Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01304:Dapk2'

73382

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dapk2

Ensembl Gene

ENSMUSG00000032380

Gene Name

death-associated protein kinase 2

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01304

Quality Score

Status

Chromosome

Chromosomal Location

66065505-66179524 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 66139139 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034944]

AlphaFold

Q8VDF3

Predicted Effect

probably benign
Transcript: ENSMUST00000034944

SMART Domains

Protein: ENSMUSP00000034944
Gene: ENSMUSG00000032380

Domain	Start	End	E-Value	Type
S_TKc	23	285	6.26e-98	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000132987

SMART Domains

Protein: ENSMUSP00000117134
Gene: ENSMUSG00000032380

Domain	Start	End	E-Value	Type
Pfam:Pkinase	1	52	2e-14	PFAM
Pfam:Pkinase_Tyr	1	53	1.7e-9	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim1	A	T	19: 57,204,153 (GRCm39)	D79E	probably benign	Het
Aplf	A	C	6: 87,618,882 (GRCm39)	S421A	possibly damaging	Het
Arnt	T	G	3: 95,355,696 (GRCm39)	D13E	probably damaging	Het
Asap1	T	C	15: 64,184,298 (GRCm39)	E45G	probably damaging	Het
C2cd2l	T	C	9: 44,230,884 (GRCm39)	N101S	probably damaging	Het
Cby2	T	A	14: 75,830,085 (GRCm39)	D36V	possibly damaging	Het
Chmp7	G	A	14: 69,956,062 (GRCm39)	P402L	probably benign	Het
Cir1	A	T	2: 73,118,068 (GRCm39)		probably null	Het
Clock	A	G	5: 76,414,202 (GRCm39)		probably null	Het
Col18a1	T	G	10: 76,911,975 (GRCm39)		probably benign	Het
Csf2ra	G	A	19: 61,215,271 (GRCm39)	H115Y	possibly damaging	Het
Cspg5	T	A	9: 110,085,236 (GRCm39)	L469H	probably damaging	Het
F13a1	T	C	13: 37,172,852 (GRCm39)	D176G	probably benign	Het
Fbn2	T	C	18: 58,194,817 (GRCm39)	E1448G	probably damaging	Het
Gtf2b	C	T	3: 142,487,359 (GRCm39)	S265L	probably benign	Het
Hmcn1	C	T	1: 150,498,675 (GRCm39)	G4068D	probably damaging	Het
Krt81	G	A	15: 101,361,269 (GRCm39)	H104Y	probably benign	Het
Ksr1	T	C	11: 78,918,468 (GRCm39)	Q562R	probably damaging	Het
Lrif1	C	T	3: 106,639,049 (GRCm39)	P20S	probably damaging	Het
Mamdc4	T	C	2: 25,453,588 (GRCm39)	T1194A	possibly damaging	Het
Med18	C	A	4: 132,186,930 (GRCm39)	A190S	probably damaging	Het
Mia2	G	A	12: 59,151,324 (GRCm39)	E105K	probably damaging	Het
Mnt	T	A	11: 74,733,011 (GRCm39)	Y48N	probably damaging	Het
Mpp4	A	C	1: 59,188,678 (GRCm39)		probably null	Het
Or4b1b	G	A	2: 90,112,425 (GRCm39)	P165S	possibly damaging	Het
Popdc3	T	G	10: 45,194,005 (GRCm39)	S269A	probably benign	Het
Ppp6r3	A	T	19: 3,517,261 (GRCm39)	M662K	probably damaging	Het
Qser1	C	A	2: 104,617,976 (GRCm39)	Q945H	probably damaging	Het
Rad52	A	G	6: 119,895,594 (GRCm39)	E198G	probably damaging	Het
Ranbp17	A	G	11: 33,216,147 (GRCm39)	V867A	possibly damaging	Het
Rdh16	G	T	10: 127,649,365 (GRCm39)	A274S	probably benign	Het
Slco1a5	G	T	6: 142,187,876 (GRCm39)	Q488K	probably benign	Het
Snai2	T	C	16: 14,524,635 (GRCm39)	I47T	probably benign	Het
Snw1	T	C	12: 87,500,685 (GRCm39)	D358G	possibly damaging	Het
Speg	T	C	1: 75,404,841 (GRCm39)	F2878L	probably benign	Het
Spg11	T	C	2: 121,902,771 (GRCm39)	Y1386C	probably damaging	Het
Tgfb2	A	C	1: 186,357,670 (GRCm39)	I435S	probably damaging	Het
Ttc9b	G	A	7: 27,355,410 (GRCm39)	D227N	probably benign	Het
Txndc2	T	C	17: 65,945,448 (GRCm39)	E243G	possibly damaging	Het
Usp28	A	G	9: 48,938,119 (GRCm39)	D563G	probably damaging	Het
Vmn1r77	T	C	7: 11,775,962 (GRCm39)	V178A	probably damaging	Het
Zfp316	A	G	5: 143,240,181 (GRCm39)	F613L	probably benign	Het
Zfp870	A	T	17: 33,101,980 (GRCm39)	C450S	possibly damaging	Het

Other mutations in Dapk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00401:Dapk2	APN	9	66,176,060 (GRCm39)	splice site	probably benign
IGL02053:Dapk2	APN	9	66,128,027 (GRCm39)	missense	probably benign	0.02
IGL02351:Dapk2	APN	9	66,153,805 (GRCm39)	missense	probably damaging	0.99
IGL02358:Dapk2	APN	9	66,153,805 (GRCm39)	missense	probably damaging	0.99
IGL02736:Dapk2	APN	9	66,176,198 (GRCm39)	missense	probably benign
IGL02742:Dapk2	APN	9	66,139,096 (GRCm39)	missense	probably damaging	1.00
PIT4618001:Dapk2	UTSW	9	66,175,968 (GRCm39)	missense	probably benign	0.01
R0367:Dapk2	UTSW	9	66,176,168 (GRCm39)	missense	probably damaging	0.99
R1375:Dapk2	UTSW	9	66,127,925 (GRCm39)	missense	probably damaging	0.97
R1376:Dapk2	UTSW	9	66,127,925 (GRCm39)	missense	probably damaging	0.97
R1376:Dapk2	UTSW	9	66,127,925 (GRCm39)	missense	probably damaging	0.97
R1752:Dapk2	UTSW	9	66,127,925 (GRCm39)	missense	probably damaging	0.97
R1924:Dapk2	UTSW	9	66,072,642 (GRCm39)	missense	probably benign	0.05
R1981:Dapk2	UTSW	9	66,176,180 (GRCm39)	missense	probably benign	0.00
R3160:Dapk2	UTSW	9	66,161,893 (GRCm39)	missense	probably damaging	0.99
R3161:Dapk2	UTSW	9	66,161,893 (GRCm39)	missense	probably damaging	0.99
R3162:Dapk2	UTSW	9	66,161,893 (GRCm39)	missense	probably damaging	0.99
R3162:Dapk2	UTSW	9	66,161,893 (GRCm39)	missense	probably damaging	0.99
R5394:Dapk2	UTSW	9	66,176,000 (GRCm39)	missense	probably benign	0.00
R6750:Dapk2	UTSW	9	66,128,034 (GRCm39)	missense	probably damaging	1.00
R6951:Dapk2	UTSW	9	66,161,904 (GRCm39)	missense	probably benign	0.01
R6952:Dapk2	UTSW	9	66,161,904 (GRCm39)	missense	probably benign	0.01
R6953:Dapk2	UTSW	9	66,161,904 (GRCm39)	missense	probably benign	0.01
R8304:Dapk2	UTSW	9	66,139,027 (GRCm39)	missense	possibly damaging	0.55
R8987:Dapk2	UTSW	9	66,157,602 (GRCm39)	intron	probably benign
Z1088:Dapk2	UTSW	9	66,153,759 (GRCm39)	missense	possibly damaging	0.56

Posted On

2013-10-07