Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01527:Vmn2r104'

89598

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r104

Ensembl Gene

ENSMUSG00000090315

Gene Name

vomeronasal 2, receptor 104

Synonyms

V2r7

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.109) question?

Stock #

IGL01527

Quality Score

Status

Chromosome

Chromosomal Location

20249687-20268467 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20263158 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 101 (I101T)

Ref Sequence

ENSEMBL: ENSMUSP00000129895 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168050]

AlphaFold

E9Q2J5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000168050
AA Change: I101T

PolyPhen 2 Score 0.818 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: I101T

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	85	457	4e-38	PFAM
Pfam:NCD3G	512	565	2.1e-20	PFAM
Pfam:7tm_3	598	833	1.7e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2300002M23Rik	G	T	17: 35,878,730 (GRCm39)		probably null	Het
Abca13	T	A	11: 9,240,788 (GRCm39)	W884R	possibly damaging	Het
Ahi1	T	C	10: 20,835,984 (GRCm39)		probably benign	Het
Ankfn1	G	T	11: 89,282,465 (GRCm39)	P394Q	probably benign	Het
Cacnb2	T	C	2: 14,989,081 (GRCm39)	I393T	possibly damaging	Het
Ces1a	G	T	8: 93,771,726 (GRCm39)	P24T	probably damaging	Het
Col22a1	T	C	15: 71,778,880 (GRCm39)	E269G	probably damaging	Het
Cyp24a1	A	G	2: 170,338,486 (GRCm39)	L70P	probably damaging	Het
Cyp8b1	T	C	9: 121,744,061 (GRCm39)	K424E	probably damaging	Het
Dicer1	G	A	12: 104,657,869 (GRCm39)	Q1902*	probably null	Het
Dst	T	A	1: 34,286,734 (GRCm39)	L544Q	probably damaging	Het
Esrp2	T	C	8: 106,858,865 (GRCm39)	T591A	probably benign	Het
Gap43	C	T	16: 42,112,516 (GRCm39)	E82K	probably benign	Het
Ift70a1	T	C	2: 75,810,860 (GRCm39)	I408V	probably benign	Het
Kif17	G	A	4: 137,996,397 (GRCm39)	V125I	probably benign	Het
Lancl2	T	C	6: 57,709,307 (GRCm39)	S370P	probably damaging	Het
Macf1	T	C	4: 123,386,953 (GRCm39)	I203V	possibly damaging	Het
Mphosph9	A	G	5: 124,421,687 (GRCm39)		probably benign	Het
Ncapg	A	G	5: 45,829,726 (GRCm39)	I143V	possibly damaging	Het
Nr3c1	A	G	18: 39,619,690 (GRCm39)	V199A	probably benign	Het
Obscn	T	A	11: 58,955,243 (GRCm39)	N3890I	possibly damaging	Het
Or2g7	A	G	17: 38,378,986 (GRCm39)	N308S	probably benign	Het
Or2h2c	A	T	17: 37,422,701 (GRCm39)	Y58N	probably damaging	Het
Or52n5	T	A	7: 104,588,198 (GRCm39)	V155E	possibly damaging	Het
Or8g32	A	G	9: 39,305,114 (GRCm39)	H6R	probably benign	Het
Palmd	C	A	3: 116,720,837 (GRCm39)	E166*	probably null	Het
Pdzd2	T	C	15: 12,445,750 (GRCm39)	E327G	probably damaging	Het
Pex13	T	C	11: 23,606,111 (GRCm39)	T40A	probably benign	Het
Pkd2	T	C	5: 104,646,750 (GRCm39)		probably benign	Het
Plb1	A	G	5: 32,474,467 (GRCm39)	T643A	probably damaging	Het
Prlr	T	A	15: 10,329,257 (GRCm39)	D577E	probably benign	Het
Rimoc1	T	C	15: 4,018,165 (GRCm39)	Y170C	probably damaging	Het
Slc44a3	A	G	3: 121,320,777 (GRCm39)	C75R	probably damaging	Het
Susd6	A	T	12: 80,921,093 (GRCm39)	N230I	possibly damaging	Het
Tbx10	A	G	19: 4,048,227 (GRCm39)	R251G	probably damaging	Het
Uap1l1	A	G	2: 25,253,816 (GRCm39)		probably null	Het
Ugt2b5	A	G	5: 87,284,068 (GRCm39)	V308A	possibly damaging	Het
Usp28	C	A	9: 48,937,173 (GRCm39)	H147Q	probably benign	Het
Vmn1r203	T	C	13: 22,708,447 (GRCm39)	I76T	possibly damaging	Het
Vmn2r17	T	A	5: 109,601,006 (GRCm39)	L768H	probably damaging	Het

Other mutations in Vmn2r104

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn2r104	APN	17	20,258,501 (GRCm39)	missense	probably damaging	0.98
IGL01098:Vmn2r104	APN	17	20,268,358 (GRCm39)	missense	probably benign	0.27
IGL01333:Vmn2r104	APN	17	20,263,055 (GRCm39)	missense	probably benign	0.17
IGL01773:Vmn2r104	APN	17	20,260,930 (GRCm39)	missense	probably benign	0.10
IGL01939:Vmn2r104	APN	17	20,250,187 (GRCm39)	missense	probably damaging	0.99
IGL02121:Vmn2r104	APN	17	20,262,056 (GRCm39)	nonsense	probably null
IGL02305:Vmn2r104	APN	17	20,263,118 (GRCm39)	missense	probably benign	0.09
IGL02374:Vmn2r104	APN	17	20,263,048 (GRCm39)	missense	probably benign	0.34
IGL03260:Vmn2r104	APN	17	20,263,083 (GRCm39)	missense	probably benign	0.05
IGL03366:Vmn2r104	APN	17	20,249,866 (GRCm39)	missense	probably damaging	1.00
R0091:Vmn2r104	UTSW	17	20,262,075 (GRCm39)	missense	possibly damaging	0.79
R0125:Vmn2r104	UTSW	17	20,250,069 (GRCm39)	missense	probably damaging	0.98
R0257:Vmn2r104	UTSW	17	20,249,889 (GRCm39)	missense	probably damaging	1.00
R0381:Vmn2r104	UTSW	17	20,268,264 (GRCm39)	nonsense	probably null
R0709:Vmn2r104	UTSW	17	20,263,166 (GRCm39)	missense	probably damaging	1.00
R0786:Vmn2r104	UTSW	17	20,262,987 (GRCm39)	missense	probably benign
R1575:Vmn2r104	UTSW	17	20,262,477 (GRCm39)	missense	probably damaging	1.00
R1827:Vmn2r104	UTSW	17	20,262,497 (GRCm39)	missense	probably damaging	0.97
R1932:Vmn2r104	UTSW	17	20,261,031 (GRCm39)	missense	probably damaging	1.00
R1956:Vmn2r104	UTSW	17	20,262,313 (GRCm39)	missense	probably damaging	0.98
R2203:Vmn2r104	UTSW	17	20,250,083 (GRCm39)	missense	probably benign	0.05
R2205:Vmn2r104	UTSW	17	20,250,083 (GRCm39)	missense	probably benign	0.05
R2859:Vmn2r104	UTSW	17	20,268,455 (GRCm39)	missense	possibly damaging	0.82
R3701:Vmn2r104	UTSW	17	20,249,818 (GRCm39)	missense	probably damaging	1.00
R3834:Vmn2r104	UTSW	17	20,250,183 (GRCm39)	missense	probably benign	0.02
R4151:Vmn2r104	UTSW	17	20,250,147 (GRCm39)	missense	probably damaging	1.00
R4470:Vmn2r104	UTSW	17	20,262,503 (GRCm39)	missense	probably damaging	1.00
R4625:Vmn2r104	UTSW	17	20,268,443 (GRCm39)	missense	probably benign	0.00
R4754:Vmn2r104	UTSW	17	20,261,030 (GRCm39)	nonsense	probably null
R4911:Vmn2r104	UTSW	17	20,250,288 (GRCm39)	missense	probably benign	0.00
R5270:Vmn2r104	UTSW	17	20,258,528 (GRCm39)	missense	probably damaging	1.00
R5279:Vmn2r104	UTSW	17	20,262,146 (GRCm39)	missense	probably benign	0.07
R5311:Vmn2r104	UTSW	17	20,250,163 (GRCm39)	missense	probably damaging	1.00
R5370:Vmn2r104	UTSW	17	20,250,450 (GRCm39)	missense	probably damaging	0.97
R5461:Vmn2r104	UTSW	17	20,250,343 (GRCm39)	missense	probably damaging	1.00
R5683:Vmn2r104	UTSW	17	20,260,981 (GRCm39)	nonsense	probably null
R5795:Vmn2r104	UTSW	17	20,250,372 (GRCm39)	missense	probably benign	0.02
R5795:Vmn2r104	UTSW	17	20,250,544 (GRCm39)	missense	possibly damaging	0.89
R5970:Vmn2r104	UTSW	17	20,249,733 (GRCm39)	missense	probably benign	0.01
R5983:Vmn2r104	UTSW	17	20,261,970 (GRCm39)	missense	probably damaging	1.00
R5992:Vmn2r104	UTSW	17	20,249,747 (GRCm39)	missense	probably damaging	1.00
R6066:Vmn2r104	UTSW	17	20,258,573 (GRCm39)	missense	possibly damaging	0.69
R6156:Vmn2r104	UTSW	17	20,261,909 (GRCm39)	missense	probably damaging	1.00
R6182:Vmn2r104	UTSW	17	20,250,507 (GRCm39)	missense	probably benign	0.16
R6245:Vmn2r104	UTSW	17	20,261,829 (GRCm39)	missense	possibly damaging	0.69
R6333:Vmn2r104	UTSW	17	20,249,848 (GRCm39)	missense	probably benign	0.30
R6573:Vmn2r104	UTSW	17	20,262,487 (GRCm39)	missense	probably damaging	1.00
R7101:Vmn2r104	UTSW	17	20,250,358 (GRCm39)	missense	possibly damaging	0.65
R7123:Vmn2r104	UTSW	17	20,261,088 (GRCm39)	missense	probably benign	0.12
R7485:Vmn2r104	UTSW	17	20,249,737 (GRCm39)	missense	probably benign	0.01
R7514:Vmn2r104	UTSW	17	20,249,791 (GRCm39)	missense	probably damaging	1.00
R7634:Vmn2r104	UTSW	17	20,261,971 (GRCm39)	missense	possibly damaging	0.48
R7958:Vmn2r104	UTSW	17	20,262,988 (GRCm39)	missense	probably benign
R8031:Vmn2r104	UTSW	17	20,263,048 (GRCm39)	missense	probably benign	0.34
R8094:Vmn2r104	UTSW	17	20,250,483 (GRCm39)	missense	possibly damaging	0.77
R8191:Vmn2r104	UTSW	17	20,250,465 (GRCm39)	missense	possibly damaging	0.89
R8308:Vmn2r104	UTSW	17	20,261,040 (GRCm39)	missense	possibly damaging	0.55
R8691:Vmn2r104	UTSW	17	20,262,110 (GRCm39)	missense	probably damaging	0.98
R8795:Vmn2r104	UTSW	17	20,262,988 (GRCm39)	missense	probably benign
R8900:Vmn2r104	UTSW	17	20,261,924 (GRCm39)	missense	probably damaging	0.99
R8913:Vmn2r104	UTSW	17	20,249,968 (GRCm39)	missense	probably damaging	1.00
R9180:Vmn2r104	UTSW	17	20,263,087 (GRCm39)	missense	probably benign	0.00
R9199:Vmn2r104	UTSW	17	20,262,097 (GRCm39)	missense	probably damaging	0.99
R9282:Vmn2r104	UTSW	17	20,261,098 (GRCm39)	missense	probably damaging	1.00
R9303:Vmn2r104	UTSW	17	20,268,439 (GRCm39)	missense	possibly damaging	0.90
R9305:Vmn2r104	UTSW	17	20,268,439 (GRCm39)	missense	possibly damaging	0.90
R9322:Vmn2r104	UTSW	17	20,263,087 (GRCm39)	missense	probably benign	0.00
R9325:Vmn2r104	UTSW	17	20,268,433 (GRCm39)	missense	possibly damaging	0.95
R9414:Vmn2r104	UTSW	17	20,250,250 (GRCm39)	missense	probably damaging	0.99
R9785:Vmn2r104	UTSW	17	20,268,409 (GRCm39)	missense	probably benign
RF007:Vmn2r104	UTSW	17	20,268,302 (GRCm39)	missense	probably benign	0.36
Z1177:Vmn2r104	UTSW	17	20,250,051 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-03