Incidental Mutation 'R7094:Or1ab2'
ID 550359
Institutional Source Beutler Lab
Gene Symbol Or1ab2
Ensembl Gene ENSMUSG00000046881
Gene Name olfactory receptor family 1 subfamily AB member 2
Synonyms MOR130-1, Olfr374, GA_x6K02T2NUPS-241490-242431
MMRRC Submission 045187-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.109) question?
Stock # R7094 (G1)
Quality Score 160.009
Status Validated
Chromosome 8
Chromosomal Location 72860884-72864353 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to T at 72863347 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147605 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000209675] [ENSMUST00000210435]
AlphaFold Q7TRY0
Predicted Effect probably benign
Transcript: ENSMUST00000209675
Predicted Effect probably benign
Transcript: ENSMUST00000210435
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 97% (59/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,248,610 (GRCm39) I2786F probably damaging Het
Actl6a A T 3: 32,760,487 (GRCm39) probably benign Het
Actn2 A G 13: 12,324,543 (GRCm39) V100A probably damaging Het
Arfgef3 G T 10: 18,522,187 (GRCm39) A613E probably damaging Het
Atf6b G A 17: 34,872,790 (GRCm39) probably null Het
Bub1 T A 2: 127,663,681 (GRCm39) E240V probably null Het
C1ra G A 6: 124,494,684 (GRCm39) E316K probably benign Het
Ccdc141 C A 2: 76,871,797 (GRCm39) R829L possibly damaging Het
Ccdc85c GCCGCCGCCGCCAGCGCCCCCCGCCGCCGCCAGCGCC GCCGCCGCCGCCAGCGCC 12: 108,240,877 (GRCm39) probably null Het
Cd209g T C 8: 4,186,790 (GRCm39) F112L possibly damaging Het
Cebpe C T 14: 54,948,060 (GRCm39) R261H probably damaging Het
Cfap100 T C 6: 90,390,436 (GRCm39) E68G Het
Chd9 A G 8: 91,716,189 (GRCm39) N921S unknown Het
Chil6 T C 3: 106,311,486 (GRCm39) N98S probably damaging Het
Clip1 T C 5: 123,761,333 (GRCm39) K734E probably benign Het
Cracd C T 5: 77,006,879 (GRCm39) P1080L unknown Het
Cyp11b2 A G 15: 74,725,507 (GRCm39) F204S possibly damaging Het
Dnah5 A G 15: 28,453,482 (GRCm39) T4418A probably damaging Het
Dysf T C 6: 84,077,184 (GRCm39) V649A probably benign Het
Ergic3 G A 2: 155,858,683 (GRCm39) V270M possibly damaging Het
Eva1a C T 6: 82,069,024 (GRCm39) T117I probably damaging Het
Fat4 G A 3: 38,944,023 (GRCm39) G972D probably damaging Het
Gm14412 A T 2: 177,009,138 (GRCm39) N39K probably damaging Het
Gm5565 T C 5: 146,095,084 (GRCm39) T221A probably benign Het
Gnptab T G 10: 88,215,366 (GRCm39) V29G possibly damaging Het
Grem2 T C 1: 174,664,555 (GRCm39) Y98C probably damaging Het
Grik2 A T 10: 49,232,012 (GRCm39) I506N possibly damaging Het
Has2 T A 15: 56,545,017 (GRCm39) Y195F probably damaging Het
Kics2 A G 10: 121,576,098 (GRCm39) Y73C possibly damaging Het
Lars2 T C 9: 123,288,650 (GRCm39) L832P probably damaging Het
Lipo5 T A 19: 33,446,249 (GRCm39) E49D probably damaging Het
Macc1 T A 12: 119,414,126 (GRCm39) Y767* probably null Het
Map2 G T 1: 66,451,886 (GRCm39) E259* probably null Het
Mcm9 T C 10: 53,496,253 (GRCm39) D310G probably damaging Het
Mink1 C A 11: 70,500,901 (GRCm39) probably null Het
Mtrr T C 13: 68,727,803 (GRCm39) T48A possibly damaging Het
Nrsn1 A T 13: 25,437,724 (GRCm39) I68N possibly damaging Het
Or4a71 A T 2: 89,357,902 (GRCm39) I284K probably damaging Het
Or51f23b A G 7: 102,402,305 (GRCm39) M277T probably benign Het
Or5p60 G T 7: 107,723,840 (GRCm39) T210N probably benign Het
Or8k36-ps1 T C 2: 86,437,672 (GRCm39) N81S unknown Het
Pcdh17 A G 14: 84,684,835 (GRCm39) D434G probably damaging Het
Rnf213 T A 11: 119,328,430 (GRCm39) probably null Het
Selplg GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT GTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCTGCCTCCATGGGTGCTGGCTGCGAGGTCTCT 5: 113,957,756 (GRCm39) probably benign Het
Sez6l2 A G 7: 126,552,096 (GRCm39) E121G probably damaging Het
Slc35e4 T C 11: 3,863,118 (GRCm39) S24G probably benign Het
Slc39a2 G T 14: 52,131,146 (GRCm39) probably benign Het
Slitrk5 C T 14: 111,918,268 (GRCm39) P631S probably benign Het
Taf2 A G 15: 54,923,482 (GRCm39) V265A probably benign Het
Tas2r106 T C 6: 131,655,542 (GRCm39) N103S probably benign Het
Tgm1 T C 14: 55,942,300 (GRCm39) T684A possibly damaging Het
Tgm7 C T 2: 120,929,489 (GRCm39) G262S probably damaging Het
Tpp2 T A 1: 44,008,148 (GRCm39) S451T probably damaging Het
Trim15 T C 17: 37,173,788 (GRCm39) Y240C probably benign Het
Trio A T 15: 27,891,534 (GRCm39) C465S unknown Het
Ttc22 G A 4: 106,493,104 (GRCm39) W250* probably null Het
Upb1 C A 10: 75,274,042 (GRCm39) F356L probably damaging Het
Vmn2r99 T A 17: 19,599,573 (GRCm39) M419K probably benign Het
Vstm2a G A 11: 16,207,990 (GRCm39) probably benign Het
Zfp820 T C 17: 22,038,246 (GRCm39) T361A probably benign Het
Other mutations in Or1ab2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03022:Or1ab2 APN 8 72,863,968 (GRCm39) missense probably damaging 0.99
IGL03059:Or1ab2 APN 8 72,863,842 (GRCm39) missense probably damaging 1.00
R1662:Or1ab2 UTSW 8 72,863,623 (GRCm39) missense probably benign 0.09
R1977:Or1ab2 UTSW 8 72,863,698 (GRCm39) missense probably benign 0.41
R3965:Or1ab2 UTSW 8 72,864,108 (GRCm39) missense probably damaging 1.00
R4577:Or1ab2 UTSW 8 72,864,167 (GRCm39) nonsense probably null
R4702:Or1ab2 UTSW 8 72,864,044 (GRCm39) missense probably damaging 1.00
R4703:Or1ab2 UTSW 8 72,864,044 (GRCm39) missense probably damaging 1.00
R4705:Or1ab2 UTSW 8 72,864,044 (GRCm39) missense probably damaging 1.00
R4909:Or1ab2 UTSW 8 72,863,425 (GRCm39) missense probably damaging 1.00
R6542:Or1ab2 UTSW 8 72,863,715 (GRCm39) missense probably damaging 0.98
R6867:Or1ab2 UTSW 8 72,863,707 (GRCm39) missense possibly damaging 0.90
R7148:Or1ab2 UTSW 8 72,864,001 (GRCm39) missense possibly damaging 0.50
R8162:Or1ab2 UTSW 8 72,864,253 (GRCm39) missense noncoding transcript
R8224:Or1ab2 UTSW 8 72,864,223 (GRCm39) missense noncoding transcript
R8904:Or1ab2 UTSW 8 72,864,276 (GRCm39) missense probably damaging 1.00
R9130:Or1ab2 UTSW 8 72,863,697 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCTGGAGAATTGCTCAGTGG -3'
(R):5'- GTACATGCTCAGGAAGGCAG -3'

Sequencing Primer
(F):5'- TGCTCAGTGGATAAGCCTTCAGAAC -3'
(R):5'- TACATGCTCAGGAAGGCAGAAAAG -3'
Posted On 2019-05-15