Incidental Mutation 'R7052:Ighg2c'
ID 547673
Institutional Source Beutler Lab
Gene Symbol Ighg2c
Ensembl Gene ENSMUSG00000076612
Gene Name immunoglobulin heavy constant gamma 2C
Synonyms
MMRRC Submission 045149-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R7052 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 113251009-113252552 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 113252343 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 70 (T70A)
Gene Model predicted gene model for transcript(s):
AlphaFold no structure available at present
Predicted Effect
SMART Domains Protein: ENSMUSP00000100212
Gene: ENSMUSG00000076612
AA Change: T70A

DomainStartEndE-ValueType
IGc1 21 91 2.4e-15 SMART
IG_like 143 218 1.64e-2 SMART
IGc1 249 322 1.97e-34 SMART
transmembrane domain 350 372 N/A INTRINSIC
Predicted Effect
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (63/63)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 C T 6: 142,604,261 (GRCm39) R658H probably benign Het
Als2cl C T 9: 110,727,151 (GRCm39) R906C probably damaging Het
Asb8 T C 15: 98,034,282 (GRCm39) H91R probably damaging Het
Atp8b3 C T 10: 80,355,858 (GRCm39) E1285K probably benign Het
Bves G A 10: 45,222,386 (GRCm39) R172H possibly damaging Het
C6 A T 15: 4,763,177 (GRCm39) N59I probably damaging Het
Capn15 A T 17: 26,180,724 (GRCm39) V782D probably damaging Het
Ccdc168 T A 1: 44,096,466 (GRCm39) Y1544F possibly damaging Het
Ccdc18 T C 5: 108,309,554 (GRCm39) L383S probably benign Het
Coro6 C A 11: 77,357,056 (GRCm39) N119K probably benign Het
Cps1 T A 1: 67,237,569 (GRCm39) D1023E probably damaging Het
Dctn1 T A 6: 83,172,262 (GRCm39) probably null Het
Ero1a T A 14: 45,544,040 (GRCm39) K55* probably null Het
Fam209 G A 2: 172,314,751 (GRCm39) G80D possibly damaging Het
Fam89b G A 19: 5,779,276 (GRCm39) R94C probably damaging Het
Fut1 A G 7: 45,269,181 (GRCm39) *323W probably null Het
Garin2 C T 12: 78,766,176 (GRCm39) T315I probably benign Het
Gm47985 T A 1: 151,058,890 (GRCm39) F177Y possibly damaging Het
Gstm7 T A 3: 107,838,633 (GRCm39) D37V probably damaging Het
H2-Aa T A 17: 34,503,484 (GRCm39) S38C possibly damaging Het
Ino80 A G 2: 119,257,068 (GRCm39) probably null Het
Irf8 C T 8: 121,466,581 (GRCm39) R9W probably damaging Het
Kcnt2 A G 1: 140,310,785 (GRCm39) N197S probably damaging Het
Kif11 T A 19: 37,373,040 (GRCm39) C86* probably null Het
Lonp1 A T 17: 56,933,549 (GRCm39) F109I probably benign Het
Mlkl G A 8: 112,046,074 (GRCm39) S312L possibly damaging Het
Mroh9 T A 1: 162,866,525 (GRCm39) Q706L possibly damaging Het
Mtmr7 T C 8: 41,008,874 (GRCm39) H315R possibly damaging Het
Myh7b G C 2: 155,456,053 (GRCm39) R146P probably damaging Het
Naip5 A G 13: 100,358,855 (GRCm39) Y794H probably benign Het
Nup153 A T 13: 46,840,949 (GRCm39) N886K probably benign Het
Nup205 A G 6: 35,192,077 (GRCm39) R1047G possibly damaging Het
Oog3 A T 4: 143,887,027 (GRCm39) L31Q probably damaging Het
Or5b123 T A 19: 13,596,990 (GRCm39) S155T probably benign Het
Or6c38 T C 10: 128,929,744 (GRCm39) Y33C probably damaging Het
Palmd T C 3: 116,717,012 (GRCm39) N495S probably benign Het
Patj A G 4: 98,565,497 (GRCm39) Q1070R probably benign Het
Pax1 G A 2: 147,207,824 (GRCm39) R232H probably damaging Het
Pcdhb1 A G 18: 37,399,582 (GRCm39) N511S probably damaging Het
Pigs C T 11: 78,232,211 (GRCm39) L448F probably damaging Het
Pih1d2 A G 9: 50,533,077 (GRCm39) Y235C probably damaging Het
Pkd2l2 T A 18: 34,558,212 (GRCm39) I297K possibly damaging Het
Pou2f1 C T 1: 165,742,684 (GRCm39) V82I possibly damaging Het
Pramel1 T C 4: 143,123,074 (GRCm39) L17P probably damaging Het
Riok1 C T 13: 38,220,991 (GRCm39) probably benign Het
Scg3 C A 9: 75,568,664 (GRCm39) E358* probably null Het
Siglec15 T C 18: 78,091,946 (GRCm39) E85G probably damaging Het
Snx20 T C 8: 89,356,606 (GRCm39) H70R probably benign Het
Spi1 T A 2: 90,943,685 (GRCm39) S76R probably damaging Het
Stat5a T C 11: 100,770,111 (GRCm39) S463P probably damaging Het
Svs5 A G 2: 164,080,126 (GRCm39) I13T unknown Het
Tmem132e T C 11: 82,328,189 (GRCm39) S406P probably damaging Het
Top1mt T C 15: 75,540,560 (GRCm39) N237S possibly damaging Het
Trav6d-4 G A 14: 52,991,053 (GRCm39) V30M possibly damaging Het
Trp73 A T 4: 154,149,140 (GRCm39) M217K probably damaging Het
Vmn1r58 A G 7: 5,414,134 (GRCm39) I32T probably benign Het
Vmn1r9 T C 6: 57,048,396 (GRCm39) M157T probably benign Het
Vmn2r100 C T 17: 19,751,556 (GRCm39) S533F possibly damaging Het
Vmn2r112 T A 17: 22,821,507 (GRCm39) M160K probably benign Het
Vps13d C A 4: 144,889,914 (GRCm39) A597S probably benign Het
Zfp27 AATCCGCTTGTGCA AA 7: 29,594,446 (GRCm39) probably benign Het
Other mutations in Ighg2c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02087:Ighg2c APN 12 113,248,986 (GRCm39) unclassified probably benign
IGL02560:Ighg2c APN 12 113,251,504 (GRCm39) missense unknown
IGL03339:Ighg2c APN 12 113,251,614 (GRCm39) missense unknown
R0047:Ighg2c UTSW 12 113,251,788 (GRCm39) splice site probably benign
R0047:Ighg2c UTSW 12 113,251,788 (GRCm39) splice site probably benign
R0415:Ighg2c UTSW 12 113,251,530 (GRCm39) missense unknown
R0571:Ighg2c UTSW 12 113,252,382 (GRCm39) nonsense probably null
R0634:Ighg2c UTSW 12 113,251,584 (GRCm39) missense unknown
R0893:Ighg2c UTSW 12 113,251,053 (GRCm39) missense unknown
R1169:Ighg2c UTSW 12 113,249,572 (GRCm39) unclassified probably benign
R3895:Ighg2c UTSW 12 113,251,278 (GRCm39) missense unknown
R5065:Ighg2c UTSW 12 113,251,708 (GRCm39) missense unknown
R6407:Ighg2c UTSW 12 113,252,271 (GRCm39) missense unknown
R6846:Ighg2c UTSW 12 113,251,930 (GRCm39) missense unknown
R7231:Ighg2c UTSW 12 113,251,636 (GRCm39) missense
R7513:Ighg2c UTSW 12 113,252,471 (GRCm39) missense
R8783:Ighg2c UTSW 12 113,252,412 (GRCm39) missense
R9175:Ighg2c UTSW 12 113,252,499 (GRCm39) missense
R9419:Ighg2c UTSW 12 113,251,015 (GRCm39) critical splice donor site probably benign
Z1177:Ighg2c UTSW 12 113,251,300 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- GTCAGAGGCAGTATCTCCTTCTC -3'
(R):5'- AACAGCCCCATCGGTCTATC -3'

Sequencing Primer
(F):5'- AAGTTCCCTTTCCTGGTGATGGC -3'
(R):5'- ATCGGTCTATCCACTGGCC -3'
Posted On 2019-05-13