Incidental Mutation 'IGL01321:Gstm6'
ID 74041
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gstm6
Ensembl Gene ENSMUSG00000068762
Gene Name glutathione S-transferase, mu 6
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01321
Quality Score
Status
Chromosome 3
Chromosomal Location 107846163-107851065 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107848379 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 180 (Q180R)
Ref Sequence ENSEMBL: ENSMUSP00000102295 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106681] [ENSMUST00000106683] [ENSMUST00000106684] [ENSMUST00000106685] [ENSMUST00000155926]
AlphaFold O35660
Predicted Effect noncoding transcript
Transcript: ENSMUST00000106680
SMART Domains Protein: ENSMUSP00000102291
Gene: ENSMUSG00000068762

DomainStartEndE-ValueType
Pfam:GST_N 3 77 6.2e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106681
AA Change: Q132R

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000102292
Gene: ENSMUSG00000068762
AA Change: Q132R

DomainStartEndE-ValueType
Pfam:GST_N 1 48 9.4e-12 PFAM
Pfam:GST_C_3 7 154 7.6e-11 PFAM
Pfam:GST_C 70 154 3.6e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106683
AA Change: Q71R

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000102294
Gene: ENSMUSG00000068762
AA Change: Q71R

DomainStartEndE-ValueType
Pfam:GST_C_3 4 95 6.3e-11 PFAM
Pfam:GST_C 6 97 2.1e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106684
AA Change: Q180R

PolyPhen 2 Score 0.147 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000102295
Gene: ENSMUSG00000068762
AA Change: Q180R

DomainStartEndE-ValueType
Pfam:GST_N 3 82 2e-22 PFAM
Pfam:GST_C_3 41 204 4.1e-12 PFAM
Pfam:GST_C 104 205 5.9e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106685
AA Change: Q166R

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000102296
Gene: ENSMUSG00000068762
AA Change: Q166R

DomainStartEndE-ValueType
Pfam:GST_N 3 82 7.9e-23 PFAM
Pfam:GST_C 104 192 8.4e-20 PFAM
Pfam:GST_C_3 113 190 6.8e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155926
SMART Domains Protein: ENSMUSP00000139500
Gene: ENSMUSG00000068762

DomainStartEndE-ValueType
Pfam:GST_N 1 48 1.9e-10 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acnat2 A G 4: 49,380,269 (GRCm39) S370P probably damaging Het
Adamts5 T C 16: 85,696,363 (GRCm39) R265G probably benign Het
Cd2ap T C 17: 43,156,280 (GRCm39) S86G possibly damaging Het
Cers3 A C 7: 66,435,751 (GRCm39) probably benign Het
Dnaaf2 G T 12: 69,243,376 (GRCm39) P562T probably damaging Het
Dnajc21 A C 15: 10,447,188 (GRCm39) V520G probably benign Het
Dync1h1 A G 12: 110,592,041 (GRCm39) probably benign Het
Extl3 T C 14: 65,304,211 (GRCm39) N733D probably benign Het
Gm5499 T A 17: 87,385,928 (GRCm39) noncoding transcript Het
Hdlbp G A 1: 93,351,524 (GRCm39) R460W probably damaging Het
Ift81 T C 5: 122,749,031 (GRCm39) D40G probably damaging Het
Igsf3 T A 3: 101,334,338 (GRCm39) probably benign Het
Kcnb2 A G 1: 15,383,147 (GRCm39) T158A probably benign Het
Lrrc59 C T 11: 94,529,426 (GRCm39) R167* probably null Het
Macf1 A G 4: 123,334,567 (GRCm39) C4397R probably damaging Het
Morc1 T C 16: 48,402,825 (GRCm39) S583P probably benign Het
Mucl3 A T 17: 35,947,758 (GRCm39) N490K probably damaging Het
Nipsnap2 T A 5: 129,834,205 (GRCm39) *282R probably null Het
Or2ag19 T C 7: 106,443,956 (GRCm39) L46P probably damaging Het
Or9m1b A T 2: 87,836,589 (GRCm39) C178S probably damaging Het
Parp14 T A 16: 35,676,929 (GRCm39) Q1013L probably benign Het
Pdzd8 A C 19: 59,289,961 (GRCm39) S480A probably benign Het
Piezo1 A T 8: 123,214,339 (GRCm39) S1609R probably damaging Het
Pkp4 G A 2: 59,180,971 (GRCm39) probably null Het
Plpp2 A T 10: 79,363,327 (GRCm39) V106D probably damaging Het
Rimbp2 T C 5: 128,863,816 (GRCm39) Y724C probably benign Het
Rpgrip1l A T 8: 91,987,501 (GRCm39) L852* probably null Het
Samd9l T A 6: 3,376,259 (GRCm39) D334V probably benign Het
Sipa1l2 G A 8: 126,218,257 (GRCm39) T360M probably damaging Het
Slc30a2 A T 4: 134,070,611 (GRCm39) D5V probably damaging Het
Spata31 T C 13: 65,069,568 (GRCm39) I572T probably benign Het
Tma16 G A 8: 66,929,512 (GRCm39) L161F probably benign Het
Trappc2b A T 11: 51,576,670 (GRCm39) V76D probably damaging Het
Trim69 A T 2: 122,003,765 (GRCm39) E238V possibly damaging Het
Zfhx4 A G 3: 5,307,388 (GRCm39) T205A probably benign Het
Other mutations in Gstm6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02100:Gstm6 APN 3 107,849,653 (GRCm39) missense probably benign 0.20
IGL02685:Gstm6 APN 3 107,848,507 (GRCm39) missense probably benign 0.25
R1221:Gstm6 UTSW 3 107,848,418 (GRCm39) missense probably damaging 1.00
R2428:Gstm6 UTSW 3 107,850,922 (GRCm39) missense possibly damaging 0.82
R2763:Gstm6 UTSW 3 107,848,358 (GRCm39) missense possibly damaging 0.65
R6178:Gstm6 UTSW 3 107,848,397 (GRCm39) missense probably benign 0.01
R6545:Gstm6 UTSW 3 107,849,681 (GRCm39) missense probably damaging 1.00
R6730:Gstm6 UTSW 3 107,850,041 (GRCm39) nonsense probably null
R8240:Gstm6 UTSW 3 107,849,453 (GRCm39) missense probably damaging 0.99
R9354:Gstm6 UTSW 3 107,850,018 (GRCm39) missense probably damaging 1.00
X0018:Gstm6 UTSW 3 107,850,063 (GRCm39) missense probably damaging 1.00
Posted On 2013-10-07