Incidental Mutation 'IGL01384:Aopep'
ID 78999
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Aopep
Ensembl Gene ENSMUSG00000021458
Gene Name aminopeptidase O
Synonyms 2010111I01Rik, ApO
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # IGL01384
Quality Score
Status
Chromosome 13
Chromosomal Location 63112707-63473910 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to T at 63338290 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152666 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021911] [ENSMUST00000091560] [ENSMUST00000222907]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000021911
SMART Domains Protein: ENSMUSP00000021911
Gene: ENSMUSG00000021458

DomainStartEndE-ValueType
low complexity region 143 154 N/A INTRINSIC
Pfam:Peptidase_M1 221 359 5.4e-11 PFAM
Pfam:Peptidase_M1 385 558 2.3e-15 PFAM
Pfam:Peptidase_MA_2 453 613 1.3e-12 PFAM
Leuk-A4-hydro_C 675 821 3.02e-37 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000091560
SMART Domains Protein: ENSMUSP00000089148
Gene: ENSMUSG00000021458

DomainStartEndE-ValueType
low complexity region 143 154 N/A INTRINSIC
Pfam:Peptidase_M1 220 359 2.7e-11 PFAM
Pfam:Peptidase_M1 386 561 1.9e-15 PFAM
Leuk-A4-hydro_C 676 822 3.02e-37 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220457
Predicted Effect probably benign
Transcript: ENSMUST00000220863
Predicted Effect probably benign
Transcript: ENSMUST00000221676
Predicted Effect probably benign
Transcript: ENSMUST00000222282
Predicted Effect probably benign
Transcript: ENSMUST00000222907
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
PHENOTYPE: Mice homozygous for one gene trapped allele are phenotypically normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik A G 2: 68,575,749 (GRCm39) R683G possibly damaging Het
Abca9 A G 11: 110,036,463 (GRCm39) S549P probably damaging Het
Adgrd1 T C 5: 129,174,273 (GRCm39) S17P possibly damaging Het
Ankrd36 C A 11: 5,578,348 (GRCm39) H546N probably benign Het
Bivm T G 1: 44,165,907 (GRCm39) I119S possibly damaging Het
Ccdc88a G T 11: 29,453,915 (GRCm39) D1693Y probably damaging Het
Clcn6 G A 4: 148,103,423 (GRCm39) R242C probably damaging Het
Clec4a2 A C 6: 123,104,947 (GRCm39) K79T probably damaging Het
Cspp1 G A 1: 10,186,905 (GRCm39) R129H probably damaging Het
Cyp2c40 A T 19: 39,801,027 (GRCm39) M47K probably benign Het
Dmxl1 A G 18: 49,990,401 (GRCm39) D280G probably benign Het
Fbxo38 A G 18: 62,655,487 (GRCm39) S400P probably damaging Het
Fsd1 C T 17: 56,303,733 (GRCm39) S491F probably damaging Het
Gen1 T C 12: 11,305,242 (GRCm39) I184M probably benign Het
Gm9949 A T 18: 62,317,089 (GRCm39) probably benign Het
Grtp1 A T 8: 13,229,629 (GRCm39) V253E probably damaging Het
Irag1 A G 7: 110,525,708 (GRCm39) V148A possibly damaging Het
Lamb1 T A 12: 31,370,930 (GRCm39) M1327K probably benign Het
Lrp2 T A 2: 69,313,846 (GRCm39) D2295V probably damaging Het
Lrp2 T C 2: 69,284,156 (GRCm39) D3874G probably null Het
Muc5b A T 7: 141,400,555 (GRCm39) I509F unknown Het
Mug1 A C 6: 121,826,433 (GRCm39) probably benign Het
Myh7 A T 14: 55,208,916 (GRCm39) L1903Q probably damaging Het
Mylk G T 16: 34,759,322 (GRCm39) A1229S probably benign Het
Myorg G T 4: 41,498,151 (GRCm39) A493E probably damaging Het
Ncam1 A T 9: 49,421,152 (GRCm39) I721N possibly damaging Het
Or8b101 T A 9: 38,020,858 (GRCm39) I287N probably damaging Het
Pla2g2c A G 4: 138,471,012 (GRCm39) K131R probably benign Het
Rpgrip1l A T 8: 92,000,268 (GRCm39) I557N probably benign Het
Sirpb1b T A 3: 15,613,789 (GRCm39) N98Y probably damaging Het
Stab1 A G 14: 30,872,365 (GRCm39) V1182A probably benign Het
Tagap1 T C 17: 7,224,282 (GRCm39) D138G probably benign Het
Tiam2 T A 17: 3,477,477 (GRCm39) F567I probably benign Het
Ush2a A T 1: 188,285,425 (GRCm39) D1987V possibly damaging Het
Vmn1r36 A T 6: 66,693,446 (GRCm39) I37N probably damaging Het
Wif1 A T 10: 120,920,855 (GRCm39) T226S possibly damaging Het
Zfp428 A G 7: 24,210,167 (GRCm39) D22G possibly damaging Het
Zfp521 A T 18: 13,976,980 (GRCm39) N1144K probably benign Het
Other mutations in Aopep
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Aopep APN 13 63,347,314 (GRCm39) splice site probably benign
IGL00329:Aopep APN 13 63,338,977 (GRCm39) missense probably damaging 1.00
IGL00336:Aopep APN 13 63,163,237 (GRCm39) missense possibly damaging 0.78
IGL01780:Aopep APN 13 63,357,939 (GRCm39) missense probably benign 0.00
IGL01876:Aopep APN 13 63,338,336 (GRCm39) missense probably damaging 1.00
IGL02096:Aopep APN 13 63,208,903 (GRCm39) missense probably benign 0.04
IGL02166:Aopep APN 13 63,163,267 (GRCm39) missense probably benign 0.02
IGL02184:Aopep APN 13 63,215,925 (GRCm39) missense possibly damaging 0.50
PIT4378001:Aopep UTSW 13 63,163,021 (GRCm39) missense probably damaging 1.00
R0139:Aopep UTSW 13 63,338,298 (GRCm39) missense probably benign 0.01
R1209:Aopep UTSW 13 63,338,878 (GRCm39) splice site probably null
R1233:Aopep UTSW 13 63,347,334 (GRCm39) missense probably damaging 0.96
R1756:Aopep UTSW 13 63,215,875 (GRCm39) missense possibly damaging 0.95
R1786:Aopep UTSW 13 63,357,963 (GRCm39) missense probably benign 0.00
R1861:Aopep UTSW 13 63,163,597 (GRCm39) missense probably damaging 1.00
R2130:Aopep UTSW 13 63,357,963 (GRCm39) missense probably benign 0.00
R2131:Aopep UTSW 13 63,357,963 (GRCm39) missense probably benign 0.00
R3076:Aopep UTSW 13 63,387,929 (GRCm39) missense probably damaging 0.96
R3702:Aopep UTSW 13 63,163,144 (GRCm39) missense probably benign 0.01
R3912:Aopep UTSW 13 63,304,520 (GRCm39) nonsense probably null
R4512:Aopep UTSW 13 63,304,481 (GRCm39) missense probably damaging 0.99
R4593:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4596:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4597:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4616:Aopep UTSW 13 63,446,565 (GRCm39) missense probably damaging 1.00
R4625:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4627:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4630:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4632:Aopep UTSW 13 63,215,906 (GRCm39) missense probably benign 0.01
R4911:Aopep UTSW 13 63,318,753 (GRCm39) critical splice acceptor site probably null
R5204:Aopep UTSW 13 63,180,904 (GRCm39) missense probably benign 0.15
R5210:Aopep UTSW 13 63,215,924 (GRCm39) missense probably benign 0.00
R5849:Aopep UTSW 13 63,163,312 (GRCm39) missense probably benign 0.00
R5861:Aopep UTSW 13 63,446,626 (GRCm39) missense probably damaging 1.00
R5960:Aopep UTSW 13 63,388,087 (GRCm39) missense probably damaging 0.99
R6021:Aopep UTSW 13 63,208,896 (GRCm39) missense probably damaging 1.00
R6048:Aopep UTSW 13 63,388,139 (GRCm39) missense probably damaging 0.99
R6379:Aopep UTSW 13 63,216,057 (GRCm39) missense probably damaging 0.97
R7038:Aopep UTSW 13 63,338,339 (GRCm39) missense possibly damaging 0.54
R7493:Aopep UTSW 13 63,163,345 (GRCm39) missense probably benign 0.01
R7788:Aopep UTSW 13 63,304,407 (GRCm39) missense possibly damaging 0.89
R7970:Aopep UTSW 13 63,180,974 (GRCm39) missense probably benign 0.11
R7988:Aopep UTSW 13 63,208,954 (GRCm39) missense probably benign 0.00
R8041:Aopep UTSW 13 63,180,921 (GRCm39) missense probably damaging 1.00
R8052:Aopep UTSW 13 63,216,065 (GRCm39) missense probably damaging 1.00
R8053:Aopep UTSW 13 63,338,345 (GRCm39) nonsense probably null
R8537:Aopep UTSW 13 63,338,364 (GRCm39) missense probably damaging 1.00
R8554:Aopep UTSW 13 63,444,711 (GRCm39) missense possibly damaging 0.94
R8681:Aopep UTSW 13 63,338,373 (GRCm39) missense probably damaging 1.00
R8909:Aopep UTSW 13 63,388,111 (GRCm39) missense possibly damaging 0.95
R8945:Aopep UTSW 13 63,388,145 (GRCm39) missense probably null 1.00
R8990:Aopep UTSW 13 63,304,428 (GRCm39) missense probably damaging 1.00
R9032:Aopep UTSW 13 63,444,681 (GRCm39) nonsense probably null
R9049:Aopep UTSW 13 63,208,852 (GRCm39) missense probably benign 0.00
R9166:Aopep UTSW 13 63,318,862 (GRCm39) critical splice donor site probably null
R9590:Aopep UTSW 13 63,208,923 (GRCm39) missense probably benign
Z1177:Aopep UTSW 13 63,318,804 (GRCm39) missense probably damaging 1.00
Posted On 2013-11-05