G 1: 74,604,994 (GRCm39) probably benign Het
Ppfia3 C A 7: 45,008,231 (GRCm39) G213V possibly damaging Het
Ppp1r1a A G 15: 103,441,513 (GRCm39) S67P probably damaging Het
Prss43 T C 9: 110,657,680 (GRCm39) F193S probably benign Het
Rfx1 A G 8: 84,822,117 (GRCm39) Y872C probably damaging Het
Rhot1 T A 11: 80,132,921 (GRCm39) N218K probably benign Het
Sall1 A G 8: 89,757,021 (GRCm39) F1028L probably damaging Het
Siglec1 G A 2: 130,919,997 (GRCm39) Q845* probably null Het
Slc38a9 C T 13: 112,838,060 (GRCm39) T275I possibly damaging Het
Slc39a4 A T 15: 76,497,470 (GRCm39) S481T probably damaging Het
Ssr1 A T 13: 38,169,998 (GRCm39) N191K probably damaging Het
Tenm4 A T 7: 96,544,757 (GRCm39) S2258C probably damaging Het
Tm7sf3 T G 6: 146,507,645 (GRCm39) R472S possibly damaging Het
Tmprss11a G A 5: 86,576,494 (GRCm39) T119M probably benign Het
Traip C T 9: 107,838,240 (GRCm39) R142* probably null Het
Utrn T C 10: 12,626,214 (GRCm39) N100D probably damaging Het
Vmn1r74 T C 7: 11,581,575 (GRCm39) S292P probably benign Het
Vmn2r71 A T 7: 85,273,108 (GRCm39) I641F probably damaging Het
Vmn2r9 T A 5: 108,996,912 (GRCm39) Y119F possibly damaging Het
Vmn2r98 A G 17: 19,285,510 (GRCm39) N110S probably damaging Het
Vwce A G 19: 10,642,057 (GRCm39) T928A probably benign Het
Zfp608 T A 18: 55,121,337 (GRCm39) K83N probably damaging Het
Zfp808 A G 13: 62,320,982 (GRCm39) H737R probably benign Het
Zswim4 T C 8: 84,940,714 (GRCm39) N795S probably benign Het
Other mutations in Or7g18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00932:Or7g18 APN 9 18,787,310 (GRCm39) nonsense probably null
IGL00954:Or7g18 APN 9 18,787,369 (GRCm39) missense probably benign 0.15
IGL01090:Or7g18 APN 9 18,787,538 (GRCm39) missense probably benign 0.00
IGL01613:Or7g18 APN 9 18,786,617 (GRCm39) splice site probably benign
IGL01987:Or7g18 APN 9 18,787,003 (GRCm39) missense probably benign 0.00
IGL03018:Or7g18 APN 9 18,787,523 (GRCm39) missense probably benign 0.15
IGL03037:Or7g18 APN 9 18,786,668 (GRCm39) missense probably damaging 0.98
R0284:Or7g18 UTSW 9 18,786,848 (GRCm39) missense probably benign
R1322:Or7g18 UTSW 9 18,786,817 (GRCm39) missense possibly damaging 0.90
R1715:Or7g18 UTSW 9 18,787,090 (GRCm39) missense probably benign 0.06
R1803:Or7g18 UTSW 9 18,787,376 (GRCm39) missense probably damaging 1.00
R4360:Or7g18 UTSW 9 18,787,013 (GRCm39) missense probably damaging 1.00
R4394:Or7g18 UTSW 9 18,786,907 (GRCm39) missense probably damaging 0.98
R4642:Or7g18 UTSW 9 18,787,463 (GRCm39) missense probably damaging 1.00
R4796:Or7g18 UTSW 9 18,787,475 (GRCm39) missense probably damaging 0.96
R4814:Or7g18 UTSW 9 18,787,213 (GRCm39) missense probably benign 0.30
R5210:Or7g18 UTSW 9 18,787,103 (GRCm39) missense probably damaging 1.00
R5375:Or7g18 UTSW 9 18,787,442 (GRCm39) missense probably benign 0.08
R6072:Or7g18 UTSW 9 18,786,718 (GRCm39) missense probably benign
R6361:Or7g18 UTSW 9 18,787,027 (GRCm39) missense probably damaging 1.00
R6602:Or7g18 UTSW 9 18,787,145 (GRCm39) missense possibly damaging 0.81
R7730:Or7g18 UTSW 9 18,786,709 (GRCm39) missense probably benign 0.00
R7780:Or7g18 UTSW 9 18,786,910 (GRCm39) missense possibly damaging 0.65
R8245:Or7g18 UTSW 9 18,787,126 (GRCm39) missense probably benign
R8274:Or7g18 UTSW 9 18,786,795 (GRCm39) missense probably benign 0.36
R8920:Or7g18 UTSW 9 18,787,394 (GRCm39) missense probably damaging 1.00
R9564:Or7g18 UTSW 9 18,786,640 (GRCm39) missense probably benign 0.00
X0026:Or7g18 UTSW 9 18,786,931 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATGGAAGTTGAAAACAAATCAGTT -3'
(R):5'- CTGGGGTTCATAAGGACTGTGTA -3'

Sequencing Primer
(F):5'- GCTGCAGCCATTCATCTT -3'
(R):5'- TGTAGCGATCATAAGCCATTACTCC -3'
Posted On 2018-11-06