Incidental Mutation 'R7164:Cdk17'
ID 557813
Institutional Source Beutler Lab
Gene Symbol Cdk17
Ensembl Gene ENSMUSG00000020015
Gene Name cyclin dependent kinase 17
Synonyms Pctk2, 6430598J10Rik
MMRRC Submission 045331-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.295) question?
Stock # R7164 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 92996492-93086956 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 93068343 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 367 (S367A)
Ref Sequence ENSEMBL: ENSMUSP00000070355 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069965] [ENSMUST00000215286]
AlphaFold Q8K0D0
Predicted Effect probably benign
Transcript: ENSMUST00000069965
AA Change: S367A

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000070355
Gene: ENSMUSG00000020015
AA Change: S367A

DomainStartEndE-ValueType
S_TKc 192 473 4.67e-97 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000215286
AA Change: S334A

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn2 G A 13: 12,293,847 (GRCm39) H558Y probably damaging Het
Ajm1 T A 2: 25,468,579 (GRCm39) H444L possibly damaging Het
Akap9 G C 5: 4,110,364 (GRCm39) E3022D probably damaging Het
Anapc2 C T 2: 25,175,011 (GRCm39) R710C probably damaging Het
Bcl6 G A 16: 23,784,976 (GRCm39) R675* probably null Het
Carmil3 A G 14: 55,738,739 (GRCm39) E844G probably damaging Het
Cfap206 T A 4: 34,719,656 (GRCm39) M253L probably benign Het
Chd3 T G 11: 69,253,132 (GRCm39) K228Q probably damaging Het
Cit T A 5: 116,123,846 (GRCm39) I1503N possibly damaging Het
Csn1s1 A G 5: 87,822,087 (GRCm39) N119S possibly damaging Het
Czib C A 4: 107,752,087 (GRCm39) D155E not run Het
Degs1 A G 1: 182,106,690 (GRCm39) S226P probably damaging Het
Espl1 T C 15: 102,221,638 (GRCm39) W976R probably damaging Het
Fbxl4 C T 4: 22,386,218 (GRCm39) P275L probably benign Het
Flnb A G 14: 7,915,944 (GRCm38) probably null Het
Gnptab T A 10: 88,269,932 (GRCm39) Y878* probably null Het
Gpr89 A T 3: 96,778,714 (GRCm39) M453K probably benign Het
Igsf5 A T 16: 96,174,048 (GRCm39) Q26L possibly damaging Het
Inpp5e T A 2: 26,297,995 (GRCm39) D202V possibly damaging Het
Itga3 C T 11: 94,943,305 (GRCm39) V931M possibly damaging Het
Kcnab3 T C 11: 69,222,184 (GRCm39) probably null Het
Klk4 T C 7: 43,531,122 (GRCm39) I17T possibly damaging Het
Lrrc73 T C 17: 46,567,169 (GRCm39) L206P probably damaging Het
Manba A T 3: 135,248,149 (GRCm39) N346I probably damaging Het
Map4k4 T C 1: 40,013,132 (GRCm39) Y76H possibly damaging Het
Map4k5 T C 12: 69,877,210 (GRCm39) T312A probably benign Het
Masp2 A G 4: 148,694,572 (GRCm39) probably null Het
Mast1 T C 8: 85,661,933 (GRCm39) D63G possibly damaging Het
Mtf2 T A 5: 108,241,235 (GRCm39) S254T possibly damaging Het
Myo16 A T 8: 10,619,585 (GRCm39) T1379S unknown Het
Myo5a A G 9: 75,087,435 (GRCm39) E1097G probably benign Het
Nat1 T C 8: 67,944,329 (GRCm39) V238A possibly damaging Het
Nhlrc2 A G 19: 56,580,931 (GRCm39) D493G probably damaging Het
Or10ak9 C T 4: 118,726,922 (GRCm39) P315S probably benign Het
Or1j21 T C 2: 36,683,709 (GRCm39) S154P probably benign Het
Or5ae2 A G 7: 84,506,251 (GRCm39) I227V possibly damaging Het
Or5b108 A T 19: 13,168,270 (GRCm39) M80L probably benign Het
Or5d20-ps1 T C 2: 87,932,176 (GRCm39) K52E probably damaging Het
Or8g51 A G 9: 38,609,515 (GRCm39) I49T possibly damaging Het
Pcsk5 C T 19: 17,429,349 (GRCm39) C1543Y probably damaging Het
Pde4d A G 13: 109,169,222 (GRCm39) D88G probably benign Het
Pld5 A T 1: 176,041,187 (GRCm39) M1K probably null Het
Prmt6 A G 3: 110,157,680 (GRCm39) M203T probably benign Het
Prr14l A T 5: 32,986,510 (GRCm39) V995D probably damaging Het
Psg18 T C 7: 18,084,862 (GRCm39) E199G possibly damaging Het
Pth1r A G 9: 110,552,815 (GRCm39) I439T possibly damaging Het
Ptprc T A 1: 138,045,600 (GRCm39) I87F probably benign Het
Slc44a1 T C 4: 53,528,711 (GRCm39) S154P probably benign Het
Slco1c1 T A 6: 141,487,855 (GRCm39) Y192* probably null Het
Spag16 A G 1: 70,764,025 (GRCm39) H615R possibly damaging Het
Spata31h1 G A 10: 82,122,063 (GRCm39) T3649I probably damaging Het
Tas2r114 G A 6: 131,666,728 (GRCm39) A100V possibly damaging Het
U2af1l4 T C 7: 30,264,544 (GRCm39) S103P probably benign Het
Usp10 T C 8: 120,668,847 (GRCm39) S383P probably damaging Het
Vmn2r113 A G 17: 23,167,137 (GRCm39) R505G probably benign Het
Vmn2r75 A C 7: 85,814,592 (GRCm39) D300E probably damaging Het
Zfp318 T A 17: 46,708,232 (GRCm39) probably null Het
Zfp318 T C 17: 46,716,865 (GRCm39) V999A probably damaging Het
Zfp324 A T 7: 12,702,810 (GRCm39) H58L probably damaging Het
Zfp707 A G 15: 75,846,967 (GRCm39) E339G possibly damaging Het
Other mutations in Cdk17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Cdk17 APN 10 93,062,633 (GRCm39) missense probably damaging 1.00
IGL00781:Cdk17 APN 10 93,068,278 (GRCm39) missense probably damaging 1.00
IGL01622:Cdk17 APN 10 93,074,824 (GRCm39) unclassified probably benign
IGL01623:Cdk17 APN 10 93,074,824 (GRCm39) unclassified probably benign
IGL01732:Cdk17 APN 10 93,053,907 (GRCm39) missense probably benign 0.01
IGL01768:Cdk17 APN 10 93,044,123 (GRCm39) missense probably damaging 0.99
IGL02942:Cdk17 APN 10 93,074,830 (GRCm39) missense probably benign
IGL03308:Cdk17 APN 10 93,057,506 (GRCm39) critical splice donor site probably null
delude UTSW 10 93,053,823 (GRCm39) splice site probably null
Imagine UTSW 10 93,068,277 (GRCm39) missense probably damaging 1.00
Magician UTSW 10 93,064,565 (GRCm39) missense probably damaging 1.00
prestidigitator UTSW 10 93,061,979 (GRCm39) missense probably damaging 1.00
R4436_Cdk17_536 UTSW 10 93,047,758 (GRCm39) splice site probably null
R0039:Cdk17 UTSW 10 93,062,640 (GRCm39) splice site probably benign
R0398:Cdk17 UTSW 10 93,073,702 (GRCm39) missense probably benign 0.01
R0432:Cdk17 UTSW 10 93,073,652 (GRCm39) unclassified probably benign
R0609:Cdk17 UTSW 10 93,052,334 (GRCm39) missense probably benign
R0781:Cdk17 UTSW 10 93,074,895 (GRCm39) nonsense probably null
R1110:Cdk17 UTSW 10 93,074,895 (GRCm39) nonsense probably null
R1604:Cdk17 UTSW 10 93,068,360 (GRCm39) missense probably damaging 1.00
R1674:Cdk17 UTSW 10 93,057,492 (GRCm39) missense probably benign 0.21
R1758:Cdk17 UTSW 10 93,044,112 (GRCm39) missense probably damaging 1.00
R1797:Cdk17 UTSW 10 93,044,114 (GRCm39) missense possibly damaging 0.76
R1864:Cdk17 UTSW 10 93,061,967 (GRCm39) missense probably damaging 1.00
R1924:Cdk17 UTSW 10 93,061,979 (GRCm39) missense probably damaging 1.00
R1929:Cdk17 UTSW 10 93,064,540 (GRCm39) missense probably damaging 1.00
R2143:Cdk17 UTSW 10 93,053,881 (GRCm39) missense probably damaging 1.00
R2207:Cdk17 UTSW 10 93,064,624 (GRCm39) missense probably damaging 1.00
R2261:Cdk17 UTSW 10 93,047,820 (GRCm39) missense possibly damaging 0.90
R2262:Cdk17 UTSW 10 93,047,820 (GRCm39) missense possibly damaging 0.90
R3737:Cdk17 UTSW 10 93,057,506 (GRCm39) critical splice donor site probably null
R3883:Cdk17 UTSW 10 93,047,939 (GRCm39) critical splice donor site probably null
R4436:Cdk17 UTSW 10 93,047,758 (GRCm39) splice site probably null
R5372:Cdk17 UTSW 10 93,061,901 (GRCm39) missense probably benign 0.03
R5444:Cdk17 UTSW 10 93,053,823 (GRCm39) splice site probably null
R5488:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R5489:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R5815:Cdk17 UTSW 10 93,064,559 (GRCm39) missense probably damaging 1.00
R6164:Cdk17 UTSW 10 93,071,331 (GRCm39) missense probably benign 0.26
R6209:Cdk17 UTSW 10 93,044,093 (GRCm39) missense probably benign 0.05
R6384:Cdk17 UTSW 10 93,047,827 (GRCm39) missense probably damaging 0.99
R6627:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R6698:Cdk17 UTSW 10 93,064,540 (GRCm39) missense probably damaging 1.00
R8096:Cdk17 UTSW 10 93,052,229 (GRCm39) missense probably damaging 0.98
R8118:Cdk17 UTSW 10 93,052,252 (GRCm39) missense possibly damaging 0.46
R8459:Cdk17 UTSW 10 93,068,289 (GRCm39) missense probably damaging 0.99
R8670:Cdk17 UTSW 10 93,061,958 (GRCm39) nonsense probably null
R8722:Cdk17 UTSW 10 93,064,565 (GRCm39) missense probably damaging 1.00
R8829:Cdk17 UTSW 10 93,042,920 (GRCm39) unclassified probably benign
R9077:Cdk17 UTSW 10 93,068,277 (GRCm39) missense probably damaging 1.00
R9488:Cdk17 UTSW 10 93,044,066 (GRCm39) missense probably damaging 0.98
R9789:Cdk17 UTSW 10 93,060,891 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GGGCTAAGACCTTCAGCATG -3'
(R):5'- CGGGCTACTAATGTGAATAAGATGG -3'

Sequencing Primer
(F):5'- GGCTAAGACCTTCAGCATGTTAATGG -3'
(R):5'- CTCACTGCTCAAACTCTTTG -3'
Posted On 2019-06-26