Incidental Mutation 'IGL01527:Or2g7'
ID 89591
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2g7
Ensembl Gene ENSMUSG00000094878
Gene Name olfactory receptor family 2 subfamily G member 7
Synonyms GA_x6K02T2PSCP-2515350-2516303, MOR256-19, Olfr130
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # IGL01527
Quality Score
Status
Chromosome 17
Chromosomal Location 38378064-38379017 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38378986 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 308 (N308S)
Ref Sequence ENSEMBL: ENSMUSP00000149601 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087129] [ENSMUST00000215726] [ENSMUST00000217390]
AlphaFold Q8VFC1
Predicted Effect probably benign
Transcript: ENSMUST00000087129
AA Change: N308S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000084369
Gene: ENSMUSG00000094878
AA Change: N308S

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 1.8e-44 PFAM
Pfam:7TM_GPCR_Srsx 34 223 1.9e-5 PFAM
Pfam:7tm_1 40 289 1.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215726
AA Change: N308S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217390
AA Change: N308S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300002M23Rik G T 17: 35,878,730 (GRCm39) probably null Het
Abca13 T A 11: 9,240,788 (GRCm39) W884R possibly damaging Het
Ahi1 T C 10: 20,835,984 (GRCm39) probably benign Het
Ankfn1 G T 11: 89,282,465 (GRCm39) P394Q probably benign Het
Cacnb2 T C 2: 14,989,081 (GRCm39) I393T possibly damaging Het
Ces1a G T 8: 93,771,726 (GRCm39) P24T probably damaging Het
Col22a1 T C 15: 71,778,880 (GRCm39) E269G probably damaging Het
Cyp24a1 A G 2: 170,338,486 (GRCm39) L70P probably damaging Het
Cyp8b1 T C 9: 121,744,061 (GRCm39) K424E probably damaging Het
Dicer1 G A 12: 104,657,869 (GRCm39) Q1902* probably null Het
Dst T A 1: 34,286,734 (GRCm39) L544Q probably damaging Het
Esrp2 T C 8: 106,858,865 (GRCm39) T591A probably benign Het
Gap43 C T 16: 42,112,516 (GRCm39) E82K probably benign Het
Ift70a1 T C 2: 75,810,860 (GRCm39) I408V probably benign Het
Kif17 G A 4: 137,996,397 (GRCm39) V125I probably benign Het
Lancl2 T C 6: 57,709,307 (GRCm39) S370P probably damaging Het
Macf1 T C 4: 123,386,953 (GRCm39) I203V possibly damaging Het
Mphosph9 A G 5: 124,421,687 (GRCm39) probably benign Het
Ncapg A G 5: 45,829,726 (GRCm39) I143V possibly damaging Het
Nr3c1 A G 18: 39,619,690 (GRCm39) V199A probably benign Het
Obscn T A 11: 58,955,243 (GRCm39) N3890I possibly damaging Het
Or2h2c A T 17: 37,422,701 (GRCm39) Y58N probably damaging Het
Or52n5 T A 7: 104,588,198 (GRCm39) V155E possibly damaging Het
Or8g32 A G 9: 39,305,114 (GRCm39) H6R probably benign Het
Palmd C A 3: 116,720,837 (GRCm39) E166* probably null Het
Pdzd2 T C 15: 12,445,750 (GRCm39) E327G probably damaging Het
Pex13 T C 11: 23,606,111 (GRCm39) T40A probably benign Het
Pkd2 T C 5: 104,646,750 (GRCm39) probably benign Het
Plb1 A G 5: 32,474,467 (GRCm39) T643A probably damaging Het
Prlr T A 15: 10,329,257 (GRCm39) D577E probably benign Het
Rimoc1 T C 15: 4,018,165 (GRCm39) Y170C probably damaging Het
Slc44a3 A G 3: 121,320,777 (GRCm39) C75R probably damaging Het
Susd6 A T 12: 80,921,093 (GRCm39) N230I possibly damaging Het
Tbx10 A G 19: 4,048,227 (GRCm39) R251G probably damaging Het
Uap1l1 A G 2: 25,253,816 (GRCm39) probably null Het
Ugt2b5 A G 5: 87,284,068 (GRCm39) V308A possibly damaging Het
Usp28 C A 9: 48,937,173 (GRCm39) H147Q probably benign Het
Vmn1r203 T C 13: 22,708,447 (GRCm39) I76T possibly damaging Het
Vmn2r104 A G 17: 20,263,158 (GRCm39) I101T possibly damaging Het
Vmn2r17 T A 5: 109,601,006 (GRCm39) L768H probably damaging Het
Other mutations in Or2g7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02158:Or2g7 APN 17 38,378,158 (GRCm39) missense probably damaging 0.97
IGL03172:Or2g7 APN 17 38,378,275 (GRCm39) missense probably damaging 0.99
R0389:Or2g7 UTSW 17 38,378,562 (GRCm39) missense possibly damaging 0.58
R0448:Or2g7 UTSW 17 38,378,563 (GRCm39) missense probably benign 0.00
R0616:Or2g7 UTSW 17 38,378,131 (GRCm39) missense probably damaging 1.00
R0961:Or2g7 UTSW 17 38,378,814 (GRCm39) missense probably damaging 1.00
R1789:Or2g7 UTSW 17 38,378,839 (GRCm39) missense probably damaging 1.00
R2108:Or2g7 UTSW 17 38,378,746 (GRCm39) missense possibly damaging 0.82
R4600:Or2g7 UTSW 17 38,378,853 (GRCm39) missense probably damaging 0.99
R4977:Or2g7 UTSW 17 38,378,638 (GRCm39) missense possibly damaging 0.67
R5120:Or2g7 UTSW 17 38,378,157 (GRCm39) missense probably damaging 0.97
R5930:Or2g7 UTSW 17 38,378,641 (GRCm39) missense probably benign 0.11
R6273:Or2g7 UTSW 17 38,378,686 (GRCm39) missense probably damaging 1.00
R6636:Or2g7 UTSW 17 38,378,115 (GRCm39) missense probably damaging 0.98
R6637:Or2g7 UTSW 17 38,378,115 (GRCm39) missense probably damaging 0.98
R7030:Or2g7 UTSW 17 38,378,948 (GRCm39) missense probably benign 0.13
R7045:Or2g7 UTSW 17 38,378,862 (GRCm39) missense probably benign 0.01
R7175:Or2g7 UTSW 17 38,378,370 (GRCm39) missense probably damaging 0.96
R7359:Or2g7 UTSW 17 38,378,506 (GRCm39) nonsense probably null
R7762:Or2g7 UTSW 17 38,378,566 (GRCm39) missense probably damaging 1.00
R7980:Or2g7 UTSW 17 38,378,412 (GRCm39) missense possibly damaging 0.64
R8050:Or2g7 UTSW 17 38,378,370 (GRCm39) missense probably damaging 1.00
R9035:Or2g7 UTSW 17 38,378,179 (GRCm39) missense probably benign 0.00
X0019:Or2g7 UTSW 17 38,378,613 (GRCm39) missense probably benign 0.01
Posted On 2013-12-03