Incidental Mutation 'R0682:Trim43a'
ID 61020
Institutional Source Beutler Lab
Gene Symbol Trim43a
Ensembl Gene ENSMUSG00000090693
Gene Name tripartite motif-containing 43A
Synonyms Gm6021
MMRRC Submission 038867-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.137) question?
Stock # R0682 (G1)
Quality Score 98
Status Not validated
Chromosome 9
Chromosomal Location 88462944-88470872 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 88464199 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 37 (E37K)
Ref Sequence ENSEMBL: ENSMUSP00000127527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164661] [ENSMUST00000215498] [ENSMUST00000216686]
AlphaFold Q3TL54
Predicted Effect probably benign
Transcript: ENSMUST00000164661
AA Change: E37K

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000127527
Gene: ENSMUSG00000090693
AA Change: E37K

DomainStartEndE-ValueType
RING 16 56 9.6e-7 SMART
Blast:BBOX 88 129 1e-7 BLAST
PDB:2VOK|B 328 445 5e-14 PDB
Blast:SPRY 335 441 1e-19 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000215498
Predicted Effect probably benign
Transcript: ENSMUST00000216686
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 95.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001J03Rik T C 5: 146,121,650 (GRCm39) H83R probably benign Het
Abcd3 A C 3: 121,563,216 (GRCm39) I471S possibly damaging Het
Abcg1 G A 17: 31,330,225 (GRCm39) V509I probably benign Het
Adamts9 A T 6: 92,880,783 (GRCm39) N497K possibly damaging Het
Agap2 A G 10: 126,919,351 (GRCm39) S479G unknown Het
Asic2 T C 11: 80,777,506 (GRCm39) I402V possibly damaging Het
Atp1a2 G A 1: 172,112,164 (GRCm39) T577I probably benign Het
Atraid T A 5: 31,209,612 (GRCm39) I92K probably damaging Het
Dpp10 C A 1: 123,832,852 (GRCm39) A31S probably damaging Het
Erich6 A T 3: 58,544,232 (GRCm39) F118L probably benign Het
Galnt18 T C 7: 111,119,222 (GRCm39) Y418C probably damaging Het
Herc1 T A 9: 66,389,263 (GRCm39) C3927S possibly damaging Het
Ifit2 G A 19: 34,551,012 (GRCm39) R184H probably benign Het
Kif24 A T 4: 41,428,620 (GRCm39) N113K probably benign Het
Lrp1b T A 2: 41,185,653 (GRCm39) Y1354F probably benign Het
Muc1 T A 3: 89,138,439 (GRCm39) I427N probably damaging Het
Muc5ac A G 7: 141,359,406 (GRCm39) T1288A possibly damaging Het
Or7g32 C A 9: 19,388,645 (GRCm39) M300I probably benign Het
Or9i14 C T 19: 13,792,501 (GRCm39) C151Y possibly damaging Het
Pex26 T A 6: 121,161,363 (GRCm39) V47E probably damaging Het
Plekhm2 T C 4: 141,355,436 (GRCm39) I871V probably damaging Het
Rasal2 A G 1: 157,006,779 (GRCm39) S111P probably damaging Het
Rnf133 A T 6: 23,649,569 (GRCm39) I163N probably damaging Het
Rrp8 A C 7: 105,383,218 (GRCm39) D349E probably damaging Het
Sdhd G T 9: 50,511,905 (GRCm39) Q38K probably benign Het
Ssh1 C T 5: 114,098,718 (GRCm39) S117N probably damaging Het
Tbc1d2b A G 9: 90,131,915 (GRCm39) M148T probably benign Het
Tnni3k A G 3: 154,645,665 (GRCm39) S470P probably damaging Het
Tnr C T 1: 159,679,877 (GRCm39) Q284* probably null Het
Trim30a A C 7: 104,078,389 (GRCm39) V229G probably damaging Het
U2surp C T 9: 95,366,496 (GRCm39) V470I probably benign Het
Uck2 T C 1: 167,064,259 (GRCm39) D90G probably damaging Het
Vmn1r229 A T 17: 21,034,950 (GRCm39) E65V probably benign Het
Vmn2r26 A G 6: 124,038,129 (GRCm39) E568G probably damaging Het
Whamm A G 7: 81,235,886 (GRCm39) E363G probably damaging Het
Wrap53 A G 11: 69,453,272 (GRCm39) S390P probably damaging Het
Wrn A G 8: 33,757,848 (GRCm39) S814P probably benign Het
Zfp329 A G 7: 12,544,211 (GRCm39) C438R probably damaging Het
Zkscan8 T C 13: 21,710,930 (GRCm39) Y60C probably damaging Het
Other mutations in Trim43a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02400:Trim43a APN 9 88,464,165 (GRCm39) missense probably benign 0.00
IGL02864:Trim43a APN 9 88,470,165 (GRCm39) missense probably benign 0.20
R0114:Trim43a UTSW 9 88,466,213 (GRCm39) missense probably damaging 1.00
R0436:Trim43a UTSW 9 88,470,240 (GRCm39) missense probably damaging 1.00
R0514:Trim43a UTSW 9 88,466,389 (GRCm39) nonsense probably null
R0709:Trim43a UTSW 9 88,464,199 (GRCm39) missense probably benign 0.08
R0727:Trim43a UTSW 9 88,464,199 (GRCm39) missense probably benign 0.08
R1237:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R1239:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R1445:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R1448:Trim43a UTSW 9 88,464,146 (GRCm39) missense probably damaging 1.00
R1584:Trim43a UTSW 9 88,470,211 (GRCm39) missense probably damaging 1.00
R1925:Trim43a UTSW 9 88,464,371 (GRCm39) missense probably benign 0.08
R1992:Trim43a UTSW 9 88,466,312 (GRCm39) missense probably damaging 1.00
R2074:Trim43a UTSW 9 88,468,147 (GRCm39) missense possibly damaging 0.91
R3927:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R3930:Trim43a UTSW 9 88,465,131 (GRCm39) missense probably benign 0.04
R4418:Trim43a UTSW 9 88,464,206 (GRCm39) missense probably damaging 1.00
R5488:Trim43a UTSW 9 88,464,229 (GRCm39) missense probably damaging 0.97
R5489:Trim43a UTSW 9 88,464,229 (GRCm39) missense probably damaging 0.97
R6498:Trim43a UTSW 9 88,464,395 (GRCm39) missense probably damaging 1.00
R6742:Trim43a UTSW 9 88,470,399 (GRCm39) missense possibly damaging 0.92
R7535:Trim43a UTSW 9 88,470,201 (GRCm39) missense probably damaging 0.99
R7539:Trim43a UTSW 9 88,465,096 (GRCm39) missense probably benign 0.08
R7580:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R7943:Trim43a UTSW 9 88,464,238 (GRCm39) missense probably benign 0.16
R8073:Trim43a UTSW 9 88,464,490 (GRCm39) missense possibly damaging 0.71
R8983:Trim43a UTSW 9 88,464,404 (GRCm39) missense probably benign 0.23
R9030:Trim43a UTSW 9 88,465,042 (GRCm39) intron probably benign
R9646:Trim43a UTSW 9 88,466,392 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- GGTAGGATCACCTCAGGCAATATGC -3'
(R):5'- GGGTCACACACTTGTGCTCCTTAG -3'

Sequencing Primer
(F):5'- CAATATGCCTGTCAGGGAAAGTTC -3'
(R):5'- CTGACAATGGACACCTGCTT -3'
Posted On 2013-07-30