Mutagenetix > Incidental Mutation

Incidental Mutation 'R6847:Ptprc'

534792

Institutional Source

Beutler Lab

Gene Symbol

Ptprc

Ensembl Gene

ENSMUSG00000026395

Gene Name

protein tyrosine phosphatase receptor type C

Synonyms

Ly-5, T200, CD45, B220, Lyt-4

MMRRC Submission

045021-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6847 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

137990599-138103446 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 138016283 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 526 (N526K)

Ref Sequence

ENSEMBL: ENSMUSP00000138275 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000182283] [ENSMUST00000182755] [ENSMUST00000183301]

AlphaFold

P06800

Predicted Effect

probably damaging
Transcript: ENSMUST00000182283
AA Change: N550K

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000138800
Gene: ENSMUSG00000026395
AA Change: N550K

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	32	4.2e-13	PFAM
low complexity region	33	66	N/A	INTRINSIC
Pfam:CD45	72	131	2.3e-24	PFAM
FN3	235	319	2.28e0	SMART
FN3	335	413	3.48e-1	SMART
transmembrane domain	428	449	N/A	INTRINSIC
PTPc	502	764	7.57e-127	SMART
PTPc	793	1079	1.39e-102	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000182755
AA Change: N526K

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000138275
Gene: ENSMUSG00000026395
AA Change: N526K

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	34	5.5e-13	PFAM
Pfam:CD45	48	107	2.3e-24	PFAM
FN3	211	295	2.28e0	SMART
FN3	311	389	3.48e-1	SMART
transmembrane domain	404	425	N/A	INTRINSIC
PTPc	478	740	7.57e-127	SMART
PTPc	769	1055	1.39e-102	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000183301
AA Change: N689K

PolyPhen 2 Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000138350
Gene: ENSMUSG00000026395
AA Change: N689K

Domain	Start	End	E-Value	Type
Pfam:PTP_N	7	33	2.7e-13	PFAM
low complexity region	111	128	N/A	INTRINSIC
low complexity region	170	205	N/A	INTRINSIC
Pfam:CD45	211	270	2.1e-24	PFAM
FN3	374	458	2.28e0	SMART
FN3	474	552	3.48e-1	SMART
transmembrane domain	567	588	N/A	INTRINSIC
PTPc	641	903	7.57e-127	SMART
PTPc	932	1218	1.39e-102	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.3%
20x: 97.8%

Validation Efficiency

100% (50/50)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
PHENOTYPE: Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam26a	A	G	8: 44,021,465 (GRCm39)	I675T	probably benign	Het
Adgrb3	A	T	1: 25,133,003 (GRCm39)	M1121K	probably benign	Het
Ak9	A	G	10: 41,233,797 (GRCm39)		probably null	Het
Akr1c6	T	A	13: 4,488,497 (GRCm39)	C34*	probably null	Het
Akt3	G	A	1: 176,859,225 (GRCm39)	P449S	probably damaging	Het
Atg2b	A	T	12: 105,602,047 (GRCm39)	V1643E	probably damaging	Het
Atp2c1	T	C	9: 105,295,778 (GRCm39)	I819V	probably damaging	Het
Casp3	C	T	8: 47,089,301 (GRCm39)	A183V	probably benign	Het
Cdk1	A	T	10: 69,174,358 (GRCm39)	D288E	probably benign	Het
Cep131	G	A	11: 119,956,517 (GRCm39)	R944W	probably damaging	Het
Cep290	A	G	10: 100,399,281 (GRCm39)	K2268E	probably damaging	Het
Crybg2	A	G	4: 133,792,857 (GRCm39)	E164G	probably benign	Het
Cubn	A	C	2: 13,449,064 (GRCm39)		probably null	Het
Dnajc14	A	T	10: 128,652,656 (GRCm39)	E571D	possibly damaging	Het
Dnase1l1	C	T	X: 73,320,644 (GRCm39)		probably null	Het
Eef1b2	A	G	1: 63,217,648 (GRCm39)	E44G	probably benign	Het
Eml6	C	T	11: 29,768,447 (GRCm39)	V747I	probably benign	Het
Ext1	T	G	15: 53,208,550 (GRCm39)	Q70H	probably benign	Het
Gbp2b	T	A	3: 142,303,940 (GRCm39)	C12S	probably damaging	Het
Gbp8	A	C	5: 105,179,093 (GRCm39)	D135E	probably benign	Het
Gm12886	A	T	4: 121,273,916 (GRCm39)	L100*	probably null	Het
Gpatch1	A	T	7: 34,992,983 (GRCm39)		probably null	Het
Ifit3b	A	T	19: 34,588,925 (GRCm39)	M34L	probably benign	Het
Il12a	G	T	3: 68,602,899 (GRCm39)	D160Y	probably damaging	Het
Klhl2	A	G	8: 65,212,816 (GRCm39)	L241P	probably damaging	Het
Krt80	T	C	15: 101,256,610 (GRCm39)	E195G	probably benign	Het
Lgi1	T	C	19: 38,289,738 (GRCm39)	V268A	probably damaging	Het
Lrrfip1	A	T	1: 91,032,850 (GRCm39)	D216V	probably damaging	Het
Meis3	A	G	7: 15,917,789 (GRCm39)	N314S	probably damaging	Het
Muc5ac	C	T	7: 141,363,481 (GRCm39)		probably benign	Het
Myh15	A	T	16: 48,965,451 (GRCm39)	I1119F	possibly damaging	Het
Nav2	A	T	7: 49,141,204 (GRCm39)	Q916H	probably benign	Het
Ncam2	A	T	16: 81,229,606 (GRCm39)	Q22L	probably damaging	Het
Or5b118	A	T	19: 13,448,402 (GRCm39)	I23F	probably benign	Het
P2rx4	G	A	5: 122,865,814 (GRCm39)	V329M	probably damaging	Het
Peg10	A	G	6: 4,754,279 (GRCm39)		probably benign	Het
Pgp	T	C	17: 24,690,375 (GRCm39)	L267P	probably damaging	Het
Pou2af2	G	A	9: 51,201,504 (GRCm39)	T184M	probably damaging	Het
Prdm2	A	C	4: 142,859,520 (GRCm39)	S1257A	probably benign	Het
Prr12	T	C	7: 44,695,164 (GRCm39)	N1434S	unknown	Het
Psmc3ip	A	T	11: 100,985,999 (GRCm39)	H40Q	probably damaging	Het
Sec63	T	A	10: 42,667,249 (GRCm39)	D138E	probably damaging	Het
Serpinb13	A	G	1: 106,926,663 (GRCm39)	N220D	probably benign	Het
Siva1	G	A	12: 112,611,344 (GRCm39)		probably benign	Het
Slc39a12	A	G	2: 14,454,728 (GRCm39)	H546R	probably damaging	Het
Slc7a1	G	A	5: 148,271,468 (GRCm39)	A497V	probably benign	Het
Smg5	G	T	3: 88,249,859 (GRCm39)	K95N	probably damaging	Het
Speer1a	G	A	5: 11,394,134 (GRCm39)	V78M	probably damaging	Het
Traj50	T	A	14: 54,405,101 (GRCm39)		probably benign	Het
Ubr3	T	C	2: 69,813,472 (GRCm39)	V1261A	probably damaging	Het
Zc3h11a	A	T	1: 133,566,700 (GRCm39)		probably null	Het

Other mutations in Ptprc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
lochy	APN	1	138,011,528 (GRCm39)	splice site	probably benign
IGL00486:Ptprc	APN	1	138,043,359 (GRCm39)	missense	probably damaging	0.97
IGL00771:Ptprc	APN	1	138,041,415 (GRCm39)	missense	probably benign	0.00
IGL00833:Ptprc	APN	1	138,006,230 (GRCm39)	missense	possibly damaging	0.55
IGL00919:Ptprc	APN	1	138,041,380 (GRCm39)	missense	probably damaging	1.00
IGL01020:Ptprc	APN	1	138,047,911 (GRCm39)	critical splice acceptor site	probably null	0.00
IGL01024:Ptprc	APN	1	138,008,650 (GRCm39)	missense	probably damaging	1.00
IGL01302:Ptprc	APN	1	138,027,369 (GRCm39)	missense	possibly damaging	0.82
IGL01548:Ptprc	APN	1	138,027,219 (GRCm39)	critical splice donor site	probably null	0.00
IGL01620:Ptprc	APN	1	137,996,148 (GRCm39)	missense	possibly damaging	0.88
IGL01775:Ptprc	APN	1	137,992,497 (GRCm39)	missense	probably damaging	1.00
IGL01820:Ptprc	APN	1	137,993,936 (GRCm39)	missense	probably damaging	1.00
IGL02340:Ptprc	APN	1	137,998,957 (GRCm39)	missense	probably damaging	1.00
IGL02943:Ptprc	APN	1	138,027,251 (GRCm39)	missense	probably damaging	0.99
IGL03169:Ptprc	APN	1	138,041,357 (GRCm39)	missense	probably benign	0.15
IGL03308:Ptprc	APN	1	138,054,058 (GRCm39)	missense	possibly damaging	0.70
IGL03404:Ptprc	APN	1	138,020,739 (GRCm39)	missense	probably damaging	1.00
belittle	UTSW	1	138,137,493 (GRCm38)	intron	probably benign
Benighted	UTSW	1	138,054,039 (GRCm39)	critical splice donor site	probably null
bletchley	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
Blush	UTSW	1	138,045,458 (GRCm39)	intron	probably benign
bruise	UTSW	1	137,992,509 (GRCm39)	missense	probably damaging	1.00
chor_muang	UTSW	1	138,041,300 (GRCm39)	critical splice donor site	probably null
crystal	UTSW	1	137,999,993 (GRCm39)	critical splice donor site	probably null
Dumpling	UTSW	1	137,995,628 (GRCm39)	missense	probably damaging	1.00
fluorescent	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
fuchsia	UTSW	1	138,028,779 (GRCm39)	critical splice donor site	probably null
Gentian	UTSW	1	137,995,623 (GRCm39)	critical splice donor site	probably null
guotie	UTSW	1	137,996,139 (GRCm39)	nonsense	probably null
guotie2	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
Guotie3	UTSW	1	138,006,189 (GRCm39)	missense	possibly damaging	0.92
Gyoza	UTSW	1	138,011,305 (GRCm39)	missense	probably damaging	1.00
Half_measure	UTSW	1	137,998,987 (GRCm39)	missense	probably damaging	0.98
jirisan	UTSW	1	138,041,416 (GRCm39)	nonsense	probably null
mauve	UTSW	1	138,027,423 (GRCm39)	missense	probably benign
Perverse	UTSW	1	138,028,782 (GRCm39)	missense	probably benign	0.02
petechiae	UTSW	1	138,041,446 (GRCm39)	nonsense	probably null
ultra	UTSW	1	138,006,183 (GRCm39)	critical splice donor site	probably null
violaceous	UTSW	1	138,011,377 (GRCm39)	missense	possibly damaging	0.77
R0013:Ptprc	UTSW	1	138,041,297 (GRCm39)	splice site	probably null
R0189:Ptprc	UTSW	1	138,010,453 (GRCm39)	missense	probably benign	0.10
R0390:Ptprc	UTSW	1	138,050,313 (GRCm39)	missense	possibly damaging	0.71
R0504:Ptprc	UTSW	1	138,016,435 (GRCm39)	missense	probably damaging	1.00
R0602:Ptprc	UTSW	1	138,017,223 (GRCm39)	splice site	probably benign
R0627:Ptprc	UTSW	1	137,996,058 (GRCm39)	missense	probably damaging	0.99
R0632:Ptprc	UTSW	1	138,001,348 (GRCm39)	missense	probably benign	0.01
R0751:Ptprc	UTSW	1	138,020,668 (GRCm39)	missense	probably damaging	1.00
R0839:Ptprc	UTSW	1	138,028,870 (GRCm39)	missense	possibly damaging	0.47
R0942:Ptprc	UTSW	1	137,996,139 (GRCm39)	nonsense	probably null
R0943:Ptprc	UTSW	1	138,038,902 (GRCm39)	missense	probably damaging	0.96
R1159:Ptprc	UTSW	1	138,000,057 (GRCm39)	missense	probably damaging	1.00
R1442:Ptprc	UTSW	1	138,000,050 (GRCm39)	missense	probably damaging	1.00
R1489:Ptprc	UTSW	1	138,047,824 (GRCm39)	missense	possibly damaging	0.91
R1728:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1728:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1728:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1728:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1728:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1729:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1729:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1729:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1729:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1730:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1730:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1730:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1730:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1730:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1739:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1739:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1739:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1739:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1739:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1762:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1762:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1762:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1762:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1762:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1783:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1783:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1783:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1783:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1784:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1784:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1784:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1784:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1785:Ptprc	UTSW	1	138,027,414 (GRCm39)	missense	probably benign	0.05
R1785:Ptprc	UTSW	1	138,035,561 (GRCm39)	missense	probably benign	0.22
R1785:Ptprc	UTSW	1	138,039,992 (GRCm39)	missense	possibly damaging	0.53
R1785:Ptprc	UTSW	1	138,035,575 (GRCm39)	missense	probably benign	0.09
R1785:Ptprc	UTSW	1	138,035,562 (GRCm39)	missense	probably benign	0.04
R1862:Ptprc	UTSW	1	138,039,965 (GRCm39)	missense	probably benign	0.13
R2145:Ptprc	UTSW	1	138,001,419 (GRCm39)	missense	probably damaging	1.00
R2290:Ptprc	UTSW	1	138,038,926 (GRCm39)	missense	probably benign	0.00
R2403:Ptprc	UTSW	1	138,016,270 (GRCm39)	missense	probably damaging	1.00
R2439:Ptprc	UTSW	1	137,993,890 (GRCm39)	missense	possibly damaging	0.67
R2887:Ptprc	UTSW	1	138,007,916 (GRCm39)	missense	probably damaging	1.00
R2906:Ptprc	UTSW	1	137,992,272 (GRCm39)	missense	possibly damaging	0.93
R3774:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3775:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3776:Ptprc	UTSW	1	137,992,511 (GRCm39)	missense	probably damaging	0.97
R3834:Ptprc	UTSW	1	138,011,305 (GRCm39)	missense	probably damaging	1.00
R4019:Ptprc	UTSW	1	138,006,254 (GRCm39)	missense	probably damaging	1.00
R4377:Ptprc	UTSW	1	137,995,663 (GRCm39)	missense	probably benign	0.04
R4580:Ptprc	UTSW	1	137,998,989 (GRCm39)	missense	probably benign	0.09
R4923:Ptprc	UTSW	1	138,006,236 (GRCm39)	missense	possibly damaging	0.93
R4925:Ptprc	UTSW	1	138,027,235 (GRCm39)	missense	probably benign	0.04
R4937:Ptprc	UTSW	1	138,017,238 (GRCm39)	missense	probably damaging	1.00
R4970:Ptprc	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
R5112:Ptprc	UTSW	1	138,022,037 (GRCm39)	missense	probably damaging	0.97
R5145:Ptprc	UTSW	1	138,017,304 (GRCm39)	missense	probably benign	0.07
R5158:Ptprc	UTSW	1	138,102,822 (GRCm39)	missense	possibly damaging	0.75
R5223:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R5593:Ptprc	UTSW	1	138,045,458 (GRCm39)	intron	probably benign
R5689:Ptprc	UTSW	1	138,045,515 (GRCm39)	missense	probably benign	0.01
R5885:Ptprc	UTSW	1	138,016,246 (GRCm39)	missense	probably damaging	1.00
R6010:Ptprc	UTSW	1	138,028,794 (GRCm39)	missense	probably benign	0.09
R6026:Ptprc	UTSW	1	137,998,987 (GRCm39)	missense	probably damaging	0.98
R6047:Ptprc	UTSW	1	138,028,779 (GRCm39)	critical splice donor site	probably null
R6173:Ptprc	UTSW	1	137,995,628 (GRCm39)	missense	probably damaging	1.00
R6328:Ptprc	UTSW	1	138,041,416 (GRCm39)	nonsense	probably null
R6383:Ptprc	UTSW	1	138,006,189 (GRCm39)	missense	possibly damaging	0.92
R6436:Ptprc	UTSW	1	138,011,377 (GRCm39)	missense	possibly damaging	0.77
R6492:Ptprc	UTSW	1	138,041,300 (GRCm39)	critical splice donor site	probably null
R6520:Ptprc	UTSW	1	138,007,881 (GRCm39)	nonsense	probably null
R6805:Ptprc	UTSW	1	137,995,623 (GRCm39)	critical splice donor site	probably null
R6830:Ptprc	UTSW	1	137,999,993 (GRCm39)	critical splice donor site	probably null
R6960:Ptprc	UTSW	1	138,006,183 (GRCm39)	critical splice donor site	probably null
R6995:Ptprc	UTSW	1	138,016,482 (GRCm39)	missense	probably damaging	1.00
R7009:Ptprc	UTSW	1	137,992,291 (GRCm39)	missense	probably damaging	0.97
R7041:Ptprc	UTSW	1	138,054,047 (GRCm39)	missense	probably benign	0.04
R7055:Ptprc	UTSW	1	138,017,309 (GRCm39)	missense	probably damaging	1.00
R7098:Ptprc	UTSW	1	138,027,423 (GRCm39)	missense	probably benign
R7164:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R7188:Ptprc	UTSW	1	137,998,918 (GRCm39)	missense	probably damaging	1.00
R7191:Ptprc	UTSW	1	138,028,782 (GRCm39)	missense	probably benign	0.02
R7204:Ptprc	UTSW	1	138,045,600 (GRCm39)	missense	probably benign
R7316:Ptprc	UTSW	1	137,992,509 (GRCm39)	missense	probably damaging	1.00
R7644:Ptprc	UTSW	1	137,995,645 (GRCm39)	missense	probably benign	0.01
R7948:Ptprc	UTSW	1	137,992,314 (GRCm39)	missense	probably benign	0.45
R8029:Ptprc	UTSW	1	138,006,197 (GRCm39)	missense	probably damaging	1.00
R8677:Ptprc	UTSW	1	138,011,335 (GRCm39)	missense	probably damaging	1.00
R8704:Ptprc	UTSW	1	138,043,362 (GRCm39)	missense	probably benign	0.34
R8824:Ptprc	UTSW	1	138,041,446 (GRCm39)	nonsense	probably null
R8921:Ptprc	UTSW	1	138,054,039 (GRCm39)	critical splice donor site	probably null
R8998:Ptprc	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
R8999:Ptprc	UTSW	1	138,028,930 (GRCm39)	missense	probably damaging	0.97
R9154:Ptprc	UTSW	1	138,016,302 (GRCm39)	missense	probably damaging	1.00
R9388:Ptprc	UTSW	1	138,011,380 (GRCm39)	missense	possibly damaging	0.87
R9428:Ptprc	UTSW	1	138,041,485 (GRCm39)	missense	probably benign	0.01
R9467:Ptprc	UTSW	1	137,993,960 (GRCm39)	missense	probably damaging	1.00
R9468:Ptprc	UTSW	1	138,044,754 (GRCm39)	missense	probably benign	0.01
R9479:Ptprc	UTSW	1	138,001,388 (GRCm39)	missense	probably benign	0.38
R9526:Ptprc	UTSW	1	137,996,111 (GRCm39)	missense	probably benign	0.02
R9632:Ptprc	UTSW	1	138,008,627 (GRCm39)	missense	probably damaging	1.00
R9710:Ptprc	UTSW	1	138,008,627 (GRCm39)	missense	probably damaging	1.00
R9714:Ptprc	UTSW	1	138,008,687 (GRCm39)	missense	probably damaging	1.00
R9777:Ptprc	UTSW	1	138,047,901 (GRCm39)	missense
Z1177:Ptprc	UTSW	1	137,995,645 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- TTTTACACCTAGCACCAGCAAG -3'
(R):5'- TTTCCCATCAAAGATGCCCG -3'

Sequencing Primer
(F):5'- CTTCGTAAACGTTAATGGATTTTGG -3'
(R):5'- TCAAAGATGCCCGAAAGCC -3'

Posted On

2018-09-12