Incidental Mutation 'R0930:Ticam1'
ID 80834
Institutional Source Beutler Lab
Gene Symbol Ticam1
Ensembl Gene ENSMUSG00000047123
Gene Name TIR domain containing adaptor molecule 1
Synonyms Trif, TICAM-1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0930 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 56576462-56583767 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 56577226 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 623 (V623D)
Ref Sequence ENSEMBL: ENSMUSP00000055104 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058136]
AlphaFold Q80UF7
Predicted Effect unknown
Transcript: ENSMUST00000058136
AA Change: V623D
SMART Domains Protein: ENSMUSP00000055104
Gene: ENSMUSG00000047123
AA Change: V623D

DomainStartEndE-ValueType
PDB:4BSX|D 5 153 3e-52 PDB
low complexity region 345 384 N/A INTRINSIC
SCOP:d1fyva_ 386 491 8e-3 SMART
PDB:2M1X|A 391 547 1e-74 PDB
Pfam:RHIM 610 698 4.7e-13 PFAM
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
PHENOTYPE: Homozygous null mice are viable but exhibit abnormalities of the innate immune system. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg8 G T 17: 84,990,705 (GRCm39) V16L probably benign Het
Adamts18 A T 8: 114,432,028 (GRCm39) probably null Het
Agpat4 A T 17: 12,417,723 (GRCm39) E88V probably damaging Het
Ahcyl2 A C 6: 29,870,627 (GRCm39) probably null Het
Ankrd2 T A 19: 42,032,292 (GRCm39) probably null Het
Anxa6 A T 11: 54,885,214 (GRCm39) probably null Het
Bpi A G 2: 158,103,346 (GRCm39) I114V possibly damaging Het
Cacna1c A T 6: 118,652,857 (GRCm39) I772N probably damaging Het
Cacna2d1 A G 5: 16,570,860 (GRCm39) N1045D possibly damaging Het
Caprin2 T C 6: 148,785,009 (GRCm39) probably null Het
Cars1 T A 7: 143,124,307 (GRCm39) H373L probably damaging Het
Ccdc191 G T 16: 43,751,618 (GRCm39) G316V probably damaging Het
Cd244a T A 1: 171,404,801 (GRCm39) probably null Het
Ces1a C T 8: 93,749,044 (GRCm39) D456N probably benign Het
Cul3 A T 1: 80,267,835 (GRCm39) M102K probably damaging Het
Dact1 A G 12: 71,365,234 (GRCm39) R672G probably damaging Het
Dapk1 T C 13: 60,905,262 (GRCm39) F991L probably benign Het
Dlg5 G A 14: 24,185,645 (GRCm39) P1920L probably damaging Het
Eme2 G A 17: 25,111,892 (GRCm39) S263F probably damaging Het
Exosc4 A G 15: 76,211,734 (GRCm39) I14M probably benign Het
Ezr G A 17: 7,021,398 (GRCm39) R180* probably null Het
Fcgbpl1 A T 7: 27,839,555 (GRCm39) Y456F probably damaging Het
Fyb1 A T 15: 6,668,309 (GRCm39) I501F probably damaging Het
Hdac5 G T 11: 102,095,472 (GRCm39) P383Q probably benign Het
Hmx3 A T 7: 131,144,813 (GRCm39) H41L probably benign Het
Krt36 A G 11: 99,994,225 (GRCm39) F284S probably damaging Het
L1td1 A G 4: 98,625,862 (GRCm39) N686D probably damaging Het
Lsamp G A 16: 41,709,327 (GRCm39) G86S probably benign Het
Myh8 A G 11: 67,196,824 (GRCm39) E1819G possibly damaging Het
Myo7a A T 7: 97,747,463 (GRCm39) I129N probably damaging Het
Nckap1 A T 2: 80,384,593 (GRCm39) C114S probably benign Het
Nphp4 T G 4: 152,622,512 (GRCm39) L599R probably benign Het
Nrcam A G 12: 44,596,667 (GRCm39) I301V probably benign Het
Or6b2b A G 1: 92,419,127 (GRCm39) S117P possibly damaging Het
Os9 C T 10: 126,932,924 (GRCm39) R547Q probably damaging Het
Oxtr A T 6: 112,466,598 (GRCm39) probably null Het
Pgm2 A T 5: 64,269,490 (GRCm39) I526F possibly damaging Het
Plekho2 T C 9: 65,464,105 (GRCm39) D248G possibly damaging Het
Rab43 A T 6: 87,769,752 (GRCm39) Y151* probably null Het
Rbm19 A G 5: 120,264,269 (GRCm39) E343G probably benign Het
Rel A T 11: 23,692,439 (GRCm39) D531E probably benign Het
Rfx4 T A 10: 84,704,291 (GRCm39) V262E probably damaging Het
Ryr3 A G 2: 112,672,178 (GRCm39) L1431P probably damaging Het
Sdk2 A G 11: 113,729,271 (GRCm39) I1102T probably benign Het
Sema3d A C 5: 12,513,183 (GRCm39) D51A possibly damaging Het
Sh2d4a T A 8: 68,787,775 (GRCm39) F294I probably damaging Het
Slc3a1 A G 17: 85,367,171 (GRCm39) T453A probably benign Het
Sod1 A G 16: 90,022,071 (GRCm39) D93G probably benign Het
Sptan1 A G 2: 29,906,040 (GRCm39) N1662S probably damaging Het
Stxbp4 A C 11: 90,512,526 (GRCm39) M1R probably null Het
Tbc1d7 A T 13: 43,318,812 (GRCm39) Y108* probably null Het
Tjap1 A C 17: 46,569,455 (GRCm39) W512G possibly damaging Het
Unc80 A T 1: 66,549,800 (GRCm39) Q686L possibly damaging Het
Wdr45b A T 11: 121,221,040 (GRCm39) F213I probably damaging Het
Xdh A C 17: 74,230,077 (GRCm39) W285G probably benign Het
Zfp646 C T 7: 127,482,982 (GRCm39) Q1500* probably null Het
Other mutations in Ticam1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02160:Ticam1 APN 17 56,577,560 (GRCm39) missense possibly damaging 0.80
IGL02164:Ticam1 APN 17 56,577,019 (GRCm39) missense unknown
Lps2 UTSW 17 56,576,969 (GRCm39) frame shift probably null
Pangu UTSW 17 56,276,693 (GRCm38) critical splice donor site probably benign
Yue UTSW 17 56,578,339 (GRCm39) missense probably benign 0.06
R0930:Ticam1 UTSW 17 56,578,687 (GRCm39) missense probably damaging 1.00
R1509:Ticam1 UTSW 17 56,578,113 (GRCm39) missense probably benign 0.43
R1837:Ticam1 UTSW 17 56,577,799 (GRCm39) missense possibly damaging 0.87
R1863:Ticam1 UTSW 17 56,578,436 (GRCm39) missense probably damaging 1.00
R1867:Ticam1 UTSW 17 56,578,718 (GRCm39) missense probably benign 0.01
R1872:Ticam1 UTSW 17 56,578,897 (GRCm39) missense probably benign 0.00
R1893:Ticam1 UTSW 17 56,578,894 (GRCm39) missense probably benign 0.36
R1980:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R1981:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R1982:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R2263:Ticam1 UTSW 17 56,578,888 (GRCm39) missense possibly damaging 0.95
R2513:Ticam1 UTSW 17 56,578,612 (GRCm39) missense possibly damaging 0.61
R4294:Ticam1 UTSW 17 56,578,339 (GRCm39) missense probably benign 0.06
R4888:Ticam1 UTSW 17 56,578,642 (GRCm39) missense probably damaging 0.98
R4982:Ticam1 UTSW 17 56,579,020 (GRCm39) missense probably benign 0.10
R5396:Ticam1 UTSW 17 56,578,117 (GRCm39) missense probably benign 0.02
R5604:Ticam1 UTSW 17 56,578,756 (GRCm39) missense probably benign 0.13
R5641:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5647:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5648:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5657:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5770:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5771:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5964:Ticam1 UTSW 17 56,578,703 (GRCm39) missense probably damaging 0.99
R5974:Ticam1 UTSW 17 56,578,178 (GRCm39) missense probably benign
R6217:Ticam1 UTSW 17 56,577,730 (GRCm39) missense probably damaging 1.00
R6983:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6984:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6985:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6986:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6987:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6988:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6989:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R7029:Ticam1 UTSW 17 56,578,154 (GRCm39) missense possibly damaging 0.51
R7684:Ticam1 UTSW 17 56,576,984 (GRCm39) missense unknown
R7755:Ticam1 UTSW 17 56,577,182 (GRCm39) missense unknown
R7885:Ticam1 UTSW 17 56,578,067 (GRCm39) missense probably benign 0.04
R8021:Ticam1 UTSW 17 56,577,089 (GRCm39) missense unknown
R8414:Ticam1 UTSW 17 56,578,340 (GRCm39) missense probably benign 0.00
R8822:Ticam1 UTSW 17 56,578,444 (GRCm39) missense probably damaging 1.00
R9442:Ticam1 UTSW 17 56,577,428 (GRCm39) missense probably benign 0.00
R9521:Ticam1 UTSW 17 56,578,388 (GRCm39) missense probably benign 0.07
V8831:Ticam1 UTSW 17 56,576,969 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- GGTTCTCCGAACACTCAGTCTTGTC -3'
(R):5'- TGCCTACACAGCCTATGTCCATAGC -3'

Sequencing Primer
(F):5'- GAACACTCAGTCTTGTCATCAG -3'
(R):5'- TAGCTATAGGGCCTGGCAAG -3'
Posted On 2013-11-07