Incidental Mutation 'R7153:Fndc1'
ID 554285
Institutional Source Beutler Lab
Gene Symbol Fndc1
Ensembl Gene ENSMUSG00000071984
Gene Name fibronectin type III domain containing 1
Synonyms 1110027O12Rik
MMRRC Submission 045255-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R7153 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 7957401-8046134 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 8020477 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 102 (V102A)
Ref Sequence ENSEMBL: ENSMUSP00000126701 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097425] [ENSMUST00000167580] [ENSMUST00000169126]
AlphaFold A0A6I8MWX0
Predicted Effect probably benign
Transcript: ENSMUST00000097425
SMART Domains Protein: ENSMUSP00000095036
Gene: ENSMUSG00000071984

DomainStartEndE-ValueType
Blast:FN3 1 50 6e-25 BLAST
FN3 54 137 7.82e-4 SMART
FN3 156 240 1.48e-4 SMART
FN3 256 340 3.67e-9 SMART
low complexity region 377 388 N/A INTRINSIC
low complexity region 579 601 N/A INTRINSIC
low complexity region 646 676 N/A INTRINSIC
low complexity region 766 777 N/A INTRINSIC
low complexity region 868 884 N/A INTRINSIC
low complexity region 1021 1027 N/A INTRINSIC
low complexity region 1036 1050 N/A INTRINSIC
low complexity region 1076 1090 N/A INTRINSIC
Blast:FN3 1227 1276 2e-18 BLAST
low complexity region 1277 1354 N/A INTRINSIC
low complexity region 1395 1403 N/A INTRINSIC
low complexity region 1407 1423 N/A INTRINSIC
FN3 1494 1577 4.32e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167580
SMART Domains Protein: ENSMUSP00000130996
Gene: ENSMUSG00000071984

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
FN3 38 121 7.82e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000169126
AA Change: V102A

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000126701
Gene: ENSMUSG00000071984
AA Change: V102A

DomainStartEndE-ValueType
low complexity region 2 30 N/A INTRINSIC
FN3 37 117 1.22e-5 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (75/75)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano2 A G 6: 125,969,906 (GRCm39) T741A possibly damaging Het
Aox4 T C 1: 58,289,378 (GRCm39) M767T probably damaging Het
Arhgap39 C A 15: 76,649,691 (GRCm39) S27I probably benign Het
AU018091 T A 7: 3,209,353 (GRCm39) M296L probably benign Het
Axin1 A G 17: 26,406,942 (GRCm39) T512A probably benign Het
B4galnt3 A T 6: 120,191,929 (GRCm39) D602E probably benign Het
Bcl6 G A 16: 23,784,976 (GRCm39) R675* probably null Het
Bsnd A T 4: 106,349,230 (GRCm39) D3E probably benign Het
Btbd18 C T 2: 84,496,772 (GRCm39) R137* probably null Het
C2cd5 A G 6: 142,965,135 (GRCm39) S871P probably benign Het
Cobl G T 11: 12,204,128 (GRCm39) P858Q probably damaging Het
Col6a1 C T 10: 76,546,175 (GRCm39) probably null Het
Crb2 A T 2: 37,677,420 (GRCm39) H304L probably benign Het
Crybg1 T A 10: 43,840,662 (GRCm39) Y1812F possibly damaging Het
Ddx60 A T 8: 62,441,142 (GRCm39) K1070N possibly damaging Het
Defb22 T C 2: 152,327,840 (GRCm39) K115R unknown Het
Dhx8 C T 11: 101,631,001 (GRCm39) probably null Het
Dnah5 T A 15: 28,365,668 (GRCm39) probably null Het
Dnah7b T A 1: 46,165,964 (GRCm39) F543Y probably benign Het
Ehhadh A G 16: 21,585,071 (GRCm39) F270S probably damaging Het
Esyt2 A G 12: 116,310,128 (GRCm39) M397V probably benign Het
Fanca A T 8: 124,043,164 (GRCm39) L74H probably damaging Het
Fbxl17 C A 17: 63,367,346 (GRCm39) V676F probably benign Het
Gpalpp1 T C 14: 76,332,451 (GRCm39) Y273C probably damaging Het
Gpatch8 TTCCTCCTCCTCCTCTTCCTCCTCCTC TTCCTCCTCCTCCTCCTCTTCCTCCTCCTC 11: 102,371,014 (GRCm39) probably benign Het
Grik2 T C 10: 49,411,463 (GRCm39) H225R probably benign Het
Helz2 A T 2: 180,873,078 (GRCm39) S2411T probably benign Het
Hnmt C T 2: 23,904,353 (GRCm39) A103T probably damaging Het
Ighv15-2 G T 12: 114,528,210 (GRCm39) Y114* probably null Het
Irak2 A G 6: 113,655,670 (GRCm39) H357R probably benign Het
Kcp T C 6: 29,499,014 (GRCm39) E320G probably damaging Het
Kpna4 A G 3: 68,997,131 (GRCm39) L352S probably damaging Het
Krt36 G A 11: 99,995,972 (GRCm39) Q151* probably null Het
Krt77 G A 15: 101,773,931 (GRCm39) T241M probably benign Het
Lca5l T A 16: 95,975,009 (GRCm39) N305I probably damaging Het
Lefty1 T A 1: 180,765,332 (GRCm39) L300Q probably benign Het
Mertk A G 2: 128,578,569 (GRCm39) Y185C probably damaging Het
Mmp14 T C 14: 54,673,708 (GRCm39) I124T possibly damaging Het
Nlrc4 T C 17: 74,754,098 (GRCm39) E95G possibly damaging Het
Npc1 A G 18: 12,346,348 (GRCm39) F283L possibly damaging Het
Or4k38 A T 2: 111,166,246 (GRCm39) M59K probably damaging Het
Or4p19 A C 2: 88,242,462 (GRCm39) L180W probably damaging Het
Pcdha11 T C 18: 37,144,278 (GRCm39) V123A probably damaging Het
Pcdhga2 T C 18: 37,802,261 (GRCm39) V35A probably damaging Het
Pgd G T 4: 149,246,135 (GRCm39) T94K probably benign Het
Pik3c2a T C 7: 115,941,487 (GRCm39) N1593S probably damaging Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 110,350,827 (GRCm39) probably benign Het
Plcb3 A G 19: 6,935,452 (GRCm39) probably null Het
Prkd3 C T 17: 79,273,784 (GRCm39) D491N probably benign Het
Ptprf T C 4: 118,088,740 (GRCm39) T688A probably damaging Het
Pycr2 T A 1: 180,734,247 (GRCm39) L210M probably damaging Het
Rpl36 T C 17: 56,921,137 (GRCm39) I81T probably benign Het
Rraga C T 4: 86,494,253 (GRCm39) A33V probably damaging Het
Slc29a1 G A 17: 45,896,688 (GRCm39) A429V probably damaging Het
Stab1 T G 14: 30,882,541 (GRCm39) E432A probably benign Het
Synj1 C T 16: 90,744,978 (GRCm39) G1189R probably benign Het
Synpo2 A G 3: 122,906,053 (GRCm39) *1088Q probably null Het
Tbc1d21 T C 9: 58,270,376 (GRCm39) D133G probably damaging Het
Tenm2 A G 11: 35,915,009 (GRCm39) V2176A probably damaging Het
Tff1 A G 17: 31,381,772 (GRCm39) I35T probably benign Het
Thnsl1 T C 2: 21,217,764 (GRCm39) V506A possibly damaging Het
Timm10b A G 7: 105,290,087 (GRCm39) Q50R unknown Het
Tjp2 A T 19: 24,079,345 (GRCm39) N843K probably benign Het
Tle1 A T 4: 72,057,298 (GRCm39) F101I probably benign Het
Tmem225 T C 9: 40,059,664 (GRCm39) F15L probably benign Het
Trav12-3 T C 14: 53,859,618 (GRCm39) L88P probably benign Het
Ttc7b A T 12: 100,321,293 (GRCm39) W613R probably damaging Het
Ttn T A 2: 76,608,848 (GRCm39) M17723L probably benign Het
Ttn T C 2: 76,775,660 (GRCm39) D1840G unknown Het
Tubgcp2 T C 7: 139,580,949 (GRCm39) H668R probably benign Het
Ush2a C A 1: 188,460,681 (GRCm39) N2647K possibly damaging Het
Vmn1r14 C T 6: 57,210,851 (GRCm39) S143F probably benign Het
Vmn2r70 A G 7: 85,214,262 (GRCm39) S297P probably damaging Het
Ywhab T C 2: 163,855,980 (GRCm39) F119L probably damaging Het
Zmym2 T A 14: 57,187,659 (GRCm39) D1108E probably benign Het
Other mutations in Fndc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00513:Fndc1 APN 17 7,984,086 (GRCm39) missense unknown
IGL00590:Fndc1 APN 17 7,983,933 (GRCm39) missense unknown
IGL00765:Fndc1 APN 17 7,991,525 (GRCm39) missense unknown
IGL00904:Fndc1 APN 17 7,975,195 (GRCm39) missense probably benign 0.35
IGL01153:Fndc1 APN 17 7,998,874 (GRCm39) critical splice donor site probably null
IGL01557:Fndc1 APN 17 7,975,221 (GRCm39) missense probably damaging 0.99
IGL02493:Fndc1 APN 17 7,994,377 (GRCm39) missense unknown
IGL02501:Fndc1 APN 17 7,984,230 (GRCm39) missense unknown
IGL02503:Fndc1 APN 17 7,990,348 (GRCm39) missense unknown
IGL02887:Fndc1 APN 17 7,992,470 (GRCm39) missense unknown
IGL03348:Fndc1 APN 17 7,991,479 (GRCm39) missense unknown
pinnacle UTSW 17 7,992,154 (GRCm39) missense unknown
spire UTSW 17 7,990,312 (GRCm39) missense unknown
IGL02988:Fndc1 UTSW 17 7,972,355 (GRCm39) missense possibly damaging 0.95
PIT4466001:Fndc1 UTSW 17 7,969,206 (GRCm39) missense probably damaging 1.00
R0336:Fndc1 UTSW 17 7,983,939 (GRCm39) missense unknown
R0403:Fndc1 UTSW 17 7,994,420 (GRCm39) splice site probably null
R0403:Fndc1 UTSW 17 7,972,555 (GRCm39) missense probably damaging 1.00
R0538:Fndc1 UTSW 17 8,003,173 (GRCm39) splice site probably benign
R0646:Fndc1 UTSW 17 7,960,505 (GRCm39) missense possibly damaging 0.92
R1140:Fndc1 UTSW 17 7,994,258 (GRCm39) missense unknown
R1523:Fndc1 UTSW 17 7,992,041 (GRCm39) missense unknown
R1609:Fndc1 UTSW 17 7,991,598 (GRCm39) missense unknown
R1632:Fndc1 UTSW 17 7,992,032 (GRCm39) missense unknown
R1888:Fndc1 UTSW 17 7,990,621 (GRCm39) missense unknown
R1888:Fndc1 UTSW 17 7,990,621 (GRCm39) missense unknown
R2004:Fndc1 UTSW 17 8,023,761 (GRCm39) missense probably damaging 1.00
R2007:Fndc1 UTSW 17 7,997,580 (GRCm39) unclassified probably benign
R2128:Fndc1 UTSW 17 7,997,497 (GRCm39) unclassified probably benign
R2187:Fndc1 UTSW 17 7,960,604 (GRCm39) missense probably damaging 1.00
R2251:Fndc1 UTSW 17 7,972,439 (GRCm39) missense probably damaging 1.00
R2322:Fndc1 UTSW 17 8,007,847 (GRCm39) missense probably damaging 0.98
R2425:Fndc1 UTSW 17 8,023,850 (GRCm39) missense probably damaging 1.00
R2921:Fndc1 UTSW 17 8,023,707 (GRCm39) missense probably damaging 0.98
R2985:Fndc1 UTSW 17 7,975,155 (GRCm39) missense possibly damaging 0.93
R3436:Fndc1 UTSW 17 7,969,189 (GRCm39) missense probably damaging 0.99
R3499:Fndc1 UTSW 17 7,972,416 (GRCm39) missense possibly damaging 0.70
R3508:Fndc1 UTSW 17 7,983,940 (GRCm39) nonsense probably null
R3766:Fndc1 UTSW 17 8,003,253 (GRCm39) missense probably damaging 1.00
R3813:Fndc1 UTSW 17 7,992,154 (GRCm39) missense unknown
R3814:Fndc1 UTSW 17 7,992,154 (GRCm39) missense unknown
R4031:Fndc1 UTSW 17 7,988,584 (GRCm39) nonsense probably null
R4544:Fndc1 UTSW 17 7,992,376 (GRCm39) missense unknown
R4583:Fndc1 UTSW 17 7,958,081 (GRCm39) missense probably damaging 1.00
R4619:Fndc1 UTSW 17 7,984,036 (GRCm39) missense unknown
R4700:Fndc1 UTSW 17 7,990,312 (GRCm39) missense unknown
R4743:Fndc1 UTSW 17 7,991,111 (GRCm39) nonsense probably null
R4803:Fndc1 UTSW 17 7,972,538 (GRCm39) missense probably damaging 0.98
R4862:Fndc1 UTSW 17 7,988,567 (GRCm39) missense unknown
R4876:Fndc1 UTSW 17 7,990,471 (GRCm39) missense unknown
R5057:Fndc1 UTSW 17 7,990,802 (GRCm39) nonsense probably null
R5327:Fndc1 UTSW 17 7,991,540 (GRCm39) missense unknown
R5372:Fndc1 UTSW 17 7,984,042 (GRCm39) missense unknown
R5533:Fndc1 UTSW 17 7,991,608 (GRCm39) missense unknown
R5754:Fndc1 UTSW 17 7,988,585 (GRCm39) missense unknown
R5762:Fndc1 UTSW 17 7,990,366 (GRCm39) missense unknown
R5830:Fndc1 UTSW 17 8,007,918 (GRCm39) missense possibly damaging 0.87
R5924:Fndc1 UTSW 17 7,992,442 (GRCm39) missense unknown
R6147:Fndc1 UTSW 17 7,972,594 (GRCm39) splice site probably null
R6175:Fndc1 UTSW 17 7,991,479 (GRCm39) missense unknown
R6303:Fndc1 UTSW 17 7,977,317 (GRCm39) missense probably damaging 0.98
R6377:Fndc1 UTSW 17 7,988,567 (GRCm39) missense unknown
R6704:Fndc1 UTSW 17 7,990,642 (GRCm39) missense unknown
R6857:Fndc1 UTSW 17 7,991,002 (GRCm39) missense unknown
R6865:Fndc1 UTSW 17 7,991,672 (GRCm39) missense unknown
R7069:Fndc1 UTSW 17 7,988,567 (GRCm39) missense unknown
R7159:Fndc1 UTSW 17 8,019,763 (GRCm39) missense probably damaging 0.97
R7359:Fndc1 UTSW 17 8,032,318 (GRCm39) splice site probably null
R7731:Fndc1 UTSW 17 7,992,271 (GRCm39) missense unknown
R7743:Fndc1 UTSW 17 7,983,969 (GRCm39) missense unknown
R7884:Fndc1 UTSW 17 7,992,029 (GRCm39) missense unknown
R8071:Fndc1 UTSW 17 7,991,362 (GRCm39) missense unknown
R8100:Fndc1 UTSW 17 7,990,685 (GRCm39) missense unknown
R8317:Fndc1 UTSW 17 8,019,720 (GRCm39) nonsense probably null
R8362:Fndc1 UTSW 17 8,001,207 (GRCm39) missense unknown
R8835:Fndc1 UTSW 17 7,958,111 (GRCm39) missense probably damaging 1.00
R8841:Fndc1 UTSW 17 7,992,181 (GRCm39) missense unknown
R8912:Fndc1 UTSW 17 8,019,778 (GRCm39) missense probably null 0.26
R9236:Fndc1 UTSW 17 7,992,460 (GRCm39) missense unknown
R9392:Fndc1 UTSW 17 7,991,957 (GRCm39) missense unknown
R9412:Fndc1 UTSW 17 7,991,198 (GRCm39) missense unknown
R9618:Fndc1 UTSW 17 7,990,313 (GRCm39) missense unknown
R9632:Fndc1 UTSW 17 7,991,622 (GRCm39) missense unknown
R9748:Fndc1 UTSW 17 7,991,929 (GRCm39) missense unknown
Z1088:Fndc1 UTSW 17 8,001,311 (GRCm39) missense probably damaging 0.96
Z1176:Fndc1 UTSW 17 8,023,709 (GRCm39) missense possibly damaging 0.90
Z1176:Fndc1 UTSW 17 7,992,425 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTTACTGTACAAGCCTACAATGAG -3'
(R):5'- CGCATGGGGAGAATGTTAGC -3'

Sequencing Primer
(F):5'- GGGCAACTTACAGAAATCGGTTCTC -3'
(R):5'- AGCGATTTCTGTAAAACCGAAG -3'
Posted On 2019-05-15