Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01601:Garnl3'

91773

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Garnl3

Ensembl Gene

ENSMUSG00000038860

Gene Name

GTPase activating RANGAP domain-like 3

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

IGL01601

Quality Score

Status

Chromosome

Chromosomal Location

32876236-33021666 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 32887701 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 770 (Q770*)

Ref Sequence

ENSEMBL: ENSMUSP00000122576 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049618] [ENSMUST00000102810] [ENSMUST00000137381]

AlphaFold

Q3V0G7

Predicted Effect

probably null
Transcript: ENSMUST00000049618
AA Change: Q729*

SMART Domains

Protein: ENSMUSP00000057582
Gene: ENSMUSG00000038860
AA Change: Q729*

Domain	Start	End	E-Value	Type
Pfam:Rap_GAP	202	383	3.4e-73	PFAM
Pfam:CNH	475	780	3.5e-67	PFAM
low complexity region	793	804	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000102810
AA Change: Q725*

SMART Domains

Protein: ENSMUSP00000099874
Gene: ENSMUSG00000038860
AA Change: Q725*

Domain	Start	End	E-Value	Type
Pfam:Rap_GAP	198	385	4.6e-67	PFAM
Pfam:CNH	471	776	1.8e-68	PFAM
low complexity region	789	800	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000137381
AA Change: Q770*

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193214

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrf2	T	C	17: 43,020,940 (GRCm39)	D628G	probably benign	Het
Aldh1l1	T	A	6: 90,568,823 (GRCm39)	I708N	probably damaging	Het
Ank3	T	A	10: 69,840,555 (GRCm39)	F985I	possibly damaging	Het
Arap2	A	G	5: 62,798,685 (GRCm39)	W1315R	probably damaging	Het
Arhgef33	C	A	17: 80,655,112 (GRCm39)	Q106K	probably damaging	Het
Atad5	G	A	11: 79,986,343 (GRCm39)	G477S	probably benign	Het
Chgb	T	A	2: 132,635,411 (GRCm39)	I451K	probably benign	Het
Cln6	T	A	9: 62,754,252 (GRCm39)	I98N	probably damaging	Het
Commd1	T	C	11: 22,849,981 (GRCm39)	E234G	probably damaging	Het
Dock2	C	A	11: 34,189,528 (GRCm39)		probably null	Het
Flrt2	T	C	12: 95,746,369 (GRCm39)	S236P	probably damaging	Het
Gpr22	C	T	12: 31,760,044 (GRCm39)		probably benign	Het
Hmcn1	A	T	1: 150,503,164 (GRCm39)	D3880E	probably benign	Het
Lgals8	T	C	13: 12,471,219 (GRCm39)		probably benign	Het
Mccc1	A	G	3: 36,044,101 (GRCm39)	V214A	probably benign	Het
Nat8l	T	C	5: 34,155,809 (GRCm39)	L155P	probably damaging	Het
Nckipsd	A	G	9: 108,691,154 (GRCm39)	S359G	probably benign	Het
Pex6	A	C	17: 47,034,650 (GRCm39)	N785T	probably damaging	Het
Potefam1	A	T	2: 111,023,823 (GRCm39)	C104S	unknown	Het
Ptprz1	T	A	6: 23,000,437 (GRCm39)	H842Q	probably damaging	Het
Rhno1	A	T	6: 128,335,021 (GRCm39)	S101T	probably damaging	Het
Rnf103	T	G	6: 71,486,167 (GRCm39)	V266G	probably damaging	Het
Slc25a39	T	C	11: 102,296,544 (GRCm39)	D100G	probably damaging	Het
Sspo	T	C	6: 48,463,313 (GRCm39)	L3746P	probably benign	Het
Svep1	C	T	4: 58,084,872 (GRCm39)	G1822E	probably damaging	Het
Tbl3	T	A	17: 24,921,291 (GRCm39)	D500V	probably damaging	Het
Tmc5	T	C	7: 118,223,047 (GRCm39)		probably benign	Het
Usp20	C	T	2: 30,901,806 (GRCm39)	R524W	probably benign	Het
Wnk2	G	T	13: 49,230,038 (GRCm39)	P829T	probably damaging	Het
Zmiz1	A	G	14: 25,582,068 (GRCm39)	N84S	possibly damaging	Het

Other mutations in Garnl3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01102:Garnl3	APN	2	32,896,828 (GRCm39)	missense	probably damaging	1.00
IGL01981:Garnl3	APN	2	32,887,741 (GRCm39)	missense	probably damaging	0.98
IGL02209:Garnl3	APN	2	32,975,942 (GRCm39)	missense	probably damaging	0.99
IGL02434:Garnl3	APN	2	32,944,217 (GRCm39)	missense	probably damaging	1.00
IGL02512:Garnl3	APN	2	32,921,150 (GRCm39)	missense	probably damaging	1.00
IGL02947:Garnl3	APN	2	32,936,606 (GRCm39)	missense	probably damaging	1.00
PIT4403001:Garnl3	UTSW	2	32,880,770 (GRCm39)	missense	probably damaging	1.00
R0123:Garnl3	UTSW	2	32,896,816 (GRCm39)	missense	possibly damaging	0.92
R0134:Garnl3	UTSW	2	32,896,816 (GRCm39)	missense	possibly damaging	0.92
R0225:Garnl3	UTSW	2	32,896,816 (GRCm39)	missense	possibly damaging	0.92
R0551:Garnl3	UTSW	2	32,906,750 (GRCm39)	missense	probably damaging	1.00
R0691:Garnl3	UTSW	2	32,975,919 (GRCm39)	missense	probably damaging	1.00
R0693:Garnl3	UTSW	2	32,975,919 (GRCm39)	missense	probably damaging	1.00
R0737:Garnl3	UTSW	2	32,880,654 (GRCm39)	missense	probably damaging	0.98
R1350:Garnl3	UTSW	2	32,942,226 (GRCm39)	missense	probably damaging	1.00
R1691:Garnl3	UTSW	2	32,887,675 (GRCm39)	nonsense	probably null
R1791:Garnl3	UTSW	2	32,924,139 (GRCm39)	missense	probably benign	0.02
R1938:Garnl3	UTSW	2	32,895,212 (GRCm39)	missense	probably damaging	0.99
R2100:Garnl3	UTSW	2	32,936,657 (GRCm39)	missense	probably benign	0.35
R2316:Garnl3	UTSW	2	32,895,164 (GRCm39)	missense	probably damaging	1.00
R2353:Garnl3	UTSW	2	32,954,046 (GRCm39)	missense	probably damaging	1.00
R3161:Garnl3	UTSW	2	32,924,723 (GRCm39)	missense	probably damaging	1.00
R3839:Garnl3	UTSW	2	32,879,558 (GRCm39)	missense	probably benign	0.00
R3847:Garnl3	UTSW	2	32,882,240 (GRCm39)	missense	probably benign
R4871:Garnl3	UTSW	2	32,977,100 (GRCm39)	start codon destroyed	probably null	0.77
R5682:Garnl3	UTSW	2	32,944,185 (GRCm39)	missense	probably damaging	1.00
R5811:Garnl3	UTSW	2	32,896,911 (GRCm39)	missense	probably damaging	0.99
R6267:Garnl3	UTSW	2	32,994,892 (GRCm39)	missense	probably benign	0.20
R6502:Garnl3	UTSW	2	32,896,833 (GRCm39)	missense	possibly damaging	0.67
R6532:Garnl3	UTSW	2	32,921,131 (GRCm39)	missense	possibly damaging	0.87
R6639:Garnl3	UTSW	2	32,879,537 (GRCm39)	missense	possibly damaging	0.75
R6763:Garnl3	UTSW	2	32,944,208 (GRCm39)	missense	probably damaging	1.00
R6866:Garnl3	UTSW	2	32,892,785 (GRCm39)	splice site	probably null
R6913:Garnl3	UTSW	2	32,876,841 (GRCm39)	missense	possibly damaging	0.91
R7002:Garnl3	UTSW	2	32,944,205 (GRCm39)	missense	possibly damaging	0.65
R7168:Garnl3	UTSW	2	32,885,090 (GRCm39)	missense	probably damaging	1.00
R7341:Garnl3	UTSW	2	32,924,141 (GRCm39)	missense	probably damaging	1.00
R7746:Garnl3	UTSW	2	32,882,269 (GRCm39)	missense	probably damaging	1.00
R7919:Garnl3	UTSW	2	32,936,611 (GRCm39)	missense	probably benign	0.38
R8079:Garnl3	UTSW	2	32,908,511 (GRCm39)	critical splice donor site	probably null
R8087:Garnl3	UTSW	2	32,935,548 (GRCm39)	missense	probably benign	0.01
R8123:Garnl3	UTSW	2	32,994,950 (GRCm39)	missense	probably damaging	0.97
R8170:Garnl3	UTSW	2	32,905,235 (GRCm39)	missense	possibly damaging	0.88
R8347:Garnl3	UTSW	2	32,975,903 (GRCm39)	missense	probably damaging	1.00
R8418:Garnl3	UTSW	2	32,942,158 (GRCm39)	missense	possibly damaging	0.73
R8679:Garnl3	UTSW	2	32,916,106 (GRCm39)	missense	probably damaging	1.00
R8940:Garnl3	UTSW	2	32,895,241 (GRCm39)	critical splice acceptor site	probably null
R9081:Garnl3	UTSW	2	32,896,920 (GRCm39)	missense	possibly damaging	0.90
R9183:Garnl3	UTSW	2	32,895,080 (GRCm39)	missense	probably damaging	1.00
R9213:Garnl3	UTSW	2	32,895,080 (GRCm39)	missense	probably damaging	1.00
R9219:Garnl3	UTSW	2	32,975,898 (GRCm39)	missense	probably damaging	1.00
R9453:Garnl3	UTSW	2	32,893,881 (GRCm39)	missense	probably damaging	1.00
X0022:Garnl3	UTSW	2	32,912,680 (GRCm39)	missense	probably damaging	1.00
X0023:Garnl3	UTSW	2	32,916,161 (GRCm39)	missense	probably damaging	1.00
X0024:Garnl3	UTSW	2	32,895,191 (GRCm39)	missense	probably damaging	0.98

Posted On

2013-12-09