Incidental Mutation 'R7238:Clip1'
| ID |
562969 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Clip1
|
| Ensembl Gene |
ENSMUSG00000049550 |
| Gene Name |
CAP-GLY domain containing linker protein 1 |
| Synonyms |
Rsn, CLIP-170, 4631429H07Rik, restin, Clip 170, 1110007I12Rik, Clip50, cytoplasmic linker protein 50 |
| MMRRC Submission |
045345-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7238 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
123715857-123822527 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 123751328 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 818
(E818K)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031382]
[ENSMUST00000063905]
[ENSMUST00000111561]
[ENSMUST00000111564]
[ENSMUST00000111566]
[ENSMUST00000149410]
|
| AlphaFold |
Q922J3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000031382
|
| SMART Domains |
Protein: ENSMUSP00000031382
Gene: ENSMUSG00000049550
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
2.28e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
2.28e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
451 |
N/A |
INTRINSIC |
|
coiled coil region
|
474 |
535 |
N/A |
INTRINSIC |
|
coiled coil region
|
581 |
620 |
N/A |
INTRINSIC |
|
coiled coil region
|
652 |
1352 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1373 |
N/A |
INTRINSIC |
|
Pfam:CLIP1_ZNF
|
1375 |
1392 |
5.8e-9 |
PFAM |
|
ZnF_C2HC
|
1417 |
1433 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063905
|
| SMART Domains |
Protein: ENSMUSP00000068241
Gene: ENSMUSG00000049550
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
3.3e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
3.3e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
524 |
N/A |
INTRINSIC |
|
coiled coil region
|
570 |
609 |
N/A |
INTRINSIC |
|
coiled coil region
|
641 |
1075 |
N/A |
INTRINSIC |
|
coiled coil region
|
1115 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1245 |
1256 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1300 |
1316 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111561
|
| SMART Domains |
Protein: ENSMUSP00000107186
Gene: ENSMUSG00000049550
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
1.93e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
1.93e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
524 |
N/A |
INTRINSIC |
|
coiled coil region
|
570 |
609 |
N/A |
INTRINSIC |
|
coiled coil region
|
641 |
1341 |
N/A |
INTRINSIC |
|
low complexity region
|
1351 |
1362 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1406 |
1422 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111564
|
| SMART Domains |
Protein: ENSMUSP00000107190
Gene: ENSMUSG00000049550
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
2.5e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
2.5e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
489 |
N/A |
INTRINSIC |
|
coiled coil region
|
535 |
574 |
N/A |
INTRINSIC |
|
coiled coil region
|
606 |
1230 |
N/A |
INTRINSIC |
|
low complexity region
|
1240 |
1251 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1295 |
1311 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111566
|
| SMART Domains |
Protein: ENSMUSP00000107192
Gene: ENSMUSG00000049550
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
2e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
2e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
489 |
N/A |
INTRINSIC |
|
coiled coil region
|
535 |
574 |
N/A |
INTRINSIC |
|
coiled coil region
|
606 |
1306 |
N/A |
INTRINSIC |
|
low complexity region
|
1316 |
1327 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1371 |
1387 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000137363
|
| SMART Domains |
Protein: ENSMUSP00000121425
Gene: ENSMUSG00000049550
| Domain | Start | End | E-Value | Type |
|---|
|
CAP_GLY
|
2 |
31 |
2.59e0 |
SMART |
|
low complexity region
|
39 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
58 |
84 |
N/A |
INTRINSIC |
|
coiled coil region
|
101 |
276 |
N/A |
INTRINSIC |
|
coiled coil region
|
322 |
361 |
N/A |
INTRINSIC |
|
coiled coil region
|
393 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
991 |
1002 |
N/A |
INTRINSIC |
|
Pfam:CLIP1_ZNF
|
1004 |
1021 |
4.2e-9 |
PFAM |
|
ZnF_C2HC
|
1046 |
1062 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144121
|
| SMART Domains |
Protein: ENSMUSP00000119641
Gene: ENSMUSG00000049550
| Domain | Start | End | E-Value | Type |
|---|
|
CAP_GLY
|
37 |
102 |
1.05e-31 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000122064
Gene: ENSMUSG00000049550
AA Change: E818K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
59 |
N/A |
INTRINSIC |
|
low complexity region
|
165 |
176 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
352 |
375 |
1.56e-8 |
PROSPERO |
|
internal_repeat_3
|
358 |
377 |
5.32e-6 |
PROSPERO |
|
internal_repeat_1
|
450 |
473 |
1.56e-8 |
PROSPERO |
|
internal_repeat_3
|
544 |
563 |
5.32e-6 |
PROSPERO |
|
internal_repeat_2
|
553 |
575 |
2.88e-7 |
PROSPERO |
|
low complexity region
|
735 |
744 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
781 |
803 |
2.88e-7 |
PROSPERO |
|
low complexity region
|
819 |
830 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
977 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1110 |
1121 |
N/A |
INTRINSIC |
|
low complexity region
|
1164 |
1175 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149410
|
| SMART Domains |
Protein: ENSMUSP00000115965
Gene: ENSMUSG00000049550
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
26 |
32 |
N/A |
INTRINSIC |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
334 |
458 |
N/A |
INTRINSIC |
|
coiled coil region
|
504 |
543 |
N/A |
INTRINSIC |
|
coiled coil region
|
575 |
827 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0852 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.9%
|
| Validation Efficiency |
97% (104/107) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a targeted allele display reduced male fertility and teratozoospermia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
A |
T |
3: 137,775,712 (GRCm39) |
T1634S |
probably damaging |
Het |
| Adgrl1 |
T |
A |
8: 84,665,693 (GRCm39) |
M1460K |
probably damaging |
Het |
| Adig |
T |
A |
2: 158,347,773 (GRCm39) |
L29Q |
unknown |
Het |
| Adnp |
T |
G |
2: 168,025,887 (GRCm39) |
K469N |
probably damaging |
Het |
| Akap3 |
A |
G |
6: 126,842,200 (GRCm39) |
D273G |
probably benign |
Het |
| Albfm1 |
A |
T |
5: 90,727,519 (GRCm39) |
Y379F |
probably damaging |
Het |
| Ankrd34b |
T |
C |
13: 92,575,139 (GRCm39) |
Y124H |
possibly damaging |
Het |
| Ap2b1 |
T |
G |
11: 83,223,948 (GRCm39) |
F221C |
possibly damaging |
Het |
| Atp2c2 |
A |
G |
8: 120,469,160 (GRCm39) |
I358V |
possibly damaging |
Het |
| BC051665 |
G |
A |
13: 60,930,536 (GRCm39) |
T272I |
probably benign |
Het |
| Cdan1 |
G |
T |
2: 120,560,783 (GRCm39) |
A262E |
probably benign |
Het |
| Ces1d |
C |
T |
8: 93,904,763 (GRCm39) |
V326I |
probably benign |
Het |
| Chd3 |
T |
C |
11: 69,254,873 (GRCm39) |
R156G |
probably benign |
Het |
| Col6a4 |
C |
T |
9: 105,877,519 (GRCm39) |
V2153M |
probably damaging |
Het |
| Crlf3 |
T |
C |
11: 79,947,351 (GRCm39) |
N296D |
possibly damaging |
Het |
| Cstdc6 |
C |
T |
16: 36,142,193 (GRCm39) |
G61D |
probably benign |
Het |
| D130052B06Rik |
A |
G |
11: 33,573,594 (GRCm39) |
I109V |
probably benign |
Het |
| Dcaf5 |
G |
T |
12: 80,385,483 (GRCm39) |
T881K |
probably benign |
Het |
| Dennd4a |
C |
A |
9: 64,769,238 (GRCm39) |
T408K |
probably damaging |
Het |
| Dnaaf9 |
C |
A |
2: 130,648,708 (GRCm39) |
R258L |
unknown |
Het |
| Dnah2 |
A |
G |
11: 69,349,972 (GRCm39) |
|
probably null |
Het |
| Eif1ad8 |
A |
T |
12: 87,564,006 (GRCm39) |
K114* |
probably null |
Het |
| Eif2ak2 |
C |
T |
17: 79,173,760 (GRCm39) |
V273I |
probably benign |
Het |
| Elac1 |
C |
T |
18: 73,872,359 (GRCm39) |
G212D |
probably damaging |
Het |
| Ercc6l2 |
A |
G |
13: 64,013,798 (GRCm39) |
D623G |
probably damaging |
Het |
| Exo1 |
T |
C |
1: 175,716,413 (GRCm39) |
F177L |
probably damaging |
Het |
| Fat4 |
A |
G |
3: 38,944,562 (GRCm39) |
T1152A |
probably benign |
Het |
| Fbxl12 |
G |
T |
9: 20,529,709 (GRCm39) |
|
probably null |
Het |
| Fbxo43 |
T |
C |
15: 36,151,971 (GRCm39) |
Y582C |
probably damaging |
Het |
| Fsip2 |
T |
A |
2: 82,812,484 (GRCm39) |
N2934K |
possibly damaging |
Het |
| Gna12 |
A |
G |
5: 140,815,847 (GRCm39) |
S69P |
probably damaging |
Het |
| Gpatch8 |
C |
A |
11: 102,369,354 (GRCm39) |
G1395C |
probably damaging |
Het |
| Gpr137c |
A |
G |
14: 45,516,148 (GRCm39) |
Y294C |
probably damaging |
Het |
| Greb1 |
A |
G |
12: 16,724,673 (GRCm39) |
S1834P |
probably damaging |
Het |
| Grin2b |
T |
C |
6: 135,757,249 (GRCm39) |
D404G |
probably damaging |
Het |
| Hectd2 |
A |
T |
19: 36,574,478 (GRCm39) |
N236I |
probably damaging |
Het |
| Hhip |
C |
T |
8: 80,713,641 (GRCm39) |
V562I |
probably benign |
Het |
| Hipk2 |
G |
T |
6: 38,692,992 (GRCm39) |
T867N |
probably benign |
Het |
| Hmgcl |
T |
C |
4: 135,689,424 (GRCm39) |
V294A |
possibly damaging |
Het |
| Hnrnpl |
T |
A |
7: 28,513,400 (GRCm39) |
F158I |
|
Het |
| Hspa5 |
T |
C |
2: 34,662,383 (GRCm39) |
V17A |
unknown |
Het |
| Hspg2 |
T |
C |
4: 137,235,704 (GRCm39) |
V168A |
probably damaging |
Het |
| Idh1 |
A |
G |
1: 65,205,284 (GRCm39) |
F227S |
probably damaging |
Het |
| Iigp1c |
A |
G |
18: 60,379,355 (GRCm39) |
S297G |
possibly damaging |
Het |
| Immp2l |
T |
C |
12: 41,160,915 (GRCm39) |
V71A |
possibly damaging |
Het |
| Iqce |
G |
A |
5: 140,675,713 (GRCm39) |
R193* |
probably null |
Het |
| Kcnq5 |
T |
C |
1: 21,472,526 (GRCm39) |
D907G |
probably benign |
Het |
| Krt17 |
T |
A |
11: 100,148,613 (GRCm39) |
T306S |
probably benign |
Het |
| Lhx3 |
T |
C |
2: 26,093,009 (GRCm39) |
D149G |
probably damaging |
Het |
| Lrrc73 |
G |
A |
17: 46,565,488 (GRCm39) |
R73H |
probably damaging |
Het |
| Mgat5b |
T |
C |
11: 116,875,809 (GRCm39) |
S678P |
probably benign |
Het |
| Mink1 |
T |
C |
11: 70,502,305 (GRCm39) |
|
probably null |
Het |
| Mroh5 |
T |
G |
15: 73,663,278 (GRCm39) |
|
probably null |
Het |
| Muc5ac |
T |
A |
7: 141,363,254 (GRCm39) |
H2188Q |
unknown |
Het |
| Muc5ac |
G |
C |
7: 141,363,424 (GRCm39) |
|
probably benign |
Het |
| Musk |
G |
A |
4: 58,344,312 (GRCm39) |
G305D |
probably benign |
Het |
| Mx1 |
A |
G |
16: 97,249,496 (GRCm39) |
I347T |
unknown |
Het |
| Mybbp1a |
G |
T |
11: 72,334,338 (GRCm39) |
V198F |
probably damaging |
Het |
| Mycbp2 |
A |
G |
14: 103,393,733 (GRCm39) |
S2943P |
probably damaging |
Het |
| Myo18a |
G |
A |
11: 77,733,059 (GRCm39) |
R1363K |
probably damaging |
Het |
| Nav3 |
T |
A |
10: 109,689,185 (GRCm39) |
D364V |
possibly damaging |
Het |
| Or13g1 |
T |
C |
7: 85,955,799 (GRCm39) |
H174R |
probably damaging |
Het |
| Or14j6 |
T |
C |
17: 38,215,328 (GRCm39) |
L297S |
probably benign |
Het |
| Or1e26 |
A |
T |
11: 73,480,561 (GRCm39) |
M1K |
probably null |
Het |
| Or1j13 |
T |
A |
2: 36,369,726 (GRCm39) |
N139Y |
possibly damaging |
Het |
| Or5k15 |
T |
A |
16: 58,710,252 (GRCm39) |
E110D |
probably damaging |
Het |
| Pecr |
T |
C |
1: 72,298,592 (GRCm39) |
D276G |
probably damaging |
Het |
| Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 110,350,827 (GRCm39) |
|
probably benign |
Het |
| Ppp1cb |
A |
T |
5: 32,648,376 (GRCm39) |
T320S |
probably benign |
Het |
| Ppp1r9a |
G |
T |
6: 5,159,716 (GRCm39) |
K1084N |
probably damaging |
Het |
| Prdm2 |
A |
G |
4: 142,862,391 (GRCm39) |
S300P |
probably benign |
Het |
| Prkg1 |
C |
T |
19: 30,602,090 (GRCm39) |
V389I |
probably damaging |
Het |
| Psg25 |
C |
T |
7: 18,266,127 (GRCm39) |
|
probably benign |
Het |
| Ptpn6 |
A |
G |
6: 124,698,821 (GRCm39) |
S498P |
possibly damaging |
Het |
| Pus3 |
A |
G |
9: 35,477,965 (GRCm39) |
H399R |
probably benign |
Het |
| Pus7 |
T |
C |
5: 23,983,450 (GRCm39) |
T6A |
probably benign |
Het |
| Rnf169 |
A |
G |
7: 99,574,954 (GRCm39) |
V547A |
probably benign |
Het |
| Rsf1 |
GGCGGCGGC |
GGCGGCGGCCGCGGCGGC |
7: 97,229,128 (GRCm39) |
|
probably benign |
Het |
| Ryr1 |
C |
T |
7: 28,794,807 (GRCm39) |
D1194N |
probably benign |
Het |
| Scn5a |
T |
C |
9: 119,320,610 (GRCm39) |
M1490V |
possibly damaging |
Het |
| Sec23b |
A |
G |
2: 144,432,258 (GRCm39) |
D756G |
possibly damaging |
Het |
| Selenoo |
T |
A |
15: 88,973,427 (GRCm39) |
M39K |
probably benign |
Het |
| Septin8 |
T |
G |
11: 53,427,519 (GRCm39) |
V246G |
possibly damaging |
Het |
| Serpina3k |
T |
A |
12: 104,309,367 (GRCm39) |
N270K |
probably damaging |
Het |
| Setd5 |
G |
A |
6: 113,098,091 (GRCm39) |
R710H |
probably damaging |
Het |
| Sirt4 |
A |
T |
5: 115,621,049 (GRCm39) |
I41N |
possibly damaging |
Het |
| Slc26a9 |
T |
A |
1: 131,686,556 (GRCm39) |
Y425* |
probably null |
Het |
| Slc4a9 |
A |
G |
18: 36,662,773 (GRCm39) |
E176G |
probably benign |
Het |
| Speer1m |
T |
C |
5: 11,970,712 (GRCm39) |
I127T |
|
Het |
| Spidr |
A |
T |
16: 15,784,680 (GRCm39) |
W463R |
probably benign |
Het |
| Tenm4 |
G |
A |
7: 96,202,703 (GRCm39) |
R106H |
probably benign |
Het |
| Tmcc1 |
G |
A |
6: 116,111,198 (GRCm39) |
Q28* |
probably null |
Het |
| Tmem52b |
A |
G |
6: 129,493,651 (GRCm39) |
E88G |
probably damaging |
Het |
| Trpc7 |
A |
T |
13: 56,974,710 (GRCm39) |
I402K |
probably benign |
Het |
| Tshz3 |
T |
C |
7: 36,469,522 (GRCm39) |
Y504H |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,542,549 (GRCm39) |
E33479G |
possibly damaging |
Het |
| Ttn |
G |
A |
2: 76,711,672 (GRCm39) |
R8290C |
unknown |
Het |
| Urb1 |
T |
C |
16: 90,549,003 (GRCm39) |
D2235G |
possibly damaging |
Het |
| Usp10 |
T |
C |
8: 120,668,283 (GRCm39) |
F195L |
probably benign |
Het |
| Vmn1r31 |
A |
T |
6: 58,449,858 (GRCm39) |
F2L |
|
Het |
| Vmn2r109 |
C |
T |
17: 20,761,336 (GRCm39) |
V674M |
probably damaging |
Het |
| Vmn2r12 |
G |
A |
5: 109,245,655 (GRCm39) |
P26S |
possibly damaging |
Het |
| Vmn2r61 |
T |
A |
7: 41,916,629 (GRCm39) |
M414K |
possibly damaging |
Het |
| Yipf3 |
T |
C |
17: 46,562,585 (GRCm39) |
V330A |
probably benign |
Het |
| Zic4 |
A |
T |
9: 91,261,450 (GRCm39) |
H235L |
probably benign |
Het |
| Zxdc |
T |
A |
6: 90,346,642 (GRCm39) |
W16R |
unknown |
Het |
|
| Other mutations in Clip1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Clip1
|
APN |
5 |
123,741,717 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01067:Clip1
|
APN |
5 |
123,768,867 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01524:Clip1
|
APN |
5 |
123,717,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01632:Clip1
|
APN |
5 |
123,755,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01798:Clip1
|
APN |
5 |
123,721,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01874:Clip1
|
APN |
5 |
123,741,729 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01908:Clip1
|
APN |
5 |
123,761,270 (GRCm39) |
splice site |
probably benign |
|
|
IGL02120:Clip1
|
APN |
5 |
123,785,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02309:Clip1
|
APN |
5 |
123,755,763 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02555:Clip1
|
APN |
5 |
123,759,857 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03027:Clip1
|
APN |
5 |
123,759,919 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03336:Clip1
|
APN |
5 |
123,791,633 (GRCm39) |
nonsense |
probably null |
|
|
IGL03365:Clip1
|
APN |
5 |
123,721,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02802:Clip1
|
UTSW |
5 |
123,769,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4812001:Clip1
|
UTSW |
5 |
123,768,738 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0254:Clip1
|
UTSW |
5 |
123,755,395 (GRCm39) |
splice site |
probably benign |
|
|
R0401:Clip1
|
UTSW |
5 |
123,791,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0530:Clip1
|
UTSW |
5 |
123,778,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0744:Clip1
|
UTSW |
5 |
123,768,784 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0833:Clip1
|
UTSW |
5 |
123,768,784 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1116:Clip1
|
UTSW |
5 |
123,717,554 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1182:Clip1
|
UTSW |
5 |
123,785,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1656:Clip1
|
UTSW |
5 |
123,768,466 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1700:Clip1
|
UTSW |
5 |
123,768,433 (GRCm39) |
missense |
probably benign |
|
|
R1889:Clip1
|
UTSW |
5 |
123,791,559 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1975:Clip1
|
UTSW |
5 |
123,761,281 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2406:Clip1
|
UTSW |
5 |
123,741,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3545:Clip1
|
UTSW |
5 |
123,769,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3547:Clip1
|
UTSW |
5 |
123,769,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3548:Clip1
|
UTSW |
5 |
123,769,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3911:Clip1
|
UTSW |
5 |
123,728,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Clip1
|
UTSW |
5 |
123,755,892 (GRCm39) |
unclassified |
probably benign |
|
|
R4660:Clip1
|
UTSW |
5 |
123,717,437 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4784:Clip1
|
UTSW |
5 |
123,717,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4785:Clip1
|
UTSW |
5 |
123,717,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4824:Clip1
|
UTSW |
5 |
123,769,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4831:Clip1
|
UTSW |
5 |
123,721,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4951:Clip1
|
UTSW |
5 |
123,768,408 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4960:Clip1
|
UTSW |
5 |
123,792,066 (GRCm39) |
nonsense |
probably null |
|
|
R5014:Clip1
|
UTSW |
5 |
123,755,793 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5116:Clip1
|
UTSW |
5 |
123,768,770 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5212:Clip1
|
UTSW |
5 |
123,768,744 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5238:Clip1
|
UTSW |
5 |
123,785,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5318:Clip1
|
UTSW |
5 |
123,751,147 (GRCm39) |
unclassified |
probably benign |
|
|
R5372:Clip1
|
UTSW |
5 |
123,768,303 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5701:Clip1
|
UTSW |
5 |
123,751,366 (GRCm39) |
unclassified |
probably benign |
|
|
R5734:Clip1
|
UTSW |
5 |
123,753,217 (GRCm39) |
unclassified |
probably benign |
|
|
R5757:Clip1
|
UTSW |
5 |
123,765,460 (GRCm39) |
missense |
probably benign |
0.21 |
|
R6024:Clip1
|
UTSW |
5 |
123,753,152 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6160:Clip1
|
UTSW |
5 |
123,751,604 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6177:Clip1
|
UTSW |
5 |
123,751,897 (GRCm39) |
unclassified |
probably benign |
|
|
R6183:Clip1
|
UTSW |
5 |
123,780,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6377:Clip1
|
UTSW |
5 |
123,741,717 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6436:Clip1
|
UTSW |
5 |
123,779,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6471:Clip1
|
UTSW |
5 |
123,778,612 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6766:Clip1
|
UTSW |
5 |
123,752,827 (GRCm39) |
unclassified |
probably benign |
|
|
R7015:Clip1
|
UTSW |
5 |
123,751,675 (GRCm39) |
unclassified |
probably benign |
|
|
R7094:Clip1
|
UTSW |
5 |
123,761,333 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7143:Clip1
|
UTSW |
5 |
123,791,673 (GRCm39) |
missense |
probably benign |
|
|
R7222:Clip1
|
UTSW |
5 |
123,749,904 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7233:Clip1
|
UTSW |
5 |
123,749,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7249:Clip1
|
UTSW |
5 |
123,741,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7283:Clip1
|
UTSW |
5 |
123,751,857 (GRCm39) |
missense |
|
|
|
R7295:Clip1
|
UTSW |
5 |
123,765,419 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7447:Clip1
|
UTSW |
5 |
123,791,696 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7458:Clip1
|
UTSW |
5 |
123,778,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Clip1
|
UTSW |
5 |
123,755,447 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7516:Clip1
|
UTSW |
5 |
123,721,448 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7619:Clip1
|
UTSW |
5 |
123,752,342 (GRCm39) |
missense |
|
|
|
R7831:Clip1
|
UTSW |
5 |
123,751,342 (GRCm39) |
missense |
|
|
|
R7897:Clip1
|
UTSW |
5 |
123,760,861 (GRCm39) |
missense |
probably benign |
|
|
R8155:Clip1
|
UTSW |
5 |
123,751,699 (GRCm39) |
missense |
|
|
|
R8157:Clip1
|
UTSW |
5 |
123,768,782 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8232:Clip1
|
UTSW |
5 |
123,785,981 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8396:Clip1
|
UTSW |
5 |
123,780,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8446:Clip1
|
UTSW |
5 |
123,794,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8486:Clip1
|
UTSW |
5 |
123,752,770 (GRCm39) |
unclassified |
probably benign |
|
|
R8511:Clip1
|
UTSW |
5 |
123,791,969 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8731:Clip1
|
UTSW |
5 |
123,752,756 (GRCm39) |
missense |
|
|
|
R8889:Clip1
|
UTSW |
5 |
123,717,565 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8892:Clip1
|
UTSW |
5 |
123,717,565 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9058:Clip1
|
UTSW |
5 |
123,752,645 (GRCm39) |
missense |
|
|
|
R9106:Clip1
|
UTSW |
5 |
123,753,223 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9212:Clip1
|
UTSW |
5 |
123,721,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9217:Clip1
|
UTSW |
5 |
123,717,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Clip1
|
UTSW |
5 |
123,784,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Clip1
|
UTSW |
5 |
123,751,186 (GRCm39) |
missense |
|
|
|
R9752:Clip1
|
UTSW |
5 |
123,760,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Clip1
|
UTSW |
5 |
123,755,413 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACCTCTCACTTTACCGTGAACG -3'
(R):5'- GACCCTCAAAAGCGACTTCG -3'
Sequencing Primer
(F):5'- CGAATGAAGGGTCTCAAGCTCTC -3'
(R):5'- GCTGCCCTTTCCAAGTCCAAG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation