Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 4
missense 1519
nonsense 313
start codon destroyed 14
start gained 1
synonymous 0
splice acceptor site 17
splice donor site 29
critical splice acceptor site 34
critical splice donor site 179
splice site 69
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 15
intragenic 0
intron 32
utr 3 prime 3
utr 5 prime 3
Total: 2236
Incidental Mutation Types
Mutation TypeNumber*
makesense 1018
missense 359189
nonsense 18075
start codon destroyed 1405
start gained 838
synonymous 243
splice acceptor site 0
splice donor site 0
critical splice acceptor site 2274
critical splice donor site 10106
splice site 20295
large deletion 0
large insertion 0
rearrangement 0
small deletion 645
small insertion 674
exon 2010
frame shift 1337
intragenic 0
intron 6163
utr 3 prime 1329
utr 5 prime 752
unclassified 10991
Total: 437344
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 47
A ⇒ G 419
A ⇒ T 306
C ⇒ A 109
C ⇒ G 12
C ⇒ T 186
G ⇒ A 185
G ⇒ C 5
G ⇒ T 111
T ⇒ A 374
T ⇒ C 419
T ⇒ G 60
Total: 2233
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 10761
A ⇒ G 90002
A ⇒ T 58488
C ⇒ A 19591
C ⇒ G 1985
C ⇒ T 35383
G ⇒ A 34928
G ⇒ C 1960
G ⇒ T 19217
T ⇒ A 59420
T ⇒ C 90838
T ⇒ G 10867
Total: 433440
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 5
Alanine Glutamic Acid 3
Alanine Glycine 1
Alanine Proline 1
Alanine Serine 4
Alanine Threonine 4
Alanine Valine 11
Arginine Cysteine 14
Arginine Glutamine 11
Arginine Glycine 11
Arginine Histidine 15
Arginine Isoleucine 0
Arginine Leucine 11
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 2
Arginine Serine 7
Arginine Threonine 0
Arginine Tryptophan 5
Arginine Stop codon 40
Asparagine Aspartic acid 11
Asparagine Histidine 0
Asparagine Isoleucine 11
Asparagine Lysine 26
Asparagine Serine 19
Asparagine Threonine 2
Asparagine Tyrosine 7
Aspartic acid Alanine 5
Aspartic acid Asparagine 4
Aspartic acid Glutamic Acid 27
Aspartic acid Glycine 62
Aspartic acid Histidine 1
Aspartic acid Tyrosine 3
Aspartic acid Valine 18
Cysteine Arginine 24
Cysteine Glycine 5
Cysteine Phenylalanine 13
Cysteine Serine 20
Cysteine Tryptophan 2
Cysteine Tyrosine 12
Cysteine Stop codon 37
Glutamic Acid Alanine 0
Glutamic Acid Aspartic acid 1
Glutamic Acid Glutamine 1
Glutamic Acid Glycine 50
Glutamic Acid Lysine 3
Glutamic Acid Valine 5
Glutamic Acid Stop codon 21
Glutamine Arginine 4
Glutamine Glutamic Acid 0
Glutamine Histidine 3
Glutamine Leucine 8
Glutamine Lysine 10
Glutamine Proline 3
Glutamine Stop codon 56
Glycine Alanine 1
Glycine Arginine 7
Glycine Aspartic acid 11
Glycine Cysteine 3
Glycine Glutamic Acid 3
Glycine Serine 4
Glycine Tryptophan 2
Glycine Valine 5
Glycine Stop codon 7
Histidine Arginine 19
Histidine Asparagine 9
Histidine Aspartic acid 2
Histidine Glutamine 16
Histidine Leucine 14
Histidine Proline 5
Histidine Tyrosine 1
Isoleucine Arginine 0
Isoleucine Asparagine 37
Isoleucine Leucine 6
Isoleucine Lysine 9
Isoleucine Methionine 1
Isoleucine Phenylalanine 19
Isoleucine Serine 1
Isoleucine Threonine 36
Isoleucine Valine 10
Leucine Arginine 10
Leucine Glutamine 22
Leucine Histidine 5
Leucine Isoleucine 1
Leucine Methionine 4
Leucine Phenylalanine 6
Leucine Proline 55
Leucine Serine 9
Leucine Tryptophan 0
Leucine Valine 2
Leucine Stop codon 24
Lysine Arginine 4
Lysine Asparagine 2
Lysine Glutamic Acid 16
Lysine Glutamine 2
Lysine Isoleucine 0
Lysine Methionine 3
Lysine Threonine 1
Lysine Stop codon 37
Methionine Arginine 3
Methionine Isoleucine 3
Methionine Leucine 10
Methionine Lysine 36
Methionine Threonine 10
Methionine Valine 14
Phenylalanine Cysteine 1
Phenylalanine Isoleucine 11
Phenylalanine Leucine 23
Phenylalanine Serine 26
Phenylalanine Tyrosine 1
Phenylalanine Valine 4
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 2
Proline Histidine 0
Proline Leucine 8
Proline Serine 7
Proline Threonine 5
Serine Alanine 3
Serine Arginine 7
Serine Asparagine 4
Serine Cysteine 5
Serine Glycine 13
Serine Isoleucine 0
Serine Leucine 2
Serine Phenylalanine 3
Serine Proline 72
Serine Threonine 14
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 6
Threonine Alanine 36
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 25
Threonine Lysine 9
Threonine Methionine 10
Threonine Proline 4
Threonine Serine 14
Tryptophan Arginine 24
Tryptophan Cysteine 1
Tryptophan Glycine 1
Tryptophan Leucine 2
Tryptophan Serine 0
Tryptophan Stop codon 10
Tyrosine Asparagine 4
Tyrosine Aspartic acid 2
Tyrosine Cysteine 52
Tyrosine Histidine 37
Tyrosine Phenylalanine 8
Tyrosine Serine 1
Tyrosine Stop codon 72
Valine Alanine 72
Valine Aspartic acid 20
Valine Glutamic Acid 35
Valine Glycine 7
Valine Isoleucine 13
Valine Leucine 6
Valine Methionine 16
Valine Phenylalanine 9
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 1
Stop codon Glycine 1
Stop codon Leucine 1
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 1
Stop codon Tyrosine 0
1840 changes of 148 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 562
Alanine Glutamic Acid 1165
Alanine Glycine 163
Alanine Proline 226
Alanine Serine 1910
Alanine Threonine 3065
Alanine Valine 2945
Arginine Cysteine 2541
Arginine Glutamine 2490
Arginine Glycine 2487
Arginine Histidine 2983
Arginine Isoleucine 88
Arginine Leucine 2396
Arginine Lysine 384
Arginine Methionine 101
Arginine Proline 190
Arginine Serine 1946
Arginine Threonine 31
Arginine Tryptophan 1803
Arginine Stop codon 2373
Asparagine Aspartic acid 2550
Asparagine Histidine 193
Asparagine Isoleucine 2227
Asparagine Lysine 5795
Asparagine Serine 6877
Asparagine Threonine 513
Asparagine Tyrosine 1236
Aspartic acid Alanine 1307
Aspartic acid Asparagine 1820
Aspartic acid Glutamic Acid 7665
Aspartic acid Glycine 15890
Aspartic acid Histidine 123
Aspartic acid Tyrosine 746
Aspartic acid Valine 4698
Cysteine Arginine 1958
Cysteine Glycine 396
Cysteine Phenylalanine 1266
Cysteine Serine 3216
Cysteine Tryptophan 234
Cysteine Tyrosine 1842
Cysteine Stop codon 2238
Glutamic Acid Alanine 573
Glutamic Acid Aspartic acid 1813
Glutamic Acid Glutamine 142
Glutamic Acid Glycine 11036
Glutamic Acid Lysine 2541
Glutamic Acid Valine 1570
Glutamic Acid Stop codon 1208
Glutamine Arginine 1598
Glutamine Glutamic Acid 104
Glutamine Histidine 573
Glutamine Leucine 2792
Glutamine Lysine 2041
Glutamine Proline 451
Glutamine Stop codon 2837
Glycine Alanine 156
Glycine Arginine 1349
Glycine Aspartic acid 1993
Glycine Cysteine 637
Glycine Glutamic Acid 678
Glycine Serine 1127
Glycine Tryptophan 444
Glycine Valine 821
Glycine Stop codon 356
Histidine Arginine 3527
Histidine Asparagine 1003
Histidine Aspartic acid 61
Histidine Glutamine 3440
Histidine Leucine 3441
Histidine Proline 382
Histidine Tyrosine 1239
Isoleucine Arginine 212
Isoleucine Asparagine 6073
Isoleucine Leucine 2299
Isoleucine Lysine 1439
Isoleucine Methionine 1393
Isoleucine Phenylalanine 6573
Isoleucine Serine 863
Isoleucine Threonine 8352
Isoleucine Valine 7290
Leucine Arginine 1242
Leucine Glutamine 3511
Leucine Histidine 1015
Leucine Isoleucine 648
Leucine Methionine 470
Leucine Phenylalanine 2192
Leucine Proline 7576
Leucine Serine 943
Leucine Tryptophan 93
Leucine Valine 412
Leucine Stop codon 1474
Lysine Arginine 2527
Lysine Asparagine 1898
Lysine Glutamic Acid 4033
Lysine Glutamine 297
Lysine Isoleucine 222
Lysine Methionine 510
Lysine Threonine 406
Lysine Stop codon 1860
Methionine Arginine 677
Methionine Isoleucine 1736
Methionine Leucine 3521
Methionine Lysine 5858
Methionine Threonine 2358
Methionine Valine 2620
Phenylalanine Cysteine 245
Phenylalanine Isoleucine 2157
Phenylalanine Leucine 6349
Phenylalanine Serine 3562
Phenylalanine Tyrosine 919
Phenylalanine Valine 619
Proline Alanine 164
Proline Arginine 156
Proline Glutamine 1005
Proline Histidine 192
Proline Leucine 2159
Proline Serine 2856
Proline Threonine 721
Serine Alanine 1411
Serine Arginine 2769
Serine Asparagine 1208
Serine Cysteine 967
Serine Glycine 2908
Serine Isoleucine 409
Serine Leucine 1161
Serine Phenylalanine 774
Serine Proline 13783
Serine Threonine 4435
Serine Tryptophan 17
Serine Tyrosine 256
Serine Stop codon 635
Threonine Alanine 15623
Threonine Arginine 98
Threonine Asparagine 715
Threonine Isoleucine 5826
Threonine Lysine 2222
Threonine Methionine 2500
Threonine Proline 925
Threonine Serine 4863
Tryptophan Arginine 2311
Tryptophan Cysteine 138
Tryptophan Glycine 159
Tryptophan Leucine 398
Tryptophan Serine 28
Tryptophan Stop codon 799
Tyrosine Asparagine 2347
Tyrosine Aspartic acid 338
Tyrosine Cysteine 7940
Tyrosine Histidine 6068
Tyrosine Phenylalanine 2782
Tyrosine Serine 351
Tyrosine Stop codon 4191
Valine Alanine 19031
Valine Aspartic acid 2947
Valine Glutamic Acid 4905
Valine Glycine 1690
Valine Isoleucine 5248
Valine Leucine 2078
Valine Methionine 3646
Valine Phenylalanine 1396
Stop codon Arginine 209
Stop codon Cysteine 63
Stop codon Glutamic Acid 18
Stop codon Glutamine 205
Stop codon Glycine 34
Stop codon Leucine 51
Stop codon Lysine 68
Stop codon Serine 6
Stop codon Tryptophan 298
Stop codon Tyrosine 19
379536 changes of 170 types
We have now tabulated 381376 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.