Incidental Mutation 'R7021:Vmn2r65'
| ID |
545628 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r65
|
| Ensembl Gene |
ENSMUSG00000066372 |
| Gene Name |
vomeronasal 2, receptor 65 |
| Synonyms |
ENSMUSG00000070600 |
| MMRRC Submission |
045122-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.071)
|
| Stock # |
R7021 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
84589377-84613217 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 84596587 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 156
(I156T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000036551
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044583]
|
| AlphaFold |
G3X931 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044583
AA Change: I156T
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000036551
Gene: ENSMUSG00000066372
AA Change: I156T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
435 |
5.6e-41 |
PFAM |
|
Pfam:NCD3G
|
501 |
553 |
1.3e-21 |
PFAM |
|
Pfam:7tm_3
|
584 |
821 |
2.3e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
99% (75/76) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AAdacl4fm3 |
A |
C |
4: 144,442,062 (GRCm39) |
L63R |
probably damaging |
Het |
| Abcb5 |
C |
T |
12: 118,895,660 (GRCm39) |
V379I |
probably benign |
Het |
| Adamts15 |
T |
C |
9: 30,832,776 (GRCm39) |
Y253C |
probably damaging |
Het |
| Ahsa1 |
T |
C |
12: 87,318,154 (GRCm39) |
S37P |
possibly damaging |
Het |
| Arnt2 |
A |
T |
7: 83,993,150 (GRCm39) |
L130H |
probably damaging |
Het |
| Atp8b5 |
T |
A |
4: 43,355,618 (GRCm39) |
F533I |
probably damaging |
Het |
| Best1 |
A |
G |
19: 9,964,143 (GRCm39) |
V439A |
probably benign |
Het |
| Bicc1 |
A |
G |
10: 70,796,978 (GRCm39) |
V127A |
probably damaging |
Het |
| Brd7 |
T |
C |
8: 89,073,632 (GRCm39) |
T253A |
probably benign |
Het |
| Btd |
A |
G |
14: 31,389,788 (GRCm39) |
D503G |
probably benign |
Het |
| Ccdc80 |
A |
G |
16: 44,924,804 (GRCm39) |
E646G |
probably damaging |
Het |
| Ccl25 |
A |
G |
8: 4,399,641 (GRCm39) |
|
probably benign |
Het |
| Ccnf |
C |
A |
17: 24,461,205 (GRCm39) |
W150L |
probably damaging |
Het |
| Cdk11b |
A |
T |
4: 155,726,024 (GRCm39) |
|
probably benign |
Het |
| Cfap73 |
T |
C |
5: 120,768,149 (GRCm39) |
E203G |
probably benign |
Het |
| Cmya5 |
T |
C |
13: 93,230,063 (GRCm39) |
E1675G |
possibly damaging |
Het |
| Copg1 |
T |
A |
6: 87,871,087 (GRCm39) |
Y268N |
possibly damaging |
Het |
| Csnk2a1 |
T |
A |
2: 152,102,732 (GRCm39) |
H126Q |
probably damaging |
Het |
| Ctbs |
G |
A |
3: 146,160,703 (GRCm39) |
G90D |
probably damaging |
Het |
| Ctnna2 |
T |
C |
6: 77,613,888 (GRCm39) |
Y221C |
probably damaging |
Het |
| Cypt12 |
C |
T |
3: 18,002,635 (GRCm39) |
R3C |
unknown |
Het |
| D630003M21Rik |
A |
T |
2: 158,058,670 (GRCm39) |
M410K |
possibly damaging |
Het |
| Dnah9 |
A |
T |
11: 65,872,057 (GRCm39) |
N2724K |
probably benign |
Het |
| Dok3 |
T |
C |
13: 55,672,097 (GRCm39) |
T194A |
probably benign |
Het |
| Edem3 |
T |
G |
1: 151,631,423 (GRCm39) |
S36A |
probably benign |
Het |
| Eed |
C |
T |
7: 89,629,727 (GRCm39) |
E3K |
possibly damaging |
Het |
| Efcab2 |
A |
G |
1: 178,308,925 (GRCm39) |
I143V |
probably benign |
Het |
| Ensa |
A |
T |
3: 95,534,359 (GRCm39) |
|
probably null |
Het |
| Galnt16 |
A |
T |
12: 80,626,826 (GRCm39) |
E219V |
probably damaging |
Het |
| Gfra3 |
C |
A |
18: 34,823,933 (GRCm39) |
R347L |
probably benign |
Het |
| Gm2042 |
T |
A |
12: 87,927,009 (GRCm39) |
I442K |
probably damaging |
Het |
| Gpld1 |
A |
T |
13: 25,168,691 (GRCm39) |
D735V |
probably damaging |
Het |
| Hspg2 |
T |
C |
4: 137,269,580 (GRCm39) |
S2253P |
possibly damaging |
Het |
| Kit |
T |
C |
5: 75,781,627 (GRCm39) |
I352T |
probably benign |
Het |
| Klra6 |
A |
T |
6: 129,995,821 (GRCm39) |
V179E |
possibly damaging |
Het |
| Lctl |
T |
A |
9: 64,040,075 (GRCm39) |
|
probably null |
Het |
| Lman1 |
C |
A |
18: 66,124,714 (GRCm39) |
V342L |
probably benign |
Het |
| Lrrn2 |
T |
C |
1: 132,866,522 (GRCm39) |
L529P |
probably damaging |
Het |
| Mab21l2 |
A |
G |
3: 86,454,793 (GRCm39) |
I69T |
probably benign |
Het |
| Mapkapk5 |
G |
T |
5: 121,665,274 (GRCm39) |
A327E |
probably benign |
Het |
| Mex3b |
G |
T |
7: 82,519,080 (GRCm39) |
R465L |
possibly damaging |
Het |
| Mgat3 |
A |
G |
15: 80,096,655 (GRCm39) |
N494S |
probably damaging |
Het |
| Mgat4c |
A |
G |
10: 102,224,289 (GRCm39) |
R168G |
possibly damaging |
Het |
| Mkks |
A |
G |
2: 136,718,007 (GRCm39) |
|
probably null |
Het |
| Muc16 |
G |
T |
9: 18,466,215 (GRCm39) |
H7368N |
unknown |
Het |
| Muc16 |
T |
C |
9: 18,462,127 (GRCm39) |
|
probably null |
Het |
| Nbeal1 |
G |
A |
1: 60,300,745 (GRCm39) |
|
probably null |
Het |
| Notch2 |
T |
C |
3: 98,042,762 (GRCm39) |
S1376P |
probably benign |
Het |
| Obox5 |
A |
G |
7: 15,491,681 (GRCm39) |
|
probably null |
Het |
| Or10j5 |
T |
C |
1: 172,784,494 (GRCm39) |
I44T |
probably benign |
Het |
| Or6c8b |
A |
T |
10: 128,882,899 (GRCm39) |
I11N |
probably damaging |
Het |
| Pbrm1 |
A |
G |
14: 30,789,773 (GRCm39) |
I807V |
probably damaging |
Het |
| Pitrm1 |
T |
A |
13: 6,628,593 (GRCm39) |
V962E |
probably damaging |
Het |
| Pkd2l1 |
T |
C |
19: 44,142,647 (GRCm39) |
Q465R |
probably damaging |
Het |
| Pla1a |
A |
G |
16: 38,221,244 (GRCm39) |
I372T |
probably damaging |
Het |
| Prmt5 |
A |
C |
14: 54,752,845 (GRCm39) |
F122C |
probably damaging |
Het |
| Prrc2b |
T |
A |
2: 32,111,498 (GRCm39) |
S1905T |
probably damaging |
Het |
| Ptprf |
T |
G |
4: 118,081,101 (GRCm39) |
K1163N |
probably benign |
Het |
| Rab3ip |
A |
G |
10: 116,775,283 (GRCm39) |
V25A |
probably damaging |
Het |
| Raf1 |
T |
C |
6: 115,597,300 (GRCm39) |
|
probably null |
Het |
| Rnf180 |
T |
C |
13: 105,407,429 (GRCm39) |
E40G |
probably benign |
Het |
| Rpl6 |
T |
A |
5: 121,346,972 (GRCm39) |
M289K |
probably benign |
Het |
| Slc25a32 |
A |
G |
15: 38,963,321 (GRCm39) |
F167L |
probably benign |
Het |
| Slc30a2 |
G |
A |
4: 134,074,726 (GRCm39) |
R161Q |
probably damaging |
Het |
| Slc4a4 |
T |
A |
5: 89,188,205 (GRCm39) |
|
probably null |
Het |
| Sppl2a |
A |
G |
2: 126,769,663 (GRCm39) |
|
probably null |
Het |
| Tbr1 |
T |
A |
2: 61,637,688 (GRCm39) |
D82E |
probably benign |
Het |
| Tbx10 |
A |
T |
19: 4,048,961 (GRCm39) |
T291S |
probably benign |
Het |
| Tlr1 |
T |
A |
5: 65,083,056 (GRCm39) |
H507L |
possibly damaging |
Het |
| Trim37 |
A |
C |
11: 87,058,335 (GRCm39) |
T338P |
probably benign |
Het |
| Trpv5 |
T |
C |
6: 41,630,204 (GRCm39) |
T629A |
probably benign |
Het |
| Ttc14 |
T |
A |
3: 33,857,646 (GRCm39) |
I249N |
probably damaging |
Het |
| Uhrf1 |
A |
G |
17: 56,627,450 (GRCm39) |
T661A |
probably benign |
Het |
| Vwde |
T |
C |
6: 13,186,905 (GRCm39) |
N861D |
probably damaging |
Het |
| Zan |
A |
G |
5: 137,422,213 (GRCm39) |
C2802R |
unknown |
Het |
|
| Other mutations in Vmn2r65 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00942:Vmn2r65
|
APN |
7 |
84,592,761 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01104:Vmn2r65
|
APN |
7 |
84,589,996 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01154:Vmn2r65
|
APN |
7 |
84,592,729 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01453:Vmn2r65
|
APN |
7 |
84,589,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Vmn2r65
|
APN |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01748:Vmn2r65
|
APN |
7 |
84,589,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01997:Vmn2r65
|
APN |
7 |
84,589,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02527:Vmn2r65
|
APN |
7 |
84,595,724 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02617:Vmn2r65
|
APN |
7 |
84,589,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02676:Vmn2r65
|
APN |
7 |
84,589,381 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL03084:Vmn2r65
|
APN |
7 |
84,592,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
A4554:Vmn2r65
|
UTSW |
7 |
84,595,791 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4651001:Vmn2r65
|
UTSW |
7 |
84,595,461 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0322:Vmn2r65
|
UTSW |
7 |
84,595,756 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0453:Vmn2r65
|
UTSW |
7 |
84,595,442 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0862:Vmn2r65
|
UTSW |
7 |
84,592,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1508:Vmn2r65
|
UTSW |
7 |
84,589,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1687:Vmn2r65
|
UTSW |
7 |
84,590,026 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1876:Vmn2r65
|
UTSW |
7 |
84,595,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Vmn2r65
|
UTSW |
7 |
84,592,781 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2259:Vmn2r65
|
UTSW |
7 |
84,590,119 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2338:Vmn2r65
|
UTSW |
7 |
84,590,051 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2880:Vmn2r65
|
UTSW |
7 |
84,613,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3410:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3411:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3770:Vmn2r65
|
UTSW |
7 |
84,589,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3800:Vmn2r65
|
UTSW |
7 |
84,589,738 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3850:Vmn2r65
|
UTSW |
7 |
84,595,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4105:Vmn2r65
|
UTSW |
7 |
84,595,691 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4568:Vmn2r65
|
UTSW |
7 |
84,596,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4677:Vmn2r65
|
UTSW |
7 |
84,613,082 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4768:Vmn2r65
|
UTSW |
7 |
84,596,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4778:Vmn2r65
|
UTSW |
7 |
84,592,801 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5057:Vmn2r65
|
UTSW |
7 |
84,589,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5279:Vmn2r65
|
UTSW |
7 |
84,589,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r65
|
UTSW |
7 |
84,595,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5394:Vmn2r65
|
UTSW |
7 |
84,595,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5487:Vmn2r65
|
UTSW |
7 |
84,595,529 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5580:Vmn2r65
|
UTSW |
7 |
84,596,802 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5638:Vmn2r65
|
UTSW |
7 |
84,590,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5673:Vmn2r65
|
UTSW |
7 |
84,596,615 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5688:Vmn2r65
|
UTSW |
7 |
84,589,900 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5935:Vmn2r65
|
UTSW |
7 |
84,592,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6354:Vmn2r65
|
UTSW |
7 |
84,589,574 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6372:Vmn2r65
|
UTSW |
7 |
84,589,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6924:Vmn2r65
|
UTSW |
7 |
84,613,198 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7195:Vmn2r65
|
UTSW |
7 |
84,592,347 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7422:Vmn2r65
|
UTSW |
7 |
84,595,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7654:Vmn2r65
|
UTSW |
7 |
84,590,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Vmn2r65
|
UTSW |
7 |
84,589,744 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7691:Vmn2r65
|
UTSW |
7 |
84,592,851 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,596,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,595,530 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8103:Vmn2r65
|
UTSW |
7 |
84,595,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8272:Vmn2r65
|
UTSW |
7 |
84,596,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8303:Vmn2r65
|
UTSW |
7 |
84,589,391 (GRCm39) |
nonsense |
probably null |
|
|
R8354:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8454:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8489:Vmn2r65
|
UTSW |
7 |
84,589,964 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8554:Vmn2r65
|
UTSW |
7 |
84,595,960 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8680:Vmn2r65
|
UTSW |
7 |
84,589,388 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8731:Vmn2r65
|
UTSW |
7 |
84,589,447 (GRCm39) |
nonsense |
probably null |
|
|
R8839:Vmn2r65
|
UTSW |
7 |
84,595,489 (GRCm39) |
nonsense |
probably null |
|
|
R8847:Vmn2r65
|
UTSW |
7 |
84,590,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8916:Vmn2r65
|
UTSW |
7 |
84,595,665 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9254:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9392:Vmn2r65
|
UTSW |
7 |
84,589,718 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9563:Vmn2r65
|
UTSW |
7 |
84,589,880 (GRCm39) |
nonsense |
probably null |
|
|
R9686:Vmn2r65
|
UTSW |
7 |
84,590,084 (GRCm39) |
missense |
probably benign |
0.45 |
|
X0067:Vmn2r65
|
UTSW |
7 |
84,590,113 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1088:Vmn2r65
|
UTSW |
7 |
84,592,473 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Vmn2r65
|
UTSW |
7 |
84,590,234 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATGCCAGTTAAAATCTGGGAAC -3'
(R):5'- GAAATATCCACCTGATTTTGGCTC -3'
Sequencing Primer
(F):5'- GCCAGTTAAAATCTGGGAACATTAG -3'
(R):5'- ATATCCACCTGATTTTGGCTCTATTG -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation