Incidental Mutation 'R7029:Zdhhc14'
ID 546202
Institutional Source Beutler Lab
Gene Symbol Zdhhc14
Ensembl Gene ENSMUSG00000034265
Gene Name zinc finger, DHHC domain containing 14
Synonyms New1cp, B530001K09Rik
MMRRC Submission 045130-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R7029 (G1)
Quality Score 216.009
Status Not validated
Chromosome 17
Chromosomal Location 5542832-5804086 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 5698186 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 85 (Y85C)
Ref Sequence ENSEMBL: ENSMUSP00000086589 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089185]
AlphaFold Q8BQQ1
Predicted Effect probably damaging
Transcript: ENSMUST00000089185
AA Change: Y85C

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000086589
Gene: ENSMUSG00000034265
AA Change: Y85C

DomainStartEndE-ValueType
transmembrane domain 62 81 N/A INTRINSIC
transmembrane domain 91 110 N/A INTRINSIC
Pfam:zf-DHHC 160 289 1.8e-38 PFAM
low complexity region 351 365 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik T C 6: 146,853,841 (GRCm39) Q271R probably benign Het
Abhd4 T A 14: 54,500,164 (GRCm39) W63R probably damaging Het
Adcy5 A G 16: 35,120,018 (GRCm39) M1176V probably null Het
Bach1 G A 16: 87,516,179 (GRCm39) R240Q probably benign Het
Brox G A 1: 183,065,750 (GRCm39) P206L possibly damaging Het
Ccn3 A G 15: 54,611,171 (GRCm39) D102G possibly damaging Het
Def6 A G 17: 28,444,943 (GRCm39) K447R probably benign Het
Dna2 T C 10: 62,799,773 (GRCm39) S726P probably damaging Het
Ell G A 8: 71,031,879 (GRCm39) V15I probably damaging Het
Entrep2 T A 7: 64,409,075 (GRCm39) T440S probably benign Het
Epha3 T A 16: 63,593,698 (GRCm39) D130V probably benign Het
Gys1 A G 7: 45,089,008 (GRCm39) T200A possibly damaging Het
Habp4 A T 13: 64,309,939 (GRCm39) H47L probably benign Het
Iqcn G T 8: 71,161,511 (GRCm39) V235L possibly damaging Het
Kcnj10 C A 1: 172,196,563 (GRCm39) R26S probably benign Het
Klhl1 T A 14: 96,755,632 (GRCm39) D41V probably benign Het
Lyn A G 4: 3,782,996 (GRCm39) T410A probably damaging Het
Mga A G 2: 119,754,031 (GRCm39) T847A probably damaging Het
Mrgpra3 G T 7: 47,239,290 (GRCm39) T212N probably benign Het
Myh4 T C 11: 67,137,251 (GRCm39) F491L probably benign Het
Neurl4 T A 11: 69,801,562 (GRCm39) I1206N probably damaging Het
Pcdhb15 T A 18: 37,608,621 (GRCm39) W618R possibly damaging Het
Pomc A G 12: 4,010,146 (GRCm39) H129R probably damaging Het
Ppm1l C A 3: 69,460,399 (GRCm39) H325Q probably benign Het
Psme4 A G 11: 30,722,474 (GRCm39) probably benign Het
Reep2 A G 18: 34,978,342 (GRCm39) I74V probably null Het
Robo2 T G 16: 73,745,225 (GRCm39) E850A probably damaging Het
Scrn2 T A 11: 96,921,262 (GRCm39) probably benign Het
Sfpq G A 4: 126,923,675 (GRCm39) R673K probably benign Het
Sh2d3c T C 2: 32,644,581 (GRCm39) *703R probably null Het
Spp1 A G 5: 104,587,167 (GRCm39) M85V probably benign Het
Srebf1 T C 11: 60,097,810 (GRCm39) E98G probably damaging Het
Srrm4 T A 5: 116,582,851 (GRCm39) probably benign Het
Ticam1 A T 17: 56,578,154 (GRCm39) S314T possibly damaging Het
Tie1 T C 4: 118,341,823 (GRCm39) I209V possibly damaging Het
Vapa G A 17: 65,889,586 (GRCm39) R194* probably null Het
Vcan C T 13: 89,838,360 (GRCm39) D2395N probably damaging Het
Whamm A G 7: 81,241,574 (GRCm39) H295R probably benign Het
Zfp35 T A 18: 24,136,583 (GRCm39) F309Y probably damaging Het
Zfp423 C A 8: 88,414,694 (GRCm39) C1187F probably damaging Het
Zfp874b T C 13: 67,622,392 (GRCm39) Y302C probably damaging Het
Other mutations in Zdhhc14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00419:Zdhhc14 APN 17 5,802,959 (GRCm39) splice site probably benign
IGL00909:Zdhhc14 APN 17 5,803,067 (GRCm39) missense probably benign
IGL00964:Zdhhc14 APN 17 5,762,756 (GRCm39) missense probably damaging 1.00
IGL01398:Zdhhc14 APN 17 5,762,738 (GRCm39) missense possibly damaging 0.90
IGL01483:Zdhhc14 APN 17 5,762,733 (GRCm39) missense probably benign 0.01
IGL02185:Zdhhc14 APN 17 5,803,157 (GRCm39) missense probably benign 0.01
IGL02801:Zdhhc14 APN 17 5,777,094 (GRCm39) splice site probably null
R0189:Zdhhc14 UTSW 17 5,775,539 (GRCm39) missense possibly damaging 0.90
R0304:Zdhhc14 UTSW 17 5,775,611 (GRCm39) splice site probably benign
R0648:Zdhhc14 UTSW 17 5,543,877 (GRCm39) missense probably benign 0.01
R1017:Zdhhc14 UTSW 17 5,543,924 (GRCm39) missense probably damaging 0.99
R1595:Zdhhc14 UTSW 17 5,543,831 (GRCm39) missense probably benign 0.00
R2416:Zdhhc14 UTSW 17 5,803,283 (GRCm39) missense probably benign
R3420:Zdhhc14 UTSW 17 5,803,366 (GRCm39) makesense probably null
R3421:Zdhhc14 UTSW 17 5,803,366 (GRCm39) makesense probably null
R4063:Zdhhc14 UTSW 17 5,802,983 (GRCm39) missense probably damaging 1.00
R4088:Zdhhc14 UTSW 17 5,777,131 (GRCm39) missense probably benign 0.01
R5359:Zdhhc14 UTSW 17 5,543,821 (GRCm39) missense probably benign
R6236:Zdhhc14 UTSW 17 5,543,918 (GRCm39) missense probably damaging 1.00
R7350:Zdhhc14 UTSW 17 5,777,151 (GRCm39) missense probably benign 0.44
R7873:Zdhhc14 UTSW 17 5,762,729 (GRCm39) missense probably benign 0.37
R8247:Zdhhc14 UTSW 17 5,736,031 (GRCm39) missense probably damaging 1.00
R8492:Zdhhc14 UTSW 17 5,762,689 (GRCm39) missense probably damaging 0.98
R8865:Zdhhc14 UTSW 17 5,775,570 (GRCm39) missense possibly damaging 0.58
R8969:Zdhhc14 UTSW 17 5,775,555 (GRCm39) missense probably benign 0.12
R9133:Zdhhc14 UTSW 17 5,803,283 (GRCm39) missense probably benign
R9291:Zdhhc14 UTSW 17 5,698,237 (GRCm39) missense probably benign 0.02
R9433:Zdhhc14 UTSW 17 5,781,779 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GGTATATGTGAGTGCGAGCC -3'
(R):5'- AGCAGAGCTTCAGTGTTACC -3'

Sequencing Primer
(F):5'- TTCTGGGATTACAAACGCGC -3'
(R):5'- AGCAGAGCTTCAGTGTTACCTATTTG -3'
Posted On 2019-05-13