Incidental Mutation 'IGL01444:Adam25'
ID 84347
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adam25
Ensembl Gene ENSMUSG00000071937
Gene Name ADAM metallopeptidase domain 25
Synonyms testase 2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # IGL01444
Quality Score
Status
Chromosome 8
Chromosomal Location 41205245-41209213 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 41207958 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 408 (R408H)
Ref Sequence ENSEMBL: ENSMUSP00000094420 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096663]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000096663
AA Change: R408H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000094420
Gene: ENSMUSG00000071937
AA Change: R408H

DomainStartEndE-ValueType
Pfam:Pep_M12B_propep 53 179 3.4e-21 PFAM
Pfam:Reprolysin_5 220 398 1.6e-16 PFAM
Pfam:Reprolysin_4 220 407 2.5e-13 PFAM
Pfam:Reprolysin 221 410 5.6e-46 PFAM
Pfam:Reprolysin_2 222 399 9.7e-14 PFAM
Pfam:Reprolysin_3 246 366 1e-18 PFAM
DISIN 428 503 3.33e-39 SMART
ACR 504 640 8.95e-74 SMART
transmembrane domain 706 728 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is expressed in a regulated fashion during spermatogenesis. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional metalloprotease enzyme. This gene is located adjacent to other ADAM genes on chromosome 8. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adad1 A T 3: 37,146,183 (GRCm39) N517I probably damaging Het
Adam34l A T 8: 44,079,470 (GRCm39) D251E probably benign Het
Ang C A 14: 51,339,124 (GRCm39) Y88* probably null Het
Ankrd42 T C 7: 92,259,793 (GRCm39) T327A probably damaging Het
Birc6 A G 17: 74,938,682 (GRCm39) D2696G probably damaging Het
Chd3 G A 11: 69,239,568 (GRCm39) T1717M probably benign Het
Csmd1 T A 8: 16,250,069 (GRCm39) M970L probably benign Het
Dhx32 T C 7: 133,350,706 (GRCm39) I121M possibly damaging Het
Dnah11 G A 12: 117,983,967 (GRCm39) S2506F possibly damaging Het
Dscam T A 16: 96,474,909 (GRCm39) I1218F possibly damaging Het
Duox1 T C 2: 122,170,571 (GRCm39) L1197P probably damaging Het
Eps8l2 T C 7: 140,941,288 (GRCm39) probably benign Het
Exoc3 T C 13: 74,355,054 (GRCm39) K49R probably damaging Het
Exoc8 T A 8: 125,622,580 (GRCm39) T596S possibly damaging Het
F13a1 C T 13: 37,102,551 (GRCm39) G391R probably null Het
Fat3 A T 9: 15,910,144 (GRCm39) S1953T probably damaging Het
Gls2 C A 10: 128,037,216 (GRCm39) N252K probably damaging Het
Haus2 G A 2: 120,446,423 (GRCm39) R115K probably benign Het
Ift122 A G 6: 115,861,340 (GRCm39) K262E probably benign Het
Islr2 C T 9: 58,105,661 (GRCm39) C533Y probably damaging Het
Lrp2 A T 2: 69,274,060 (GRCm39) F3997I possibly damaging Het
Nt5c1a C T 4: 123,109,962 (GRCm39) R354W probably damaging Het
Or6c206 T A 10: 129,097,204 (GRCm39) C125S probably damaging Het
Pcolce A T 5: 137,605,738 (GRCm39) S200R probably damaging Het
Plec A G 15: 76,063,497 (GRCm39) V2213A possibly damaging Het
Prmt3 T A 7: 49,430,120 (GRCm39) D74E probably benign Het
Ptk7 A G 17: 46,876,313 (GRCm39) F1046S probably damaging Het
Ranbp2 T C 10: 58,311,122 (GRCm39) Y887H possibly damaging Het
Sanbr T G 11: 23,570,225 (GRCm39) probably benign Het
Sez6l2 G A 7: 126,561,055 (GRCm39) E447K possibly damaging Het
Shld2 C A 14: 33,959,514 (GRCm39) V823F probably damaging Het
Snrnp70 C T 7: 45,036,660 (GRCm39) probably null Het
Timm10 T A 2: 84,660,208 (GRCm39) V49E probably damaging Het
Tox2 T C 2: 163,067,386 (GRCm39) probably benign Het
Usp20 T A 2: 30,888,801 (GRCm39) M1K probably null Het
Usp32 A C 11: 84,949,990 (GRCm39) L223V probably damaging Het
Zeb1 G T 18: 5,767,906 (GRCm39) A806S probably damaging Het
Zeb1 T C 18: 5,767,138 (GRCm39) S550P probably benign Het
Other mutations in Adam25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01977:Adam25 APN 8 41,208,134 (GRCm39) missense probably benign 0.00
IGL02098:Adam25 APN 8 41,208,680 (GRCm39) missense probably benign 0.12
IGL02233:Adam25 APN 8 41,208,423 (GRCm39) missense probably damaging 1.00
IGL02458:Adam25 APN 8 41,206,844 (GRCm39) missense probably benign 0.01
IGL02527:Adam25 APN 8 41,206,785 (GRCm39) missense possibly damaging 0.78
IGL02632:Adam25 APN 8 41,208,237 (GRCm39) missense possibly damaging 0.90
IGL02995:Adam25 APN 8 41,206,760 (GRCm39) missense probably benign 0.00
H8786:Adam25 UTSW 8 41,207,261 (GRCm39) missense probably benign 0.00
R0062:Adam25 UTSW 8 41,207,829 (GRCm39) missense probably damaging 1.00
R0062:Adam25 UTSW 8 41,207,829 (GRCm39) missense probably damaging 1.00
R0189:Adam25 UTSW 8 41,208,467 (GRCm39) missense probably damaging 1.00
R0505:Adam25 UTSW 8 41,208,261 (GRCm39) missense probably damaging 1.00
R0532:Adam25 UTSW 8 41,208,987 (GRCm39) missense probably benign 0.00
R0699:Adam25 UTSW 8 41,209,011 (GRCm39) missense probably benign
R0972:Adam25 UTSW 8 41,208,168 (GRCm39) missense probably damaging 1.00
R1053:Adam25 UTSW 8 41,207,768 (GRCm39) missense probably benign 0.30
R1079:Adam25 UTSW 8 41,208,513 (GRCm39) missense possibly damaging 0.87
R1872:Adam25 UTSW 8 41,208,263 (GRCm39) nonsense probably null
R1933:Adam25 UTSW 8 41,207,922 (GRCm39) missense probably benign 0.01
R1934:Adam25 UTSW 8 41,207,922 (GRCm39) missense probably benign 0.01
R4061:Adam25 UTSW 8 41,206,819 (GRCm39) missense possibly damaging 0.67
R4702:Adam25 UTSW 8 41,207,163 (GRCm39) missense probably damaging 1.00
R4703:Adam25 UTSW 8 41,207,163 (GRCm39) missense probably damaging 1.00
R4705:Adam25 UTSW 8 41,207,163 (GRCm39) missense probably damaging 1.00
R4859:Adam25 UTSW 8 41,207,580 (GRCm39) missense probably benign 0.01
R5015:Adam25 UTSW 8 41,207,671 (GRCm39) missense probably benign 0.22
R5249:Adam25 UTSW 8 41,208,991 (GRCm39) missense probably benign
R5628:Adam25 UTSW 8 41,208,747 (GRCm39) missense probably benign 0.00
R5791:Adam25 UTSW 8 41,207,257 (GRCm39) missense probably benign
R6439:Adam25 UTSW 8 41,207,627 (GRCm39) missense possibly damaging 0.92
R6693:Adam25 UTSW 8 41,207,568 (GRCm39) missense probably damaging 1.00
R7041:Adam25 UTSW 8 41,207,121 (GRCm39) missense probably benign 0.04
R7101:Adam25 UTSW 8 41,208,438 (GRCm39) missense probably benign 0.00
R7531:Adam25 UTSW 8 41,206,914 (GRCm39) missense probably damaging 0.99
R7600:Adam25 UTSW 8 41,208,854 (GRCm39) missense probably benign 0.01
R7634:Adam25 UTSW 8 41,207,883 (GRCm39) missense probably benign 0.00
R7964:Adam25 UTSW 8 41,208,576 (GRCm39) missense probably damaging 0.99
R8017:Adam25 UTSW 8 41,207,124 (GRCm39) missense possibly damaging 0.56
R8021:Adam25 UTSW 8 41,207,796 (GRCm39) missense probably damaging 1.00
R8499:Adam25 UTSW 8 41,208,189 (GRCm39) missense probably damaging 1.00
R8686:Adam25 UTSW 8 41,208,521 (GRCm39) missense probably benign 0.44
R8715:Adam25 UTSW 8 41,207,099 (GRCm39) missense probably benign 0.00
R8847:Adam25 UTSW 8 41,206,746 (GRCm39) missense probably benign
R8921:Adam25 UTSW 8 41,207,710 (GRCm39) nonsense probably null
R9120:Adam25 UTSW 8 41,209,141 (GRCm39) utr 3 prime probably benign
R9158:Adam25 UTSW 8 41,208,645 (GRCm39) missense probably damaging 1.00
R9339:Adam25 UTSW 8 41,206,911 (GRCm39) missense probably damaging 1.00
R9348:Adam25 UTSW 8 41,208,953 (GRCm39) missense probably benign
R9454:Adam25 UTSW 8 41,207,486 (GRCm39) missense probably damaging 0.99
R9492:Adam25 UTSW 8 41,206,736 (GRCm39) start codon destroyed probably benign 0.12
R9680:Adam25 UTSW 8 41,208,239 (GRCm39) missense probably damaging 1.00
RF006:Adam25 UTSW 8 41,208,834 (GRCm39) missense probably benign
Posted On 2013-11-11