Incidental Mutation 'R5615:Zfp599'
ID 438198
Institutional Source Beutler Lab
Gene Symbol Zfp599
Ensembl Gene ENSMUSG00000062794
Gene Name zinc finger protein 599
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R5615 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 22158726-22171191 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 22165165 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 70 (D70G)
Ref Sequence ENSEMBL: ENSMUSP00000083462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086281]
AlphaFold E9PWP1
Predicted Effect probably benign
Transcript: ENSMUST00000086281
AA Change: D70G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000083462
Gene: ENSMUSG00000062794
AA Change: D70G

DomainStartEndE-ValueType
KRAB 4 64 5.35e-33 SMART
ZnF_C2H2 228 250 5.59e-4 SMART
ZnF_C2H2 256 278 2.43e-4 SMART
ZnF_C2H2 284 306 1.69e-3 SMART
ZnF_C2H2 312 334 8.94e-3 SMART
ZnF_C2H2 340 362 8.47e-4 SMART
ZnF_C2H2 368 390 5.06e-2 SMART
ZnF_C2H2 396 418 7.9e-4 SMART
ZnF_C2H2 424 446 7.67e-2 SMART
ZnF_C2H2 452 474 1.64e-1 SMART
ZnF_C2H2 480 503 7.37e-4 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A T 1: 71,346,218 (GRCm39) L884H probably damaging Het
Ahr A G 12: 35,553,884 (GRCm39) V745A probably benign Het
Ankrd17 A T 5: 90,431,295 (GRCm39) S830T possibly damaging Het
Aox1 A G 1: 58,136,125 (GRCm39) T1123A probably benign Het
Arhgef11 T C 3: 87,629,792 (GRCm39) probably null Het
Bcas3 T A 11: 85,361,587 (GRCm39) C250S probably damaging Het
Bckdk T C 7: 127,506,489 (GRCm39) I272T probably damaging Het
Cacna1e T C 1: 154,287,916 (GRCm39) K1897E probably damaging Het
Cd180 A T 13: 102,842,711 (GRCm39) I586F probably benign Het
Cep290 A G 10: 100,367,012 (GRCm39) D1121G probably damaging Het
Clasrp A G 7: 19,320,372 (GRCm39) probably benign Het
Col27a1 G T 4: 63,199,351 (GRCm39) K912N probably damaging Het
Dock4 G T 12: 40,699,479 (GRCm39) R231L probably benign Het
Ell G A 8: 71,043,382 (GRCm39) S505N probably benign Het
Ephb6 A G 6: 41,596,225 (GRCm39) T833A probably benign Het
Hemk1 T A 9: 107,208,023 (GRCm39) probably null Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hspa12a T C 19: 58,793,082 (GRCm39) I368V possibly damaging Het
Igkv3-3 A T 6: 70,664,214 (GRCm39) T19S probably benign Het
Itpr1 G A 6: 108,465,561 (GRCm39) A2158T possibly damaging Het
Lancl2 T C 6: 57,699,496 (GRCm39) Y104H probably damaging Het
Leng8 G T 7: 4,147,957 (GRCm39) E634* probably null Het
Lrrk1 A T 7: 65,937,363 (GRCm39) C930S probably damaging Het
Lvrn C T 18: 46,983,395 (GRCm39) S46L possibly damaging Het
Mcidas G A 13: 113,133,959 (GRCm39) V148I probably benign Het
Mprip A T 11: 59,649,313 (GRCm39) T1006S probably benign Het
Mrgprb3 T A 7: 48,293,234 (GRCm39) M106L probably benign Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Mtor G A 4: 148,622,733 (GRCm39) V1938I possibly damaging Het
Muc2 A G 7: 141,277,446 (GRCm39) D46G probably damaging Het
Nfkb2 G T 19: 46,296,006 (GRCm39) E170D probably benign Het
Or10ag52 T A 2: 87,044,083 (GRCm39) F282L probably benign Het
Or6c215 A T 10: 129,637,636 (GRCm39) C253S probably damaging Het
Osbp2 C T 11: 3,813,356 (GRCm39) G171D probably benign Het
Otud6b A T 4: 14,818,187 (GRCm39) M238K possibly damaging Het
Pcdhac2 G A 18: 37,279,476 (GRCm39) G819R probably benign Het
Pcdhac2 G T 18: 37,279,477 (GRCm39) G819V probably benign Het
Pcdhga12 T G 18: 37,901,132 (GRCm39) S655A probably damaging Het
Pkd1l3 A G 8: 110,356,842 (GRCm39) I756V probably benign Het
Plekhd1 T A 12: 80,767,364 (GRCm39) S251T probably damaging Het
Ppp2r1a A T 17: 21,179,249 (GRCm39) T96S probably benign Het
Qser1 A C 2: 104,620,039 (GRCm39) S258A possibly damaging Het
Rsph4a G A 10: 33,785,324 (GRCm39) A412T probably benign Het
Sanbr A T 11: 23,556,759 (GRCm39) L407H probably damaging Het
Sass6 T A 3: 116,401,135 (GRCm39) C159S probably benign Het
Scaf4 T C 16: 90,048,848 (GRCm39) Q322R unknown Het
Sema6d C T 2: 124,498,821 (GRCm39) H244Y probably damaging Het
Sigirr T G 7: 140,672,632 (GRCm39) L163F probably damaging Het
Spata31d1c C A 13: 65,183,078 (GRCm39) L207I possibly damaging Het
Tacstd2 A G 6: 67,512,033 (GRCm39) F220L probably damaging Het
Tdpoz4 A T 3: 93,704,806 (GRCm39) T368S probably benign Het
Tnxb C A 17: 34,902,392 (GRCm39) Q1082K probably damaging Het
Trim41 GCCTAGGCGCCCA G 11: 48,698,192 (GRCm39) probably benign Het
Trpm6 C T 19: 18,807,297 (GRCm39) R1014C probably damaging Het
Ugt1a10 TTCATCA TTCA 1: 88,143,880 (GRCm39) probably benign Het
Vmn2r114 ATTT ATT 17: 23,509,906 (GRCm39) probably null Het
Vmn2r61 T A 7: 41,916,677 (GRCm39) M430K probably benign Het
Vmn2r61 A G 7: 41,949,917 (GRCm39) E779G probably damaging Het
Zmym1 A T 4: 126,943,191 (GRCm39) I301N probably damaging Het
Other mutations in Zfp599
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00580:Zfp599 APN 9 22,160,768 (GRCm39) missense possibly damaging 0.94
IGL00845:Zfp599 APN 9 22,162,814 (GRCm39) splice site probably benign
R0136:Zfp599 UTSW 9 22,161,038 (GRCm39) missense probably benign 0.13
R0239:Zfp599 UTSW 9 22,161,055 (GRCm39) missense probably damaging 1.00
R0239:Zfp599 UTSW 9 22,161,055 (GRCm39) missense probably damaging 1.00
R0421:Zfp599 UTSW 9 22,161,843 (GRCm39) splice site probably benign
R1699:Zfp599 UTSW 9 22,161,700 (GRCm39) missense probably benign 0.20
R1723:Zfp599 UTSW 9 22,169,361 (GRCm39) missense probably damaging 1.00
R1899:Zfp599 UTSW 9 22,162,845 (GRCm39) missense probably benign 0.00
R4231:Zfp599 UTSW 9 22,161,041 (GRCm39) nonsense probably null
R4233:Zfp599 UTSW 9 22,161,041 (GRCm39) nonsense probably null
R4236:Zfp599 UTSW 9 22,161,041 (GRCm39) nonsense probably null
R4931:Zfp599 UTSW 9 22,169,419 (GRCm39) missense probably damaging 0.98
R5117:Zfp599 UTSW 9 22,161,396 (GRCm39) nonsense probably null
R5759:Zfp599 UTSW 9 22,160,957 (GRCm39) missense probably damaging 1.00
R5915:Zfp599 UTSW 9 22,161,130 (GRCm39) missense probably damaging 1.00
R6184:Zfp599 UTSW 9 22,160,947 (GRCm39) missense probably benign 0.18
R6188:Zfp599 UTSW 9 22,161,286 (GRCm39) missense probably damaging 1.00
R6657:Zfp599 UTSW 9 22,161,538 (GRCm39) missense probably damaging 1.00
R6736:Zfp599 UTSW 9 22,161,140 (GRCm39) missense probably damaging 1.00
R6752:Zfp599 UTSW 9 22,160,840 (GRCm39) missense probably damaging 1.00
R7071:Zfp599 UTSW 9 22,169,392 (GRCm39) missense probably benign 0.38
R7643:Zfp599 UTSW 9 22,161,188 (GRCm39) missense probably benign 0.19
R7714:Zfp599 UTSW 9 22,161,811 (GRCm39) missense probably benign 0.07
R7951:Zfp599 UTSW 9 22,160,764 (GRCm39) missense probably damaging 1.00
R7967:Zfp599 UTSW 9 22,160,830 (GRCm39) missense possibly damaging 0.66
R8014:Zfp599 UTSW 9 22,160,777 (GRCm39) missense probably benign 0.03
R8187:Zfp599 UTSW 9 22,161,111 (GRCm39) nonsense probably null
R9562:Zfp599 UTSW 9 22,160,999 (GRCm39) missense probably damaging 0.98
R9684:Zfp599 UTSW 9 22,160,824 (GRCm39) missense probably damaging 1.00
R9722:Zfp599 UTSW 9 22,160,741 (GRCm39) missense probably damaging 0.96
RF005:Zfp599 UTSW 9 22,165,180 (GRCm39) missense probably benign 0.03
RF024:Zfp599 UTSW 9 22,165,180 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GTCTCCTTCCATCTTAAGAGGC -3'
(R):5'- AAAGGTTTCTAATCCTGATCACAGC -3'

Sequencing Primer
(F):5'- CCATCTTAAGAGGCTTTCTGATTTAC -3'
(R):5'- TCCTGATCACAGCAGCGATTATG -3'
Posted On 2016-10-26