Incidental Mutation 'R7164:Zfp707'
ID 557821
Institutional Source Beutler Lab
Gene Symbol Zfp707
Ensembl Gene ENSMUSG00000034429
Gene Name zinc finger protein 707
Synonyms 1500031N24Rik
MMRRC Submission 045331-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R7164 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 75840972-75847717 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 75846967 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 339 (E339G)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109966] [ENSMUST00000109967] [ENSMUST00000182172] [ENSMUST00000183130] [ENSMUST00000229652]
AlphaFold D3Z445
Predicted Effect possibly damaging
Transcript: ENSMUST00000109966
AA Change: E333G

PolyPhen 2 Score 0.912 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000105592
Gene: ENSMUSG00000034429
AA Change: E333G

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
KRAB 39 99 2.42e-31 SMART
ZnF_C2H2 189 211 9.96e-1 SMART
ZnF_C2H2 217 239 9.08e-4 SMART
ZnF_C2H2 245 267 3.58e-2 SMART
ZnF_C2H2 273 295 1.04e-3 SMART
ZnF_C2H2 301 323 2.09e-3 SMART
ZnF_C2H2 329 351 9.58e-3 SMART
ZnF_C2H2 357 379 1.28e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000109967
AA Change: E287G

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000105593
Gene: ENSMUSG00000034429
AA Change: E287G

DomainStartEndE-ValueType
KRAB 4 53 3.59e-16 SMART
ZnF_C2H2 143 165 9.96e-1 SMART
ZnF_C2H2 171 193 9.08e-4 SMART
ZnF_C2H2 199 221 3.58e-2 SMART
ZnF_C2H2 227 249 1.04e-3 SMART
ZnF_C2H2 255 277 2.09e-3 SMART
ZnF_C2H2 283 305 9.58e-3 SMART
ZnF_C2H2 311 333 1.28e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000145100
SMART Domains Protein: ENSMUSP00000120565
Gene: ENSMUSG00000034429

DomainStartEndE-ValueType
KRAB 23 83 2.42e-31 SMART
ZnF_C2H2 173 195 9.96e-1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000147641
AA Change: E339G

PolyPhen 2 Score 0.863 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000119705
Gene: ENSMUSG00000034429
AA Change: E339G

DomainStartEndE-ValueType
low complexity region 1 15 N/A INTRINSIC
KRAB 46 106 2.42e-31 SMART
ZnF_C2H2 196 218 9.96e-1 SMART
ZnF_C2H2 224 246 9.08e-4 SMART
ZnF_C2H2 252 274 3.58e-2 SMART
ZnF_C2H2 280 302 1.04e-3 SMART
ZnF_C2H2 308 330 2.09e-3 SMART
ZnF_C2H2 336 358 9.58e-3 SMART
ZnF_C2H2 364 386 1.28e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000182172
SMART Domains Protein: ENSMUSP00000138510
Gene: ENSMUSG00000098176

DomainStartEndE-ValueType
Pfam:DUF4515 67 146 9.4e-6 PFAM
low complexity region 180 189 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000183130
SMART Domains Protein: ENSMUSP00000138115
Gene: ENSMUSG00000098176

DomainStartEndE-ValueType
Pfam:DUF4515 67 260 2.3e-25 PFAM
low complexity region 265 288 N/A INTRINSIC
low complexity region 433 444 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000229652
AA Change: E266G

PolyPhen 2 Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn2 G A 13: 12,293,847 (GRCm39) H558Y probably damaging Het
Ajm1 T A 2: 25,468,579 (GRCm39) H444L possibly damaging Het
Akap9 G C 5: 4,110,364 (GRCm39) E3022D probably damaging Het
Anapc2 C T 2: 25,175,011 (GRCm39) R710C probably damaging Het
Bcl6 G A 16: 23,784,976 (GRCm39) R675* probably null Het
Carmil3 A G 14: 55,738,739 (GRCm39) E844G probably damaging Het
Cdk17 T G 10: 93,068,343 (GRCm39) S367A probably benign Het
Cfap206 T A 4: 34,719,656 (GRCm39) M253L probably benign Het
Chd3 T G 11: 69,253,132 (GRCm39) K228Q probably damaging Het
Cit T A 5: 116,123,846 (GRCm39) I1503N possibly damaging Het
Csn1s1 A G 5: 87,822,087 (GRCm39) N119S possibly damaging Het
Czib C A 4: 107,752,087 (GRCm39) D155E not run Het
Degs1 A G 1: 182,106,690 (GRCm39) S226P probably damaging Het
Espl1 T C 15: 102,221,638 (GRCm39) W976R probably damaging Het
Fbxl4 C T 4: 22,386,218 (GRCm39) P275L probably benign Het
Flnb A G 14: 7,915,944 (GRCm38) probably null Het
Gnptab T A 10: 88,269,932 (GRCm39) Y878* probably null Het
Gpr89 A T 3: 96,778,714 (GRCm39) M453K probably benign Het
Igsf5 A T 16: 96,174,048 (GRCm39) Q26L possibly damaging Het
Inpp5e T A 2: 26,297,995 (GRCm39) D202V possibly damaging Het
Itga3 C T 11: 94,943,305 (GRCm39) V931M possibly damaging Het
Kcnab3 T C 11: 69,222,184 (GRCm39) probably null Het
Klk4 T C 7: 43,531,122 (GRCm39) I17T possibly damaging Het
Lrrc73 T C 17: 46,567,169 (GRCm39) L206P probably damaging Het
Manba A T 3: 135,248,149 (GRCm39) N346I probably damaging Het
Map4k4 T C 1: 40,013,132 (GRCm39) Y76H possibly damaging Het
Map4k5 T C 12: 69,877,210 (GRCm39) T312A probably benign Het
Masp2 A G 4: 148,694,572 (GRCm39) probably null Het
Mast1 T C 8: 85,661,933 (GRCm39) D63G possibly damaging Het
Mtf2 T A 5: 108,241,235 (GRCm39) S254T possibly damaging Het
Myo16 A T 8: 10,619,585 (GRCm39) T1379S unknown Het
Myo5a A G 9: 75,087,435 (GRCm39) E1097G probably benign Het
Nat1 T C 8: 67,944,329 (GRCm39) V238A possibly damaging Het
Nhlrc2 A G 19: 56,580,931 (GRCm39) D493G probably damaging Het
Or10ak9 C T 4: 118,726,922 (GRCm39) P315S probably benign Het
Or1j21 T C 2: 36,683,709 (GRCm39) S154P probably benign Het
Or5ae2 A G 7: 84,506,251 (GRCm39) I227V possibly damaging Het
Or5b108 A T 19: 13,168,270 (GRCm39) M80L probably benign Het
Or5d20-ps1 T C 2: 87,932,176 (GRCm39) K52E probably damaging Het
Or8g51 A G 9: 38,609,515 (GRCm39) I49T possibly damaging Het
Pcsk5 C T 19: 17,429,349 (GRCm39) C1543Y probably damaging Het
Pde4d A G 13: 109,169,222 (GRCm39) D88G probably benign Het
Pld5 A T 1: 176,041,187 (GRCm39) M1K probably null Het
Prmt6 A G 3: 110,157,680 (GRCm39) M203T probably benign Het
Prr14l A T 5: 32,986,510 (GRCm39) V995D probably damaging Het
Psg18 T C 7: 18,084,862 (GRCm39) E199G possibly damaging Het
Pth1r A G 9: 110,552,815 (GRCm39) I439T possibly damaging Het
Ptprc T A 1: 138,045,600 (GRCm39) I87F probably benign Het
Slc44a1 T C 4: 53,528,711 (GRCm39) S154P probably benign Het
Slco1c1 T A 6: 141,487,855 (GRCm39) Y192* probably null Het
Spag16 A G 1: 70,764,025 (GRCm39) H615R possibly damaging Het
Spata31h1 G A 10: 82,122,063 (GRCm39) T3649I probably damaging Het
Tas2r114 G A 6: 131,666,728 (GRCm39) A100V possibly damaging Het
U2af1l4 T C 7: 30,264,544 (GRCm39) S103P probably benign Het
Usp10 T C 8: 120,668,847 (GRCm39) S383P probably damaging Het
Vmn2r113 A G 17: 23,167,137 (GRCm39) R505G probably benign Het
Vmn2r75 A C 7: 85,814,592 (GRCm39) D300E probably damaging Het
Zfp318 T A 17: 46,708,232 (GRCm39) probably null Het
Zfp318 T C 17: 46,716,865 (GRCm39) V999A probably damaging Het
Zfp324 A T 7: 12,702,810 (GRCm39) H58L probably damaging Het
Other mutations in Zfp707
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01110:Zfp707 APN 15 75,847,044 (GRCm39) missense probably damaging 1.00
R0505:Zfp707 UTSW 15 75,847,105 (GRCm39) missense probably damaging 1.00
R0638:Zfp707 UTSW 15 75,846,978 (GRCm39) missense possibly damaging 0.80
R1389:Zfp707 UTSW 15 75,846,465 (GRCm39) missense probably damaging 0.99
R4806:Zfp707 UTSW 15 75,845,000 (GRCm39) nonsense probably null
R6810:Zfp707 UTSW 15 75,846,748 (GRCm39) missense probably damaging 1.00
R6823:Zfp707 UTSW 15 75,841,572 (GRCm39) unclassified probably benign
R7105:Zfp707 UTSW 15 75,846,595 (GRCm39) missense
R7124:Zfp707 UTSW 15 75,845,398 (GRCm39) nonsense probably null
R8549:Zfp707 UTSW 15 75,846,547 (GRCm39) missense probably benign 0.15
R9124:Zfp707 UTSW 15 75,845,468 (GRCm39) missense
R9668:Zfp707 UTSW 15 75,847,085 (GRCm39) missense possibly damaging 0.83
R9758:Zfp707 UTSW 15 75,845,418 (GRCm39) missense
Z1177:Zfp707 UTSW 15 75,846,963 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- GAAAAGCCCTTCTGCTGTGAG -3'
(R):5'- CAGGACCTGCTACACTTCTC -3'

Sequencing Primer
(F):5'- TTCAGCTTGAAGGACCGC -3'
(R):5'- ACTTCTCCTCGCCCGTGAG -3'
Posted On 2019-06-26