Mutation Statistics

*Note: the numbers of strains with the indicated mutation types, DNA base changes,
or amino acid changes include some strains not shown on the Mutations lists.


Institution
Phenotypic Mutation Types
Mutation TypeNumber*
makesense 6
missense 1826
nonsense 334
start codon destroyed 15
start gained 1
synonymous 0
splice acceptor site 17
splice donor site 29
critical splice acceptor site 37
critical splice donor site 199
splice site 85
large deletion 2
large insertion 0
rearrangement 0
small deletion 2
small insertion 0
exon 0
frame shift 16
intragenic 0
intron 42
utr 3 prime 4
utr 5 prime 4
Total: 2619
Incidental Mutation Types
Mutation TypeNumber*
makesense 1050
missense 371656
nonsense 18740
start codon destroyed 1460
start gained 945
synonymous 249
splice acceptor site 0
splice donor site 0
critical splice acceptor site 2347
critical splice donor site 10445
splice site 20380
large deletion 0
large insertion 0
rearrangement 0
small deletion 699
small insertion 695
exon 2010
frame shift 1395
intragenic 0
intron 6252
utr 3 prime 1343
utr 5 prime 756
unclassified 11084
Total: 451506
Phenotypic Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 55
A ⇒ G 497
A ⇒ T 360
C ⇒ A 122
C ⇒ G 13
C ⇒ T 210
G ⇒ A 217
G ⇒ C 8
G ⇒ T 127
T ⇒ A 435
T ⇒ C 510
T ⇒ G 66
Total: 2620
Incidental Mutation
DNA Base Changes (assembly)
DNA Base ChangeNumber*
A ⇒ C 11115
A ⇒ G 92781
A ⇒ T 60600
C ⇒ A 20229
C ⇒ G 2042
C ⇒ T 36442
G ⇒ A 36012
G ⇒ C 2045
G ⇒ T 19803
T ⇒ A 61443
T ⇒ C 93617
T ⇒ G 11234
Total: 447363
Phenotypic Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 5
Alanine Glutamic Acid 3
Alanine Glycine 1
Alanine Proline 2
Alanine Serine 4
Alanine Threonine 4
Alanine Valine 14
Arginine Cysteine 16
Arginine Glutamine 13
Arginine Glycine 12
Arginine Histidine 17
Arginine Isoleucine 0
Arginine Leucine 17
Arginine Lysine 1
Arginine Methionine 0
Arginine Proline 2
Arginine Serine 8
Arginine Threonine 0
Arginine Tryptophan 5
Arginine Stop codon 46
Asparagine Aspartic acid 12
Asparagine Histidine 0
Asparagine Isoleucine 12
Asparagine Lysine 34
Asparagine Serine 24
Asparagine Threonine 2
Asparagine Tyrosine 10
Aspartic acid Alanine 7
Aspartic acid Asparagine 5
Aspartic acid Glutamic Acid 30
Aspartic acid Glycine 82
Aspartic acid Histidine 1
Aspartic acid Tyrosine 4
Aspartic acid Valine 21
Cysteine Arginine 28
Cysteine Glycine 5
Cysteine Phenylalanine 13
Cysteine Serine 25
Cysteine Tryptophan 2
Cysteine Tyrosine 14
Cysteine Stop codon 41
Glutamic Acid Alanine 1
Glutamic Acid Aspartic acid 2
Glutamic Acid Glutamine 1
Glutamic Acid Glycine 57
Glutamic Acid Lysine 6
Glutamic Acid Valine 6
Glutamic Acid Stop codon 21
Glutamine Arginine 5
Glutamine Glutamic Acid 0
Glutamine Histidine 5
Glutamine Leucine 13
Glutamine Lysine 12
Glutamine Proline 3
Glutamine Stop codon 59
Glycine Alanine 1
Glycine Arginine 7
Glycine Aspartic acid 11
Glycine Cysteine 3
Glycine Glutamic Acid 3
Glycine Serine 5
Glycine Tryptophan 3
Glycine Valine 4
Glycine Stop codon 7
Histidine Arginine 24
Histidine Asparagine 11
Histidine Aspartic acid 2
Histidine Glutamine 18
Histidine Leucine 14
Histidine Proline 5
Histidine Tyrosine 2
Isoleucine Arginine 0
Isoleucine Asparagine 49
Isoleucine Leucine 8
Isoleucine Lysine 10
Isoleucine Methionine 2
Isoleucine Phenylalanine 26
Isoleucine Serine 2
Isoleucine Threonine 43
Isoleucine Valine 17
Leucine Arginine 11
Leucine Glutamine 24
Leucine Histidine 6
Leucine Isoleucine 1
Leucine Methionine 5
Leucine Phenylalanine 6
Leucine Proline 64
Leucine Serine 10
Leucine Tryptophan 0
Leucine Valine 3
Leucine Stop codon 27
Lysine Arginine 5
Lysine Asparagine 5
Lysine Glutamic Acid 17
Lysine Glutamine 2
Lysine Isoleucine 0
Lysine Methionine 3
Lysine Threonine 1
Lysine Stop codon 38
Methionine Arginine 3
Methionine Isoleucine 4
Methionine Leucine 16
Methionine Lysine 38
Methionine Threonine 12
Methionine Valine 14
Phenylalanine Cysteine 1
Phenylalanine Isoleucine 13
Phenylalanine Leucine 29
Phenylalanine Serine 29
Phenylalanine Tyrosine 2
Phenylalanine Valine 4
Proline Alanine 0
Proline Arginine 0
Proline Glutamine 2
Proline Histidine 0
Proline Leucine 10
Proline Serine 7
Proline Threonine 5
Serine Alanine 4
Serine Arginine 11
Serine Asparagine 7
Serine Cysteine 6
Serine Glycine 14
Serine Isoleucine 1
Serine Leucine 2
Serine Phenylalanine 3
Serine Proline 87
Serine Threonine 18
Serine Tryptophan 0
Serine Tyrosine 1
Serine Stop codon 6
Threonine Alanine 42
Threonine Arginine 0
Threonine Asparagine 1
Threonine Isoleucine 32
Threonine Lysine 10
Threonine Methionine 12
Threonine Proline 4
Threonine Serine 18
Tryptophan Arginine 30
Tryptophan Cysteine 1
Tryptophan Glycine 1
Tryptophan Leucine 2
Tryptophan Serine 0
Tryptophan Stop codon 10
Tyrosine Asparagine 7
Tyrosine Aspartic acid 2
Tyrosine Cysteine 60
Tyrosine Histidine 44
Tyrosine Phenylalanine 8
Tyrosine Serine 1
Tyrosine Stop codon 76
Valine Alanine 93
Valine Aspartic acid 21
Valine Glutamic Acid 43
Valine Glycine 7
Valine Isoleucine 19
Valine Leucine 7
Valine Methionine 16
Valine Phenylalanine 10
Stop codon Arginine 0
Stop codon Cysteine 0
Stop codon Glutamic Acid 0
Stop codon Glutamine 2
Stop codon Glycine 1
Stop codon Leucine 1
Stop codon Lysine 0
Stop codon Serine 0
Stop codon Tryptophan 2
Stop codon Tyrosine 0
2170 changes of 150 types
Incidental Mutation
Amino Acid Changes
Amino Acid Change 
From To Number*
Alanine Aspartic acid 588
Alanine Glutamic Acid 1194
Alanine Glycine 166
Alanine Proline 230
Alanine Serine 1980
Alanine Threonine 3163
Alanine Valine 3051
Arginine Cysteine 2624
Arginine Glutamine 2570
Arginine Glycine 2569
Arginine Histidine 3082
Arginine Isoleucine 91
Arginine Leucine 2479
Arginine Lysine 392
Arginine Methionine 103
Arginine Proline 193
Arginine Serine 2005
Arginine Threonine 32
Arginine Tryptophan 1860
Arginine Stop codon 2464
Asparagine Aspartic acid 2647
Asparagine Histidine 198
Asparagine Isoleucine 2308
Asparagine Lysine 6016
Asparagine Serine 7133
Asparagine Threonine 532
Asparagine Tyrosine 1287
Aspartic acid Alanine 1358
Aspartic acid Asparagine 1884
Aspartic acid Glutamic Acid 7974
Aspartic acid Glycine 16392
Aspartic acid Histidine 125
Aspartic acid Tyrosine 774
Aspartic acid Valine 4881
Cysteine Arginine 2031
Cysteine Glycine 408
Cysteine Phenylalanine 1314
Cysteine Serine 3345
Cysteine Tryptophan 245
Cysteine Tyrosine 1904
Cysteine Stop codon 2330
Glutamic Acid Alanine 597
Glutamic Acid Aspartic acid 1876
Glutamic Acid Glutamine 153
Glutamic Acid Glycine 11385
Glutamic Acid Lysine 2597
Glutamic Acid Valine 1627
Glutamic Acid Stop codon 1253
Glutamine Arginine 1663
Glutamine Glutamic Acid 108
Glutamine Histidine 590
Glutamine Leucine 2907
Glutamine Lysine 2115
Glutamine Proline 471
Glutamine Stop codon 2947
Glycine Alanine 161
Glycine Arginine 1391
Glycine Aspartic acid 2076
Glycine Cysteine 666
Glycine Glutamic Acid 694
Glycine Serine 1163
Glycine Tryptophan 463
Glycine Valine 844
Glycine Stop codon 367
Histidine Arginine 3660
Histidine Asparagine 1030
Histidine Aspartic acid 64
Histidine Glutamine 3575
Histidine Leucine 3571
Histidine Proline 398
Histidine Tyrosine 1289
Isoleucine Arginine 222
Isoleucine Asparagine 6298
Isoleucine Leucine 2371
Isoleucine Lysine 1503
Isoleucine Methionine 1439
Isoleucine Phenylalanine 6799
Isoleucine Serine 896
Isoleucine Threonine 8617
Isoleucine Valine 7505
Leucine Arginine 1291
Leucine Glutamine 3650
Leucine Histidine 1043
Leucine Isoleucine 664
Leucine Methionine 485
Leucine Phenylalanine 2259
Leucine Proline 7843
Leucine Serine 972
Leucine Tryptophan 99
Leucine Valine 422
Leucine Stop codon 1520
Lysine Arginine 2599
Lysine Asparagine 1964
Lysine Glutamic Acid 4162
Lysine Glutamine 311
Lysine Isoleucine 229
Lysine Methionine 521
Lysine Threonine 414
Lysine Stop codon 1930
Methionine Arginine 697
Methionine Isoleucine 1784
Methionine Leucine 3649
Methionine Lysine 6135
Methionine Threonine 2439
Methionine Valine 2704
Phenylalanine Cysteine 251
Phenylalanine Isoleucine 2233
Phenylalanine Leucine 6574
Phenylalanine Serine 3678
Phenylalanine Tyrosine 950
Phenylalanine Valine 639
Proline Alanine 166
Proline Arginine 162
Proline Glutamine 1042
Proline Histidine 197
Proline Leucine 2236
Proline Serine 2950
Proline Threonine 745
Serine Alanine 1455
Serine Arginine 2876
Serine Asparagine 1249
Serine Cysteine 1004
Serine Glycine 3014
Serine Isoleucine 426
Serine Leucine 1200
Serine Phenylalanine 790
Serine Proline 14245
Serine Threonine 4592
Serine Tryptophan 18
Serine Tyrosine 260
Serine Stop codon 651
Threonine Alanine 16185
Threonine Arginine 101
Threonine Asparagine 736
Threonine Isoleucine 6027
Threonine Lysine 2288
Threonine Methionine 2589
Threonine Proline 957
Threonine Serine 5068
Tryptophan Arginine 2388
Tryptophan Cysteine 143
Tryptophan Glycine 166
Tryptophan Leucine 418
Tryptophan Serine 29
Tryptophan Stop codon 823
Tyrosine Asparagine 2449
Tyrosine Aspartic acid 346
Tyrosine Cysteine 8175
Tyrosine Histidine 6285
Tyrosine Phenylalanine 2886
Tyrosine Serine 361
Tyrosine Stop codon 4350
Valine Alanine 19652
Valine Aspartic acid 3054
Valine Glutamic Acid 5084
Valine Glycine 1760
Valine Isoleucine 5413
Valine Leucine 2153
Valine Methionine 3764
Valine Phenylalanine 1439
Stop codon Arginine 219
Stop codon Cysteine 66
Stop codon Glutamic Acid 18
Stop codon Glutamine 211
Stop codon Glycine 34
Stop codon Leucine 51
Stop codon Lysine 71
Stop codon Serine 6
Stop codon Tryptophan 306
Stop codon Tyrosine 19
392752 changes of 170 types
We have now tabulated 394922 coding changes induced by ENU.
Of 170 possible types of coding change that can be caused by single nucleotide substitutions,
ENU has so far been observed to cause 170 types of coding change.