Incidental Mutation 'R7053:Lrp1'
ID 547722
Institutional Source Beutler Lab
Gene Symbol Lrp1
Ensembl Gene ENSMUSG00000040249
Gene Name low density lipoprotein receptor-related protein 1
Synonyms b2b1554Clo, CD91, A2mr
MMRRC Submission 045150-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7053 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 127374030-127457017 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 127376963 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 4205 (C4205R)
Ref Sequence ENSEMBL: ENSMUSP00000044004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049149]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000049149
AA Change: C4205R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000044004
Gene: ENSMUSG00000040249
AA Change: C4205R

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
LDLa 27 67 1.03e-15 SMART
LDLa 72 111 1.04e-11 SMART
EGF 115 150 8.78e-2 SMART
EGF_CA 151 190 4.49e-8 SMART
low complexity region 222 232 N/A INTRINSIC
LY 273 315 7.07e-6 SMART
LY 316 359 2.31e-10 SMART
LY 360 402 8.3e-12 SMART
EGF 478 521 9.93e-1 SMART
LY 552 594 8.84e-7 SMART
LY 595 638 6.54e-10 SMART
LY 641 690 2.5e-15 SMART
LY 691 734 1.06e-9 SMART
EGF 807 844 1.38e1 SMART
LDLa 854 893 3.39e-16 SMART
LDLa 895 934 1.73e-13 SMART
LDLa 936 974 4.47e-16 SMART
LDLa 976 1014 2.53e-15 SMART
LDLa 1015 1054 2.95e-16 SMART
LDLa 1062 1100 3.24e-13 SMART
LDLa 1104 1143 2.97e-12 SMART
LDLa 1145 1185 1.24e-9 SMART
EGF 1185 1223 4.97e-1 SMART
EGF 1227 1263 6.02e0 SMART
LY 1290 1332 3.76e-1 SMART
LY 1337 1379 8.56e-14 SMART
LY 1380 1424 8.43e-13 SMART
LY 1425 1469 3.05e-10 SMART
LY 1471 1513 3.88e-3 SMART
EGF 1540 1580 1.85e0 SMART
LY 1606 1650 2.83e-5 SMART
LY 1651 1695 2.01e-10 SMART
LY 1698 1735 1.87e-5 SMART
LY 1736 1777 3.54e-6 SMART
LY 1778 1820 4.17e1 SMART
EGF 1850 1888 1.24e-1 SMART
LY 1915 1957 3.2e-4 SMART
LY 1958 2000 2.33e-15 SMART
LY 2001 2044 7.45e-14 SMART
LY 2045 2087 3.87e-12 SMART
LY 2089 2131 1.37e0 SMART
EGF 2159 2196 1.66e1 SMART
LY 2276 2318 5.57e-4 SMART
LY 2324 2369 3.3e-6 SMART
LY 2370 2412 3.93e-13 SMART
LY 2413 2454 3.62e-3 SMART
EGF_like 2482 2519 3.16e1 SMART
LDLa 2524 2564 3.31e-10 SMART
LDLa 2566 2603 7.21e-11 SMART
LDLa 2605 2642 1.09e-10 SMART
LDLa 2660 2691 6.05e-4 SMART
LDLa 2696 2733 2.49e-14 SMART
LDLa 2734 2772 4.65e-14 SMART
LDLa 2774 2815 3.92e-12 SMART
LDLa 2818 2856 1.51e-13 SMART
LDLa 2858 2900 1.93e-11 SMART
LDLa 2904 2942 1.73e-13 SMART
EGF_CA 2941 2982 6.16e-6 SMART
EGF_CA 2983 3023 2.66e-10 SMART
LY 3050 3094 6.64e-11 SMART
LY 3095 3137 7.17e-16 SMART
LY 3138 3181 4.28e-14 SMART
LY 3182 3224 8.11e-15 SMART
LY 3225 3265 1.44e-6 SMART
EGF 3294 3332 1.02e-2 SMART
LDLa 3334 3372 2.25e-12 SMART
LDLa 3374 3411 9.81e-13 SMART
LDLa 3413 3451 9.81e-13 SMART
LDLa 3453 3492 5.67e-18 SMART
LDLa 3494 3534 7.15e-15 SMART
LDLa 3536 3573 1.79e-15 SMART
EGF_like 3575 3611 4.83e1 SMART
LDLa 3575 3612 1.92e-15 SMART
LDLa 3613 3650 1.18e-15 SMART
LDLa 3654 3693 7.55e-14 SMART
LDLa 3695 3734 1.14e-8 SMART
LDLa 3741 3779 6.28e-11 SMART
EGF 3785 3824 1.06e1 SMART
EGF 3828 3862 1.51e0 SMART
LY 3893 3935 9.43e0 SMART
LY 3951 3993 1.23e-14 SMART
LY 3994 4037 2.98e-13 SMART
LY 4038 4080 4.28e-14 SMART
EGF 4151 4184 3.76e-1 SMART
low complexity region 4185 4198 N/A INTRINSIC
EGF 4200 4233 3.82e-2 SMART
EGF 4236 4269 4.03e-1 SMART
EGF 4272 4305 5.2e-4 SMART
EGF 4308 4341 1.22e0 SMART
EGF_like 4344 4376 4.11e1 SMART
EGF 4377 4410 5.12e-3 SMART
transmembrane domain 4423 4445 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit lethality during late organogenesis. [provided by MGI curators]
Allele List at MGI

All alleles(42) : Targeted(9) Gene trapped(33)

Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a A T 8: 44,021,836 (GRCm39) C551* probably null Het
Aldh1l1 C A 6: 90,540,420 (GRCm39) T235K possibly damaging Het
Atp6v0a2 A G 5: 124,783,923 (GRCm39) E257G probably damaging Het
AW146154 A G 7: 41,131,988 (GRCm39) probably null Het
BC048507 T C 13: 68,011,772 (GRCm39) Y50H probably benign Het
Brip1 T C 11: 86,083,791 (GRCm39) N77D possibly damaging Het
Ccdc13 T C 9: 121,662,904 (GRCm39) E37G probably damaging Het
Ccn6 A G 10: 39,034,297 (GRCm39) Y102H probably damaging Het
Col27a1 T A 4: 63,251,404 (GRCm39) probably benign Het
Corin T A 5: 72,458,870 (GRCm39) I960L probably benign Het
Csnk2b A G 17: 35,335,422 (GRCm39) probably benign Het
Cyp2d26 T C 15: 82,676,801 (GRCm39) S182G probably benign Het
Dennd1a A G 2: 37,851,666 (GRCm39) L74P probably damaging Het
Dip2c A G 13: 9,660,740 (GRCm39) D838G probably damaging Het
Dkkl1 G T 7: 44,857,022 (GRCm39) Q182K probably damaging Het
Dnai2 T C 11: 114,629,521 (GRCm39) S183P probably damaging Het
Dnhd1 T C 7: 105,344,161 (GRCm39) L1835P probably damaging Het
Espl1 T C 15: 102,225,328 (GRCm39) probably null Het
Fam174a C T 1: 95,252,953 (GRCm39) A185V probably damaging Het
Fhip1b C T 7: 105,033,779 (GRCm39) G479D probably damaging Het
Gm40460 CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,554 (GRCm39) probably benign Het
Grid2 G T 6: 64,677,402 (GRCm39) A74S unknown Het
Gsdma3 T A 11: 98,520,621 (GRCm39) M84K possibly damaging Het
Hlcs A T 16: 94,068,874 (GRCm39) S262R possibly damaging Het
Mdc1 C T 17: 36,157,218 (GRCm39) A181V probably benign Het
Mdga2 T A 12: 66,736,158 (GRCm39) I357F probably benign Het
Mfn1 A G 3: 32,586,114 (GRCm39) I21V probably benign Het
Mgat4b C T 11: 50,124,367 (GRCm39) T409M probably damaging Het
Mgat4d G T 8: 84,098,261 (GRCm39) K341N probably damaging Het
Mpo A T 11: 87,694,336 (GRCm39) N109Y probably damaging Het
Mvp T C 7: 126,586,776 (GRCm39) Q785R possibly damaging Het
Nim1k A G 13: 120,189,145 (GRCm39) V88A probably damaging Het
Oasl2 A T 5: 115,049,291 (GRCm39) I464L possibly damaging Het
Or5m11b G T 2: 85,806,358 (GRCm39) C257F possibly damaging Het
Pkd1l2 A G 8: 117,740,681 (GRCm39) F2139L probably damaging Het
Pop1 T G 15: 34,530,421 (GRCm39) S940A probably benign Het
Ppp1r9a T A 6: 4,905,670 (GRCm39) M75K probably damaging Het
Prdm15 G A 16: 97,595,742 (GRCm39) Q1029* probably null Het
Rffl T C 11: 82,703,497 (GRCm39) K142R probably null Het
Rhou A G 8: 124,380,934 (GRCm39) probably benign Het
Rp1l1 A T 14: 64,268,958 (GRCm39) T1515S possibly damaging Het
Serpina1b T A 12: 103,698,688 (GRCm39) S54C possibly damaging Het
Slc30a2 G A 4: 134,074,726 (GRCm39) R161Q probably damaging Het
Taok3 T A 5: 117,390,627 (GRCm39) D529E probably benign Het
Tmem18 T A 12: 30,634,506 (GRCm39) M1K probably null Het
Tmem269 T A 4: 119,066,464 (GRCm39) H198L probably damaging Het
Tnrc18 A G 5: 142,772,984 (GRCm39) V432A unknown Het
Ttc6 A T 12: 57,707,318 (GRCm39) T742S probably benign Het
Uhrf2 T A 19: 30,069,519 (GRCm39) C749S probably damaging Het
Unc13c G A 9: 73,839,579 (GRCm39) T424I probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Vmn2r61 A C 7: 41,916,557 (GRCm39) D390A probably damaging Het
Xpo7 A G 14: 70,922,298 (GRCm39) probably null Het
Zfp948 T A 17: 21,805,121 (GRCm39) L37* probably null Het
Other mutations in Lrp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00793:Lrp1 APN 10 127,378,074 (GRCm39) missense possibly damaging 0.89
IGL01065:Lrp1 APN 10 127,410,907 (GRCm39) missense probably benign 0.10
IGL01121:Lrp1 APN 10 127,419,722 (GRCm39) nonsense probably null
IGL01360:Lrp1 APN 10 127,381,689 (GRCm39) missense possibly damaging 0.93
IGL01402:Lrp1 APN 10 127,430,901 (GRCm39) missense probably damaging 1.00
IGL01404:Lrp1 APN 10 127,430,901 (GRCm39) missense probably damaging 1.00
IGL01411:Lrp1 APN 10 127,417,634 (GRCm39) nonsense probably null
IGL01469:Lrp1 APN 10 127,420,283 (GRCm39) missense probably damaging 1.00
IGL01552:Lrp1 APN 10 127,424,379 (GRCm39) nonsense probably null
IGL01682:Lrp1 APN 10 127,410,847 (GRCm39) missense probably benign 0.00
IGL01760:Lrp1 APN 10 127,409,370 (GRCm39) missense probably benign 0.00
IGL01918:Lrp1 APN 10 127,390,458 (GRCm39) missense probably damaging 0.99
IGL01989:Lrp1 APN 10 127,413,998 (GRCm39) missense probably damaging 1.00
IGL02105:Lrp1 APN 10 127,380,448 (GRCm39) missense probably damaging 1.00
IGL02158:Lrp1 APN 10 127,390,140 (GRCm39) missense probably benign 0.02
IGL02164:Lrp1 APN 10 127,399,536 (GRCm39) missense probably benign 0.39
IGL02337:Lrp1 APN 10 127,412,756 (GRCm39) missense possibly damaging 0.87
IGL02425:Lrp1 APN 10 127,407,756 (GRCm39) critical splice donor site probably null
IGL02493:Lrp1 APN 10 127,417,647 (GRCm39) missense probably damaging 0.99
IGL02563:Lrp1 APN 10 127,387,555 (GRCm39) missense probably damaging 1.00
IGL02590:Lrp1 APN 10 127,388,660 (GRCm39) missense probably damaging 1.00
IGL02624:Lrp1 APN 10 127,408,291 (GRCm39) missense probably damaging 0.98
IGL02625:Lrp1 APN 10 127,410,355 (GRCm39) missense probably damaging 1.00
IGL02825:Lrp1 APN 10 127,378,474 (GRCm39) missense probably damaging 1.00
IGL02880:Lrp1 APN 10 127,376,091 (GRCm39) missense probably benign 0.12
IGL02900:Lrp1 APN 10 127,412,516 (GRCm39) splice site probably benign
IGL02956:Lrp1 APN 10 127,380,428 (GRCm39) missense probably benign 0.00
IGL02974:Lrp1 APN 10 127,390,885 (GRCm39) missense probably damaging 0.99
IGL02983:Lrp1 APN 10 127,386,068 (GRCm39) missense probably damaging 1.00
IGL03002:Lrp1 APN 10 127,425,505 (GRCm39) missense probably damaging 1.00
IGL03091:Lrp1 APN 10 127,394,993 (GRCm39) missense probably benign 0.30
IGL03109:Lrp1 APN 10 127,402,514 (GRCm39) missense probably benign
IGL03194:Lrp1 APN 10 127,404,554 (GRCm39) missense probably damaging 1.00
IGL03232:Lrp1 APN 10 127,375,245 (GRCm39) missense probably damaging 1.00
calculus UTSW 10 127,393,937 (GRCm39) splice site probably null
Delimiter UTSW 10 127,382,731 (GRCm39) missense probably damaging 1.00
extremis UTSW 10 127,392,857 (GRCm39) missense probably benign 0.00
Jockey UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
peripheral UTSW 10 127,446,250 (GRCm39) missense probably damaging 1.00
tangential UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
P0015:Lrp1 UTSW 10 127,402,532 (GRCm39) missense probably damaging 0.99
PIT4519001:Lrp1 UTSW 10 127,443,843 (GRCm39) missense possibly damaging 0.91
PIT4520001:Lrp1 UTSW 10 127,443,843 (GRCm39) missense possibly damaging 0.91
R0004:Lrp1 UTSW 10 127,377,694 (GRCm39) splice site probably null
R0034:Lrp1 UTSW 10 127,381,520 (GRCm39) missense probably benign 0.42
R0091:Lrp1 UTSW 10 127,376,848 (GRCm39) missense probably damaging 1.00
R0098:Lrp1 UTSW 10 127,388,607 (GRCm39) missense probably benign
R0098:Lrp1 UTSW 10 127,388,607 (GRCm39) missense probably benign
R0143:Lrp1 UTSW 10 127,429,811 (GRCm39) missense probably damaging 1.00
R0372:Lrp1 UTSW 10 127,428,005 (GRCm39) missense probably damaging 1.00
R0379:Lrp1 UTSW 10 127,430,838 (GRCm39) missense probably damaging 1.00
R0445:Lrp1 UTSW 10 127,426,505 (GRCm39) nonsense probably null
R0529:Lrp1 UTSW 10 127,377,463 (GRCm39) splice site probably null
R0551:Lrp1 UTSW 10 127,407,827 (GRCm39) missense probably benign
R0570:Lrp1 UTSW 10 127,390,878 (GRCm39) nonsense probably null
R0600:Lrp1 UTSW 10 127,403,252 (GRCm39) missense probably benign 0.00
R0626:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R0647:Lrp1 UTSW 10 127,407,346 (GRCm39) missense probably damaging 1.00
R0680:Lrp1 UTSW 10 127,425,530 (GRCm39) missense probably damaging 1.00
R0792:Lrp1 UTSW 10 127,411,155 (GRCm39) missense probably benign 0.04
R0792:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R0848:Lrp1 UTSW 10 127,389,231 (GRCm39) splice site probably null
R0866:Lrp1 UTSW 10 127,375,147 (GRCm39) missense probably damaging 1.00
R0918:Lrp1 UTSW 10 127,429,834 (GRCm39) missense probably damaging 1.00
R1076:Lrp1 UTSW 10 127,399,666 (GRCm39) splice site probably benign
R1107:Lrp1 UTSW 10 127,393,304 (GRCm39) missense probably damaging 1.00
R1346:Lrp1 UTSW 10 127,441,735 (GRCm39) missense probably damaging 1.00
R1403:Lrp1 UTSW 10 127,417,760 (GRCm39) critical splice acceptor site probably null
R1403:Lrp1 UTSW 10 127,417,760 (GRCm39) critical splice acceptor site probably null
R1496:Lrp1 UTSW 10 127,374,880 (GRCm39) missense probably damaging 1.00
R1522:Lrp1 UTSW 10 127,411,155 (GRCm39) missense probably benign 0.04
R1522:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R1525:Lrp1 UTSW 10 127,375,398 (GRCm39) missense probably damaging 1.00
R1539:Lrp1 UTSW 10 127,420,250 (GRCm39) splice site probably null
R1589:Lrp1 UTSW 10 127,441,475 (GRCm39) missense probably benign 0.00
R1591:Lrp1 UTSW 10 127,441,475 (GRCm39) missense probably benign 0.00
R1663:Lrp1 UTSW 10 127,392,790 (GRCm39) missense probably damaging 1.00
R1682:Lrp1 UTSW 10 127,410,201 (GRCm39) missense probably damaging 1.00
R1717:Lrp1 UTSW 10 127,399,534 (GRCm39) missense probably damaging 1.00
R1717:Lrp1 UTSW 10 127,392,138 (GRCm39) missense possibly damaging 0.59
R1758:Lrp1 UTSW 10 127,424,453 (GRCm39) missense possibly damaging 0.76
R1826:Lrp1 UTSW 10 127,389,576 (GRCm39) missense probably damaging 1.00
R1842:Lrp1 UTSW 10 127,409,337 (GRCm39) missense possibly damaging 0.93
R1844:Lrp1 UTSW 10 127,431,152 (GRCm39) critical splice donor site probably null
R1845:Lrp1 UTSW 10 127,414,542 (GRCm39) missense probably damaging 1.00
R1896:Lrp1 UTSW 10 127,395,867 (GRCm39) missense possibly damaging 0.64
R1952:Lrp1 UTSW 10 127,403,300 (GRCm39) missense probably damaging 1.00
R2009:Lrp1 UTSW 10 127,380,385 (GRCm39) missense probably damaging 1.00
R2015:Lrp1 UTSW 10 127,376,563 (GRCm39) missense probably benign 0.00
R2116:Lrp1 UTSW 10 127,412,362 (GRCm39) nonsense probably null
R2161:Lrp1 UTSW 10 127,391,607 (GRCm39) missense probably damaging 1.00
R2199:Lrp1 UTSW 10 127,382,709 (GRCm39) missense probably damaging 1.00
R2213:Lrp1 UTSW 10 127,376,571 (GRCm39) missense probably damaging 1.00
R2300:Lrp1 UTSW 10 127,392,784 (GRCm39) nonsense probably null
R2324:Lrp1 UTSW 10 127,402,455 (GRCm39) missense possibly damaging 0.92
R2849:Lrp1 UTSW 10 127,378,165 (GRCm39) missense probably damaging 1.00
R2926:Lrp1 UTSW 10 127,423,982 (GRCm39) missense probably damaging 0.98
R2993:Lrp1 UTSW 10 127,446,250 (GRCm39) missense probably damaging 1.00
R3522:Lrp1 UTSW 10 127,389,424 (GRCm39) missense probably damaging 1.00
R3702:Lrp1 UTSW 10 127,430,972 (GRCm39) missense probably damaging 1.00
R3789:Lrp1 UTSW 10 127,407,838 (GRCm39) missense possibly damaging 0.94
R3898:Lrp1 UTSW 10 127,427,969 (GRCm39) nonsense probably null
R3941:Lrp1 UTSW 10 127,389,265 (GRCm39) missense probably damaging 1.00
R3958:Lrp1 UTSW 10 127,407,827 (GRCm39) missense probably benign
R4369:Lrp1 UTSW 10 127,386,155 (GRCm39) missense possibly damaging 0.87
R4510:Lrp1 UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
R4511:Lrp1 UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
R4576:Lrp1 UTSW 10 127,376,057 (GRCm39) small deletion probably benign
R4583:Lrp1 UTSW 10 127,377,241 (GRCm39) missense probably benign 0.00
R4662:Lrp1 UTSW 10 127,388,054 (GRCm39) nonsense probably null
R4721:Lrp1 UTSW 10 127,390,928 (GRCm39) missense possibly damaging 0.58
R4728:Lrp1 UTSW 10 127,399,606 (GRCm39) missense probably damaging 1.00
R4745:Lrp1 UTSW 10 127,385,813 (GRCm39) missense probably benign 0.20
R4785:Lrp1 UTSW 10 127,394,002 (GRCm39) missense probably benign 0.12
R4841:Lrp1 UTSW 10 127,419,805 (GRCm39) missense probably damaging 1.00
R4842:Lrp1 UTSW 10 127,419,805 (GRCm39) missense probably damaging 1.00
R4855:Lrp1 UTSW 10 127,446,311 (GRCm39) missense probably benign 0.03
R4860:Lrp1 UTSW 10 127,389,693 (GRCm39) missense probably damaging 1.00
R4860:Lrp1 UTSW 10 127,389,693 (GRCm39) missense probably damaging 1.00
R4891:Lrp1 UTSW 10 127,377,621 (GRCm39) missense probably damaging 1.00
R4925:Lrp1 UTSW 10 127,410,944 (GRCm39) nonsense probably null
R4970:Lrp1 UTSW 10 127,375,389 (GRCm39) missense probably benign 0.11
R4999:Lrp1 UTSW 10 127,389,648 (GRCm39) missense probably damaging 1.00
R5044:Lrp1 UTSW 10 127,403,364 (GRCm39) missense probably damaging 1.00
R5127:Lrp1 UTSW 10 127,375,503 (GRCm39) intron probably benign
R5188:Lrp1 UTSW 10 127,443,821 (GRCm39) missense probably damaging 1.00
R5218:Lrp1 UTSW 10 127,384,488 (GRCm39) missense probably damaging 1.00
R5225:Lrp1 UTSW 10 127,391,965 (GRCm39) missense probably benign 0.04
R5291:Lrp1 UTSW 10 127,429,747 (GRCm39) missense probably damaging 1.00
R5386:Lrp1 UTSW 10 127,427,983 (GRCm39) missense probably damaging 1.00
R5395:Lrp1 UTSW 10 127,431,166 (GRCm39) missense probably damaging 1.00
R5413:Lrp1 UTSW 10 127,423,936 (GRCm39) critical splice donor site probably null
R5430:Lrp1 UTSW 10 127,376,930 (GRCm39) missense probably damaging 0.99
R5499:Lrp1 UTSW 10 127,408,813 (GRCm39) missense possibly damaging 0.58
R5526:Lrp1 UTSW 10 127,391,593 (GRCm39) missense probably benign 0.37
R5580:Lrp1 UTSW 10 127,424,389 (GRCm39) missense probably benign
R5583:Lrp1 UTSW 10 127,424,332 (GRCm39) missense probably benign 0.08
R5599:Lrp1 UTSW 10 127,429,738 (GRCm39) missense probably damaging 1.00
R5639:Lrp1 UTSW 10 127,429,708 (GRCm39) missense probably damaging 0.99
R5677:Lrp1 UTSW 10 127,410,298 (GRCm39) missense probably damaging 1.00
R5730:Lrp1 UTSW 10 127,419,703 (GRCm39) missense probably benign 0.00
R5742:Lrp1 UTSW 10 127,384,216 (GRCm39) missense probably damaging 0.98
R5764:Lrp1 UTSW 10 127,431,187 (GRCm39) missense probably benign 0.41
R5864:Lrp1 UTSW 10 127,403,374 (GRCm39) missense possibly damaging 0.58
R5937:Lrp1 UTSW 10 127,419,745 (GRCm39) missense possibly damaging 0.93
R5947:Lrp1 UTSW 10 127,425,423 (GRCm39) critical splice donor site probably null
R5976:Lrp1 UTSW 10 127,419,770 (GRCm39) missense probably damaging 1.00
R6021:Lrp1 UTSW 10 127,413,883 (GRCm39) missense probably damaging 1.00
R6026:Lrp1 UTSW 10 127,409,272 (GRCm39) missense probably damaging 1.00
R6045:Lrp1 UTSW 10 127,402,469 (GRCm39) missense probably damaging 0.98
R6057:Lrp1 UTSW 10 127,403,359 (GRCm39) missense probably damaging 1.00
R6084:Lrp1 UTSW 10 127,396,422 (GRCm39) missense probably benign 0.09
R6131:Lrp1 UTSW 10 127,396,026 (GRCm39) missense probably benign
R6235:Lrp1 UTSW 10 127,424,046 (GRCm39) missense probably damaging 1.00
R6280:Lrp1 UTSW 10 127,425,453 (GRCm39) missense probably benign 0.04
R6307:Lrp1 UTSW 10 127,427,944 (GRCm39) missense probably damaging 1.00
R6532:Lrp1 UTSW 10 127,377,551 (GRCm39) missense probably damaging 1.00
R6532:Lrp1 UTSW 10 127,385,276 (GRCm39) missense probably damaging 1.00
R6536:Lrp1 UTSW 10 127,393,937 (GRCm39) splice site probably null
R6605:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6607:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6631:Lrp1 UTSW 10 127,410,201 (GRCm39) missense probably damaging 1.00
R6676:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6678:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6809:Lrp1 UTSW 10 127,390,925 (GRCm39) missense probably benign 0.04
R6884:Lrp1 UTSW 10 127,394,986 (GRCm39) missense probably benign 0.00
R6925:Lrp1 UTSW 10 127,392,857 (GRCm39) missense probably benign 0.00
R6987:Lrp1 UTSW 10 127,410,874 (GRCm39) missense probably damaging 1.00
R7016:Lrp1 UTSW 10 127,395,836 (GRCm39) critical splice donor site probably null
R7030:Lrp1 UTSW 10 127,388,745 (GRCm39) missense probably damaging 0.97
R7076:Lrp1 UTSW 10 127,386,052 (GRCm39) critical splice donor site probably null
R7136:Lrp1 UTSW 10 127,394,491 (GRCm39) missense probably damaging 1.00
R7180:Lrp1 UTSW 10 127,392,834 (GRCm39) missense probably damaging 1.00
R7199:Lrp1 UTSW 10 127,409,325 (GRCm39) missense probably damaging 0.99
R7219:Lrp1 UTSW 10 127,393,097 (GRCm39) missense probably benign 0.40
R7233:Lrp1 UTSW 10 127,430,930 (GRCm39) missense probably damaging 1.00
R7251:Lrp1 UTSW 10 127,408,423 (GRCm39) missense probably damaging 1.00
R7264:Lrp1 UTSW 10 127,427,962 (GRCm39) missense probably damaging 1.00
R7302:Lrp1 UTSW 10 127,374,856 (GRCm39) missense probably benign 0.01
R7313:Lrp1 UTSW 10 127,389,337 (GRCm39) missense probably damaging 1.00
R7322:Lrp1 UTSW 10 127,381,433 (GRCm39) missense probably benign 0.24
R7354:Lrp1 UTSW 10 127,407,277 (GRCm39) missense probably damaging 1.00
R7375:Lrp1 UTSW 10 127,375,217 (GRCm39) missense probably damaging 1.00
R7388:Lrp1 UTSW 10 127,419,766 (GRCm39) nonsense probably null
R7404:Lrp1 UTSW 10 127,418,577 (GRCm39) missense
R7405:Lrp1 UTSW 10 127,417,620 (GRCm39) missense possibly damaging 0.93
R7477:Lrp1 UTSW 10 127,404,789 (GRCm39) missense probably damaging 1.00
R7555:Lrp1 UTSW 10 127,382,731 (GRCm39) missense probably damaging 1.00
R7600:Lrp1 UTSW 10 127,391,575 (GRCm39) missense probably benign
R7678:Lrp1 UTSW 10 127,409,922 (GRCm39) missense probably damaging 1.00
R7679:Lrp1 UTSW 10 127,424,297 (GRCm39) nonsense probably null
R7951:Lrp1 UTSW 10 127,374,933 (GRCm39) nonsense probably null
R7964:Lrp1 UTSW 10 127,410,913 (GRCm39) missense possibly damaging 0.94
R8006:Lrp1 UTSW 10 127,425,488 (GRCm39) missense probably damaging 1.00
R8021:Lrp1 UTSW 10 127,384,215 (GRCm39) missense possibly damaging 0.92
R8098:Lrp1 UTSW 10 127,410,324 (GRCm39) missense possibly damaging 0.78
R8112:Lrp1 UTSW 10 127,441,715 (GRCm39) missense probably damaging 1.00
R8210:Lrp1 UTSW 10 127,412,354 (GRCm39) missense probably damaging 1.00
R8249:Lrp1 UTSW 10 127,441,412 (GRCm39) missense probably benign
R8291:Lrp1 UTSW 10 127,425,572 (GRCm39) missense probably damaging 1.00
R8332:Lrp1 UTSW 10 127,407,805 (GRCm39) missense probably damaging 1.00
R8435:Lrp1 UTSW 10 127,392,199 (GRCm39) missense probably damaging 0.97
R8467:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8468:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8474:Lrp1 UTSW 10 127,375,572 (GRCm39) missense probably damaging 1.00
R8481:Lrp1 UTSW 10 127,404,779 (GRCm39) missense probably damaging 1.00
R8483:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8485:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8488:Lrp1 UTSW 10 127,396,356 (GRCm39) missense probably damaging 1.00
R8715:Lrp1 UTSW 10 127,396,490 (GRCm39) missense possibly damaging 0.77
R8790:Lrp1 UTSW 10 127,374,946 (GRCm39) missense probably damaging 1.00
R8854:Lrp1 UTSW 10 127,378,968 (GRCm39) missense probably damaging 1.00
R8926:Lrp1 UTSW 10 127,381,671 (GRCm39) missense probably benign
R8949:Lrp1 UTSW 10 127,425,405 (GRCm39) intron probably benign
R8971:Lrp1 UTSW 10 127,391,896 (GRCm39) missense possibly damaging 0.94
R9103:Lrp1 UTSW 10 127,430,979 (GRCm39) nonsense probably null
R9108:Lrp1 UTSW 10 127,390,206 (GRCm39) missense probably damaging 0.99
R9130:Lrp1 UTSW 10 127,382,281 (GRCm39) missense probably benign 0.18
R9157:Lrp1 UTSW 10 127,410,209 (GRCm39) missense probably damaging 1.00
R9162:Lrp1 UTSW 10 127,441,368 (GRCm39) missense probably benign 0.32
R9205:Lrp1 UTSW 10 127,430,850 (GRCm39) nonsense probably null
R9228:Lrp1 UTSW 10 127,382,807 (GRCm39) missense probably damaging 0.98
R9231:Lrp1 UTSW 10 127,382,268 (GRCm39) missense probably benign 0.06
R9287:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R9381:Lrp1 UTSW 10 127,441,337 (GRCm39) missense probably benign 0.17
R9412:Lrp1 UTSW 10 127,409,287 (GRCm39) missense probably damaging 1.00
R9434:Lrp1 UTSW 10 127,381,689 (GRCm39) missense possibly damaging 0.93
R9463:Lrp1 UTSW 10 127,429,334 (GRCm39) nonsense probably null
R9526:Lrp1 UTSW 10 127,431,229 (GRCm39) missense probably damaging 0.96
R9548:Lrp1 UTSW 10 127,388,733 (GRCm39) missense probably damaging 0.99
R9599:Lrp1 UTSW 10 127,410,246 (GRCm39) missense probably damaging 1.00
R9649:Lrp1 UTSW 10 127,409,368 (GRCm39) missense probably benign 0.14
R9687:Lrp1 UTSW 10 127,402,562 (GRCm39) missense probably damaging 1.00
R9707:Lrp1 UTSW 10 127,408,414 (GRCm39) missense probably benign 0.08
R9770:Lrp1 UTSW 10 127,420,268 (GRCm39) missense probably damaging 1.00
V3553:Lrp1 UTSW 10 127,407,311 (GRCm39) missense probably damaging 1.00
Y5406:Lrp1 UTSW 10 127,390,152 (GRCm39) missense probably damaging 1.00
Z1088:Lrp1 UTSW 10 127,420,248 (GRCm39) missense probably damaging 1.00
Z1176:Lrp1 UTSW 10 127,390,831 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCTTGACGAACAGATGGGG -3'
(R):5'- GCTGGATAATGGCACCTGTGTG -3'

Sequencing Primer
(F):5'- CTTGACGAACAGATGGGGTTGAAG -3'
(R):5'- ACCTGTGTGCCTGTGCC -3'
Posted On 2019-05-13