Mutagenetix > Incidental Mutation

Incidental Mutation 'R5615:Vmn2r114'

501164

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r114

Ensembl Gene

ENSMUSG00000091945

Gene Name

vomeronasal 2, receptor 114

Synonyms

EG666002

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.131) question?

Stock #

R5615 (G1)

Quality Score

144

Status

Not validated

Chromosome

Chromosomal Location

23509908-23531287 bp(-) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

ATTT to ATT at 23509906 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000127505 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168033]

AlphaFold

E9Q281

Predicted Effect

probably null
Transcript: ENSMUST00000168033

SMART Domains

Protein: ENSMUSP00000127505
Gene: ENSMUSG00000091945

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	154	470	1.5e-24	PFAM
Pfam:NCD3G	511	564	1.5e-18	PFAM
Pfam:7tm_3	597	832	1.4e-55	PFAM

Coding Region Coverage

1x: 99.8%
3x: 99.5%
10x: 97.6%
20x: 92.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	A	T	1: 71,346,218 (GRCm39)	L884H	probably damaging	Het
Ahr	A	G	12: 35,553,884 (GRCm39)	V745A	probably benign	Het
Ankrd17	A	T	5: 90,431,295 (GRCm39)	S830T	possibly damaging	Het
Aox1	A	G	1: 58,136,125 (GRCm39)	T1123A	probably benign	Het
Arhgef11	T	C	3: 87,629,792 (GRCm39)		probably null	Het
Bcas3	T	A	11: 85,361,587 (GRCm39)	C250S	probably damaging	Het
Bckdk	T	C	7: 127,506,489 (GRCm39)	I272T	probably damaging	Het
Cacna1e	T	C	1: 154,287,916 (GRCm39)	K1897E	probably damaging	Het
Cd180	A	T	13: 102,842,711 (GRCm39)	I586F	probably benign	Het
Cep290	A	G	10: 100,367,012 (GRCm39)	D1121G	probably damaging	Het
Clasrp	A	G	7: 19,320,372 (GRCm39)		probably benign	Het
Col27a1	G	T	4: 63,199,351 (GRCm39)	K912N	probably damaging	Het
Dock4	G	T	12: 40,699,479 (GRCm39)	R231L	probably benign	Het
Ell	G	A	8: 71,043,382 (GRCm39)	S505N	probably benign	Het
Ephb6	A	G	6: 41,596,225 (GRCm39)	T833A	probably benign	Het
Hemk1	T	A	9: 107,208,023 (GRCm39)		probably null	Het
Hjurp	GT	GTT	1: 88,194,246 (GRCm39)		probably null	Het
Hspa12a	T	C	19: 58,793,082 (GRCm39)	I368V	possibly damaging	Het
Igkv3-3	A	T	6: 70,664,214 (GRCm39)	T19S	probably benign	Het
Itpr1	G	A	6: 108,465,561 (GRCm39)	A2158T	possibly damaging	Het
Lancl2	T	C	6: 57,699,496 (GRCm39)	Y104H	probably damaging	Het
Leng8	G	T	7: 4,147,957 (GRCm39)	E634*	probably null	Het
Lrrk1	A	T	7: 65,937,363 (GRCm39)	C930S	probably damaging	Het
Lvrn	C	T	18: 46,983,395 (GRCm39)	S46L	possibly damaging	Het
Mcidas	G	A	13: 113,133,959 (GRCm39)	V148I	probably benign	Het
Mprip	A	T	11: 59,649,313 (GRCm39)	T1006S	probably benign	Het
Mrgprb3	T	A	7: 48,293,234 (GRCm39)	M106L	probably benign	Het
Mroh2a	GCCC	GC	1: 88,159,979 (GRCm39)		probably null	Het
Mtor	G	A	4: 148,622,733 (GRCm39)	V1938I	possibly damaging	Het
Muc2	A	G	7: 141,277,446 (GRCm39)	D46G	probably damaging	Het
Nfkb2	G	T	19: 46,296,006 (GRCm39)	E170D	probably benign	Het
Or10ag52	T	A	2: 87,044,083 (GRCm39)	F282L	probably benign	Het
Or6c215	A	T	10: 129,637,636 (GRCm39)	C253S	probably damaging	Het
Osbp2	C	T	11: 3,813,356 (GRCm39)	G171D	probably benign	Het
Otud6b	A	T	4: 14,818,187 (GRCm39)	M238K	possibly damaging	Het
Pcdhac2	G	A	18: 37,279,476 (GRCm39)	G819R	probably benign	Het
Pcdhac2	G	T	18: 37,279,477 (GRCm39)	G819V	probably benign	Het
Pcdhga12	T	G	18: 37,901,132 (GRCm39)	S655A	probably damaging	Het
Pkd1l3	A	G	8: 110,356,842 (GRCm39)	I756V	probably benign	Het
Plekhd1	T	A	12: 80,767,364 (GRCm39)	S251T	probably damaging	Het
Ppp2r1a	A	T	17: 21,179,249 (GRCm39)	T96S	probably benign	Het
Qser1	A	C	2: 104,620,039 (GRCm39)	S258A	possibly damaging	Het
Rsph4a	G	A	10: 33,785,324 (GRCm39)	A412T	probably benign	Het
Sanbr	A	T	11: 23,556,759 (GRCm39)	L407H	probably damaging	Het
Sass6	T	A	3: 116,401,135 (GRCm39)	C159S	probably benign	Het
Scaf4	T	C	16: 90,048,848 (GRCm39)	Q322R	unknown	Het
Sema6d	C	T	2: 124,498,821 (GRCm39)	H244Y	probably damaging	Het
Sigirr	T	G	7: 140,672,632 (GRCm39)	L163F	probably damaging	Het
Spata31d1c	C	A	13: 65,183,078 (GRCm39)	L207I	possibly damaging	Het
Tacstd2	A	G	6: 67,512,033 (GRCm39)	F220L	probably damaging	Het
Tdpoz4	A	T	3: 93,704,806 (GRCm39)	T368S	probably benign	Het
Tnxb	C	A	17: 34,902,392 (GRCm39)	Q1082K	probably damaging	Het
Trim41	GCCTAGGCGCCCA	G	11: 48,698,192 (GRCm39)		probably benign	Het
Trpm6	C	T	19: 18,807,297 (GRCm39)	R1014C	probably damaging	Het
Ugt1a10	TTCATCA	TTCA	1: 88,143,880 (GRCm39)		probably benign	Het
Vmn2r61	T	A	7: 41,916,677 (GRCm39)	M430K	probably benign	Het
Vmn2r61	A	G	7: 41,949,917 (GRCm39)	E779G	probably damaging	Het
Zfp599	T	C	9: 22,165,165 (GRCm39)	D70G	probably benign	Het
Zmym1	A	T	4: 126,943,191 (GRCm39)	I301N	probably damaging	Het

Other mutations in Vmn2r114

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Vmn2r114	APN	17	23,510,639 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r114	APN	17	23,510,212 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r114	APN	17	23,509,957 (GRCm39)	missense	probably benign	0.23
IGL00990:Vmn2r114	APN	17	23,509,939 (GRCm39)	missense	probably benign
IGL01838:Vmn2r114	APN	17	23,515,956 (GRCm39)	missense	probably benign	0.44
IGL01990:Vmn2r114	APN	17	23,529,355 (GRCm39)	missense	probably benign	0.22
IGL01994:Vmn2r114	APN	17	23,529,451 (GRCm39)	missense	probably damaging	1.00
IGL02153:Vmn2r114	APN	17	23,510,782 (GRCm39)	missense	probably benign	0.01
IGL02453:Vmn2r114	APN	17	23,530,108 (GRCm39)	missense	probably benign	0.00
IGL02621:Vmn2r114	APN	17	23,529,494 (GRCm39)	missense	probably damaging	0.98
IGL02938:Vmn2r114	APN	17	23,510,263 (GRCm39)	missense	probably benign	0.10
IGL03130:Vmn2r114	APN	17	23,515,970 (GRCm39)	splice site	probably benign
IGL03325:Vmn2r114	APN	17	23,510,652 (GRCm39)	missense	probably damaging	1.00
BB004:Vmn2r114	UTSW	17	23,510,619 (GRCm39)	missense	probably damaging	1.00
R0109:Vmn2r114	UTSW	17	23,529,549 (GRCm39)	nonsense	probably null
R0164:Vmn2r114	UTSW	17	23,528,800 (GRCm39)	critical splice donor site	probably null
R0310:Vmn2r114	UTSW	17	23,509,917 (GRCm39)	missense	probably benign	0.23
R0583:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R0677:Vmn2r114	UTSW	17	23,529,568 (GRCm39)	missense	probably damaging	1.00
R1127:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R1147:Vmn2r114	UTSW	17	23,530,037 (GRCm39)	missense	probably benign	0.00
R1147:Vmn2r114	UTSW	17	23,530,037 (GRCm39)	missense	probably benign	0.00
R1157:Vmn2r114	UTSW	17	23,529,314 (GRCm39)	missense	possibly damaging	0.60
R1323:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R1347:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R1435:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R1437:Vmn2r114	UTSW	17	23,510,185 (GRCm39)	missense	probably damaging	1.00
R1585:Vmn2r114	UTSW	17	23,510,675 (GRCm39)	missense	probably damaging	0.98
R1641:Vmn2r114	UTSW	17	23,515,962 (GRCm39)	missense	probably benign	0.00
R1748:Vmn2r114	UTSW	17	23,527,035 (GRCm39)	missense	probably benign	0.17
R1954:Vmn2r114	UTSW	17	23,530,086 (GRCm39)	missense	probably benign	0.32
R2081:Vmn2r114	UTSW	17	23,510,083 (GRCm39)	missense	possibly damaging	0.91
R2103:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R2113:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R2134:Vmn2r114	UTSW	17	23,510,737 (GRCm39)	missense	probably damaging	1.00
R2149:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R2424:Vmn2r114	UTSW	17	23,515,842 (GRCm39)	missense	possibly damaging	0.90
R2847:Vmn2r114	UTSW	17	23,509,948 (GRCm39)	missense	probably benign	0.00
R2848:Vmn2r114	UTSW	17	23,509,948 (GRCm39)	missense	probably benign	0.00
R2893:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R3017:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R3018:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R3019:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R3020:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R3021:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R4628:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R4668:Vmn2r114	UTSW	17	23,529,447 (GRCm39)	missense	possibly damaging	0.83
R4840:Vmn2r114	UTSW	17	23,510,353 (GRCm39)	missense	probably damaging	0.97
R4841:Vmn2r114	UTSW	17	23,529,336 (GRCm39)	missense	probably benign	0.04
R4842:Vmn2r114	UTSW	17	23,529,336 (GRCm39)	missense	probably benign	0.04
R4856:Vmn2r114	UTSW	17	23,527,008 (GRCm39)	missense	probably benign	0.11
R4886:Vmn2r114	UTSW	17	23,527,008 (GRCm39)	missense	probably benign	0.11
R4992:Vmn2r114	UTSW	17	23,510,765 (GRCm39)	missense	probably benign	0.03
R5182:Vmn2r114	UTSW	17	23,510,632 (GRCm39)	missense	probably damaging	0.96
R5223:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R5405:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R5449:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null
R5834:Vmn2r114	UTSW	17	23,529,599 (GRCm39)	missense	possibly damaging	0.90
R6150:Vmn2r114	UTSW	17	23,510,269 (GRCm39)	missense	probably benign	0.03
R6277:Vmn2r114	UTSW	17	23,509,954 (GRCm39)	missense	possibly damaging	0.93
R6403:Vmn2r114	UTSW	17	23,528,939 (GRCm39)	missense	probably damaging	0.99
R6589:Vmn2r114	UTSW	17	23,510,642 (GRCm39)	missense	probably damaging	1.00
R6613:Vmn2r114	UTSW	17	23,529,220 (GRCm39)	missense	possibly damaging	0.82
R6747:Vmn2r114	UTSW	17	23,528,850 (GRCm39)	missense	probably benign	0.00
R6837:Vmn2r114	UTSW	17	23,529,176 (GRCm39)	missense	probably benign	0.10
R6911:Vmn2r114	UTSW	17	23,510,104 (GRCm39)	missense	probably damaging	0.98
R6950:Vmn2r114	UTSW	17	23,529,137 (GRCm39)	missense	probably benign	0.03
R7276:Vmn2r114	UTSW	17	23,509,934 (GRCm39)	missense	probably damaging	0.97
R7482:Vmn2r114	UTSW	17	23,510,468 (GRCm39)	missense	probably damaging	1.00
R7514:Vmn2r114	UTSW	17	23,527,035 (GRCm39)	missense	probably null	0.96
R7523:Vmn2r114	UTSW	17	23,529,611 (GRCm39)	missense	probably benign	0.01
R7563:Vmn2r114	UTSW	17	23,510,000 (GRCm39)	missense	probably benign	0.01
R7585:Vmn2r114	UTSW	17	23,510,239 (GRCm39)	missense	probably damaging	1.00
R7593:Vmn2r114	UTSW	17	23,510,817 (GRCm39)	nonsense	probably null
R7611:Vmn2r114	UTSW	17	23,515,944 (GRCm39)	missense	probably damaging	0.97
R7641:Vmn2r114	UTSW	17	23,527,177 (GRCm39)	missense	possibly damaging	0.53
R7651:Vmn2r114	UTSW	17	23,509,986 (GRCm39)	nonsense	probably null
R7970:Vmn2r114	UTSW	17	23,530,186 (GRCm39)	missense	probably benign	0.00
R8737:Vmn2r114	UTSW	17	23,529,142 (GRCm39)	missense	probably benign	0.36
R8802:Vmn2r114	UTSW	17	23,528,836 (GRCm39)	missense	possibly damaging	0.65
R8847:Vmn2r114	UTSW	17	23,528,986 (GRCm39)	missense	probably damaging	1.00
R8991:Vmn2r114	UTSW	17	23,529,286 (GRCm39)	missense	probably damaging	1.00
R9138:Vmn2r114	UTSW	17	23,510,578 (GRCm39)	missense	probably damaging	1.00
R9173:Vmn2r114	UTSW	17	23,510,527 (GRCm39)	missense	probably damaging	0.99
R9175:Vmn2r114	UTSW	17	23,527,212 (GRCm39)	missense	probably damaging	1.00
R9657:Vmn2r114	UTSW	17	23,510,690 (GRCm39)	missense	probably damaging	1.00
R9670:Vmn2r114	UTSW	17	23,531,098 (GRCm39)	missense
X0065:Vmn2r114	UTSW	17	23,529,931 (GRCm39)	missense	probably benign	0.34
Z1088:Vmn2r114	UTSW	17	23,509,906 (GRCm39)	makesense	probably null

Predicted Primers

PCR Primer
(F):5'- CTCCCAGTGTAAAGATTTTGTCAC -3'
(R):5'- TTACCATAGCACCAAAGGCAGG -3'

Sequencing Primer
(F):5'- CAGGCCATGATTATATCTGCAGAGAC -3'
(R):5'- CACCAAAGGCAGGGTCATG -3'

Posted On

2017-12-01