Incidental Mutation 'IGL01517:Zyg11a'
ID 90438
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zyg11a
Ensembl Gene ENSMUSG00000034645
Gene Name zyg-11 family member A, cell cycle regulator
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # IGL01517
Quality Score
Status
Chromosome 4
Chromosomal Location 108038935-108075245 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 108058391 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Methionine at position 383 (K383M)
Ref Sequence ENSEMBL: ENSMUSP00000152477 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043793] [ENSMUST00000106690] [ENSMUST00000223127]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000043793
AA Change: K381M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000038478
Gene: ENSMUSG00000034645
AA Change: K381M

DomainStartEndE-ValueType
SCOP:d1jdha_ 218 700 2e-11 SMART
Blast:ARM 497 544 1e-5 BLAST
Blast:ARM 547 587 5e-7 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000106690
AA Change: K383M

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000102301
Gene: ENSMUSG00000034645
AA Change: K383M

DomainStartEndE-ValueType
SCOP:d1jdha_ 139 621 1e-11 SMART
Blast:ARM 418 465 1e-5 BLAST
Blast:ARM 468 508 1e-7 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000223127
AA Change: K383M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts6 A T 13: 104,526,700 (GRCm39) probably benign Het
Arpc1b A G 5: 145,064,679 (GRCm39) probably benign Het
Ccdc54 G A 16: 50,410,280 (GRCm39) L329F possibly damaging Het
Cdc42bpg G A 19: 6,368,467 (GRCm39) R1055H probably damaging Het
Cylc1 A G X: 110,162,799 (GRCm39) T29A possibly damaging Het
Ddx50 T C 10: 62,482,911 (GRCm39) T53A probably benign Het
Dmap1 G A 4: 117,533,206 (GRCm39) R283C probably damaging Het
Extl3 A T 14: 65,314,156 (GRCm39) L342H probably damaging Het
Gjb3 A C 4: 127,219,914 (GRCm39) I206S probably damaging Het
Gphn T A 12: 78,423,148 (GRCm39) I53K probably damaging Het
Gpr22 C T 12: 31,758,709 (GRCm39) probably benign Het
Inpp5b T A 4: 124,676,229 (GRCm39) C362S probably benign Het
Iqgap3 C A 3: 88,016,703 (GRCm39) Q1062K probably benign Het
Kdm2a A G 19: 4,412,089 (GRCm39) probably benign Het
Ltbp3 A G 19: 5,807,760 (GRCm39) D1167G possibly damaging Het
Mpo A G 11: 87,686,647 (GRCm39) N65D possibly damaging Het
Mrpl2 A G 17: 46,960,909 (GRCm39) R268G probably damaging Het
Nfkbia C T 12: 55,537,430 (GRCm39) A220T probably damaging Het
Nlrc3 T A 16: 3,765,351 (GRCm39) I1091F probably damaging Het
Notch2 T A 3: 98,045,971 (GRCm39) S1674R probably benign Het
Or10h28 T A 17: 33,488,629 (GRCm39) N310K probably benign Het
Or14a257 T C 7: 86,138,765 (GRCm39) probably benign Het
Pde8b A G 13: 95,237,395 (GRCm39) probably null Het
Pla2r1 A G 2: 60,334,597 (GRCm39) Y392H probably damaging Het
Plekhm1 A T 11: 103,285,609 (GRCm39) N275K possibly damaging Het
Prdm16 T C 4: 154,412,882 (GRCm39) H1041R probably damaging Het
Rapsn C A 2: 90,866,963 (GRCm39) N88K probably damaging Het
Rasef T A 4: 73,688,059 (GRCm39) Q31H probably benign Het
Rpl28-ps4 T C 6: 117,190,813 (GRCm39) noncoding transcript Het
Trpc7 T C 13: 57,008,878 (GRCm39) Y263C probably damaging Het
Ttn T C 2: 76,577,940 (GRCm39) T24318A probably damaging Het
Vmn1r35 T C 6: 66,656,434 (GRCm39) T79A probably benign Het
Vmn2r100 T A 17: 19,742,225 (GRCm39) S200T probably benign Het
Wnt9b A G 11: 103,621,907 (GRCm39) V250A probably benign Het
Other mutations in Zyg11a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Zyg11a APN 4 108,062,099 (GRCm39) missense probably damaging 0.99
IGL01619:Zyg11a APN 4 108,062,414 (GRCm39) missense probably damaging 1.00
IGL02253:Zyg11a APN 4 108,040,892 (GRCm39) missense probably null 0.99
R0090:Zyg11a UTSW 4 108,058,544 (GRCm39) splice site probably benign
R0225:Zyg11a UTSW 4 108,061,838 (GRCm39) missense probably damaging 1.00
R0610:Zyg11a UTSW 4 108,062,054 (GRCm39) missense probably damaging 1.00
R0827:Zyg11a UTSW 4 108,067,239 (GRCm39) splice site probably benign
R1568:Zyg11a UTSW 4 108,040,843 (GRCm39) critical splice donor site probably null
R1752:Zyg11a UTSW 4 108,062,479 (GRCm39) missense possibly damaging 0.81
R2051:Zyg11a UTSW 4 108,049,244 (GRCm39) splice site probably benign
R2358:Zyg11a UTSW 4 108,053,343 (GRCm39) missense possibly damaging 0.94
R3898:Zyg11a UTSW 4 108,067,391 (GRCm39) missense probably damaging 0.99
R4288:Zyg11a UTSW 4 108,041,666 (GRCm39) missense probably damaging 1.00
R4381:Zyg11a UTSW 4 108,058,517 (GRCm39) missense possibly damaging 0.58
R4709:Zyg11a UTSW 4 108,062,268 (GRCm39) missense probably benign 0.00
R4859:Zyg11a UTSW 4 108,067,387 (GRCm39) missense probably damaging 0.98
R5303:Zyg11a UTSW 4 108,041,629 (GRCm39) critical splice donor site probably null
R5349:Zyg11a UTSW 4 108,040,929 (GRCm39) missense probably damaging 1.00
R5363:Zyg11a UTSW 4 108,046,819 (GRCm39) missense probably damaging 1.00
R5517:Zyg11a UTSW 4 108,061,943 (GRCm39) missense possibly damaging 0.94
R6175:Zyg11a UTSW 4 108,046,878 (GRCm39) missense probably benign 0.01
R6254:Zyg11a UTSW 4 108,038,991 (GRCm39) missense probably damaging 1.00
R6678:Zyg11a UTSW 4 108,046,878 (GRCm39) missense probably benign 0.01
R7524:Zyg11a UTSW 4 108,049,271 (GRCm39) missense probably damaging 1.00
R7789:Zyg11a UTSW 4 108,040,845 (GRCm39) missense probably damaging 1.00
R8022:Zyg11a UTSW 4 108,046,765 (GRCm39) critical splice donor site probably null
R8437:Zyg11a UTSW 4 108,075,103 (GRCm39) missense probably damaging 1.00
R8986:Zyg11a UTSW 4 108,041,628 (GRCm39) critical splice donor site probably null
R9129:Zyg11a UTSW 4 108,039,009 (GRCm39) missense probably benign 0.00
R9383:Zyg11a UTSW 4 108,046,926 (GRCm39) missense probably damaging 1.00
R9457:Zyg11a UTSW 4 108,075,102 (GRCm39) missense probably damaging 1.00
R9489:Zyg11a UTSW 4 108,062,376 (GRCm39) missense probably damaging 0.96
R9511:Zyg11a UTSW 4 108,062,420 (GRCm39) missense probably damaging 1.00
X0061:Zyg11a UTSW 4 108,051,190 (GRCm39) missense probably damaging 1.00
Z1176:Zyg11a UTSW 4 108,058,479 (GRCm39) missense probably damaging 1.00
Z1177:Zyg11a UTSW 4 108,061,997 (GRCm39) missense possibly damaging 0.90
Posted On 2013-12-09