Incidental Mutation 'IGL01566:Ppp2cb'
ID 90993
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ppp2cb
Ensembl Gene ENSMUSG00000009630
Gene Name protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Synonyms PP2Ac, D8Ertd766e
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01566
Quality Score
Status
Chromosome 8
Chromosomal Location 34089653-34109469 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 34101791 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 110 (R110S)
Ref Sequence ENSEMBL: ENSMUSP00000009774 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009774]
AlphaFold P62715
Predicted Effect probably benign
Transcript: ENSMUST00000009774
AA Change: R110S

PolyPhen 2 Score 0.383 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000009774
Gene: ENSMUSG00000009630
AA Change: R110S

DomainStartEndE-ValueType
PP2Ac 23 293 2.48e-156 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AB124611 T C 9: 21,447,285 (GRCm39) V149A possibly damaging Het
Casc3 T C 11: 98,714,227 (GRCm39) probably null Het
Dhdds T C 4: 133,718,648 (GRCm39) I162V probably damaging Het
Dsg1a T C 18: 20,469,840 (GRCm39) probably benign Het
E030025P04Rik T A 11: 109,034,714 (GRCm39) D58V unknown Het
Gcn1 A G 5: 115,749,117 (GRCm39) N1883S probably damaging Het
Gucy1a2 T C 9: 3,634,661 (GRCm39) L235P probably damaging Het
Jkampl G A 6: 73,445,673 (GRCm39) T292I probably damaging Het
Kprp T C 3: 92,731,271 (GRCm39) N593S probably benign Het
Mme T C 3: 63,269,350 (GRCm39) probably benign Het
Nr6a1 G T 2: 38,617,901 (GRCm39) Q419K probably benign Het
Pcolce A G 5: 137,603,422 (GRCm39) probably benign Het
Slc35f1 A G 10: 52,965,551 (GRCm39) Y322C probably damaging Het
Slc5a3 T C 16: 91,874,465 (GRCm39) V174A probably damaging Het
St8sia4 G T 1: 95,581,482 (GRCm39) R87S probably benign Het
Tfdp2 A G 9: 96,177,083 (GRCm39) E5G probably damaging Het
Tmem161b T C 13: 84,442,881 (GRCm39) I267T probably benign Het
Ttn A G 2: 76,782,365 (GRCm39) L957P probably damaging Het
Ttn A G 2: 76,612,445 (GRCm39) probably benign Het
Ubqln1 A T 13: 58,327,481 (GRCm39) probably null Het
Wdfy3 A C 5: 102,044,454 (GRCm39) probably benign Het
Other mutations in Ppp2cb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02985:Ppp2cb APN 8 34,105,474 (GRCm39) unclassified probably benign
IGL03251:Ppp2cb APN 8 34,100,679 (GRCm39) splice site probably benign
Breakthrough UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R0940:Ppp2cb UTSW 8 34,105,689 (GRCm39) splice site probably null
R1688:Ppp2cb UTSW 8 34,105,480 (GRCm39) missense probably benign 0.02
R2187:Ppp2cb UTSW 8 34,100,705 (GRCm39) missense possibly damaging 0.95
R2350:Ppp2cb UTSW 8 34,101,855 (GRCm39) missense probably null 1.00
R4418:Ppp2cb UTSW 8 34,107,077 (GRCm39) missense probably benign
R4566:Ppp2cb UTSW 8 34,100,723 (GRCm39) missense possibly damaging 0.67
R6187:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R6990:Ppp2cb UTSW 8 34,109,161 (GRCm39) missense probably benign 0.01
R7477:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably benign 0.01
R9018:Ppp2cb UTSW 8 34,105,787 (GRCm39) missense probably benign 0.17
R9301:Ppp2cb UTSW 8 34,090,038 (GRCm39) missense possibly damaging 0.68
Posted On 2013-12-09