Mutagenetix > Incidental Mutation

Incidental Mutation 'R6047:Ptprc'

483330

Institutional Source

Beutler Lab

Gene Symbol

Ptprc

Ensembl Gene

ENSMUSG00000026395

Gene Name

protein tyrosine phosphatase receptor type C

Synonyms

Ly-5, T200, CD45, B220, Lyt-4

MMRRC Submission

044215-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6047 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

137990599-138103446 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

C to T at 138028779 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000138350 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000182283] [ENSMUST00000182283] [ENSMUST00000182755] [ENSMUST00000182755] [ENSMUST00000183301] [ENSMUST00000183301]

AlphaFold

P06800

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000112036

SMART Domains

Protein: ENSMUSP00000107667
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	5	30	5.8e-13	PFAM
low complexity region	31	64	N/A	INTRINSIC
Pfam:CD45	70	129	1.8e-24	PFAM
FN3	233	317	2.28e0	SMART
FN3	333	411	3.48e-1	SMART
transmembrane domain	426	447	N/A	INTRINSIC
PTPc	500	762	7.57e-127	SMART
PTPc	791	1077	1.39e-102	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000182283

SMART Domains

Protein: ENSMUSP00000138800
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	32	4.2e-13	PFAM
low complexity region	33	66	N/A	INTRINSIC
Pfam:CD45	72	131	2.3e-24	PFAM
FN3	235	319	2.28e0	SMART
FN3	335	413	3.48e-1	SMART
transmembrane domain	428	449	N/A	INTRINSIC
PTPc	502	764	7.57e-127	SMART
PTPc	793	1079	1.39e-102	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000182283

SMART Domains

Protein: ENSMUSP00000138800
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	32	4.2e-13	PFAM
low complexity region	33	66	N/A	INTRINSIC
Pfam:CD45	72	131	2.3e-24	PFAM
FN3	235	319	2.28e0	SMART
FN3	335	413	3.48e-1	SMART
transmembrane domain	428	449	N/A	INTRINSIC
PTPc	502	764	7.57e-127	SMART
PTPc	793	1079	1.39e-102	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000182755

SMART Domains

Protein: ENSMUSP00000138275
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	34	5.5e-13	PFAM
Pfam:CD45	48	107	2.3e-24	PFAM
FN3	211	295	2.28e0	SMART
FN3	311	389	3.48e-1	SMART
transmembrane domain	404	425	N/A	INTRINSIC
PTPc	478	740	7.57e-127	SMART
PTPc	769	1055	1.39e-102	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000182755

SMART Domains

Protein: ENSMUSP00000138275
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	34	5.5e-13	PFAM
Pfam:CD45	48	107	2.3e-24	PFAM
FN3	211	295	2.28e0	SMART
FN3	311	389	3.48e-1	SMART
transmembrane domain	404	425	N/A	INTRINSIC
PTPc	478	740	7.57e-127	SMART
PTPc	769	1055	1.39e-102	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000183301

SMART Domains

Protein: ENSMUSP00000138350
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	2.7e-13	PFAM
low complexity region	111	128	N/A	INTRINSIC
low complexity region	170	205	N/A	INTRINSIC
Pfam:CD45	211	270	2.1e-24	PFAM
FN3	374	458	2.28e0	SMART
FN3	474	552	3.48e-1	SMART
transmembrane domain	567	588	N/A	INTRINSIC
PTPc	641	903	7.57e-127	SMART
PTPc	932	1218	1.39e-102	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000183301

SMART Domains

Protein: ENSMUSP00000138350
Gene: ENSMUSG00000026395

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	2.7e-13	PFAM
low complexity region	111	128	N/A	INTRINSIC
low complexity region	170	205	N/A	INTRINSIC
Pfam:CD45	211	270	2.1e-24	PFAM
FN3	374	458	2.28e0	SMART
FN3	474	552	3.48e-1	SMART
transmembrane domain	567	588	N/A	INTRINSIC
PTPc	641	903	7.57e-127	SMART
PTPc	932	1218	1.39e-102	SMART

Meta Mutation Damage Score

0.9580

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.6%

Validation Efficiency

100% (36/36)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
PHENOTYPE: Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1b	T	C	5: 8,856,066 (GRCm39)	I58T	probably damaging	Het
Adgrb2	G	T	4: 129,912,498 (GRCm39)	G1208C	probably damaging	Het
Antxrl	T	C	14: 33,775,433 (GRCm39)		probably benign	Het
Appl2	C	T	10: 83,448,765 (GRCm39)		probably null	Het
Bloc1s2	T	C	19: 44,130,629 (GRCm39)	I112V	possibly damaging	Het
Cblb	G	T	16: 51,932,611 (GRCm39)		probably null	Het
Cdk9	T	C	2: 32,598,285 (GRCm39)		probably null	Het
Dok7	G	A	5: 35,236,651 (GRCm39)	G206D	probably damaging	Het
Ftsj3	C	T	11: 106,143,144 (GRCm39)	R390H	probably damaging	Het
Gpr179	G	T	11: 97,229,242 (GRCm39)	P971Q	probably damaging	Het
Hic1	A	T	11: 75,057,675 (GRCm39)	S405T	possibly damaging	Het
Ifngr1	T	C	10: 19,482,061 (GRCm39)	L217P	probably damaging	Het
Insrr	A	G	3: 87,711,483 (GRCm39)	K468E	probably damaging	Het
Lce1j	G	C	3: 92,696,503 (GRCm39)	R92G	unknown	Het
Lrp12	T	C	15: 39,735,463 (GRCm39)	E823G	probably damaging	Het
Lrp1b	A	G	2: 40,527,787 (GRCm39)	I98T	probably benign	Het
Mbd3l2	A	T	9: 18,356,212 (GRCm39)	H179L	possibly damaging	Het
Med24	A	T	11: 98,598,591 (GRCm39)	C691*	probably null	Het
Mical1	T	C	10: 41,357,703 (GRCm39)		probably null	Het
Msantd2	A	T	9: 37,434,738 (GRCm39)	Y326F	probably damaging	Het
Nfyc	T	A	4: 120,636,314 (GRCm39)		probably null	Het
Nrg3	T	A	14: 38,119,309 (GRCm39)		probably null	Het
Nt5c3	G	A	6: 56,859,964 (GRCm39)	S291L	probably damaging	Het
Pak4	A	G	7: 28,262,461 (GRCm39)	Y384H	probably benign	Het
Pdia5	T	C	16: 35,217,848 (GRCm39)	K512E	probably damaging	Het
Pfpl	T	C	19: 12,406,597 (GRCm39)	F283L	probably damaging	Het
Pick1	A	G	15: 79,139,895 (GRCm39)		probably benign	Het
Pkd1	T	C	17: 24,814,059 (GRCm39)	V4143A	probably damaging	Het
Scn10a	A	G	9: 119,451,897 (GRCm39)	F1342S	probably benign	Het
Slc17a7	A	T	7: 44,822,830 (GRCm39)	I436F	probably benign	Het
Slc34a1	G	T	13: 55,559,884 (GRCm39)	A403S	probably damaging	Het
Stmn3	A	T	2: 180,950,952 (GRCm39)	Y35N	possibly damaging	Het
Tldc2	A	G	2: 156,938,382 (GRCm39)	E207G	probably damaging	Het
Unc79	A	G	12: 103,027,717 (GRCm39)	N436S	probably damaging	Het
Uty	G	T	Y: 1,158,288 (GRCm39)	P538Q	probably damaging	Het
Zzef1	A	G	11: 72,756,921 (GRCm39)	D1142G	probably damaging	Het

Other mutations in Ptprc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
lochy	APN	1	138,011,528 (GRCm39)	splice site	probably benign
IGL00486:Ptprc	APN	1	138,043,359 (GRCm39)	missense	probably damaging	0.97
IGL00771:Ptprc	APN	1	138,041,415 (GRCm39)	missense	probably benign	0.00
IGL00833:Ptprc	APN	1	138,006,230 (GRCm39)	missense	possibly damaging	0.55
IGL00919:Ptprc	APN	1	138,041,380 (GRCm39)	missense	probably damaging	1.00
IGL01020:Ptprc	APN	1	138,047,911 (GRCm39)	critical splice acceptor site	probably null	0.00
IGL01024:Ptprc	APN	1	138,008,650 (GRCm39)	missense	probably damaging	1.00
IGL01302:Ptprc	APN	1	138,027,369 (GRCm39)	missense	possibly damaging	0.82
IGL01548:Ptprc	APN	1	138,027,219 (GRCm39)	critical splice donor site	probably null	0.00
IGL01620:Ptprc	APN	1	137,996,148 (GRCm39)	missense	possibly damaging	0.88
IGL01775:Ptprc	APN	1	137,992,497 (GRCm39)	missense	probably damaging	1.00
IGL01820:Ptprc	APN	1	137,993,936 (GRCm39)	missense	probably damaging	1.00
IGL02340:Ptprc	APN	1	137,998,957 (GRCm39)	missense	probably damaging	1.00
IGL02943:Ptprc	APN	1	138,027,251 (GRCm39)	missense	probably damaging	0.99
IGL03169:Ptprc	APN	1	138,041,357 (GRCm39)	missense	probably benign	0.15
IGL03308:Ptprc	APN	1	138,054,058 (GRCm39)	missense	possibly damaging	0.70
IGL03404:Ptprc	APN	1	138,020,739 (GRCm39)	missense	probably damaging	1.00
belittle	UTSW	1	138,137,493 (GRCm38)	intron	probably benign
Benighted	UTSW	1	138,054,039 (GRCm39)	critical splice donor site	probably null
bletchley	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
Blush	UTSW	1	138,045,458 (GRCm39)	intron	probably benign
bruise	UTSW	1	137,992,509 (GRCm39)	missense	probably damaging	1.00
chor_muang	UTSW	1	138,041,300 (GRCm39)	critical splice donor site	probably null
crystal	UTSW	1	137,999,993 (GRCm39)	critical splice donor site	probably null
Dumpling	UTSW	1	137,995,628 (GRCm39)	missense	probably damaging	1.00
fluorescent	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
fuchsia	UTSW	1	138,028,779 (GRCm39)	critical splice donor site	probably null
Gentian	UTSW	1	137,995,623 (GRCm39)	critical splice donor site	probably null
guotie	UTSW	1	137,996,139 (GRCm39)	nonsense	probably null
guotie2	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
Guotie3	UTSW	1	138,006,189 (GRCm39)	missense	possibly damaging	0.92
Gyoza	UTSW	1	138,011,305 (GRCm39)	missense	probably damaging	1.00
Half_measure	UTSW	1	137,998,987 (GRCm39)	missense	probably damaging	0.98
jirisan	UTSW	1	138,041,416 (GRCm39)	nonsense	probably null
mauve	UTSW	1	138,027,423 (GRCm39)	missense	probably benign
Perverse	UTSW	1	138,028,782 (GRCm39)	missense	probably benign	0.02
petechiae	UTSW	1	138,041,446 (GRCm39)	nonsense	probably null
ultra	UTSW	1	138,006,183 (GRCm39)	critical splice donor site	probably null
violaceous	UTSW	1	138,011,377 (GRCm39)	missense	possibly damaging	0.77
R0013:Ptprc	UTSW	1	138,041,297 (GRCm39)	splice site	probably null
R0189:Ptprc	UTSW	1	138,010,453 (GRCm39)	missense	probably benign	0.10
R0390:Ptprc	UTSW	1	138,050,313 (GRCm39)	missense	possibly damaging	0.71
R0504:Ptprc	UTSW	1	138,016,435 (GRCm39)	missense	probably damaging	1.00
R0602:Ptprc	UTSW	1	138,017,223 (GRCm39)	splice site	probably benign
R0627:Ptprc	UTSW	1	137,996,058 (GRCm39)	missense	probably damaging	0.99
R0632:Ptprc	UTSW	1	138,001,348 (GRCm39)	missense	probably benign	0.01
R0751:Ptprc	UTSW	1	138,020,668 (GRCm39)	missense	probably damaging	1.00
R0839:Ptprc	UTSW	1	138,028,870 (GRCm39)	missense	possibly damaging	0.47
R0942:Ptprc	UTSW	1	137,996,139 (GRCm39)	nonsense	probably null
R0943:Ptprc	UTSW	1	138,038,902 (GRCm39)	missense	probably damaging	0.96
R1159:Ptprc	UTSW	1	138,000,057 (GRCm39)	missense	probably damaging	1.00
R1442:Ptprc	UTSW	1	138,000,050 (GRCm39)	missense	probably damaging	1.00
R1489:Ptprc	UTSW	1	138,047,824 (GRCm39)	missense	possibly damaging	0.91
R1728:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1728:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1728:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1728:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1728:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1729:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1729:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1729:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1730:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1730:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1730:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1730:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1730:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1739:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1739:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1739:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1739:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1739:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1762:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1762:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1762:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1762:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1762:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1783:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1783:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1783:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1784:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1784:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1784:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1785:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1785:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1785:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1785:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1785:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1862:Ptprc	UTSW	1	138,039,965 (GRCm39)	missense	probably benign	0.13
R2145:Ptprc	UTSW	1	138,001,419 (GRCm39)	missense	probably damaging	1.00
R2290:Ptprc	UTSW	1	138,038,926 (GRCm39)	missense	probably benign	0.00
R2403:Ptprc	UTSW	1	138,016,270 (GRCm39)	missense	probably damaging	1.00
R2439:Ptprc	UTSW	1	137,993,890 (GRCm39)	missense	possibly damaging	0.67
R2887:Ptprc	UTSW	1	138,007,916 (GRCm39)	missense	probably damaging	1.00
R2906:Ptprc	UTSW	1	137,992,272 (GRCm39)	missense	possibly damaging	0.93
R3774:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3775:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3776:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3834:Ptprc	UTSW	1	138,011,305 (GRCm39)	missense	probably damaging	1.00
R4019:Ptprc	UTSW	1	138,006,254 (GRCm39)	missense	probably damaging	1.00
R4377:Ptprc	UTSW	1	137,995,663 (GRCm39)	missense	probably benign	0.04
R4580:Ptprc	UTSW	1	137,998,989 (GRCm39)	missense	probably benign	0.09
R4923:Ptprc	UTSW	1	138,006,236 (GRCm39)	missense	possibly damaging	0.93
R4925:Ptprc	UTSW	1	138,027,235 (GRCm39)	missense	probably benign	0.04
R4937:Ptprc	UTSW	1	138,017,238 (GRCm39)	missense	probably damaging	1.00
R4970:Ptprc	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
R5112:Ptprc	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
R5145:Ptprc	UTSW	1	138,017,304 (GRCm39)	missense	probably benign	0.07
R5158:Ptprc	UTSW	1	138,102,822 (GRCm39)	missense	possibly damaging	0.75
R5223:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R5593:Ptprc	UTSW	1	138,045,458 (GRCm39)	intron	probably benign
R5689:Ptprc	UTSW	1	138,045,515 (GRCm39)	missense	probably benign	0.01
R5885:Ptprc	UTSW	1	138,016,246 (GRCm39)	missense	probably damaging	1.00
R6010:Ptprc	UTSW	1	138,028,794 (GRCm39)	missense	probably benign	0.09
R6026:Ptprc	UTSW	1	137,998,987 (GRCm39)	missense	probably damaging	0.98
R6173:Ptprc	UTSW	1	137,995,628 (GRCm39)	missense	probably damaging	1.00
R6328:Ptprc	UTSW	1	138,041,416 (GRCm39)	nonsense	probably null
R6383:Ptprc	UTSW	1	138,006,189 (GRCm39)	missense	possibly damaging	0.92
R6436:Ptprc	UTSW	1	138,011,377 (GRCm39)	missense	possibly damaging	0.77
R6492:Ptprc	UTSW	1	138,041,300 (GRCm39)	critical splice donor site	probably null
R6520:Ptprc	UTSW	1	138,007,881 (GRCm39)	nonsense	probably null
R6805:Ptprc	UTSW	1	137,995,623 (GRCm39)	critical splice donor site	probably null
R6830:Ptprc	UTSW	1	137,999,993 (GRCm39)	critical splice donor site	probably null
R6847:Ptprc	UTSW	1	138,016,283 (GRCm39)	missense	probably damaging	0.99
R6960:Ptprc	UTSW	1	138,006,183 (GRCm39)	critical splice donor site	probably null
R6995:Ptprc	UTSW	1	138,016,482 (GRCm39)	missense	probably damaging	1.00
R7009:Ptprc	UTSW	1	137,992,291 (GRCm39)	missense	probably damaging	0.97
R7041:Ptprc	UTSW	1	138,054,047 (GRCm39)	missense	probably benign	0.04
R7055:Ptprc	UTSW	1	138,017,309 (GRCm39)	missense	probably damaging	1.00
R7098:Ptprc	UTSW	1	138,027,423 (GRCm39)	missense	probably benign
R7164:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R7188:Ptprc	UTSW	1	137,998,918 (GRCm39)	missense	probably damaging	1.00
R7191:Ptprc	UTSW	1	138,028,782 (GRCm39)	missense	probably benign	0.02
R7204:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R7316:Ptprc	UTSW	1	137,992,509 (GRCm39)	missense	probably damaging	1.00
R7644:Ptprc	UTSW	1	137,995,645 (GRCm39)	missense	probably benign	0.01
R7948:Ptprc	UTSW	1	137,992,314 (GRCm39)	missense	probably benign	0.45
R8029:Ptprc	UTSW	1	138,006,197 (GRCm39)	missense	probably damaging	1.00
R8677:Ptprc	UTSW	1	138,011,335 (GRCm39)	missense	probably damaging	1.00
R8704:Ptprc	UTSW	1	138,043,362 (GRCm39)	missense	probably benign	0.34
R8824:Ptprc	UTSW	1	138,041,446 (GRCm39)	nonsense	probably null
R8921:Ptprc	UTSW	1	138,054,039 (GRCm39)	critical splice donor site	probably null
R8998:Ptprc	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
R8999:Ptprc	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
R9154:Ptprc	UTSW	1	138,016,302 (GRCm39)	missense	probably damaging	1.00
R9388:Ptprc	UTSW	1	138,011,380 (GRCm39)	missense	possibly damaging	0.87
R9428:Ptprc	UTSW	1	138,041,485 (GRCm39)	missense	probably benign	0.01
R9467:Ptprc	UTSW	1	137,993,960 (GRCm39)	missense	probably damaging	1.00
R9468:Ptprc	UTSW	1	138,044,754 (GRCm39)	missense	probably benign	0.01
R9479:Ptprc	UTSW	1	138,001,388 (GRCm39)	missense	probably benign	0.38
R9526:Ptprc	UTSW	1	137,996,111 (GRCm39)	missense	probably benign	0.02
R9632:Ptprc	UTSW	1	138,008,627 (GRCm39)	missense	probably damaging	1.00
R9710:Ptprc	UTSW	1	138,008,627 (GRCm39)	missense	probably damaging	1.00
R9714:Ptprc	UTSW	1	138,008,687 (GRCm39)	missense	probably damaging	1.00
R9777:Ptprc	UTSW	1	138,047,901 (GRCm39)	missense
Z1177:Ptprc	UTSW	1	137,995,645 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- AGGAAGTACACTGGCTGGTG -3'
(R):5'- CTTTCAGAAACTTACTAACTCAGGC -3'

Sequencing Primer
(F):5'- TCAACTCTGTCACTCTATCAGATAG -3'
(R):5'- GACCAGTTTTGAGGTGGAA -3'

Posted On

2017-07-14