Incidental Mutation 'R7187:Mtus2'
ID 559351
Institutional Source Beutler Lab
Gene Symbol Mtus2
Ensembl Gene ENSMUSG00000029651
Gene Name microtubule associated tumor suppressor candidate 2
Synonyms C130038G02Rik, A730013O20Rik, 5730592G18Rik
MMRRC Submission 045377-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.174) question?
Stock # R7187 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 147894130-148252875 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 148013515 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 103 (T103A)
Ref Sequence ENSEMBL: ENSMUSP00000082694 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085558] [ENSMUST00000129092]
AlphaFold Q3UHD3
Predicted Effect probably benign
Transcript: ENSMUST00000085558
AA Change: T103A

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000082694
Gene: ENSMUSG00000029651
AA Change: T103A

DomainStartEndE-ValueType
internal_repeat_1 57 290 2.46e-5 PROSPERO
internal_repeat_1 312 525 2.46e-5 PROSPERO
low complexity region 530 541 N/A INTRINSIC
low complexity region 802 818 N/A INTRINSIC
low complexity region 841 852 N/A INTRINSIC
low complexity region 893 904 N/A INTRINSIC
coiled coil region 1029 1080 N/A INTRINSIC
SCOP:d1fxkc_ 1167 1294 3e-4 SMART
low complexity region 1332 1349 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000129092
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca2 A G 2: 25,327,733 (GRCm39) Y716C probably damaging Het
Abcc1 A G 16: 14,284,861 (GRCm39) I1237V probably benign Het
Adam34 C T 8: 44,105,565 (GRCm39) A27T probably benign Het
Aff3 T C 1: 38,257,478 (GRCm39) S415G probably damaging Het
Ak7 T C 12: 105,711,532 (GRCm39) Y390H probably benign Het
Arap2 A C 5: 62,826,396 (GRCm39) M1056R probably damaging Het
Brf1 T C 12: 112,923,945 (GRCm39) Y676C unknown Het
Cachd1 T A 4: 100,833,552 (GRCm39) H776Q possibly damaging Het
Cacng7 T C 7: 3,385,183 (GRCm39) V28A probably damaging Het
Camk2g A T 14: 20,792,780 (GRCm39) D359E probably benign Het
Cd209b T C 8: 3,976,638 (GRCm39) D16G probably benign Het
Ceacam5 A G 7: 17,493,410 (GRCm39) E811G possibly damaging Het
Cecr2 T A 6: 120,733,647 (GRCm39) S545T probably benign Het
Cep55 T C 19: 38,048,806 (GRCm39) probably null Het
Ctif C A 18: 75,770,290 (GRCm39) V32L probably damaging Het
Cwc27 G A 13: 104,797,900 (GRCm39) A353V probably benign Het
Dclk3 T A 9: 111,314,064 (GRCm39) S713R probably damaging Het
Dlec1 C T 9: 118,941,214 (GRCm39) H255Y probably benign Het
Dlgap1 A G 17: 70,823,093 (GRCm39) H26R possibly damaging Het
Dydc1 C T 14: 40,800,051 (GRCm39) T19I possibly damaging Het
Efcab12 G A 6: 115,800,474 (GRCm39) P183L not run Het
Eif1ad19 T C 12: 87,740,708 (GRCm39) probably benign Het
Eri3 C A 4: 117,446,343 (GRCm39) Q219K probably benign Het
Fam135a A G 1: 24,083,295 (GRCm39) L310P probably damaging Het
Fgd5 T A 6: 91,965,272 (GRCm39) S502T possibly damaging Het
Fgf8 A G 19: 45,730,106 (GRCm39) S57P probably benign Het
Gls T C 1: 52,259,139 (GRCm39) E154G probably damaging Het
Gm28042 T C 2: 119,870,176 (GRCm39) L705P probably damaging Het
Golgb1 C A 16: 36,736,512 (GRCm39) Q1961K probably benign Het
Herc3 C A 6: 58,833,616 (GRCm39) Q168K probably benign Het
Il31ra C A 13: 112,682,845 (GRCm39) C168F probably benign Het
Ino80 A T 2: 119,257,072 (GRCm39) D860E probably benign Het
Iqcm T G 8: 76,480,044 (GRCm39) L334R probably benign Het
Lrrk2 A G 15: 91,641,204 (GRCm39) D1587G possibly damaging Het
Map4 T A 9: 109,882,201 (GRCm39) V355E probably benign Het
Mapk13 T A 17: 28,995,361 (GRCm39) I194N probably damaging Het
Naglu G T 11: 100,961,158 (GRCm39) G70W probably benign Het
Nlrp4f A T 13: 65,343,201 (GRCm39) M126K possibly damaging Het
Or4c120 T C 2: 89,001,714 (GRCm39) probably benign Het
Or5p61 A T 7: 107,758,585 (GRCm39) V165E probably benign Het
Pdia4 T C 6: 47,790,193 (GRCm39) T16A unknown Het
Pou6f2 G A 13: 18,414,298 (GRCm39) A159V Het
Ripor1 A G 8: 106,344,506 (GRCm39) T547A probably benign Het
Rundc3b A G 5: 8,542,506 (GRCm39) S389P probably damaging Het
Sorbs1 G C 19: 40,365,244 (GRCm39) R180G probably benign Het
Spats2 T C 15: 99,110,054 (GRCm39) S484P probably benign Het
Supv3l1 G A 10: 62,271,328 (GRCm39) T403I probably damaging Het
Tacstd2 G A 6: 67,512,180 (GRCm39) R171W probably damaging Het
Taok2 A T 7: 126,471,552 (GRCm39) F542L probably damaging Het
Tbc1d31 T A 15: 57,801,459 (GRCm39) N331K possibly damaging Het
Tff2 A T 17: 31,361,200 (GRCm39) C118S probably damaging Het
Tmprss7 G A 16: 45,498,317 (GRCm39) T354I possibly damaging Het
Tmtc3 A T 10: 100,313,774 (GRCm39) F33I probably damaging Het
Tpbpa G A 13: 61,088,399 (GRCm39) probably benign Het
Ube3a G T 7: 58,925,653 (GRCm39) V165F probably benign Het
Vmn2r4 T G 3: 64,322,681 (GRCm39) T13P probably benign Het
Wnt8b A G 19: 44,500,121 (GRCm39) D236G probably benign Het
Ythdf3 C A 3: 16,258,451 (GRCm39) D210E probably benign Het
Zfp110 T A 7: 12,583,753 (GRCm39) Y800* probably null Het
Other mutations in Mtus2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01104:Mtus2 APN 5 148,013,819 (GRCm39) splice site probably null
IGL01911:Mtus2 APN 5 148,015,030 (GRCm39) missense probably benign 0.00
IGL01973:Mtus2 APN 5 148,240,286 (GRCm39) splice site probably benign
IGL02452:Mtus2 APN 5 148,014,473 (GRCm39) missense probably benign 0.01
IGL02476:Mtus2 APN 5 148,014,748 (GRCm39) missense probably benign 0.01
IGL02716:Mtus2 APN 5 148,173,120 (GRCm39) missense probably benign 0.05
IGL03194:Mtus2 APN 5 148,043,913 (GRCm39) missense probably damaging 1.00
rumblado UTSW 5 148,243,518 (GRCm39) nonsense probably null
IGL02991:Mtus2 UTSW 5 148,250,310 (GRCm39) missense probably damaging 1.00
PIT4431001:Mtus2 UTSW 5 148,013,515 (GRCm39) missense probably benign 0.01
R0101:Mtus2 UTSW 5 148,019,845 (GRCm39) missense probably damaging 1.00
R0101:Mtus2 UTSW 5 148,019,845 (GRCm39) missense probably damaging 1.00
R0310:Mtus2 UTSW 5 148,043,829 (GRCm39) missense probably benign 0.17
R0729:Mtus2 UTSW 5 148,014,097 (GRCm39) missense probably benign 0.08
R0968:Mtus2 UTSW 5 148,014,994 (GRCm39) missense probably benign 0.09
R1231:Mtus2 UTSW 5 148,014,198 (GRCm39) missense probably benign 0.01
R1253:Mtus2 UTSW 5 148,240,380 (GRCm39) nonsense probably null
R1556:Mtus2 UTSW 5 148,014,198 (GRCm39) missense probably benign 0.01
R1561:Mtus2 UTSW 5 148,013,362 (GRCm39) missense probably benign 0.07
R1574:Mtus2 UTSW 5 148,013,362 (GRCm39) missense probably benign 0.07
R1750:Mtus2 UTSW 5 148,214,443 (GRCm39) missense probably damaging 0.97
R2318:Mtus2 UTSW 5 148,043,892 (GRCm39) nonsense probably null
R2327:Mtus2 UTSW 5 148,014,725 (GRCm39) missense probably benign 0.00
R3153:Mtus2 UTSW 5 148,019,870 (GRCm39) missense probably damaging 1.00
R3154:Mtus2 UTSW 5 148,240,083 (GRCm39) intron probably benign
R3158:Mtus2 UTSW 5 148,168,637 (GRCm39) missense probably damaging 1.00
R3548:Mtus2 UTSW 5 148,232,316 (GRCm39) missense probably damaging 1.00
R3861:Mtus2 UTSW 5 148,250,223 (GRCm39) missense probably damaging 1.00
R4395:Mtus2 UTSW 5 148,013,432 (GRCm39) missense probably benign 0.17
R4396:Mtus2 UTSW 5 148,140,748 (GRCm39) missense possibly damaging 0.81
R4667:Mtus2 UTSW 5 148,235,070 (GRCm39) missense possibly damaging 0.64
R4887:Mtus2 UTSW 5 148,013,913 (GRCm39) nonsense probably null
R4931:Mtus2 UTSW 5 148,014,226 (GRCm39) missense probably benign 0.09
R5097:Mtus2 UTSW 5 148,232,392 (GRCm39) missense probably damaging 0.99
R5318:Mtus2 UTSW 5 148,013,382 (GRCm39) missense probably benign 0.05
R5372:Mtus2 UTSW 5 148,250,222 (GRCm39) missense probably damaging 1.00
R5388:Mtus2 UTSW 5 148,243,518 (GRCm39) nonsense probably null
R5622:Mtus2 UTSW 5 148,015,244 (GRCm39) missense probably benign 0.09
R6009:Mtus2 UTSW 5 148,243,462 (GRCm39) missense probably damaging 1.00
R6379:Mtus2 UTSW 5 148,014,008 (GRCm39) missense probably benign 0.00
R6409:Mtus2 UTSW 5 148,014,425 (GRCm39) missense probably benign
R6527:Mtus2 UTSW 5 148,214,408 (GRCm39) critical splice acceptor site probably null
R6853:Mtus2 UTSW 5 148,043,821 (GRCm39) missense probably damaging 1.00
R7001:Mtus2 UTSW 5 148,214,438 (GRCm39) missense probably damaging 1.00
R7276:Mtus2 UTSW 5 148,013,368 (GRCm39) missense probably benign
R7594:Mtus2 UTSW 5 148,014,216 (GRCm39) missense probably benign 0.44
R7790:Mtus2 UTSW 5 148,014,998 (GRCm39) missense probably benign 0.09
R7967:Mtus2 UTSW 5 148,014,656 (GRCm39) missense probably benign 0.32
R7987:Mtus2 UTSW 5 148,168,836 (GRCm39) splice site probably null
R8112:Mtus2 UTSW 5 148,013,713 (GRCm39) nonsense probably null
R8273:Mtus2 UTSW 5 148,043,815 (GRCm39) missense probably damaging 1.00
R8527:Mtus2 UTSW 5 148,240,408 (GRCm39) missense probably damaging 1.00
R8542:Mtus2 UTSW 5 148,240,408 (GRCm39) missense probably damaging 1.00
R8783:Mtus2 UTSW 5 148,019,861 (GRCm39) missense probably damaging 1.00
R8805:Mtus2 UTSW 5 148,015,303 (GRCm39) missense possibly damaging 0.58
R9204:Mtus2 UTSW 5 148,238,293 (GRCm39) missense probably damaging 1.00
R9210:Mtus2 UTSW 5 148,014,124 (GRCm39) missense probably benign 0.00
R9261:Mtus2 UTSW 5 148,243,453 (GRCm39) nonsense probably null
R9419:Mtus2 UTSW 5 148,243,451 (GRCm39) missense probably damaging 1.00
R9477:Mtus2 UTSW 5 148,014,740 (GRCm39) missense probably benign
R9483:Mtus2 UTSW 5 148,232,300 (GRCm39) missense possibly damaging 0.80
R9563:Mtus2 UTSW 5 148,250,217 (GRCm39) missense
R9643:Mtus2 UTSW 5 148,014,025 (GRCm39) missense probably benign 0.04
R9716:Mtus2 UTSW 5 148,013,464 (GRCm39) missense possibly damaging 0.82
R9745:Mtus2 UTSW 5 148,013,311 (GRCm39) missense possibly damaging 0.81
X0017:Mtus2 UTSW 5 148,214,410 (GRCm39) missense possibly damaging 0.83
X0028:Mtus2 UTSW 5 148,014,128 (GRCm39) missense probably benign 0.03
Z1088:Mtus2 UTSW 5 148,240,073 (GRCm39) intron probably benign
Z1176:Mtus2 UTSW 5 148,014,068 (GRCm39) missense probably benign 0.05
Z1176:Mtus2 UTSW 5 148,013,552 (GRCm39) missense probably benign 0.31
Z1177:Mtus2 UTSW 5 148,140,887 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2019-06-26