Incidental Mutation 'R0102:Or8h10'
ID 63275
Institutional Source Beutler Lab
Gene Symbol Or8h10
Ensembl Gene ENSMUSG00000070875
Gene Name olfactory receptor family 8 subfamily H member 10
Synonyms Olfr1100, GA_x6K02T2Q125-48465387-48464422, MOR206-4
MMRRC Submission 038388-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R0102 (G1)
Quality Score 146
Status Validated
Chromosome 2
Chromosomal Location 86808173-86809138 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 86808549 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 197 (I197N)
Ref Sequence ENSEMBL: ENSMUSP00000151088 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094913] [ENSMUST00000117211]
AlphaFold Q8VFM1
Predicted Effect possibly damaging
Transcript: ENSMUST00000094913
AA Change: I197N

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000092517
Gene: ENSMUSG00000070875
AA Change: I197N

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.7e-51 PFAM
Pfam:7tm_1 41 314 2.3e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000117211
AA Change: I197N

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.1323 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.5%
  • 20x: 91.8%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik A G 3: 137,773,874 (GRCm39) K1021R probably damaging Het
2610528J11Rik G A 4: 118,386,762 (GRCm39) V36M probably damaging Het
4930402F06Rik T A 2: 35,265,795 (GRCm39) R292* probably null Het
Abcb4 T C 5: 8,959,194 (GRCm39) F207S probably damaging Het
Afap1l2 G T 19: 56,916,872 (GRCm39) probably benign Het
Arfgef2 A T 2: 166,687,385 (GRCm39) H203L probably benign Het
Cfi A C 3: 129,642,416 (GRCm39) H90P probably damaging Het
Col1a2 T A 6: 4,520,775 (GRCm39) S371T possibly damaging Het
Cyp2d10 C T 15: 82,288,794 (GRCm39) M229I probably benign Het
Dnah5 A G 15: 28,245,897 (GRCm39) probably benign Het
Dnttip2 G T 3: 122,069,452 (GRCm39) M222I probably benign Het
Dync1li2 A T 8: 105,154,757 (GRCm39) Y284N probably benign Het
Ebf1 T C 11: 44,882,282 (GRCm39) Y413H probably benign Het
Exog A G 9: 119,281,319 (GRCm39) T186A possibly damaging Het
Fam171a2 T C 11: 102,334,939 (GRCm39) N66S possibly damaging Het
Gad1 G A 2: 70,417,583 (GRCm39) probably null Het
Golgb1 C A 16: 36,695,830 (GRCm39) probably benign Het
Gprc5a A T 6: 135,056,033 (GRCm39) N160I probably damaging Het
Haus3 A G 5: 34,323,258 (GRCm39) probably null Het
Klhl20 A T 1: 160,918,015 (GRCm39) C90* probably null Het
Krt84 T A 15: 101,437,138 (GRCm39) I342L probably damaging Het
Lifr G A 15: 7,208,373 (GRCm39) D584N probably damaging Het
Lrp1b G A 2: 41,298,997 (GRCm39) probably benign Het
Lrtm1 T A 14: 28,744,184 (GRCm39) probably benign Het
Med25 C T 7: 44,534,904 (GRCm39) V80I possibly damaging Het
Mest A G 6: 30,746,269 (GRCm39) I279V probably damaging Het
Mki67 T C 7: 135,315,532 (GRCm39) R81G probably benign Het
Naa25 A G 5: 121,573,632 (GRCm39) D787G possibly damaging Het
Naaladl1 C T 19: 6,162,534 (GRCm39) P465S probably damaging Het
Nanos3 C T 8: 84,902,763 (GRCm39) R133Q probably damaging Het
Necab3 G A 2: 154,387,232 (GRCm39) R302C probably damaging Het
Nsg1 A T 5: 38,316,254 (GRCm39) D32E probably damaging Het
Nuggc A G 14: 65,851,000 (GRCm39) D290G probably null Het
Nup205 A T 6: 35,202,715 (GRCm39) probably benign Het
Or11g27 T A 14: 50,771,088 (GRCm39) L73Q probably damaging Het
Or2w6 T C 13: 21,842,905 (GRCm39) D196G probably damaging Het
Or4a77 T C 2: 89,486,999 (GRCm39) N262S probably benign Het
Or4c111 T C 2: 88,844,015 (GRCm39) Y131C probably damaging Het
Or4f57 G C 2: 111,790,942 (GRCm39) Q159E probably damaging Het
Otp T C 13: 95,013,663 (GRCm39) V27A probably benign Het
Phip A T 9: 82,787,845 (GRCm39) probably null Het
Pon2 A G 6: 5,289,091 (GRCm39) probably benign Het
Ppp1r12b T A 1: 134,763,637 (GRCm39) probably null Het
Ppp1r15b A G 1: 133,060,908 (GRCm39) N475S probably damaging Het
Prrt3 A T 6: 113,474,790 (GRCm39) L144H probably damaging Het
Psmb7 A G 2: 38,533,377 (GRCm39) V50A possibly damaging Het
Sacs T A 14: 61,442,017 (GRCm39) S1354R probably damaging Het
Sdcbp2 A G 2: 151,425,884 (GRCm39) T29A probably benign Het
Shbg T A 11: 69,508,415 (GRCm39) probably benign Het
Shcbp1 A G 8: 4,794,452 (GRCm39) I447T probably damaging Het
Tbc1d9b T C 11: 50,026,676 (GRCm39) V48A probably damaging Het
Thbd A T 2: 148,248,903 (GRCm39) C322S probably damaging Het
Tnfrsf21 C T 17: 43,349,104 (GRCm39) H239Y probably benign Het
Trappc12 A T 12: 28,796,751 (GRCm39) F260L probably damaging Het
Trim10 C A 17: 37,181,074 (GRCm39) H102N probably damaging Het
Ube2u A G 4: 100,407,122 (GRCm39) T215A possibly damaging Het
Vcan T G 13: 89,851,787 (GRCm39) T1058P probably benign Het
Other mutations in Or8h10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02387:Or8h10 APN 2 86,808,193 (GRCm39) nonsense probably null
R0477:Or8h10 UTSW 2 86,808,567 (GRCm39) missense probably damaging 0.99
R0586:Or8h10 UTSW 2 86,809,126 (GRCm39) missense probably damaging 0.99
R0743:Or8h10 UTSW 2 86,808,843 (GRCm39) missense probably benign 0.12
R1163:Or8h10 UTSW 2 86,809,020 (GRCm39) missense probably damaging 1.00
R1640:Or8h10 UTSW 2 86,808,963 (GRCm39) missense probably damaging 1.00
R2865:Or8h10 UTSW 2 86,808,805 (GRCm39) missense possibly damaging 0.56
R4478:Or8h10 UTSW 2 86,808,562 (GRCm39) missense probably benign
R4548:Or8h10 UTSW 2 86,809,014 (GRCm39) missense probably damaging 0.98
R4618:Or8h10 UTSW 2 86,808,618 (GRCm39) missense possibly damaging 0.87
R4829:Or8h10 UTSW 2 86,808,918 (GRCm39) missense probably damaging 0.99
R4858:Or8h10 UTSW 2 86,808,693 (GRCm39) missense probably damaging 1.00
R5071:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5072:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5073:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5074:Or8h10 UTSW 2 86,808,666 (GRCm39) missense possibly damaging 0.88
R5574:Or8h10 UTSW 2 86,808,867 (GRCm39) missense probably benign 0.00
R5735:Or8h10 UTSW 2 86,809,044 (GRCm39) missense probably benign 0.08
R5874:Or8h10 UTSW 2 86,808,786 (GRCm39) missense probably damaging 0.99
R6228:Or8h10 UTSW 2 86,809,035 (GRCm39) missense probably damaging 1.00
R6689:Or8h10 UTSW 2 86,808,498 (GRCm39) missense probably benign 0.36
R6979:Or8h10 UTSW 2 86,808,577 (GRCm39) missense probably damaging 1.00
R7006:Or8h10 UTSW 2 86,808,303 (GRCm39) missense probably damaging 0.99
R7274:Or8h10 UTSW 2 86,808,867 (GRCm39) missense probably benign 0.00
R7399:Or8h10 UTSW 2 86,808,501 (GRCm39) missense probably benign 0.19
R7560:Or8h10 UTSW 2 86,809,122 (GRCm39) missense probably benign 0.00
R7765:Or8h10 UTSW 2 86,808,538 (GRCm39) missense probably damaging 0.98
R8381:Or8h10 UTSW 2 86,808,373 (GRCm39) missense probably benign 0.36
R8390:Or8h10 UTSW 2 86,808,501 (GRCm39) missense probably benign 0.19
R8694:Or8h10 UTSW 2 86,808,591 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAGAAGCCACTTGTTCCTTTCCTG -3'
(R):5'- AGATGCTCAGCTTCACACTCCAATG -3'

Sequencing Primer
(F):5'- ACTTGTTCCTTTCCTGAGTAGTAG -3'
(R):5'- GATATGTGGCTATTTGCAACCC -3'
Posted On 2013-07-30