Incidental Mutation 'R0968:Dnm3'
ID 83936
Institutional Source Beutler Lab
Gene Symbol Dnm3
Ensembl Gene ENSMUSG00000040265
Gene Name dynamin 3
Synonyms 9630020E24Rik, B230343F03Rik
MMRRC Submission 039097-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0968 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 161810022-162305603 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 161847388 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000124593 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070330] [ENSMUST00000086074] [ENSMUST00000159763] [ENSMUST00000160665]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000070330
SMART Domains Protein: ENSMUSP00000064538
Gene: ENSMUSG00000040265

DomainStartEndE-ValueType
DYNc 6 245 1.48e-182 SMART
PH 516 623 1.58e-11 SMART
GED 644 735 6.82e-33 SMART
low complexity region 738 751 N/A INTRINSIC
low complexity region 756 771 N/A INTRINSIC
low complexity region 799 812 N/A INTRINSIC
low complexity region 824 852 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000086074
SMART Domains Protein: ENSMUSP00000083241
Gene: ENSMUSG00000040265

DomainStartEndE-ValueType
DYNc 6 245 1.48e-182 SMART
PH 516 623 1.58e-11 SMART
GED 648 739 6.82e-33 SMART
low complexity region 742 755 N/A INTRINSIC
low complexity region 760 775 N/A INTRINSIC
low complexity region 803 816 N/A INTRINSIC
low complexity region 828 856 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000159763
SMART Domains Protein: ENSMUSP00000125356
Gene: ENSMUSG00000040265

DomainStartEndE-ValueType
PH 1 94 5.13e-2 SMART
GED 115 206 6.82e-33 SMART
low complexity region 209 222 N/A INTRINSIC
low complexity region 227 242 N/A INTRINSIC
low complexity region 270 283 N/A INTRINSIC
low complexity region 295 319 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160555
Predicted Effect probably benign
Transcript: ENSMUST00000160665
SMART Domains Protein: ENSMUSP00000124593
Gene: ENSMUSG00000040265

DomainStartEndE-ValueType
PH 1 94 5.13e-2 SMART
GED 115 206 6.82e-33 SMART
low complexity region 209 222 N/A INTRINSIC
low complexity region 227 242 N/A INTRINSIC
low complexity region 270 283 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161539
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161583
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161826
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.0%
  • 10x: 98.0%
  • 20x: 96.7%
Validation Efficiency 94% (34/36)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
PHENOTYPE: Mice homozygous for a targeted allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik G A 3: 137,772,967 (GRCm39) V719M probably damaging Het
Abca13 A G 11: 9,248,016 (GRCm39) S2588G probably benign Het
Acaca C T 11: 84,129,859 (GRCm39) Q405* probably null Het
Brms1l G A 12: 55,912,798 (GRCm39) D264N possibly damaging Het
Cabcoco1 T C 10: 68,272,202 (GRCm39) M254V probably benign Het
Cndp1 G A 18: 84,652,777 (GRCm39) probably benign Het
Coro7 G C 16: 4,487,919 (GRCm39) probably benign Het
Cylc2 A G 4: 51,216,706 (GRCm39) M1V probably null Het
Cyp3a11 G A 5: 145,799,324 (GRCm39) probably benign Het
Dnah10 C T 5: 124,906,641 (GRCm39) T4224M probably damaging Het
Dnah2 T C 11: 69,339,345 (GRCm39) E3054G possibly damaging Het
Efcab5 G A 11: 77,031,749 (GRCm39) R42W probably damaging Het
Fgf12 T C 16: 27,981,185 (GRCm39) N177S probably null Het
Flt3 C T 5: 147,278,037 (GRCm39) V846I possibly damaging Het
Gm11569 A T 11: 99,689,250 (GRCm39) probably benign Het
Gm12695 A C 4: 96,650,303 (GRCm39) V181G probably damaging Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Lars1 C A 18: 42,351,648 (GRCm39) R852L probably benign Het
Lca5 T C 9: 83,305,222 (GRCm39) T195A probably benign Het
Lrrc40 G A 3: 157,742,426 (GRCm39) D14N probably damaging Het
Map4k2 T C 19: 6,395,487 (GRCm39) S327P probably damaging Het
Mpp4 A G 1: 59,169,249 (GRCm39) F397L probably damaging Het
Mtus2 T C 5: 148,014,994 (GRCm39) S596P probably benign Het
Myo3a T A 2: 22,448,301 (GRCm39) N25K probably damaging Het
Nadsyn1 T C 7: 143,359,770 (GRCm39) T401A probably benign Het
Pde6a A T 18: 61,386,809 (GRCm39) E395D probably damaging Het
Plekhm2 A G 4: 141,357,243 (GRCm39) V743A probably benign Het
Pzp A T 6: 128,502,108 (GRCm39) D80E probably benign Het
Rp1 A T 1: 4,415,575 (GRCm39) C1846S probably benign Het
Shbg A G 11: 69,508,014 (GRCm39) L117P probably damaging Het
Slc35e1 T C 8: 73,246,415 (GRCm39) probably benign Het
Slc5a2 G C 7: 127,869,803 (GRCm39) R412P probably damaging Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Supt20 A G 3: 54,615,821 (GRCm39) probably benign Het
Vcpip1 A T 1: 9,816,604 (GRCm39) I593N probably damaging Het
Other mutations in Dnm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00552:Dnm3 APN 1 161,839,495 (GRCm39) missense probably damaging 1.00
IGL02444:Dnm3 APN 1 161,838,444 (GRCm39) missense possibly damaging 0.46
IGL02481:Dnm3 APN 1 161,838,471 (GRCm39) missense probably damaging 0.99
IGL02623:Dnm3 APN 1 162,183,001 (GRCm39) missense probably damaging 0.99
IGL03132:Dnm3 APN 1 161,838,674 (GRCm39) critical splice acceptor site probably null
IGL03330:Dnm3 APN 1 162,148,560 (GRCm39) missense probably benign 0.00
fever UTSW 1 162,148,696 (GRCm39) splice site probably null
nobel UTSW 1 162,305,274 (GRCm39) missense probably damaging 1.00
splotare UTSW 1 162,148,556 (GRCm39) missense probably damaging 0.98
LCD18:Dnm3 UTSW 1 162,234,130 (GRCm39) intron probably benign
R0066:Dnm3 UTSW 1 162,234,930 (GRCm39) missense probably damaging 0.98
R0066:Dnm3 UTSW 1 162,234,930 (GRCm39) missense probably damaging 0.98
R0240:Dnm3 UTSW 1 162,181,194 (GRCm39) missense probably benign 0.00
R0240:Dnm3 UTSW 1 162,181,194 (GRCm39) missense probably benign 0.00
R1161:Dnm3 UTSW 1 162,181,143 (GRCm39) missense probably benign 0.06
R1680:Dnm3 UTSW 1 161,838,545 (GRCm39) missense probably benign 0.12
R1747:Dnm3 UTSW 1 162,141,153 (GRCm39) missense probably damaging 1.00
R1881:Dnm3 UTSW 1 162,305,517 (GRCm39) start gained probably benign
R1997:Dnm3 UTSW 1 162,181,281 (GRCm39) missense possibly damaging 0.60
R2157:Dnm3 UTSW 1 162,135,462 (GRCm39) missense possibly damaging 0.95
R2270:Dnm3 UTSW 1 162,305,358 (GRCm39) missense probably damaging 1.00
R2897:Dnm3 UTSW 1 162,113,643 (GRCm39) splice site probably benign
R3018:Dnm3 UTSW 1 162,149,328 (GRCm39) nonsense probably null
R3851:Dnm3 UTSW 1 162,148,696 (GRCm39) splice site probably null
R3861:Dnm3 UTSW 1 162,138,974 (GRCm39) missense possibly damaging 0.79
R3930:Dnm3 UTSW 1 161,911,699 (GRCm39) missense probably damaging 1.00
R4432:Dnm3 UTSW 1 161,819,566 (GRCm39) intron probably benign
R5318:Dnm3 UTSW 1 161,839,376 (GRCm39) nonsense probably null
R5361:Dnm3 UTSW 1 161,838,471 (GRCm39) missense probably damaging 0.99
R5606:Dnm3 UTSW 1 162,113,587 (GRCm39) missense probably damaging 0.99
R5783:Dnm3 UTSW 1 162,183,040 (GRCm39) missense possibly damaging 0.70
R6019:Dnm3 UTSW 1 161,962,070 (GRCm39) missense probably damaging 0.99
R6072:Dnm3 UTSW 1 161,838,637 (GRCm39) small deletion probably benign
R6086:Dnm3 UTSW 1 162,148,602 (GRCm39) missense probably damaging 0.99
R6110:Dnm3 UTSW 1 161,838,637 (GRCm39) small deletion probably benign
R6158:Dnm3 UTSW 1 162,148,556 (GRCm39) missense probably damaging 0.98
R6473:Dnm3 UTSW 1 162,305,274 (GRCm39) missense probably damaging 1.00
R6499:Dnm3 UTSW 1 162,141,164 (GRCm39) missense probably damaging 1.00
R6702:Dnm3 UTSW 1 162,146,256 (GRCm39) missense probably benign 0.04
R6703:Dnm3 UTSW 1 162,146,256 (GRCm39) missense probably benign 0.04
R6739:Dnm3 UTSW 1 162,305,352 (GRCm39) missense probably damaging 0.99
R6811:Dnm3 UTSW 1 162,148,652 (GRCm39) missense probably damaging 0.96
R6915:Dnm3 UTSW 1 162,145,966 (GRCm39) splice site probably null
R6946:Dnm3 UTSW 1 162,141,224 (GRCm39) missense possibly damaging 0.91
R7062:Dnm3 UTSW 1 161,962,060 (GRCm39) nonsense probably null
R7067:Dnm3 UTSW 1 162,148,540 (GRCm39) missense probably damaging 1.00
R7071:Dnm3 UTSW 1 161,847,412 (GRCm39) missense probably damaging 0.99
R7468:Dnm3 UTSW 1 162,149,198 (GRCm39) splice site probably null
R7521:Dnm3 UTSW 1 161,962,113 (GRCm39) missense probably damaging 1.00
R7583:Dnm3 UTSW 1 162,305,343 (GRCm39) missense possibly damaging 0.93
R7667:Dnm3 UTSW 1 161,839,399 (GRCm39) missense probably damaging 1.00
R7711:Dnm3 UTSW 1 161,819,622 (GRCm39) missense possibly damaging 0.83
R7837:Dnm3 UTSW 1 161,819,619 (GRCm39) missense possibly damaging 0.94
R7838:Dnm3 UTSW 1 161,819,619 (GRCm39) missense possibly damaging 0.94
R7900:Dnm3 UTSW 1 162,182,940 (GRCm39) missense probably benign 0.00
R7939:Dnm3 UTSW 1 162,123,165 (GRCm39) missense possibly damaging 0.91
R8059:Dnm3 UTSW 1 161,911,708 (GRCm39) missense probably damaging 1.00
R8123:Dnm3 UTSW 1 161,838,672 (GRCm39) missense probably benign 0.01
R8246:Dnm3 UTSW 1 162,135,486 (GRCm39) missense probably damaging 1.00
R8249:Dnm3 UTSW 1 162,305,312 (GRCm39) nonsense probably null
R8511:Dnm3 UTSW 1 162,113,611 (GRCm39) missense possibly damaging 0.69
R8900:Dnm3 UTSW 1 162,135,445 (GRCm39) missense probably benign 0.17
R8976:Dnm3 UTSW 1 162,135,505 (GRCm39) missense probably damaging 1.00
R9455:Dnm3 UTSW 1 162,148,524 (GRCm39) missense possibly damaging 0.88
R9604:Dnm3 UTSW 1 161,838,584 (GRCm39) missense possibly damaging 0.55
R9617:Dnm3 UTSW 1 162,149,354 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAGTTAGAGGCAAGTCGATGCAG -3'
(R):5'- TTTATTTGGACTCAGGCCACGGG -3'

Sequencing Primer
(F):5'- ATGCAGTGGTTGGACATTTCC -3'
(R):5'- GATTCTGACTGACTATCCTAAGCGG -3'
Posted On 2013-11-08