Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 8
missense 2070
nonsense 370
start codon destroyed 19
start gained 2
synonymous 0
splice acceptor site 17
splice donor site 29
critical splice acceptor site 40
critical splice donor site 223
splice site 106
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 18
intragenic 0
intron 44
utr 3 prime 5
utr 5 prime 4
Total: 2959
Incidental Mutation Types
Mutation TypeNumber*
makesense 1062
missense 376906
nonsense 19011
start codon destroyed 1477
start gained 994
synonymous 262
splice acceptor site 0
splice donor site 0
critical splice acceptor site 2384
critical splice donor site 10581
splice site 20530
large deletion 0
large insertion 0
rearrangement 0
small deletion 708
small insertion 704
exon 2010
frame shift 1412
intragenic 0
intron 6378
utr 3 prime 1348
utr 5 prime 764
unclassified 11114
Total: 457645
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 66
A ⇒ G 555
A ⇒ T 404
C ⇒ A 135
C ⇒ G 14
C ⇒ T 239
G ⇒ A 238
G ⇒ C 8
G ⇒ T 155
T ⇒ A 491
T ⇒ C 586
T ⇒ G 72
Total: 2963
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 11278
A ⇒ G 93975
A ⇒ T 61519
C ⇒ A 20509
C ⇒ G 2073
C ⇒ T 36893
G ⇒ A 36486
G ⇒ C 2080
G ⇒ T 20084
T ⇒ A 62366
T ⇒ C 94802
T ⇒ G 11391
Total: 453456
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 5
Alanine Glutamic Acid 4
Alanine Glycine 1
Alanine Proline 2
Alanine Serine 5
Alanine Threonine 6
Alanine Valine 15
Arginine Cysteine 19
Arginine Glutamine 13
Arginine Glycine 12
Arginine Histidine 22
Arginine Isoleucine 0
Arginine Leucine 18
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 2
Arginine Serine 8
Arginine Threonine 0
Arginine Tryptophan 8
Arginine Stop codon 52
Asparagine Aspartic acid 12
Asparagine Histidine 0
Asparagine Isoleucine 15
Asparagine Lysine 39
Asparagine Serine 27
Asparagine Threonine 3
Asparagine Tyrosine 12
Aspartic acid Alanine 8
Aspartic acid Asparagine 5
Aspartic acid Glutamic Acid 33
Aspartic acid Glycine 93
Aspartic acid Histidine 1
Aspartic acid Tyrosine 4
Aspartic acid Valine 23
Cysteine Arginine 28
Cysteine Glycine 5
Cysteine Phenylalanine 15
Cysteine Serine 26
Cysteine Tryptophan 2
Cysteine Tyrosine 15
Cysteine Stop codon 43
Glutamic Acid Alanine 1
Glutamic Acid Aspartic acid 3
Glutamic Acid Glutamine 1
Glutamic Acid Glycine 68
Glutamic Acid Lysine 6
Glutamic Acid Valine 6
Glutamic Acid Stop codon 27
Glutamine Arginine 5
Glutamine Glutamic Acid 0
Glutamine Histidine 5
Glutamine Leucine 13
Glutamine Lysine 12
Glutamine Proline 3
Glutamine Stop codon 67
Glycine Alanine 1
Glycine Arginine 7
Glycine Aspartic acid 12
Glycine Cysteine 3
Glycine Glutamic Acid 3
Glycine Serine 8
Glycine Tryptophan 3
Glycine Valine 6
Glycine Stop codon 7
Histidine Arginine 28
Histidine Asparagine 11
Histidine Aspartic acid 2
Histidine Glutamine 20
Histidine Leucine 17
Histidine Proline 5
Histidine Tyrosine 3
Isoleucine Arginine 0
Isoleucine Asparagine 54
Isoleucine Leucine 9
Isoleucine Lysine 12
Isoleucine Methionine 3
Isoleucine Phenylalanine 30
Isoleucine Serine 3
Isoleucine Threonine 49
Isoleucine Valine 22
Leucine Arginine 13
Leucine Glutamine 25
Leucine Histidine 7
Leucine Isoleucine 2
Leucine Methionine 5
Leucine Phenylalanine 9
Leucine Proline 71
Leucine Serine 12
Leucine Tryptophan 0
Leucine Valine 4
Leucine Stop codon 27
Lysine Arginine 6
Lysine Asparagine 6
Lysine Glutamic Acid 20
Lysine Glutamine 2
Lysine Isoleucine 0
Lysine Methionine 4
Lysine Threonine 1
Lysine Stop codon 42
Methionine Arginine 5
Methionine Isoleucine 6
Methionine Leucine 18
Methionine Lysine 43
Methionine Threonine 12
Methionine Valine 17
Phenylalanine Cysteine 1
Phenylalanine Isoleucine 13
Phenylalanine Leucine 37
Phenylalanine Serine 30
Phenylalanine Tyrosine 2
Phenylalanine Valine 5
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 2
Proline Histidine 0
Proline Leucine 10
Proline Serine 8
Proline Threonine 6
Serine Alanine 4
Serine Arginine 11
Serine Asparagine 7
Serine Cysteine 7
Serine Glycine 17
Serine Isoleucine 1
Serine Leucine 5
Serine Phenylalanine 3
Serine Proline 91
Serine Threonine 20
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 10
Threonine Alanine 50
Threonine Arginine 0
Threonine Asparagine 2
Threonine Isoleucine 34
Threonine Lysine 16
Threonine Methionine 13
Threonine Proline 5
Threonine Serine 20
Tryptophan Arginine 33
Tryptophan Cysteine 1
Tryptophan Glycine 1
Tryptophan Leucine 4
Tryptophan Serine 0
Tryptophan Stop codon 10
Tyrosine Asparagine 9
Tyrosine Aspartic acid 3
Tyrosine Cysteine 65
Tyrosine Histidine 49
Tyrosine Phenylalanine 11
Tyrosine Serine 2
Tyrosine Stop codon 82
Valine Alanine 108
Valine Aspartic acid 24
Valine Glutamic Acid 50
Valine Glycine 8
Valine Isoleucine 22
Valine Leucine 11
Valine Methionine 18
Valine Phenylalanine 10
Stop codon Arginine 1
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 3
Stop codon Glycine 1
Stop codon Leucine 1
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 2
Stop codon Tyrosine 0
2454 changes of 151 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 599
Alanine Glutamic Acid 1208
Alanine Glycine 170
Alanine Proline 233
Alanine Serine 1996
Alanine Threonine 3213
Alanine Valine 3093
Arginine Cysteine 2653
Arginine Glutamine 2601
Arginine Glycine 2600
Arginine Histidine 3125
Arginine Isoleucine 92
Arginine Leucine 2517
Arginine Lysine 400
Arginine Methionine 103
Arginine Proline 192
Arginine Serine 2046
Arginine Threonine 34
Arginine Tryptophan 1886
Arginine Stop codon 2487
Asparagine Aspartic acid 2696
Asparagine Histidine 200
Asparagine Isoleucine 2349
Asparagine Lysine 6106
Asparagine Serine 7223
Asparagine Threonine 537
Asparagine Tyrosine 1303
Aspartic acid Alanine 1379
Aspartic acid Asparagine 1908
Aspartic acid Glutamic Acid 8098
Aspartic acid Glycine 16625
Aspartic acid Histidine 126
Aspartic acid Tyrosine 781
Aspartic acid Valine 4945
Cysteine Arginine 2065
Cysteine Glycine 415
Cysteine Phenylalanine 1330
Cysteine Serine 3405
Cysteine Tryptophan 249
Cysteine Tyrosine 1928
Cysteine Stop codon 2354
Glutamic Acid Alanine 606
Glutamic Acid Aspartic acid 1893
Glutamic Acid Glutamine 153
Glutamic Acid Glycine 11522
Glutamic Acid Lysine 2622
Glutamic Acid Valine 1663
Glutamic Acid Stop codon 1272
Glutamine Arginine 1690
Glutamine Glutamic Acid 113
Glutamine Histidine 601
Glutamine Leucine 2956
Glutamine Lysine 2148
Glutamine Proline 479
Glutamine Stop codon 2988
Glycine Alanine 163
Glycine Arginine 1412
Glycine Aspartic acid 2106
Glycine Cysteine 677
Glycine Glutamic Acid 701
Glycine Serine 1193
Glycine Tryptophan 473
Glycine Valine 854
Glycine Stop codon 370
Histidine Arginine 3702
Histidine Asparagine 1040
Histidine Aspartic acid 65
Histidine Glutamine 3628
Histidine Leucine 3621
Histidine Proline 401
Histidine Tyrosine 1303
Isoleucine Arginine 224
Isoleucine Asparagine 6394
Isoleucine Leucine 2406
Isoleucine Lysine 1528
Isoleucine Methionine 1451
Isoleucine Phenylalanine 6890
Isoleucine Serine 905
Isoleucine Threonine 8737
Isoleucine Valine 7599
Leucine Arginine 1309
Leucine Glutamine 3706
Leucine Histidine 1061
Leucine Isoleucine 675
Leucine Methionine 490
Leucine Phenylalanine 2289
Leucine Proline 7952
Leucine Serine 988
Leucine Tryptophan 99
Leucine Valine 428
Leucine Stop codon 1548
Lysine Arginine 2631
Lysine Asparagine 1984
Lysine Glutamic Acid 4217
Lysine Glutamine 314
Lysine Isoleucine 233
Lysine Methionine 528
Lysine Threonine 420
Lysine Stop codon 1955
Methionine Arginine 706
Methionine Isoleucine 1804
Methionine Leucine 3701
Methionine Lysine 6222
Methionine Threonine 2473
Methionine Valine 2736
Phenylalanine Cysteine 255
Phenylalanine Isoleucine 2268
Phenylalanine Leucine 6663
Phenylalanine Serine 3729
Phenylalanine Tyrosine 961
Phenylalanine Valine 647
Proline Alanine 170
Proline Arginine 165
Proline Glutamine 1065
Proline Histidine 198
Proline Leucine 2253
Proline Serine 2985
Proline Threonine 758
Serine Alanine 1483
Serine Arginine 2913
Serine Asparagine 1267
Serine Cysteine 1021
Serine Glycine 3060
Serine Isoleucine 432
Serine Leucine 1220
Serine Phenylalanine 804
Serine Proline 14423
Serine Threonine 4659
Serine Tryptophan 18
Serine Tyrosine 262
Serine Stop codon 666
Threonine Alanine 16435
Threonine Arginine 108
Threonine Asparagine 744
Threonine Isoleucine 6111
Threonine Lysine 2327
Threonine Methionine 2620
Threonine Proline 980
Threonine Serine 5145
Tryptophan Arginine 2433
Tryptophan Cysteine 145
Tryptophan Glycine 172
Tryptophan Leucine 424
Tryptophan Serine 32
Tryptophan Stop codon 839
Tyrosine Asparagine 2495
Tyrosine Aspartic acid 349
Tyrosine Cysteine 8285
Tyrosine Histidine 6369
Tyrosine Phenylalanine 2927
Tyrosine Serine 367
Tyrosine Stop codon 4428
Valine Alanine 19920
Valine Aspartic acid 3100
Valine Glutamic Acid 5174
Valine Glycine 1784
Valine Isoleucine 5503
Valine Leucine 2187
Valine Methionine 3799
Valine Phenylalanine 1455
Stop codon Arginine 223
Stop codon Cysteine 66
Stop codon Glutamic Acid 19
Stop codon Glutamine 215
Stop codon Glycine 34
Stop codon Leucine 51
Stop codon Lysine 71
Stop codon Serine 6
Stop codon Tryptophan 308
Stop codon Tyrosine 19
398302 changes of 170 types
We have now tabulated 400756 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.