Incidental Mutation 'R7082:Pappa2'
| ID |
549574 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pappa2
|
| Ensembl Gene |
ENSMUSG00000073530 |
| Gene Name |
pappalysin 2 |
| Synonyms |
PAPP-A2, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PLAC3, Pappe |
| MMRRC Submission |
045176-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7082 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
158539297-158788019 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 158590689 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 1655
(T1655I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124022
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159861]
|
| AlphaFold |
E9PZ87 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159861
AA Change: T1655I
PolyPhen 2
Score 0.652 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000124022
Gene: ENSMUSG00000073530
AA Change: T1655I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Laminin_G_3
|
271 |
440 |
1.2e-25 |
PFAM |
|
NL
|
572 |
614 |
2.81e-5 |
SMART |
|
Pfam:Peptidase_M43
|
669 |
832 |
1.5e-12 |
PFAM |
|
Blast:FN3
|
844 |
1103 |
1e-169 |
BLAST |
|
low complexity region
|
1130 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1361 |
1370 |
N/A |
INTRINSIC |
|
CCP
|
1394 |
1457 |
4.97e0 |
SMART |
|
CCP
|
1462 |
1519 |
4.81e-1 |
SMART |
|
CCP
|
1523 |
1588 |
2.58e-4 |
SMART |
|
CCP
|
1593 |
1644 |
1.13e0 |
SMART |
|
NL
|
1720 |
1757 |
2.66e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161589
|
| SMART Domains |
Protein: ENSMUSP00000124316
Gene: ENSMUSG00000073530
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
32 |
N/A |
INTRINSIC |
|
CCP
|
67 |
130 |
4.97e0 |
SMART |
|
CCP
|
135 |
192 |
4.81e-1 |
SMART |
|
CCP
|
196 |
245 |
2.84e0 |
SMART |
|
| Meta Mutation Damage Score |
0.1712 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
100% (88/88) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5730596B20Rik |
A |
T |
6: 52,156,260 (GRCm39) |
N109Y |
unknown |
Het |
| A430005L14Rik |
C |
T |
4: 154,044,221 (GRCm39) |
R11W |
probably damaging |
Het |
| Aadacl2 |
T |
A |
3: 59,932,306 (GRCm39) |
S274T |
probably damaging |
Het |
| Ahctf1 |
T |
C |
1: 179,602,898 (GRCm39) |
R887G |
probably benign |
Het |
| Aox4 |
G |
T |
1: 58,263,352 (GRCm39) |
R158L |
possibly damaging |
Het |
| Atp10a |
T |
C |
7: 58,308,567 (GRCm39) |
I122T |
probably damaging |
Het |
| Batf2 |
G |
T |
19: 6,221,405 (GRCm39) |
A72S |
possibly damaging |
Het |
| Bltp3a |
G |
T |
17: 28,109,039 (GRCm39) |
R1086L |
probably damaging |
Het |
| Bptf |
T |
C |
11: 106,977,573 (GRCm39) |
D749G |
probably benign |
Het |
| Cacybp |
A |
G |
1: 160,031,229 (GRCm39) |
Y200H |
probably damaging |
Het |
| Cdc40 |
A |
T |
10: 40,743,869 (GRCm39) |
V76D |
probably benign |
Het |
| Cdc42ep4 |
T |
C |
11: 113,619,944 (GRCm39) |
D149G |
probably benign |
Het |
| Chtop |
A |
G |
3: 90,414,891 (GRCm39) |
V9A |
probably benign |
Het |
| Cnot9 |
A |
G |
1: 74,566,165 (GRCm39) |
I185M |
probably damaging |
Het |
| Col6a5 |
A |
G |
9: 105,808,438 (GRCm39) |
I870T |
unknown |
Het |
| Cr1l |
A |
G |
1: 194,806,006 (GRCm39) |
I159T |
probably benign |
Het |
| Cthrc1 |
T |
C |
15: 38,940,495 (GRCm39) |
S33P |
probably benign |
Het |
| Dlg2 |
T |
A |
7: 90,381,192 (GRCm39) |
W44R |
probably benign |
Het |
| Dlgap4 |
T |
C |
2: 156,590,342 (GRCm39) |
|
probably null |
Het |
| Dna2 |
A |
G |
10: 62,790,096 (GRCm39) |
H193R |
possibly damaging |
Het |
| Espnl |
T |
A |
1: 91,262,521 (GRCm39) |
F322Y |
probably benign |
Het |
| Fam171a1 |
G |
A |
2: 3,224,512 (GRCm39) |
V293I |
probably benign |
Het |
| Fam76b |
A |
G |
9: 13,744,308 (GRCm39) |
Y135C |
probably damaging |
Het |
| Flvcr2 |
A |
T |
12: 85,793,728 (GRCm39) |
I35F |
probably benign |
Het |
| Gm9195 |
T |
A |
14: 72,680,152 (GRCm39) |
Q2219L |
probably benign |
Het |
| Gnptg |
T |
C |
17: 25,453,694 (GRCm39) |
T283A |
probably benign |
Het |
| Grap2 |
G |
A |
15: 80,532,699 (GRCm39) |
V289M |
probably benign |
Het |
| Hk3 |
T |
C |
13: 55,154,710 (GRCm39) |
T767A |
probably benign |
Het |
| Hs3st5 |
A |
G |
10: 36,708,833 (GRCm39) |
I123V |
probably benign |
Het |
| Il6st |
A |
G |
13: 112,640,566 (GRCm39) |
T781A |
probably damaging |
Het |
| Inpp5d |
T |
A |
1: 87,623,102 (GRCm39) |
H398Q |
probably damaging |
Het |
| Kcnk1 |
A |
G |
8: 126,722,287 (GRCm39) |
Y30C |
probably damaging |
Het |
| Klhl6 |
T |
C |
16: 19,801,633 (GRCm39) |
T41A |
probably benign |
Het |
| Krt14 |
G |
A |
11: 100,094,167 (GRCm39) |
H476Y |
possibly damaging |
Het |
| Lingo3 |
G |
C |
10: 80,671,625 (GRCm39) |
R102G |
probably benign |
Het |
| Map3k9 |
G |
A |
12: 81,771,476 (GRCm39) |
T704M |
probably damaging |
Het |
| Mdn1 |
C |
A |
4: 32,762,341 (GRCm39) |
N5088K |
probably benign |
Het |
| Mmp9 |
T |
A |
2: 164,790,812 (GRCm39) |
S67T |
probably benign |
Het |
| Mrps18c |
A |
G |
5: 100,952,270 (GRCm39) |
E143G |
probably damaging |
Het |
| Msantd5f9 |
G |
T |
4: 73,835,808 (GRCm39) |
L219M |
probably benign |
Het |
| Muc21 |
A |
T |
17: 35,932,093 (GRCm39) |
S698T |
unknown |
Het |
| Nags |
C |
A |
11: 102,038,298 (GRCm39) |
R335S |
possibly damaging |
Het |
| Nars1 |
A |
G |
18: 64,637,425 (GRCm39) |
V385A |
possibly damaging |
Het |
| Nipal2 |
A |
C |
15: 34,584,809 (GRCm39) |
V253G |
possibly damaging |
Het |
| Nos2 |
C |
A |
11: 78,819,405 (GRCm39) |
T39K |
probably benign |
Het |
| Or10p1 |
T |
A |
10: 129,443,416 (GRCm39) |
*311Y |
probably null |
Het |
| Or10p1 |
T |
A |
10: 129,443,417 (GRCm39) |
*311L |
probably null |
Het |
| Or51t4 |
T |
C |
7: 102,598,455 (GRCm39) |
V261A |
probably damaging |
Het |
| Or52s19 |
C |
A |
7: 103,007,495 (GRCm39) |
R302L |
possibly damaging |
Het |
| Or6c66 |
C |
T |
10: 129,461,634 (GRCm39) |
V99M |
probably benign |
Het |
| Or9s15 |
G |
A |
1: 92,524,140 (GRCm39) |
|
probably benign |
Het |
| Panx3 |
G |
A |
9: 37,577,913 (GRCm39) |
P106S |
probably benign |
Het |
| Pcdhb1 |
A |
G |
18: 37,400,044 (GRCm39) |
D665G |
probably damaging |
Het |
| Pde2a |
T |
C |
7: 101,157,303 (GRCm39) |
L676P |
probably damaging |
Het |
| Pf4 |
A |
G |
5: 90,920,851 (GRCm39) |
T60A |
possibly damaging |
Het |
| Pira12 |
C |
T |
7: 3,898,510 (GRCm39) |
V313M |
probably damaging |
Het |
| Pld5 |
A |
T |
1: 175,917,442 (GRCm39) |
C164S |
probably benign |
Het |
| Psd3 |
A |
T |
8: 68,356,800 (GRCm39) |
M640K |
probably benign |
Het |
| Ptf1a |
A |
G |
2: 19,450,676 (GRCm39) |
D2G |
possibly damaging |
Het |
| Ptprq |
C |
T |
10: 107,544,591 (GRCm39) |
C313Y |
probably benign |
Het |
| Ranbp10 |
A |
G |
8: 106,500,578 (GRCm39) |
S467P |
probably damaging |
Het |
| Rap1gap |
C |
T |
4: 137,446,247 (GRCm39) |
T333M |
probably damaging |
Het |
| Rfpl4 |
A |
G |
7: 5,118,558 (GRCm39) |
L4P |
probably benign |
Het |
| Rgs12 |
A |
G |
5: 35,124,050 (GRCm39) |
N611S |
probably benign |
Het |
| Sacs |
C |
A |
14: 61,447,966 (GRCm39) |
N3337K |
possibly damaging |
Het |
| Sbno2 |
A |
T |
10: 79,895,924 (GRCm39) |
|
probably null |
Het |
| Scrn2 |
T |
A |
11: 96,923,908 (GRCm39) |
V264E |
possibly damaging |
Het |
| Serpinb9c |
T |
A |
13: 33,338,390 (GRCm39) |
I198L |
probably benign |
Het |
| Shank2 |
T |
C |
7: 143,964,096 (GRCm39) |
F568S |
probably damaging |
Het |
| Slc47a1 |
C |
T |
11: 61,268,767 (GRCm39) |
R36Q |
probably benign |
Het |
| Slc4a8 |
A |
C |
15: 100,688,908 (GRCm39) |
E406A |
probably damaging |
Het |
| Speg |
C |
T |
1: 75,388,091 (GRCm39) |
T1483I |
probably damaging |
Het |
| Srbd1 |
A |
G |
17: 86,365,160 (GRCm39) |
V632A |
probably damaging |
Het |
| Srd5a2 |
A |
T |
17: 74,328,515 (GRCm39) |
Y188N |
probably damaging |
Het |
| Sspo |
A |
T |
6: 48,455,543 (GRCm39) |
|
probably null |
Het |
| Ssx2ip |
A |
T |
3: 146,136,703 (GRCm39) |
D317V |
probably benign |
Het |
| Tmco3 |
G |
T |
8: 13,370,847 (GRCm39) |
E172* |
probably null |
Het |
| Trpc4 |
G |
A |
3: 54,206,519 (GRCm39) |
W573* |
probably null |
Het |
| Ttn |
T |
C |
2: 76,580,340 (GRCm39) |
I23518V |
probably benign |
Het |
| Tubal3 |
A |
G |
13: 3,983,050 (GRCm39) |
T277A |
possibly damaging |
Het |
| Unc5b |
A |
T |
10: 60,610,867 (GRCm39) |
L391H |
probably damaging |
Het |
| Vmn2r76 |
A |
G |
7: 85,874,440 (GRCm39) |
F846L |
probably benign |
Het |
| Vps13c |
T |
A |
9: 67,790,735 (GRCm39) |
Y338N |
probably damaging |
Het |
| Zc3hav1 |
G |
T |
6: 38,309,328 (GRCm39) |
S498* |
probably null |
Het |
| Zfand4 |
T |
A |
6: 116,305,337 (GRCm39) |
|
probably null |
Het |
| Zfp451 |
A |
T |
1: 33,811,972 (GRCm39) |
|
probably null |
Het |
| Zfp607a |
A |
T |
7: 27,578,183 (GRCm39) |
I418F |
probably damaging |
Het |
| Zfp612 |
A |
G |
8: 110,816,337 (GRCm39) |
T515A |
probably damaging |
Het |
| Zfp708 |
G |
T |
13: 67,219,200 (GRCm39) |
L208I |
possibly damaging |
Het |
|
| Other mutations in Pappa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Pappa2
|
APN |
1 |
158,684,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01394:Pappa2
|
APN |
1 |
158,592,674 (GRCm39) |
splice site |
probably benign |
|
|
IGL01570:Pappa2
|
APN |
1 |
158,642,110 (GRCm39) |
nonsense |
probably null |
|
|
IGL01618:Pappa2
|
APN |
1 |
158,684,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01717:Pappa2
|
APN |
1 |
158,684,702 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01804:Pappa2
|
APN |
1 |
158,764,089 (GRCm39) |
missense |
probably benign |
|
|
IGL01904:Pappa2
|
APN |
1 |
158,611,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02116:Pappa2
|
APN |
1 |
158,672,695 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02174:Pappa2
|
APN |
1 |
158,589,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02302:Pappa2
|
APN |
1 |
158,542,571 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02422:Pappa2
|
APN |
1 |
158,764,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02572:Pappa2
|
APN |
1 |
158,678,786 (GRCm39) |
missense |
probably benign |
|
|
IGL02659:Pappa2
|
APN |
1 |
158,764,364 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02887:Pappa2
|
APN |
1 |
158,609,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02981:Pappa2
|
APN |
1 |
158,678,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03128:Pappa2
|
APN |
1 |
158,764,054 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03142:Pappa2
|
APN |
1 |
158,682,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03270:Pappa2
|
APN |
1 |
158,592,637 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Fritas
|
UTSW |
1 |
158,675,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
Gulliver
|
UTSW |
1 |
158,684,706 (GRCm39) |
missense |
probably null |
1.00 |
|
Lilliputian
|
UTSW |
1 |
158,544,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Lilliputian2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
lilliputian3
|
UTSW |
1 |
158,609,973 (GRCm39) |
splice site |
probably null |
|
|
Pitzel
|
UTSW |
1 |
158,784,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
shrink
|
UTSW |
1 |
158,590,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,542,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,542,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0172:Pappa2
|
UTSW |
1 |
158,682,419 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0194:Pappa2
|
UTSW |
1 |
158,592,671 (GRCm39) |
splice site |
probably benign |
|
|
R0418:Pappa2
|
UTSW |
1 |
158,544,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0421:Pappa2
|
UTSW |
1 |
158,675,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0441:Pappa2
|
UTSW |
1 |
158,590,628 (GRCm39) |
unclassified |
probably benign |
|
|
R0602:Pappa2
|
UTSW |
1 |
158,590,625 (GRCm39) |
unclassified |
probably benign |
|
|
R0630:Pappa2
|
UTSW |
1 |
158,660,343 (GRCm39) |
missense |
probably benign |
|
|
R0760:Pappa2
|
UTSW |
1 |
158,544,531 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1146:Pappa2
|
UTSW |
1 |
158,682,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1146:Pappa2
|
UTSW |
1 |
158,682,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1243:Pappa2
|
UTSW |
1 |
158,672,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Pappa2
|
UTSW |
1 |
158,764,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1502:Pappa2
|
UTSW |
1 |
158,784,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1599:Pappa2
|
UTSW |
1 |
158,684,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1689:Pappa2
|
UTSW |
1 |
158,784,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1750:Pappa2
|
UTSW |
1 |
158,590,720 (GRCm39) |
nonsense |
probably null |
|
|
R1772:Pappa2
|
UTSW |
1 |
158,641,938 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1832:Pappa2
|
UTSW |
1 |
158,684,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Pappa2
|
UTSW |
1 |
158,631,073 (GRCm39) |
splice site |
probably null |
|
|
R1914:Pappa2
|
UTSW |
1 |
158,578,133 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2013:Pappa2
|
UTSW |
1 |
158,662,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2037:Pappa2
|
UTSW |
1 |
158,784,214 (GRCm39) |
nonsense |
probably null |
|
|
R2118:Pappa2
|
UTSW |
1 |
158,684,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2268:Pappa2
|
UTSW |
1 |
158,684,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Pappa2
|
UTSW |
1 |
158,684,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2347:Pappa2
|
UTSW |
1 |
158,592,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3024:Pappa2
|
UTSW |
1 |
158,763,795 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3706:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R3707:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R3708:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R4600:Pappa2
|
UTSW |
1 |
158,642,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4738:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,784,572 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4788:Pappa2
|
UTSW |
1 |
158,611,487 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4798:Pappa2
|
UTSW |
1 |
158,684,949 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4952:Pappa2
|
UTSW |
1 |
158,684,706 (GRCm39) |
missense |
probably null |
1.00 |
|
R5121:Pappa2
|
UTSW |
1 |
158,666,197 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5144:Pappa2
|
UTSW |
1 |
158,784,703 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5159:Pappa2
|
UTSW |
1 |
158,589,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Pappa2
|
UTSW |
1 |
158,609,973 (GRCm39) |
splice site |
probably null |
|
|
R5428:Pappa2
|
UTSW |
1 |
158,642,355 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5452:Pappa2
|
UTSW |
1 |
158,666,172 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5477:Pappa2
|
UTSW |
1 |
158,784,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5504:Pappa2
|
UTSW |
1 |
158,675,615 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5852:Pappa2
|
UTSW |
1 |
158,544,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6003:Pappa2
|
UTSW |
1 |
158,763,820 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6129:Pappa2
|
UTSW |
1 |
158,542,567 (GRCm39) |
nonsense |
probably null |
|
|
R6137:Pappa2
|
UTSW |
1 |
158,699,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6374:Pappa2
|
UTSW |
1 |
158,784,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6472:Pappa2
|
UTSW |
1 |
158,662,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6804:Pappa2
|
UTSW |
1 |
158,764,438 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7020:Pappa2
|
UTSW |
1 |
158,675,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7051:Pappa2
|
UTSW |
1 |
158,784,753 (GRCm39) |
missense |
unknown |
|
|
R7111:Pappa2
|
UTSW |
1 |
158,784,096 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7213:Pappa2
|
UTSW |
1 |
158,764,456 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7575:Pappa2
|
UTSW |
1 |
158,642,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7587:Pappa2
|
UTSW |
1 |
158,678,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7826:Pappa2
|
UTSW |
1 |
158,764,010 (GRCm39) |
nonsense |
probably null |
|
|
R7957:Pappa2
|
UTSW |
1 |
158,589,131 (GRCm39) |
nonsense |
probably null |
|
|
R8007:Pappa2
|
UTSW |
1 |
158,609,874 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8050:Pappa2
|
UTSW |
1 |
158,675,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Pappa2
|
UTSW |
1 |
158,764,126 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8068:Pappa2
|
UTSW |
1 |
158,763,555 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8128:Pappa2
|
UTSW |
1 |
158,764,234 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8264:Pappa2
|
UTSW |
1 |
158,682,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8317:Pappa2
|
UTSW |
1 |
158,592,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8499:Pappa2
|
UTSW |
1 |
158,764,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8744:Pappa2
|
UTSW |
1 |
158,611,487 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8793:Pappa2
|
UTSW |
1 |
158,678,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8932:Pappa2
|
UTSW |
1 |
158,590,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9004:Pappa2
|
UTSW |
1 |
158,764,518 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9004:Pappa2
|
UTSW |
1 |
158,763,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Pappa2
|
UTSW |
1 |
158,763,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9191:Pappa2
|
UTSW |
1 |
158,684,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9243:Pappa2
|
UTSW |
1 |
158,763,763 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9280:Pappa2
|
UTSW |
1 |
158,675,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9301:Pappa2
|
UTSW |
1 |
158,672,614 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9306:Pappa2
|
UTSW |
1 |
158,764,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Pappa2
|
UTSW |
1 |
158,784,542 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9471:Pappa2
|
UTSW |
1 |
158,642,029 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9544:Pappa2
|
UTSW |
1 |
158,784,817 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9680:Pappa2
|
UTSW |
1 |
158,609,818 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9762:Pappa2
|
UTSW |
1 |
158,684,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Pappa2
|
UTSW |
1 |
158,675,920 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Pappa2
|
UTSW |
1 |
158,611,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0058:Pappa2
|
UTSW |
1 |
158,641,967 (GRCm39) |
missense |
probably null |
|
|
X0061:Pappa2
|
UTSW |
1 |
158,764,188 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,784,503 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Pappa2
|
UTSW |
1 |
158,642,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,642,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGCAACAGAAGAGGTTATACAGG -3'
(R):5'- GCCCAAGTTCCAGAAGTTAAAGG -3'
Sequencing Primer
(F):5'- AGGAGGCCTGCATCATGTG -3'
(R):5'- TTGATATTCTAGATTCCCATCC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation