Mutagenetix > Incidental Mutation

Incidental Mutation 'R7030:Lrp1'

546253

Institutional Source

Beutler Lab

Gene Symbol

Lrp1

Ensembl Gene

ENSMUSG00000040249

Gene Name

low density lipoprotein receptor-related protein 1

Synonyms

b2b1554Clo, CD91, A2mr

MMRRC Submission

045131-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R7030 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

127374030-127457017 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 127388745 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 3235 (I3235V)

Ref Sequence

ENSEMBL: ENSMUSP00000044004 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049149] [ENSMUST00000129727]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000049149
AA Change: I3235V

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000044004
Gene: ENSMUSG00000040249
AA Change: I3235V

Domain	Start	End	E-Value	Type
low complexity region	2	13	N/A	INTRINSIC
LDLa	27	67	1.03e-15	SMART
LDLa	72	111	1.04e-11	SMART
EGF	115	150	8.78e-2	SMART
EGF_CA	151	190	4.49e-8	SMART
low complexity region	222	232	N/A	INTRINSIC
LY	273	315	7.07e-6	SMART
LY	316	359	2.31e-10	SMART
LY	360	402	8.3e-12	SMART
EGF	478	521	9.93e-1	SMART
LY	552	594	8.84e-7	SMART
LY	595	638	6.54e-10	SMART
LY	641	690	2.5e-15	SMART
LY	691	734	1.06e-9	SMART
EGF	807	844	1.38e1	SMART
LDLa	854	893	3.39e-16	SMART
LDLa	895	934	1.73e-13	SMART
LDLa	936	974	4.47e-16	SMART
LDLa	976	1014	2.53e-15	SMART
LDLa	1015	1054	2.95e-16	SMART
LDLa	1062	1100	3.24e-13	SMART
LDLa	1104	1143	2.97e-12	SMART
LDLa	1145	1185	1.24e-9	SMART
EGF	1185	1223	4.97e-1	SMART
EGF	1227	1263	6.02e0	SMART
LY	1290	1332	3.76e-1	SMART
LY	1337	1379	8.56e-14	SMART
LY	1380	1424	8.43e-13	SMART
LY	1425	1469	3.05e-10	SMART
LY	1471	1513	3.88e-3	SMART
EGF	1540	1580	1.85e0	SMART
LY	1606	1650	2.83e-5	SMART
LY	1651	1695	2.01e-10	SMART
LY	1698	1735	1.87e-5	SMART
LY	1736	1777	3.54e-6	SMART
LY	1778	1820	4.17e1	SMART
EGF	1850	1888	1.24e-1	SMART
LY	1915	1957	3.2e-4	SMART
LY	1958	2000	2.33e-15	SMART
LY	2001	2044	7.45e-14	SMART
LY	2045	2087	3.87e-12	SMART
LY	2089	2131	1.37e0	SMART
EGF	2159	2196	1.66e1	SMART
LY	2276	2318	5.57e-4	SMART
LY	2324	2369	3.3e-6	SMART
LY	2370	2412	3.93e-13	SMART
LY	2413	2454	3.62e-3	SMART
EGF_like	2482	2519	3.16e1	SMART
LDLa	2524	2564	3.31e-10	SMART
LDLa	2566	2603	7.21e-11	SMART
LDLa	2605	2642	1.09e-10	SMART
LDLa	2660	2691	6.05e-4	SMART
LDLa	2696	2733	2.49e-14	SMART
LDLa	2734	2772	4.65e-14	SMART
LDLa	2774	2815	3.92e-12	SMART
LDLa	2818	2856	1.51e-13	SMART
LDLa	2858	2900	1.93e-11	SMART
LDLa	2904	2942	1.73e-13	SMART
EGF_CA	2941	2982	6.16e-6	SMART
EGF_CA	2983	3023	2.66e-10	SMART
LY	3050	3094	6.64e-11	SMART
LY	3095	3137	7.17e-16	SMART
LY	3138	3181	4.28e-14	SMART
LY	3182	3224	8.11e-15	SMART
LY	3225	3265	1.44e-6	SMART
EGF	3294	3332	1.02e-2	SMART
LDLa	3334	3372	2.25e-12	SMART
LDLa	3374	3411	9.81e-13	SMART
LDLa	3413	3451	9.81e-13	SMART
LDLa	3453	3492	5.67e-18	SMART
LDLa	3494	3534	7.15e-15	SMART
LDLa	3536	3573	1.79e-15	SMART
EGF_like	3575	3611	4.83e1	SMART
LDLa	3575	3612	1.92e-15	SMART
LDLa	3613	3650	1.18e-15	SMART
LDLa	3654	3693	7.55e-14	SMART
LDLa	3695	3734	1.14e-8	SMART
LDLa	3741	3779	6.28e-11	SMART
EGF	3785	3824	1.06e1	SMART
EGF	3828	3862	1.51e0	SMART
LY	3893	3935	9.43e0	SMART
LY	3951	3993	1.23e-14	SMART
LY	3994	4037	2.98e-13	SMART
LY	4038	4080	4.28e-14	SMART
EGF	4151	4184	3.76e-1	SMART
low complexity region	4185	4198	N/A	INTRINSIC
EGF	4200	4233	3.82e-2	SMART
EGF	4236	4269	4.03e-1	SMART
EGF	4272	4305	5.2e-4	SMART
EGF	4308	4341	1.22e0	SMART
EGF_like	4344	4376	4.11e1	SMART
EGF	4377	4410	5.12e-3	SMART
transmembrane domain	4423	4445	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000129727

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

98% (92/94)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit lethality during late organogenesis. [provided by MGI curators]

Allele List at MGI

All alleles(42) : Targeted(9) Gene trapped(33)

Other mutations in this stock

Total: 93 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AAdacl4fm3	G	T	4: 144,430,173 (GRCm39)	A272D	possibly damaging	Het
Abr	A	T	11: 76,350,038 (GRCm39)	I347N	probably damaging	Het
Acbd4	T	A	11: 102,994,985 (GRCm39)	L50Q	probably damaging	Het
Acsl5	T	G	19: 55,261,251 (GRCm39)	Y69*	probably null	Het
Agtpbp1	G	A	13: 59,652,108 (GRCm39)	T401I	probably damaging	Het
Ap3m2	C	T	8: 23,289,807 (GRCm39)	E99K	probably damaging	Het
Arhgef28	A	T	13: 98,124,769 (GRCm39)	S504R	possibly damaging	Het
Arsj	T	A	3: 126,232,752 (GRCm39)	D499E	probably damaging	Het
Bach1	G	A	16: 87,516,179 (GRCm39)	R240Q	probably benign	Het
Camk2b	T	C	11: 5,939,575 (GRCm39)	D232G	probably damaging	Het
Casc3	C	T	11: 98,713,359 (GRCm39)	P258S	possibly damaging	Het
Catspere2	T	A	1: 177,845,280 (GRCm39)	I100N	probably damaging	Het
Ccdc80	T	A	16: 44,943,252 (GRCm39)	N787K	possibly damaging	Het
Celsr1	C	A	15: 85,789,679 (GRCm39)	C2653F	probably damaging	Het
Cep170	T	C	1: 176,584,051 (GRCm39)	E11G	probably damaging	Het
Chia1	A	C	3: 106,022,641 (GRCm39)	N12H	probably damaging	Het
Chrna4	T	C	2: 180,671,334 (GRCm39)	T141A	probably damaging	Het
Col25a1	T	C	3: 130,272,671 (GRCm39)		probably null	Het
Dcstamp	A	T	15: 39,622,929 (GRCm39)	I417F	probably damaging	Het
Dnah5	A	G	15: 28,238,738 (GRCm39)	I427V	probably benign	Het
Dnah5	A	G	15: 28,333,208 (GRCm39)	E2203G	probably benign	Het
Dnmt3c	A	T	2: 153,559,345 (GRCm39)	S409C	probably damaging	Het
Dock6	A	T	9: 21,724,375 (GRCm39)	M1541K	probably damaging	Het
Dzip1l	C	T	9: 99,547,888 (GRCm39)	T714I	probably benign	Het
Exoc6b	T	C	6: 84,825,807 (GRCm39)	R535G	probably damaging	Het
Fam83h	A	G	15: 75,876,588 (GRCm39)	S250P	probably benign	Het
Fat4	C	T	3: 39,036,107 (GRCm39)	T3253I	probably damaging	Het
Fer1l6	T	A	15: 58,501,227 (GRCm39)	F1302I	probably damaging	Het
Fmnl1	T	G	11: 103,085,600 (GRCm39)		probably benign	Het
Gckr	C	A	5: 31,459,554 (GRCm39)	F201L	possibly damaging	Het
Gm10036	A	G	18: 15,966,292 (GRCm39)	T148A	probably benign	Het
Gm5142	G	A	14: 59,415,909 (GRCm39)	S83F	probably benign	Het
Gpr37	A	T	6: 25,689,004 (GRCm39)	V31D	possibly damaging	Het
Gramd2b	A	T	18: 56,618,321 (GRCm39)	Y207F	probably damaging	Het
Hr	T	C	14: 70,801,124 (GRCm39)		probably null	Het
Igf2r	A	G	17: 12,952,753 (GRCm39)	L231P	probably damaging	Het
Ighv1-66	A	T	12: 115,557,157 (GRCm39)	W3R	probably damaging	Het
Insyn2b	T	A	11: 34,352,030 (GRCm39)	V24E	probably damaging	Het
Kcnu1	T	C	8: 26,408,491 (GRCm39)	S101P	probably benign	Het
Klhl23	T	G	2: 69,664,310 (GRCm39)	V553G	probably damaging	Het
Mb	A	T	15: 76,900,256 (GRCm39)	I57N	probably damaging	Het
Micu1	T	C	10: 59,624,843 (GRCm39)	I295T	possibly damaging	Het
Mink1	G	A	11: 70,498,601 (GRCm39)	V589I	possibly damaging	Het
Mndal	T	C	1: 173,703,160 (GRCm39)	K82E	probably damaging	Het
Mroh1	A	C	15: 76,321,517 (GRCm39)	K1066T	probably benign	Het
Muc5b	T	A	7: 141,396,192 (GRCm39)	N149K	unknown	Het
Myo7b	G	T	18: 32,104,626 (GRCm39)	L1404I	probably damaging	Het
Nlrc4	A	G	17: 74,753,001 (GRCm39)	S461P	probably damaging	Het
Nudt12	A	T	17: 59,310,348 (GRCm39)	D418E	probably benign	Het
Or2g7	T	A	17: 38,378,948 (GRCm39)	D295E	probably benign	Het
Or5g27	G	T	2: 85,409,746 (GRCm39)	R54S	possibly damaging	Het
Pcdha1	A	G	18: 37,292,326 (GRCm39)	H817R	probably damaging	Het
Pcdha4	A	G	18: 37,087,080 (GRCm39)	Y421C	probably damaging	Het
Pcf11	T	C	7: 92,306,886 (GRCm39)	D1094G	probably benign	Het
Pck2	A	T	14: 55,785,223 (GRCm39)	D427V	probably damaging	Het
Pclo	A	G	5: 14,726,421 (GRCm39)	T1760A	probably benign	Het
Pdzk1ip1	T	A	4: 114,950,188 (GRCm39)	Y83N	probably damaging	Het
Pgs1	T	C	11: 117,893,312 (GRCm39)	I213T	probably damaging	Het
Plin4	T	A	17: 56,410,969 (GRCm39)	T1021S	probably damaging	Het
Plxnb1	T	A	9: 108,941,375 (GRCm39)	I1677N	probably damaging	Het
Pm20d2	T	C	4: 33,174,752 (GRCm39)	E378G	possibly damaging	Het
Prkcq	T	G	2: 11,231,661 (GRCm39)		probably null	Het
Psmd2	C	T	16: 20,480,883 (GRCm39)	P780L	probably damaging	Het
Pvr	A	G	7: 19,639,105 (GRCm39)	S392P	possibly damaging	Het
Rad51ap2	G	C	12: 11,507,432 (GRCm39)	L451F	possibly damaging	Het
Rbm20	A	G	19: 53,823,197 (GRCm39)	E598G	probably damaging	Het
Rho	A	T	6: 115,912,504 (GRCm39)	N123Y	possibly damaging	Het
Rictor	T	C	15: 6,737,934 (GRCm39)		probably null	Het
Rilpl2	T	G	5: 124,606,656 (GRCm39)	K186T	probably damaging	Het
Rps6ka4	A	C	19: 6,816,992 (GRCm39)	L61R	probably damaging	Het
Sds	C	A	5: 120,618,890 (GRCm39)	Q118K	probably benign	Het
Septin1	C	T	7: 126,816,157 (GRCm39)	R91K	probably benign	Het
Sf3a3	A	G	4: 124,616,673 (GRCm39)	Y185C	probably damaging	Het
Shtn1	T	C	19: 58,998,266 (GRCm39)	M376V	possibly damaging	Het
Slc6a9	A	G	4: 117,714,633 (GRCm39)	T189A	possibly damaging	Het
Slc7a6	T	G	8: 106,922,606 (GRCm39)	V464G	possibly damaging	Het
Smg8	T	A	11: 86,975,919 (GRCm39)	D554V	probably damaging	Het
Sox8	A	G	17: 25,789,082 (GRCm39)		probably null	Het
Spata31e4	G	T	13: 50,857,019 (GRCm39)	V886L	possibly damaging	Het
Spats2l	T	A	1: 57,918,689 (GRCm39)	V41D	probably damaging	Het
Sult2a3	A	T	7: 13,801,493 (GRCm39)	F282Y	probably damaging	Het
Svs3a	T	G	2: 164,132,091 (GRCm39)	Y220D	probably damaging	Het
Teddm1a	T	A	1: 153,768,369 (GRCm39)	Y278N	probably damaging	Het
Tlk1	T	C	2: 70,552,272 (GRCm39)	Y526C	probably damaging	Het
Tmc3	T	A	7: 83,266,025 (GRCm39)		probably null	Het
Ttn	T	A	2: 76,596,583 (GRCm39)	E20110V	probably damaging	Het
Tulp4	A	G	17: 6,264,941 (GRCm39)	D235G	probably damaging	Het
Usp50	T	C	2: 126,622,395 (GRCm39)	Y55C	possibly damaging	Het
Vmn1r224	T	C	17: 20,639,789 (GRCm39)	L122P	probably benign	Het
Vmn2r62	A	G	7: 42,438,473 (GRCm39)	L121P	possibly damaging	Het
Whrn	G	T	4: 63,413,368 (GRCm39)		probably benign	Het
Zer1	G	T	2: 30,001,033 (GRCm39)	H129Q	probably benign	Het
Zfand4	G	A	6: 116,282,618 (GRCm39)	A64T	probably benign	Het

Other mutations in Lrp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00793:Lrp1	APN	10	127,378,074 (GRCm39)	missense	possibly damaging	0.89
IGL01065:Lrp1	APN	10	127,410,907 (GRCm39)	missense	probably benign	0.10
IGL01121:Lrp1	APN	10	127,419,722 (GRCm39)	nonsense	probably null
IGL01360:Lrp1	APN	10	127,381,689 (GRCm39)	missense	possibly damaging	0.93
IGL01402:Lrp1	APN	10	127,430,901 (GRCm39)	missense	probably damaging	1.00
IGL01404:Lrp1	APN	10	127,430,901 (GRCm39)	missense	probably damaging	1.00
IGL01411:Lrp1	APN	10	127,417,634 (GRCm39)	nonsense	probably null
IGL01469:Lrp1	APN	10	127,420,283 (GRCm39)	missense	probably damaging	1.00
IGL01552:Lrp1	APN	10	127,424,379 (GRCm39)	nonsense	probably null
IGL01682:Lrp1	APN	10	127,410,847 (GRCm39)	missense	probably benign	0.00
IGL01760:Lrp1	APN	10	127,409,370 (GRCm39)	missense	probably benign	0.00
IGL01918:Lrp1	APN	10	127,390,458 (GRCm39)	missense	probably damaging	0.99
IGL01989:Lrp1	APN	10	127,413,998 (GRCm39)	missense	probably damaging	1.00
IGL02105:Lrp1	APN	10	127,380,448 (GRCm39)	missense	probably damaging	1.00
IGL02158:Lrp1	APN	10	127,390,140 (GRCm39)	missense	probably benign	0.02
IGL02164:Lrp1	APN	10	127,399,536 (GRCm39)	missense	probably benign	0.39
IGL02337:Lrp1	APN	10	127,412,756 (GRCm39)	missense	possibly damaging	0.87
IGL02425:Lrp1	APN	10	127,407,756 (GRCm39)	critical splice donor site	probably null
IGL02493:Lrp1	APN	10	127,417,647 (GRCm39)	missense	probably damaging	0.99
IGL02563:Lrp1	APN	10	127,387,555 (GRCm39)	missense	probably damaging	1.00
IGL02590:Lrp1	APN	10	127,388,660 (GRCm39)	missense	probably damaging	1.00
IGL02624:Lrp1	APN	10	127,408,291 (GRCm39)	missense	probably damaging	0.98
IGL02625:Lrp1	APN	10	127,410,355 (GRCm39)	missense	probably damaging	1.00
IGL02825:Lrp1	APN	10	127,378,474 (GRCm39)	missense	probably damaging	1.00
IGL02880:Lrp1	APN	10	127,376,091 (GRCm39)	missense	probably benign	0.12
IGL02900:Lrp1	APN	10	127,412,516 (GRCm39)	splice site	probably benign
IGL02956:Lrp1	APN	10	127,380,428 (GRCm39)	missense	probably benign	0.00
IGL02974:Lrp1	APN	10	127,390,885 (GRCm39)	missense	probably damaging	0.99
IGL02983:Lrp1	APN	10	127,386,068 (GRCm39)	missense	probably damaging	1.00
IGL03002:Lrp1	APN	10	127,425,505 (GRCm39)	missense	probably damaging	1.00
IGL03091:Lrp1	APN	10	127,394,993 (GRCm39)	missense	probably benign	0.30
IGL03109:Lrp1	APN	10	127,402,514 (GRCm39)	missense	probably benign
IGL03194:Lrp1	APN	10	127,404,554 (GRCm39)	missense	probably damaging	1.00
IGL03232:Lrp1	APN	10	127,375,245 (GRCm39)	missense	probably damaging	1.00
calculus	UTSW	10	127,393,937 (GRCm39)	splice site	probably null
Delimiter	UTSW	10	127,382,731 (GRCm39)	missense	probably damaging	1.00
extremis	UTSW	10	127,392,857 (GRCm39)	missense	probably benign	0.00
Jockey	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
peripheral	UTSW	10	127,446,250 (GRCm39)	missense	probably damaging	1.00
tangential	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
P0015:Lrp1	UTSW	10	127,402,532 (GRCm39)	missense	probably damaging	0.99
PIT4519001:Lrp1	UTSW	10	127,443,843 (GRCm39)	missense	possibly damaging	0.91
PIT4520001:Lrp1	UTSW	10	127,443,843 (GRCm39)	missense	possibly damaging	0.91
R0004:Lrp1	UTSW	10	127,377,694 (GRCm39)	splice site	probably null
R0034:Lrp1	UTSW	10	127,381,520 (GRCm39)	missense	probably benign	0.42
R0091:Lrp1	UTSW	10	127,376,848 (GRCm39)	missense	probably damaging	1.00
R0098:Lrp1	UTSW	10	127,388,607 (GRCm39)	missense	probably benign
R0098:Lrp1	UTSW	10	127,388,607 (GRCm39)	missense	probably benign
R0143:Lrp1	UTSW	10	127,429,811 (GRCm39)	missense	probably damaging	1.00
R0372:Lrp1	UTSW	10	127,428,005 (GRCm39)	missense	probably damaging	1.00
R0379:Lrp1	UTSW	10	127,430,838 (GRCm39)	missense	probably damaging	1.00
R0445:Lrp1	UTSW	10	127,426,505 (GRCm39)	nonsense	probably null
R0529:Lrp1	UTSW	10	127,377,463 (GRCm39)	splice site	probably null
R0551:Lrp1	UTSW	10	127,407,827 (GRCm39)	missense	probably benign
R0570:Lrp1	UTSW	10	127,390,878 (GRCm39)	nonsense	probably null
R0600:Lrp1	UTSW	10	127,403,252 (GRCm39)	missense	probably benign	0.00
R0626:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R0647:Lrp1	UTSW	10	127,407,346 (GRCm39)	missense	probably damaging	1.00
R0680:Lrp1	UTSW	10	127,425,530 (GRCm39)	missense	probably damaging	1.00
R0792:Lrp1	UTSW	10	127,411,155 (GRCm39)	missense	probably benign	0.04
R0792:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R0848:Lrp1	UTSW	10	127,389,231 (GRCm39)	splice site	probably null
R0866:Lrp1	UTSW	10	127,375,147 (GRCm39)	missense	probably damaging	1.00
R0918:Lrp1	UTSW	10	127,429,834 (GRCm39)	missense	probably damaging	1.00
R1076:Lrp1	UTSW	10	127,399,666 (GRCm39)	splice site	probably benign
R1107:Lrp1	UTSW	10	127,393,304 (GRCm39)	missense	probably damaging	1.00
R1346:Lrp1	UTSW	10	127,441,735 (GRCm39)	missense	probably damaging	1.00
R1403:Lrp1	UTSW	10	127,417,760 (GRCm39)	critical splice acceptor site	probably null
R1403:Lrp1	UTSW	10	127,417,760 (GRCm39)	critical splice acceptor site	probably null
R1496:Lrp1	UTSW	10	127,374,880 (GRCm39)	missense	probably damaging	1.00
R1522:Lrp1	UTSW	10	127,411,155 (GRCm39)	missense	probably benign	0.04
R1522:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R1525:Lrp1	UTSW	10	127,375,398 (GRCm39)	missense	probably damaging	1.00
R1539:Lrp1	UTSW	10	127,420,250 (GRCm39)	splice site	probably null
R1589:Lrp1	UTSW	10	127,441,475 (GRCm39)	missense	probably benign	0.00
R1591:Lrp1	UTSW	10	127,441,475 (GRCm39)	missense	probably benign	0.00
R1663:Lrp1	UTSW	10	127,392,790 (GRCm39)	missense	probably damaging	1.00
R1682:Lrp1	UTSW	10	127,410,201 (GRCm39)	missense	probably damaging	1.00
R1717:Lrp1	UTSW	10	127,399,534 (GRCm39)	missense	probably damaging	1.00
R1717:Lrp1	UTSW	10	127,392,138 (GRCm39)	missense	possibly damaging	0.59
R1758:Lrp1	UTSW	10	127,424,453 (GRCm39)	missense	possibly damaging	0.76
R1826:Lrp1	UTSW	10	127,389,576 (GRCm39)	missense	probably damaging	1.00
R1842:Lrp1	UTSW	10	127,409,337 (GRCm39)	missense	possibly damaging	0.93
R1844:Lrp1	UTSW	10	127,431,152 (GRCm39)	critical splice donor site	probably null
R1845:Lrp1	UTSW	10	127,414,542 (GRCm39)	missense	probably damaging	1.00
R1896:Lrp1	UTSW	10	127,395,867 (GRCm39)	missense	possibly damaging	0.64
R1952:Lrp1	UTSW	10	127,403,300 (GRCm39)	missense	probably damaging	1.00
R2009:Lrp1	UTSW	10	127,380,385 (GRCm39)	missense	probably damaging	1.00
R2015:Lrp1	UTSW	10	127,376,563 (GRCm39)	missense	probably benign	0.00
R2116:Lrp1	UTSW	10	127,412,362 (GRCm39)	nonsense	probably null
R2161:Lrp1	UTSW	10	127,391,607 (GRCm39)	missense	probably damaging	1.00
R2199:Lrp1	UTSW	10	127,382,709 (GRCm39)	missense	probably damaging	1.00
R2213:Lrp1	UTSW	10	127,376,571 (GRCm39)	missense	probably damaging	1.00
R2300:Lrp1	UTSW	10	127,392,784 (GRCm39)	nonsense	probably null
R2324:Lrp1	UTSW	10	127,402,455 (GRCm39)	missense	possibly damaging	0.92
R2849:Lrp1	UTSW	10	127,378,165 (GRCm39)	missense	probably damaging	1.00
R2926:Lrp1	UTSW	10	127,423,982 (GRCm39)	missense	probably damaging	0.98
R2993:Lrp1	UTSW	10	127,446,250 (GRCm39)	missense	probably damaging	1.00
R3522:Lrp1	UTSW	10	127,389,424 (GRCm39)	missense	probably damaging	1.00
R3702:Lrp1	UTSW	10	127,430,972 (GRCm39)	missense	probably damaging	1.00
R3789:Lrp1	UTSW	10	127,407,838 (GRCm39)	missense	possibly damaging	0.94
R3898:Lrp1	UTSW	10	127,427,969 (GRCm39)	nonsense	probably null
R3941:Lrp1	UTSW	10	127,389,265 (GRCm39)	missense	probably damaging	1.00
R3958:Lrp1	UTSW	10	127,407,827 (GRCm39)	missense	probably benign
R4369:Lrp1	UTSW	10	127,386,155 (GRCm39)	missense	possibly damaging	0.87
R4510:Lrp1	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
R4511:Lrp1	UTSW	10	127,429,717 (GRCm39)	missense	probably damaging	0.99
R4576:Lrp1	UTSW	10	127,376,057 (GRCm39)	small deletion	probably benign
R4583:Lrp1	UTSW	10	127,377,241 (GRCm39)	missense	probably benign	0.00
R4662:Lrp1	UTSW	10	127,388,054 (GRCm39)	nonsense	probably null
R4721:Lrp1	UTSW	10	127,390,928 (GRCm39)	missense	possibly damaging	0.58
R4728:Lrp1	UTSW	10	127,399,606 (GRCm39)	missense	probably damaging	1.00
R4745:Lrp1	UTSW	10	127,385,813 (GRCm39)	missense	probably benign	0.20
R4785:Lrp1	UTSW	10	127,394,002 (GRCm39)	missense	probably benign	0.12
R4841:Lrp1	UTSW	10	127,419,805 (GRCm39)	missense	probably damaging	1.00
R4842:Lrp1	UTSW	10	127,419,805 (GRCm39)	missense	probably damaging	1.00
R4855:Lrp1	UTSW	10	127,446,311 (GRCm39)	missense	probably benign	0.03
R4860:Lrp1	UTSW	10	127,389,693 (GRCm39)	missense	probably damaging	1.00
R4860:Lrp1	UTSW	10	127,389,693 (GRCm39)	missense	probably damaging	1.00
R4891:Lrp1	UTSW	10	127,377,621 (GRCm39)	missense	probably damaging	1.00
R4925:Lrp1	UTSW	10	127,410,944 (GRCm39)	nonsense	probably null
R4970:Lrp1	UTSW	10	127,375,389 (GRCm39)	missense	probably benign	0.11
R4999:Lrp1	UTSW	10	127,389,648 (GRCm39)	missense	probably damaging	1.00
R5044:Lrp1	UTSW	10	127,403,364 (GRCm39)	missense	probably damaging	1.00
R5127:Lrp1	UTSW	10	127,375,503 (GRCm39)	intron	probably benign
R5188:Lrp1	UTSW	10	127,443,821 (GRCm39)	missense	probably damaging	1.00
R5218:Lrp1	UTSW	10	127,384,488 (GRCm39)	missense	probably damaging	1.00
R5225:Lrp1	UTSW	10	127,391,965 (GRCm39)	missense	probably benign	0.04
R5291:Lrp1	UTSW	10	127,429,747 (GRCm39)	missense	probably damaging	1.00
R5386:Lrp1	UTSW	10	127,427,983 (GRCm39)	missense	probably damaging	1.00
R5395:Lrp1	UTSW	10	127,431,166 (GRCm39)	missense	probably damaging	1.00
R5413:Lrp1	UTSW	10	127,423,936 (GRCm39)	critical splice donor site	probably null
R5430:Lrp1	UTSW	10	127,376,930 (GRCm39)	missense	probably damaging	0.99
R5499:Lrp1	UTSW	10	127,408,813 (GRCm39)	missense	possibly damaging	0.58
R5526:Lrp1	UTSW	10	127,391,593 (GRCm39)	missense	probably benign	0.37
R5580:Lrp1	UTSW	10	127,424,389 (GRCm39)	missense	probably benign
R5583:Lrp1	UTSW	10	127,424,332 (GRCm39)	missense	probably benign	0.08
R5599:Lrp1	UTSW	10	127,429,738 (GRCm39)	missense	probably damaging	1.00
R5639:Lrp1	UTSW	10	127,429,708 (GRCm39)	missense	probably damaging	0.99
R5677:Lrp1	UTSW	10	127,410,298 (GRCm39)	missense	probably damaging	1.00
R5730:Lrp1	UTSW	10	127,419,703 (GRCm39)	missense	probably benign	0.00
R5742:Lrp1	UTSW	10	127,384,216 (GRCm39)	missense	probably damaging	0.98
R5764:Lrp1	UTSW	10	127,431,187 (GRCm39)	missense	probably benign	0.41
R5864:Lrp1	UTSW	10	127,403,374 (GRCm39)	missense	possibly damaging	0.58
R5937:Lrp1	UTSW	10	127,419,745 (GRCm39)	missense	possibly damaging	0.93
R5947:Lrp1	UTSW	10	127,425,423 (GRCm39)	critical splice donor site	probably null
R5976:Lrp1	UTSW	10	127,419,770 (GRCm39)	missense	probably damaging	1.00
R6021:Lrp1	UTSW	10	127,413,883 (GRCm39)	missense	probably damaging	1.00
R6026:Lrp1	UTSW	10	127,409,272 (GRCm39)	missense	probably damaging	1.00
R6045:Lrp1	UTSW	10	127,402,469 (GRCm39)	missense	probably damaging	0.98
R6057:Lrp1	UTSW	10	127,403,359 (GRCm39)	missense	probably damaging	1.00
R6084:Lrp1	UTSW	10	127,396,422 (GRCm39)	missense	probably benign	0.09
R6131:Lrp1	UTSW	10	127,396,026 (GRCm39)	missense	probably benign
R6235:Lrp1	UTSW	10	127,424,046 (GRCm39)	missense	probably damaging	1.00
R6280:Lrp1	UTSW	10	127,425,453 (GRCm39)	missense	probably benign	0.04
R6307:Lrp1	UTSW	10	127,427,944 (GRCm39)	missense	probably damaging	1.00
R6532:Lrp1	UTSW	10	127,377,551 (GRCm39)	missense	probably damaging	1.00
R6532:Lrp1	UTSW	10	127,385,276 (GRCm39)	missense	probably damaging	1.00
R6536:Lrp1	UTSW	10	127,393,937 (GRCm39)	splice site	probably null
R6605:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6607:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6631:Lrp1	UTSW	10	127,410,201 (GRCm39)	missense	probably damaging	1.00
R6676:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6678:Lrp1	UTSW	10	127,396,005 (GRCm39)	missense	probably damaging	1.00
R6809:Lrp1	UTSW	10	127,390,925 (GRCm39)	missense	probably benign	0.04
R6884:Lrp1	UTSW	10	127,394,986 (GRCm39)	missense	probably benign	0.00
R6925:Lrp1	UTSW	10	127,392,857 (GRCm39)	missense	probably benign	0.00
R6987:Lrp1	UTSW	10	127,410,874 (GRCm39)	missense	probably damaging	1.00
R7016:Lrp1	UTSW	10	127,395,836 (GRCm39)	critical splice donor site	probably null
R7053:Lrp1	UTSW	10	127,376,963 (GRCm39)	missense	probably damaging	1.00
R7076:Lrp1	UTSW	10	127,386,052 (GRCm39)	critical splice donor site	probably null
R7136:Lrp1	UTSW	10	127,394,491 (GRCm39)	missense	probably damaging	1.00
R7180:Lrp1	UTSW	10	127,392,834 (GRCm39)	missense	probably damaging	1.00
R7199:Lrp1	UTSW	10	127,409,325 (GRCm39)	missense	probably damaging	0.99
R7219:Lrp1	UTSW	10	127,393,097 (GRCm39)	missense	probably benign	0.40
R7233:Lrp1	UTSW	10	127,430,930 (GRCm39)	missense	probably damaging	1.00
R7251:Lrp1	UTSW	10	127,408,423 (GRCm39)	missense	probably damaging	1.00
R7264:Lrp1	UTSW	10	127,427,962 (GRCm39)	missense	probably damaging	1.00
R7302:Lrp1	UTSW	10	127,374,856 (GRCm39)	missense	probably benign	0.01
R7313:Lrp1	UTSW	10	127,389,337 (GRCm39)	missense	probably damaging	1.00
R7322:Lrp1	UTSW	10	127,381,433 (GRCm39)	missense	probably benign	0.24
R7354:Lrp1	UTSW	10	127,407,277 (GRCm39)	missense	probably damaging	1.00
R7375:Lrp1	UTSW	10	127,375,217 (GRCm39)	missense	probably damaging	1.00
R7388:Lrp1	UTSW	10	127,419,766 (GRCm39)	nonsense	probably null
R7404:Lrp1	UTSW	10	127,418,577 (GRCm39)	missense
R7405:Lrp1	UTSW	10	127,417,620 (GRCm39)	missense	possibly damaging	0.93
R7477:Lrp1	UTSW	10	127,404,789 (GRCm39)	missense	probably damaging	1.00
R7555:Lrp1	UTSW	10	127,382,731 (GRCm39)	missense	probably damaging	1.00
R7600:Lrp1	UTSW	10	127,391,575 (GRCm39)	missense	probably benign
R7678:Lrp1	UTSW	10	127,409,922 (GRCm39)	missense	probably damaging	1.00
R7679:Lrp1	UTSW	10	127,424,297 (GRCm39)	nonsense	probably null
R7951:Lrp1	UTSW	10	127,374,933 (GRCm39)	nonsense	probably null
R7964:Lrp1	UTSW	10	127,410,913 (GRCm39)	missense	possibly damaging	0.94
R8006:Lrp1	UTSW	10	127,425,488 (GRCm39)	missense	probably damaging	1.00
R8021:Lrp1	UTSW	10	127,384,215 (GRCm39)	missense	possibly damaging	0.92
R8098:Lrp1	UTSW	10	127,410,324 (GRCm39)	missense	possibly damaging	0.78
R8112:Lrp1	UTSW	10	127,441,715 (GRCm39)	missense	probably damaging	1.00
R8210:Lrp1	UTSW	10	127,412,354 (GRCm39)	missense	probably damaging	1.00
R8249:Lrp1	UTSW	10	127,441,412 (GRCm39)	missense	probably benign
R8291:Lrp1	UTSW	10	127,425,572 (GRCm39)	missense	probably damaging	1.00
R8332:Lrp1	UTSW	10	127,407,805 (GRCm39)	missense	probably damaging	1.00
R8435:Lrp1	UTSW	10	127,392,199 (GRCm39)	missense	probably damaging	0.97
R8467:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8468:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8474:Lrp1	UTSW	10	127,375,572 (GRCm39)	missense	probably damaging	1.00
R8481:Lrp1	UTSW	10	127,404,779 (GRCm39)	missense	probably damaging	1.00
R8483:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8485:Lrp1	UTSW	10	127,394,519 (GRCm39)	missense	probably damaging	1.00
R8488:Lrp1	UTSW	10	127,396,356 (GRCm39)	missense	probably damaging	1.00
R8715:Lrp1	UTSW	10	127,396,490 (GRCm39)	missense	possibly damaging	0.77
R8790:Lrp1	UTSW	10	127,374,946 (GRCm39)	missense	probably damaging	1.00
R8854:Lrp1	UTSW	10	127,378,968 (GRCm39)	missense	probably damaging	1.00
R8926:Lrp1	UTSW	10	127,381,671 (GRCm39)	missense	probably benign
R8949:Lrp1	UTSW	10	127,425,405 (GRCm39)	intron	probably benign
R8971:Lrp1	UTSW	10	127,391,896 (GRCm39)	missense	possibly damaging	0.94
R9103:Lrp1	UTSW	10	127,430,979 (GRCm39)	nonsense	probably null
R9108:Lrp1	UTSW	10	127,390,206 (GRCm39)	missense	probably damaging	0.99
R9130:Lrp1	UTSW	10	127,382,281 (GRCm39)	missense	probably benign	0.18
R9157:Lrp1	UTSW	10	127,410,209 (GRCm39)	missense	probably damaging	1.00
R9162:Lrp1	UTSW	10	127,441,368 (GRCm39)	missense	probably benign	0.32
R9205:Lrp1	UTSW	10	127,430,850 (GRCm39)	nonsense	probably null
R9228:Lrp1	UTSW	10	127,382,807 (GRCm39)	missense	probably damaging	0.98
R9231:Lrp1	UTSW	10	127,382,268 (GRCm39)	missense	probably benign	0.06
R9287:Lrp1	UTSW	10	127,403,233 (GRCm39)	missense	probably damaging	1.00
R9381:Lrp1	UTSW	10	127,441,337 (GRCm39)	missense	probably benign	0.17
R9412:Lrp1	UTSW	10	127,409,287 (GRCm39)	missense	probably damaging	1.00
R9434:Lrp1	UTSW	10	127,381,689 (GRCm39)	missense	possibly damaging	0.93
R9463:Lrp1	UTSW	10	127,429,334 (GRCm39)	nonsense	probably null
R9526:Lrp1	UTSW	10	127,431,229 (GRCm39)	missense	probably damaging	0.96
R9548:Lrp1	UTSW	10	127,388,733 (GRCm39)	missense	probably damaging	0.99
R9599:Lrp1	UTSW	10	127,410,246 (GRCm39)	missense	probably damaging	1.00
R9649:Lrp1	UTSW	10	127,409,368 (GRCm39)	missense	probably benign	0.14
R9687:Lrp1	UTSW	10	127,402,562 (GRCm39)	missense	probably damaging	1.00
R9707:Lrp1	UTSW	10	127,408,414 (GRCm39)	missense	probably benign	0.08
R9770:Lrp1	UTSW	10	127,420,268 (GRCm39)	missense	probably damaging	1.00
V3553:Lrp1	UTSW	10	127,407,311 (GRCm39)	missense	probably damaging	1.00
Y5406:Lrp1	UTSW	10	127,390,152 (GRCm39)	missense	probably damaging	1.00
Z1088:Lrp1	UTSW	10	127,420,248 (GRCm39)	missense	probably damaging	1.00
Z1176:Lrp1	UTSW	10	127,390,831 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CTGCTCGATTACCATCTGGCTG -3'
(R):5'- TCACACTTCCTGAGAGAAGCTG -3'

Sequencing Primer
(F):5'- TTACCATCTGGCTGGCGCAG -3'
(R):5'- TTCCTGAGAGAAGCTGTGACCTAC -3'

Posted On

2019-05-13