Incidental Mutation 'R0801:Or13a19'
ID 76281
Institutional Source Beutler Lab
Gene Symbol Or13a19
Ensembl Gene ENSMUSG00000061489
Gene Name olfactory receptor family 13 subfamily A member 19
Synonyms Olfr525, MOR251-2, GA_x6K02T2PBJ9-42472898-42473827
MMRRC Submission 038981-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R0801 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 139902614-139903543 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 139902831 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 73 (C73Y)
Ref Sequence ENSEMBL: ENSMUSP00000149361 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078103] [ENSMUST00000214594]
AlphaFold Q8VGL5
Predicted Effect probably damaging
Transcript: ENSMUST00000078103
AA Change: C73Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077243
Gene: ENSMUSG00000061489
AA Change: C73Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.1e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 260 1.5e-5 PFAM
Pfam:7tm_1 41 290 1.3e-26 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214594
AA Change: C73Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215542
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.2%
  • 10x: 97.6%
  • 20x: 94.7%
Validation Efficiency 98% (48/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030612E09Rik A G 10: 43,050,987 (GRCm39) K94E possibly damaging Het
Aldh16a1 A T 7: 44,796,900 (GRCm39) C228S probably benign Het
Arnt G T 3: 95,401,157 (GRCm39) R702L possibly damaging Het
Ccdc174 A G 6: 91,872,313 (GRCm39) E314G possibly damaging Het
Ccdc81 T C 7: 89,536,866 (GRCm39) probably null Het
Ccdc92 T C 5: 124,913,335 (GRCm39) T65A probably benign Het
Cenpm A T 15: 82,118,667 (GRCm39) I149N probably benign Het
Cfap44 C T 16: 44,242,849 (GRCm39) S751L probably benign Het
Cntrl A G 2: 35,065,107 (GRCm39) probably benign Het
Col1a2 A G 6: 4,531,316 (GRCm39) T762A unknown Het
Crebbp T C 16: 3,906,140 (GRCm39) K1621E probably damaging Het
Cux1 T A 5: 136,355,783 (GRCm39) I374L probably damaging Het
Dgkq A T 5: 108,808,586 (GRCm39) probably null Het
Dis3l T C 9: 64,226,436 (GRCm39) I365V probably benign Het
Dock2 T C 11: 34,599,620 (GRCm39) R320G probably damaging Het
Dst A G 1: 34,209,470 (GRCm39) N853S probably damaging Het
Egf T C 3: 129,496,234 (GRCm39) probably benign Het
Eif2ak2 T A 17: 79,173,778 (GRCm39) R267* probably null Het
Ern2 A G 7: 121,780,085 (GRCm39) probably benign Het
Ero1b A G 13: 12,596,568 (GRCm39) S123G probably benign Het
Fam13a G T 6: 58,960,997 (GRCm39) N118K probably benign Het
Gcn1 T A 5: 115,729,065 (GRCm39) M792K probably benign Het
Iqca1 C A 1: 90,070,453 (GRCm39) G133V probably null Het
Irf3 C T 7: 44,650,058 (GRCm39) probably benign Het
Map2k5 T A 9: 63,265,261 (GRCm39) probably benign Het
Mcf2l T A 8: 13,064,020 (GRCm39) probably benign Het
Mdga2 A T 12: 66,533,507 (GRCm39) I878K probably damaging Het
Mdn1 T C 4: 32,668,895 (GRCm39) S318P probably benign Het
Or5aq1b G A 2: 86,902,407 (GRCm39) Q24* probably null Het
Pklr G A 3: 89,052,829 (GRCm39) W527* probably null Het
Pnpla5 T C 15: 83,998,121 (GRCm39) M374V probably benign Het
Ptprn G T 1: 75,228,909 (GRCm39) H835Q probably damaging Het
R3hdm4 A G 10: 79,749,191 (GRCm39) probably benign Het
Rgs8 T A 1: 153,546,557 (GRCm39) C19S probably damaging Het
Smarca4 C A 9: 21,553,850 (GRCm39) Q575K possibly damaging Het
Srgap1 A T 10: 121,643,780 (GRCm39) F612L probably damaging Het
Svil A G 18: 5,099,443 (GRCm39) R1256G probably benign Het
Tox4 T C 14: 52,517,335 (GRCm39) S22P probably benign Het
Ttc39d A G 17: 80,523,644 (GRCm39) Y101C probably damaging Het
Usb1 T C 8: 96,060,168 (GRCm39) probably null Het
Vps13a T C 19: 16,664,020 (GRCm39) probably benign Het
Vps26a G A 10: 62,294,857 (GRCm39) probably benign Het
Zfp638 T A 6: 83,949,220 (GRCm39) probably benign Het
Other mutations in Or13a19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02143:Or13a19 APN 7 139,903,505 (GRCm39) nonsense probably null
IGL02450:Or13a19 APN 7 139,903,140 (GRCm39) missense possibly damaging 0.95
IGL02927:Or13a19 APN 7 139,902,654 (GRCm39) missense probably damaging 1.00
IGL03008:Or13a19 APN 7 139,903,445 (GRCm39) missense probably damaging 1.00
IGL03202:Or13a19 APN 7 139,903,019 (GRCm39) missense possibly damaging 0.96
R0268:Or13a19 UTSW 7 139,903,068 (GRCm39) missense possibly damaging 0.63
R0612:Or13a19 UTSW 7 139,903,101 (GRCm39) missense possibly damaging 0.63
R0751:Or13a19 UTSW 7 139,903,238 (GRCm39) missense probably benign
R0940:Or13a19 UTSW 7 139,903,065 (GRCm39) missense probably benign 0.01
R2220:Or13a19 UTSW 7 139,903,484 (GRCm39) missense probably benign 0.03
R3748:Or13a19 UTSW 7 139,903,041 (GRCm39) missense possibly damaging 0.87
R4660:Or13a19 UTSW 7 139,903,325 (GRCm39) missense possibly damaging 0.67
R4683:Or13a19 UTSW 7 139,902,681 (GRCm39) missense probably benign 0.01
R4887:Or13a19 UTSW 7 139,903,014 (GRCm39) missense probably benign
R4919:Or13a19 UTSW 7 139,903,427 (GRCm39) nonsense probably null
R5097:Or13a19 UTSW 7 139,903,008 (GRCm39) missense probably damaging 1.00
R5836:Or13a19 UTSW 7 139,902,827 (GRCm39) missense probably benign
R7024:Or13a19 UTSW 7 139,902,759 (GRCm39) missense possibly damaging 0.75
R8242:Or13a19 UTSW 7 139,902,696 (GRCm39) nonsense probably null
R8390:Or13a19 UTSW 7 139,903,027 (GRCm39) missense possibly damaging 0.56
R8739:Or13a19 UTSW 7 139,902,647 (GRCm39) missense probably damaging 1.00
R8813:Or13a19 UTSW 7 139,902,793 (GRCm39) nonsense probably null
R8876:Or13a19 UTSW 7 139,902,716 (GRCm39) missense probably damaging 1.00
R8988:Or13a19 UTSW 7 139,902,938 (GRCm39) missense possibly damaging 0.87
R9044:Or13a19 UTSW 7 139,902,485 (GRCm39) splice site probably benign
R9176:Or13a19 UTSW 7 139,903,121 (GRCm39) missense probably damaging 1.00
R9626:Or13a19 UTSW 7 139,903,236 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- AATGATGGCTGCCTCACACCTG -3'
(R):5'- TGCACTGATGACCCACACACTG -3'

Sequencing Primer
(F):5'- TGTGTCACAGTAACTCCCAGG -3'
(R):5'- ATGGGCCAGCTCATCAGC -3'
Posted On 2013-10-16