Incidental Mutation 'IGL01522:Pla2g15'
ID 89433
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pla2g15
Ensembl Gene ENSMUSG00000031903
Gene Name phospholipase A2, group XV
Synonyms Lpla2, C87498, Lypla3, LLPL
Accession Numbers
Essential gene? Probably non essential (E-score: 0.203) question?
Stock # IGL01522
Quality Score
Status
Chromosome 8
Chromosomal Location 106877031-106891347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106889748 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 340 (N340S)
Ref Sequence ENSEMBL: ENSMUSP00000034377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034377] [ENSMUST00000212963]
AlphaFold Q8VEB4
Predicted Effect probably benign
Transcript: ENSMUST00000034377
AA Change: N340S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000034377
Gene: ENSMUSG00000031903
AA Change: N340S

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:LCAT 72 399 6.2e-84 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212116
Predicted Effect probably benign
Transcript: ENSMUST00000212963
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutant mice do not develop atherosclerotic lesions even when fed an atherogenic diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts12 T C 15: 11,065,245 (GRCm39) probably null Het
Adamts3 T C 5: 89,850,802 (GRCm39) N579S probably benign Het
Akr1c19 A G 13: 4,289,098 (GRCm39) probably benign Het
Ankrd39 T A 1: 36,581,142 (GRCm39) H69L probably damaging Het
Apcdd1 T A 18: 63,085,186 (GRCm39) M461K possibly damaging Het
Bpifa3 G A 2: 153,979,502 (GRCm39) C209Y probably damaging Het
Cep131 T C 11: 119,957,989 (GRCm39) E779G probably benign Het
Cep85 T C 4: 133,879,566 (GRCm39) Q394R probably damaging Het
Cep85 G T 4: 133,879,567 (GRCm39) Q394K probably damaging Het
Clcn6 T C 4: 148,101,992 (GRCm39) Y364C probably benign Het
Fetub G A 16: 22,748,391 (GRCm39) M1I probably null Het
Greb1 T C 12: 16,751,202 (GRCm39) I1003V probably damaging Het
Hsf3 A G X: 95,364,200 (GRCm39) probably benign Het
Jcad A G 18: 4,673,312 (GRCm39) N358S probably damaging Het
Kndc1 T C 7: 139,493,888 (GRCm39) probably benign Het
Lama1 A T 17: 68,059,769 (GRCm39) probably benign Het
Mark2 A G 19: 7,258,603 (GRCm39) V50A probably benign Het
Mmp7 T C 9: 7,692,229 (GRCm39) W35R probably damaging Het
Ndc80 A G 17: 71,806,320 (GRCm39) V578A probably benign Het
Nfyc T C 4: 120,638,721 (GRCm39) E42G probably damaging Het
Or1j15 A G 2: 36,459,233 (GRCm39) T208A probably benign Het
Or52b4 A T 7: 102,184,391 (GRCm39) I146F probably damaging Het
Or5d37 T C 2: 87,923,360 (GRCm39) K307E possibly damaging Het
Or8g21 A T 9: 38,906,396 (GRCm39) C112S probably benign Het
Or9i16 A T 19: 13,864,722 (GRCm39) L284* probably null Het
Pcdha11 T C 18: 37,318,061 (GRCm39) F925L probably damaging Het
Pdcd1 T G 1: 93,968,571 (GRCm39) R154S probably benign Het
Pepd T A 7: 34,623,865 (GRCm39) D87E probably benign Het
Pfn4 A G 12: 4,820,240 (GRCm39) T30A probably benign Het
Pgpep1l A G 7: 67,887,456 (GRCm39) M48T possibly damaging Het
Plcb4 A G 2: 135,844,547 (GRCm39) D155G probably damaging Het
Plg G A 17: 12,622,956 (GRCm39) G499S probably damaging Het
Plin3 C T 17: 56,587,799 (GRCm39) W305* probably null Het
Polq C A 16: 36,848,265 (GRCm39) L291I probably damaging Het
Sanbr A G 11: 23,532,865 (GRCm39) probably null Het
Sdf2l1 T A 16: 16,950,014 (GRCm39) H54L probably damaging Het
Slc38a2 C T 15: 96,590,936 (GRCm39) D276N possibly damaging Het
Syk A G 13: 52,797,097 (GRCm39) T576A probably benign Het
Tas2r119 G A 15: 32,178,339 (GRCm39) V302I probably benign Het
Uso1 T C 5: 92,329,278 (GRCm39) F389L probably damaging Het
Wwc2 T A 8: 48,321,668 (GRCm39) Y482F unknown Het
Other mutations in Pla2g15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02719:Pla2g15 APN 8 106,886,828 (GRCm39) missense probably benign 0.01
IGL03065:Pla2g15 APN 8 106,886,851 (GRCm39) missense probably benign 0.20
R0125:Pla2g15 UTSW 8 106,889,756 (GRCm39) missense probably benign 0.00
R1691:Pla2g15 UTSW 8 106,881,581 (GRCm39) missense possibly damaging 0.93
R1939:Pla2g15 UTSW 8 106,889,927 (GRCm39) missense probably damaging 0.96
R3887:Pla2g15 UTSW 8 106,887,767 (GRCm39) missense probably damaging 0.99
R4633:Pla2g15 UTSW 8 106,886,887 (GRCm39) missense probably damaging 1.00
R4702:Pla2g15 UTSW 8 106,889,691 (GRCm39) missense probably benign 0.08
R4703:Pla2g15 UTSW 8 106,889,691 (GRCm39) missense probably benign 0.08
R4705:Pla2g15 UTSW 8 106,889,691 (GRCm39) missense probably benign 0.08
R4766:Pla2g15 UTSW 8 106,889,703 (GRCm39) missense probably damaging 1.00
R4928:Pla2g15 UTSW 8 106,889,850 (GRCm39) nonsense probably null
R5543:Pla2g15 UTSW 8 106,887,775 (GRCm39) missense probably damaging 0.99
R6489:Pla2g15 UTSW 8 106,889,826 (GRCm39) missense probably benign 0.10
R6802:Pla2g15 UTSW 8 106,877,213 (GRCm39) missense probably damaging 0.99
R7381:Pla2g15 UTSW 8 106,889,576 (GRCm39) missense probably benign 0.03
R9245:Pla2g15 UTSW 8 106,889,539 (GRCm39) missense possibly damaging 0.81
R9302:Pla2g15 UTSW 8 106,877,201 (GRCm39) missense probably benign 0.04
R9623:Pla2g15 UTSW 8 106,887,275 (GRCm39) missense possibly damaging 0.90
Z1177:Pla2g15 UTSW 8 106,889,619 (GRCm39) missense probably benign 0.19
Posted On 2013-12-03