Incidental Mutation 'R0041:Olfml1'
ID 64706
Institutional Source Beutler Lab
Gene Symbol Olfml1
Ensembl Gene ENSMUSG00000051041
Gene Name olfactomedin-like 1
Synonyms mONT2, ONT2, MVAL564
MMRRC Submission 038335-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R0041 (G1)
Quality Score 127
Status Validated
Chromosome 7
Chromosomal Location 107166653-107190301 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 107189393 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 153 (I153L)
Ref Sequence ENSEMBL: ENSMUSP00000114029 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120990]
AlphaFold Q8BSH2
Predicted Effect possibly damaging
Transcript: ENSMUST00000120990
AA Change: I153L

PolyPhen 2 Score 0.813 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000114029
Gene: ENSMUSG00000051041
AA Change: I153L

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
coiled coil region 78 105 N/A INTRINSIC
low complexity region 115 132 N/A INTRINSIC
Pfam:OLF 145 233 5.5e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207374
Meta Mutation Damage Score 0.0910 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.8%
  • 20x: 96.3%
Validation Efficiency 97% (58/60)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts13 A G 2: 26,873,986 (GRCm39) R412G probably damaging Het
Adamts3 T A 5: 89,832,326 (GRCm39) N927Y probably benign Het
Adgra3 A G 5: 50,117,901 (GRCm39) Y1216H probably benign Het
Agpat3 C A 10: 78,123,881 (GRCm39) probably benign Het
AI182371 T A 2: 34,975,733 (GRCm39) Q277L possibly damaging Het
Arhgef15 A T 11: 68,845,342 (GRCm39) L170Q possibly damaging Het
Avpi1 C A 19: 42,112,223 (GRCm39) E112* probably null Het
Braf C T 6: 39,617,413 (GRCm39) A534T probably damaging Het
Bspry G C 4: 62,404,791 (GRCm39) A196P probably damaging Het
Cacna1c T A 6: 118,570,988 (GRCm39) L2095F probably damaging Het
Cdhr2 A T 13: 54,874,651 (GRCm39) S908C probably damaging Het
Cntnap5c C A 17: 58,183,464 (GRCm39) Q57K probably benign Het
Dtna C T 18: 23,779,932 (GRCm39) probably benign Het
Dynap A G 18: 70,375,105 (GRCm39) S37P possibly damaging Het
Efna5 A T 17: 62,914,467 (GRCm39) probably benign Het
Fancm T A 12: 65,153,217 (GRCm39) C1224* probably null Het
Fbxw16 T A 9: 109,277,232 (GRCm39) S37C probably damaging Het
Galnt4 A G 10: 98,944,374 (GRCm39) Y33C probably benign Het
Kcnk2 G T 1: 189,027,888 (GRCm39) N122K probably benign Het
Krt71 C A 15: 101,647,753 (GRCm39) E222D probably damaging Het
Ltf T A 9: 110,858,636 (GRCm39) D461E possibly damaging Het
Mapk4 A T 18: 74,068,109 (GRCm39) L274Q probably damaging Het
Mbd6 A G 10: 127,122,741 (GRCm39) C103R probably damaging Het
Nbeal1 A G 1: 60,321,030 (GRCm39) N2047S probably benign Het
Nefh C T 11: 4,895,184 (GRCm39) S335N possibly damaging Het
Obscn G T 11: 58,934,803 (GRCm39) H4715N probably damaging Het
Or6d13 G A 6: 116,518,295 (GRCm39) V294I possibly damaging Het
Or8g34 T A 9: 39,372,772 (GRCm39) F12Y probably benign Het
Pck1 A G 2: 172,997,003 (GRCm39) E215G probably benign Het
Peg12 T A 7: 62,113,308 (GRCm39) E263V unknown Het
Phkg1 T A 5: 129,903,103 (GRCm39) T15S probably benign Het
Plekhg1 T A 10: 3,914,076 (GRCm39) L1120* probably null Het
Prss59 A T 6: 40,903,042 (GRCm39) L110* probably null Het
Rlf T A 4: 121,007,126 (GRCm39) H618L probably damaging Het
Rnf112 T A 11: 61,343,181 (GRCm39) R165W probably damaging Het
Rnf213 A G 11: 119,293,401 (GRCm39) T51A probably benign Het
Rnf220 A G 4: 117,130,481 (GRCm39) L293P probably damaging Het
Rock1 T C 18: 10,140,240 (GRCm39) D117G probably damaging Het
Rp1 A G 1: 4,414,851 (GRCm39) V2087A probably benign Het
Rpl7a A G 2: 26,801,563 (GRCm39) probably null Het
Serpinb6d A G 13: 33,851,615 (GRCm39) D124G probably damaging Het
Skor1 T G 9: 63,053,133 (GRCm39) T279P probably damaging Het
Son A T 16: 91,456,221 (GRCm39) E1656V probably damaging Het
Swap70 A G 7: 109,878,562 (GRCm39) K511E probably benign Het
Treh T C 9: 44,594,910 (GRCm39) V262A probably benign Het
Trpm4 A G 7: 44,954,370 (GRCm39) probably null Het
Ugt8a T C 3: 125,708,739 (GRCm39) I124V probably benign Het
Wdr53 T C 16: 32,075,473 (GRCm39) V226A probably damaging Het
Wdr64 G A 1: 175,554,037 (GRCm39) W189* probably null Het
Other mutations in Olfml1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Olfml1 APN 7 107,189,364 (GRCm39) missense possibly damaging 0.80
IGL02355:Olfml1 APN 7 107,167,010 (GRCm39) missense probably benign 0.00
IGL02362:Olfml1 APN 7 107,167,010 (GRCm39) missense probably benign 0.00
IGL03218:Olfml1 APN 7 107,170,476 (GRCm39) missense possibly damaging 0.87
IGL03291:Olfml1 APN 7 107,189,436 (GRCm39) missense probably damaging 1.00
R0041:Olfml1 UTSW 7 107,189,393 (GRCm39) missense possibly damaging 0.81
R0081:Olfml1 UTSW 7 107,170,506 (GRCm39) missense probably benign 0.08
R0524:Olfml1 UTSW 7 107,189,384 (GRCm39) missense probably damaging 1.00
R1311:Olfml1 UTSW 7 107,167,103 (GRCm39) critical splice donor site probably null
R1548:Olfml1 UTSW 7 107,189,582 (GRCm39) missense possibly damaging 0.88
R1564:Olfml1 UTSW 7 107,170,346 (GRCm39) missense possibly damaging 0.89
R4347:Olfml1 UTSW 7 107,167,040 (GRCm39) missense probably benign 0.00
R4997:Olfml1 UTSW 7 107,170,413 (GRCm39) missense probably damaging 1.00
R6788:Olfml1 UTSW 7 107,167,075 (GRCm39) missense probably damaging 1.00
R7282:Olfml1 UTSW 7 107,189,530 (GRCm39) missense possibly damaging 0.85
R7703:Olfml1 UTSW 7 107,170,392 (GRCm39) missense probably damaging 1.00
R7922:Olfml1 UTSW 7 107,170,356 (GRCm39) missense probably damaging 1.00
R8324:Olfml1 UTSW 7 107,189,570 (GRCm39) missense probably benign 0.04
R8441:Olfml1 UTSW 7 107,166,977 (GRCm39) missense probably benign 0.00
R9002:Olfml1 UTSW 7 107,189,423 (GRCm39) missense probably damaging 1.00
R9261:Olfml1 UTSW 7 107,167,007 (GRCm39) missense possibly damaging 0.88
R9797:Olfml1 UTSW 7 107,167,069 (GRCm39) missense probably benign 0.25
Predicted Primers PCR Primer
(F):5'- TGCATACAAGTTAAGACCAGGCAGC -3'
(R):5'- TTGGTAGACCACTTGCCCTGATCC -3'

Sequencing Primer
(F):5'- CTTCTACTACAGGTAAGGGTCAG -3'
(R):5'- TGATCCCTGCCAGGAAAGTG -3'
Posted On 2013-08-06