Incidental Mutation 'IGL01285:Adam6a'
ID 72674
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adam6a
Ensembl Gene ENSMUSG00000043945
Gene Name a disintegrin and metallopeptidase domain 6A
Synonyms Adam6
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # IGL01285
Quality Score
Status
Chromosome 12
Chromosomal Location 113507528-113510034 bp(+) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) A to T at 113509893 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Tyrosine at position 755 (*755Y)
Ref Sequence ENSEMBL: ENSMUSP00000059315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053086]
AlphaFold B2RSY5
Predicted Effect probably null
Transcript: ENSMUST00000053086
AA Change: *755Y
SMART Domains Protein: ENSMUSP00000059315
Gene: ENSMUSG00000043945
AA Change: *755Y

DomainStartEndE-ValueType
Pfam:Pep_M12B_propep 30 167 6.9e-17 PFAM
Pfam:Reprolysin 222 407 4e-15 PFAM
DISIN 427 502 1.63e-33 SMART
ACR 503 640 7.46e-62 SMART
transmembrane domain 704 726 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 T C 8: 25,271,610 (GRCm39) N599S probably benign Het
Adgrb3 G T 1: 25,132,868 (GRCm39) T1166K probably benign Het
Ano1 T C 7: 144,198,479 (GRCm39) Y345C probably benign Het
Ano1 A G 7: 144,149,275 (GRCm39) V862A probably damaging Het
Asap2 C T 12: 21,279,264 (GRCm39) A382V probably damaging Het
Asb18 A G 1: 89,923,963 (GRCm39) V100A probably benign Het
Bdnf G A 2: 109,553,931 (GRCm39) A102T probably benign Het
Ccser2 G A 14: 36,660,626 (GRCm39) T509M probably damaging Het
Cfap47 A G X: 78,532,764 (GRCm39) I767T possibly damaging Het
Des G A 1: 75,339,227 (GRCm39) A251T probably benign Het
Dmd C T X: 84,153,590 (GRCm39) Q3224* probably null Het
Endog G T 2: 30,061,975 (GRCm39) probably null Het
Ggt7 A G 2: 155,342,691 (GRCm39) V269A probably damaging Het
Gucy2c A G 6: 136,686,739 (GRCm39) F808S probably damaging Het
Hira A G 16: 18,730,930 (GRCm39) T210A probably benign Het
Ifitm5 C A 7: 140,530,076 (GRCm39) R16L probably benign Het
Igdcc4 T C 9: 65,031,273 (GRCm39) C404R probably damaging Het
Ints7 G A 1: 191,347,890 (GRCm39) R754H probably benign Het
Irf9 A G 14: 55,845,058 (GRCm39) E258G probably damaging Het
Megf11 T C 9: 64,567,728 (GRCm39) C406R probably damaging Het
Olfml1 A G 7: 107,189,364 (GRCm39) N143S possibly damaging Het
Or4m1 A G 14: 50,557,713 (GRCm39) F193S possibly damaging Het
Or6c66b T A 10: 129,376,711 (GRCm39) F102I probably benign Het
Or7g30 A G 9: 19,352,266 (GRCm39) D19G probably benign Het
Otof G T 5: 30,562,527 (GRCm39) Q254K probably damaging Het
Pate7 A T 9: 35,688,044 (GRCm39) N65K possibly damaging Het
Plcd3 A G 11: 102,968,696 (GRCm39) F332L probably benign Het
Plxnc1 T C 10: 94,635,230 (GRCm39) D1332G probably damaging Het
Rnasel A T 1: 153,634,130 (GRCm39) D521V probably benign Het
Sema5a T A 15: 32,575,143 (GRCm39) V417D possibly damaging Het
Senp6 G A 9: 80,044,000 (GRCm39) R877Q probably benign Het
Shroom2 A T X: 151,442,353 (GRCm39) D937E probably damaging Het
Slc35a3 A G 3: 116,488,262 (GRCm39) S142P probably damaging Het
Srpx A T X: 9,905,298 (GRCm39) V398E probably damaging Het
Stk10 A T 11: 32,560,653 (GRCm39) K669N possibly damaging Het
Sumf2 A G 5: 129,878,811 (GRCm39) D49G probably damaging Het
Syde1 T A 10: 78,424,721 (GRCm39) E370D probably damaging Het
Tas2r115 G T 6: 132,714,641 (GRCm39) S103R probably damaging Het
Top2a G A 11: 98,896,985 (GRCm39) probably benign Het
Ttn T A 2: 76,550,842 (GRCm39) T23190S probably damaging Het
Ttyh3 C A 5: 140,615,167 (GRCm39) C407F probably damaging Het
Vmn2r27 G T 6: 124,169,370 (GRCm39) H587N possibly damaging Het
Vmn2r74 A G 7: 85,606,692 (GRCm39) I218T possibly damaging Het
Vsig10 A G 5: 117,462,954 (GRCm39) N60S probably benign Het
Zc3h7a A G 16: 10,956,979 (GRCm39) S877P probably damaging Het
Zfp979 G T 4: 147,699,853 (GRCm39) T29N probably damaging Het
Znfx1 G A 2: 166,880,615 (GRCm39) R390C possibly damaging Het
Other mutations in Adam6a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00580:Adam6a APN 12 113,508,845 (GRCm39) missense probably benign 0.00
IGL00896:Adam6a APN 12 113,509,030 (GRCm39) missense possibly damaging 0.56
IGL01146:Adam6a APN 12 113,507,840 (GRCm39) missense probably damaging 1.00
IGL01839:Adam6a APN 12 113,508,242 (GRCm39) missense probably benign 0.03
IGL01906:Adam6a APN 12 113,507,951 (GRCm39) missense probably benign 0.19
IGL02306:Adam6a APN 12 113,509,343 (GRCm39) missense possibly damaging 0.93
IGL03146:Adam6a APN 12 113,509,144 (GRCm39) missense probably damaging 1.00
IGL03176:Adam6a APN 12 113,509,822 (GRCm39) missense probably benign 0.00
IGL03365:Adam6a APN 12 113,507,765 (GRCm39) missense possibly damaging 0.86
IGL03373:Adam6a APN 12 113,509,172 (GRCm39) missense possibly damaging 0.55
PIT4802001:Adam6a UTSW 12 113,509,078 (GRCm39) missense probably damaging 1.00
R0091:Adam6a UTSW 12 113,507,849 (GRCm39) missense possibly damaging 0.46
R0149:Adam6a UTSW 12 113,509,369 (GRCm39) missense probably damaging 1.00
R0348:Adam6a UTSW 12 113,508,337 (GRCm39) missense probably damaging 0.99
R0376:Adam6a UTSW 12 113,508,310 (GRCm39) missense probably damaging 1.00
R1471:Adam6a UTSW 12 113,508,013 (GRCm39) missense probably damaging 1.00
R1474:Adam6a UTSW 12 113,508,069 (GRCm39) missense possibly damaging 0.66
R1553:Adam6a UTSW 12 113,508,835 (GRCm39) missense probably damaging 1.00
R1679:Adam6a UTSW 12 113,508,376 (GRCm39) missense probably benign 0.00
R1808:Adam6a UTSW 12 113,508,334 (GRCm39) missense probably benign 0.00
R1826:Adam6a UTSW 12 113,509,742 (GRCm39) missense possibly damaging 0.46
R1856:Adam6a UTSW 12 113,508,923 (GRCm39) missense probably damaging 1.00
R1916:Adam6a UTSW 12 113,509,556 (GRCm39) missense probably benign
R2011:Adam6a UTSW 12 113,508,998 (GRCm39) missense probably benign 0.09
R2049:Adam6a UTSW 12 113,508,049 (GRCm39) missense probably benign 0.17
R2364:Adam6a UTSW 12 113,508,250 (GRCm39) missense probably benign 0.05
R3820:Adam6a UTSW 12 113,507,798 (GRCm39) missense probably benign 0.00
R4119:Adam6a UTSW 12 113,508,194 (GRCm39) missense probably benign 0.06
R4540:Adam6a UTSW 12 113,508,119 (GRCm39) missense probably damaging 1.00
R4627:Adam6a UTSW 12 113,508,569 (GRCm39) missense probably benign
R4665:Adam6a UTSW 12 113,507,992 (GRCm39) missense possibly damaging 0.64
R4859:Adam6a UTSW 12 113,509,609 (GRCm39) missense probably damaging 1.00
R4997:Adam6a UTSW 12 113,508,991 (GRCm39) missense probably damaging 1.00
R5270:Adam6a UTSW 12 113,507,747 (GRCm39) missense possibly damaging 0.46
R5751:Adam6a UTSW 12 113,508,447 (GRCm39) missense possibly damaging 0.79
R5775:Adam6a UTSW 12 113,509,886 (GRCm39) missense possibly damaging 0.47
R5863:Adam6a UTSW 12 113,507,987 (GRCm39) missense probably benign 0.01
R6154:Adam6a UTSW 12 113,509,292 (GRCm39) missense probably benign 0.11
R6313:Adam6a UTSW 12 113,508,670 (GRCm39) missense possibly damaging 0.56
R6316:Adam6a UTSW 12 113,509,196 (GRCm39) missense probably benign 0.27
R6706:Adam6a UTSW 12 113,508,886 (GRCm39) missense probably benign 0.00
R6845:Adam6a UTSW 12 113,507,717 (GRCm39) missense possibly damaging 0.96
R7134:Adam6a UTSW 12 113,508,655 (GRCm39) missense probably benign 0.04
R7179:Adam6a UTSW 12 113,509,291 (GRCm39) missense probably benign 0.02
R7206:Adam6a UTSW 12 113,509,654 (GRCm39) missense probably damaging 1.00
R7230:Adam6a UTSW 12 113,509,202 (GRCm39) missense probably damaging 1.00
R7296:Adam6a UTSW 12 113,509,192 (GRCm39) missense probably damaging 1.00
R7676:Adam6a UTSW 12 113,508,196 (GRCm39) missense probably benign 0.00
R7730:Adam6a UTSW 12 113,507,660 (GRCm39) missense possibly damaging 0.86
R7743:Adam6a UTSW 12 113,508,152 (GRCm39) missense probably benign
R7841:Adam6a UTSW 12 113,509,078 (GRCm39) missense probably damaging 1.00
R8356:Adam6a UTSW 12 113,509,757 (GRCm39) missense probably benign 0.08
R8531:Adam6a UTSW 12 113,508,917 (GRCm39) missense probably damaging 1.00
R9568:Adam6a UTSW 12 113,508,020 (GRCm39) missense possibly damaging 0.74
R9624:Adam6a UTSW 12 113,509,070 (GRCm39) missense probably damaging 1.00
R9679:Adam6a UTSW 12 113,509,542 (GRCm39) missense probably benign 0.00
R9680:Adam6a UTSW 12 113,509,484 (GRCm39) nonsense probably null
X0027:Adam6a UTSW 12 113,508,863 (GRCm39) missense probably benign 0.01
Z1176:Adam6a UTSW 12 113,508,941 (GRCm39) missense possibly damaging 0.92
Posted On 2013-10-07