Incidental Mutation 'R0591:Carf'
ID 55950
Institutional Source Beutler Lab
Gene Symbol Carf
Ensembl Gene ENSMUSG00000026017
Gene Name calcium response factor
Synonyms Als2cr8
MMRRC Submission 038781-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0591 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 60137406-60193112 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to T at 60165073 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000141169 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027171] [ENSMUST00000124986] [ENSMUST00000130075] [ENSMUST00000180952] [ENSMUST00000186107] [ENSMUST00000187978]
AlphaFold Q8VHI4
Predicted Effect probably benign
Transcript: ENSMUST00000027171
SMART Domains Protein: ENSMUSP00000027171
Gene: ENSMUSG00000026017

DomainStartEndE-ValueType
Pfam:ALS2CR8 227 457 6.4e-63 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124986
Predicted Effect probably benign
Transcript: ENSMUST00000130075
Predicted Effect probably benign
Transcript: ENSMUST00000180952
SMART Domains Protein: ENSMUSP00000137825
Gene: ENSMUSG00000026017

DomainStartEndE-ValueType
Pfam:ALS2CR8 224 458 1.2e-64 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000186107
SMART Domains Protein: ENSMUSP00000139554
Gene: ENSMUSG00000026017

DomainStartEndE-ValueType
low complexity region 239 255 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000187978
SMART Domains Protein: ENSMUSP00000141169
Gene: ENSMUSG00000026017

DomainStartEndE-ValueType
Pfam:ALS2CR8 224 458 1.2e-64 PFAM
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.2%
  • 10x: 97.7%
  • 20x: 95.3%
Validation Efficiency 100% (62/62)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele have aberrant learning and memory. [provided by MGI curators]
Allele List at MGI

All alleles(3) : Targeted, knock-out(1) Gene trapped(2)

Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik G T 3: 137,774,704 (GRCm39) E1298* probably null Het
Aadacl2fm2 C A 3: 59,659,550 (GRCm39) Y334* probably null Het
Adam19 T C 11: 46,012,238 (GRCm39) probably benign Het
Agt A T 8: 125,283,678 (GRCm39) S480R possibly damaging Het
Anapc1 G T 2: 128,461,252 (GRCm39) D1769E probably benign Het
Aox4 T C 1: 58,278,261 (GRCm39) probably benign Het
Apol9b G A 15: 77,619,830 (GRCm39) V209I possibly damaging Het
Appl2 A T 10: 83,460,509 (GRCm39) I116K possibly damaging Het
BC051665 A G 13: 60,932,422 (GRCm39) probably benign Het
Cactin G T 10: 81,159,837 (GRCm39) E89* probably null Het
Ccdc167 A G 17: 29,924,235 (GRCm39) probably benign Het
Ceacam3 G A 7: 16,885,808 (GRCm39) probably null Het
Clca4b T A 3: 144,621,353 (GRCm39) K574* probably null Het
Crabp1 T A 9: 54,672,887 (GRCm39) I64N probably damaging Het
Dgkd T A 1: 87,842,826 (GRCm39) I118N probably damaging Het
Dglucy T C 12: 100,825,777 (GRCm39) probably benign Het
Dock10 C T 1: 80,518,936 (GRCm39) probably benign Het
Ednrb A T 14: 104,060,710 (GRCm39) probably null Het
Ercc6 T C 14: 32,279,973 (GRCm39) probably benign Het
Golga3 A C 5: 110,336,609 (GRCm39) Q416P probably damaging Het
Gpr12 A G 5: 146,520,445 (GRCm39) V159A probably benign Het
Heatr5a A T 12: 51,956,884 (GRCm39) probably benign Het
Helz2 A G 2: 180,873,909 (GRCm39) I2195T probably damaging Het
Hikeshi A T 7: 89,569,295 (GRCm39) N76K possibly damaging Het
Hsd11b1 T C 1: 192,911,984 (GRCm39) probably benign Het
Iftap A T 2: 101,406,462 (GRCm39) D155E probably benign Het
Inhba A T 13: 16,201,405 (GRCm39) K322N probably damaging Het
Katnal1 A T 5: 148,829,326 (GRCm39) F291L probably damaging Het
Kcnj9 T C 1: 172,150,665 (GRCm39) E316G probably damaging Het
Lrsam1 A G 2: 32,823,935 (GRCm39) probably benign Het
Mcf2l T G 8: 13,068,751 (GRCm39) S1075A probably benign Het
Mios T C 6: 8,215,470 (GRCm39) V222A possibly damaging Het
Mycbp2 A T 14: 103,433,827 (GRCm39) probably benign Het
Nars1 A T 18: 64,633,638 (GRCm39) I544N probably damaging Het
Or5ak23 A G 2: 85,245,034 (GRCm39) L63P possibly damaging Het
Pbrm1 A G 14: 30,768,387 (GRCm39) probably benign Het
Plcb4 A G 2: 135,796,932 (GRCm39) probably benign Het
Pnliprp1 A G 19: 58,723,138 (GRCm39) D213G probably damaging Het
Psap A G 10: 60,136,634 (GRCm39) N538D possibly damaging Het
Ptdss1 A G 13: 67,120,714 (GRCm39) probably benign Het
Rap1b G A 10: 117,654,522 (GRCm39) probably benign Het
Rhcg T A 7: 79,244,520 (GRCm39) probably benign Het
Ryr1 G A 7: 28,804,220 (GRCm39) T550I possibly damaging Het
Samm50 G A 15: 84,095,369 (GRCm39) G452R probably benign Het
Scin A G 12: 40,130,929 (GRCm39) probably null Het
Sesn3 T C 9: 14,219,854 (GRCm39) L81S probably damaging Het
Skint6 A C 4: 112,715,366 (GRCm39) probably benign Het
Slc30a4 A T 2: 122,527,160 (GRCm39) L411H probably damaging Het
Slc44a5 C T 3: 153,939,782 (GRCm39) probably benign Het
Slc4a3 C T 1: 75,525,665 (GRCm39) A255V probably damaging Het
Slc9b1 A G 3: 135,088,593 (GRCm39) N318S possibly damaging Het
Tcp11l2 A T 10: 84,440,458 (GRCm39) H287L probably benign Het
Tex10 C T 4: 48,456,800 (GRCm39) R637Q probably benign Het
Tnks2 T A 19: 36,849,962 (GRCm39) Y605N probably damaging Het
Topbp1 T A 9: 103,227,037 (GRCm39) N1490K probably benign Het
Ube4b T G 4: 149,442,034 (GRCm39) probably benign Het
Usp4 G A 9: 108,225,228 (GRCm39) probably benign Het
Vezf1 A T 11: 88,068,435 (GRCm38) probably benign Het
Vmn1r184 A T 7: 25,966,500 (GRCm39) D82V probably damaging Het
Other mutations in Carf
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00321:Carf APN 1 60,164,001 (GRCm39) splice site probably benign
IGL00730:Carf APN 1 60,186,577 (GRCm39) nonsense probably null
IGL00792:Carf APN 1 60,165,168 (GRCm39) missense possibly damaging 0.73
IGL00913:Carf APN 1 60,187,114 (GRCm39) missense probably benign 0.20
IGL01487:Carf APN 1 60,148,538 (GRCm39) missense probably damaging 1.00
IGL02214:Carf APN 1 60,187,240 (GRCm39) missense probably damaging 1.00
IGL03258:Carf APN 1 60,148,388 (GRCm39) missense possibly damaging 0.93
IGL03285:Carf APN 1 60,185,313 (GRCm39) missense probably damaging 1.00
3-1:Carf UTSW 1 60,180,627 (GRCm39) missense possibly damaging 0.93
PIT4283001:Carf UTSW 1 60,167,161 (GRCm39) missense probably benign 0.32
R0375:Carf UTSW 1 60,183,161 (GRCm39) missense probably damaging 1.00
R0465:Carf UTSW 1 60,171,142 (GRCm39) missense probably damaging 1.00
R1158:Carf UTSW 1 60,186,998 (GRCm39) missense probably benign 0.22
R1433:Carf UTSW 1 60,164,017 (GRCm39) missense probably damaging 1.00
R1464:Carf UTSW 1 60,165,065 (GRCm39) splice site probably benign
R1467:Carf UTSW 1 60,167,152 (GRCm39) missense possibly damaging 0.58
R1467:Carf UTSW 1 60,167,152 (GRCm39) missense possibly damaging 0.58
R1546:Carf UTSW 1 60,165,195 (GRCm39) critical splice donor site probably null
R1801:Carf UTSW 1 60,180,664 (GRCm39) missense possibly damaging 0.60
R1977:Carf UTSW 1 60,185,295 (GRCm39) missense probably damaging 1.00
R2086:Carf UTSW 1 60,148,570 (GRCm39) missense probably damaging 1.00
R2163:Carf UTSW 1 60,186,645 (GRCm39) splice site probably benign
R2198:Carf UTSW 1 60,180,643 (GRCm39) missense probably damaging 1.00
R2238:Carf UTSW 1 60,187,193 (GRCm39) missense probably benign
R2981:Carf UTSW 1 60,178,391 (GRCm39) missense probably damaging 1.00
R4090:Carf UTSW 1 60,175,506 (GRCm39) missense possibly damaging 0.94
R4573:Carf UTSW 1 60,187,271 (GRCm39) missense probably benign 0.39
R4737:Carf UTSW 1 60,148,477 (GRCm39) missense probably benign 0.00
R4906:Carf UTSW 1 60,180,526 (GRCm39) missense probably damaging 1.00
R4965:Carf UTSW 1 60,189,796 (GRCm39) missense probably damaging 0.99
R5080:Carf UTSW 1 60,189,772 (GRCm39) missense probably damaging 0.98
R5184:Carf UTSW 1 60,147,333 (GRCm39) missense probably damaging 0.99
R5949:Carf UTSW 1 60,178,472 (GRCm39) missense probably damaging 1.00
R6135:Carf UTSW 1 60,187,122 (GRCm39) missense probably damaging 1.00
R6346:Carf UTSW 1 60,180,699 (GRCm39) nonsense probably null
R6886:Carf UTSW 1 60,175,413 (GRCm39) splice site probably null
R7115:Carf UTSW 1 60,187,309 (GRCm39) missense probably damaging 1.00
R7228:Carf UTSW 1 60,148,553 (GRCm39) missense probably damaging 0.99
R7459:Carf UTSW 1 60,167,198 (GRCm39) missense possibly damaging 0.93
R7755:Carf UTSW 1 60,187,214 (GRCm39) missense probably benign 0.00
R7809:Carf UTSW 1 60,183,226 (GRCm39) missense probably damaging 0.98
R8053:Carf UTSW 1 60,167,197 (GRCm39) missense probably benign 0.42
R8137:Carf UTSW 1 60,187,124 (GRCm39) missense probably benign 0.00
R8423:Carf UTSW 1 60,189,752 (GRCm39) missense possibly damaging 0.95
R9155:Carf UTSW 1 60,189,842 (GRCm39) missense possibly damaging 0.85
R9177:Carf UTSW 1 60,148,558 (GRCm39) missense possibly damaging 0.61
R9215:Carf UTSW 1 60,189,804 (GRCm39) missense possibly damaging 0.62
R9268:Carf UTSW 1 60,148,558 (GRCm39) missense possibly damaging 0.61
R9750:Carf UTSW 1 60,171,158 (GRCm39) nonsense probably null
Z1177:Carf UTSW 1 60,175,421 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- CCCTCCCATTTGTCTCACATTCAGAGAA -3'
(R):5'- AACAGACTTCCATTGTGACAGCAAAGA -3'

Sequencing Primer
(F):5'- CATTAACTGTCACTGAAAGTTAAACC -3'
(R):5'- TTGTGACAGCAAAGACAAGCTC -3'
Posted On 2013-07-11