Incidental Mutation 'R7001:Mtss1'
ID 544565
Institutional Source Beutler Lab
Gene Symbol Mtss1
Ensembl Gene ENSMUSG00000022353
Gene Name MTSS I-BAR domain containing 1
Synonyms 2310003N14Rik, D130001D01Rik, MIM
MMRRC Submission 045106-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.835) question?
Stock # R7001 (G1)
Quality Score 217.009
Status Validated
Chromosome 15
Chromosomal Location 58813083-58953854 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to C at 58820183 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000080371]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000080371
SMART Domains Protein: ENSMUSP00000079239
Gene: ENSMUSG00000022353

DomainStartEndE-ValueType
Pfam:IMD 16 241 2.1e-107 PFAM
low complexity region 257 309 N/A INTRINSIC
low complexity region 443 459 N/A INTRINSIC
low complexity region 612 628 N/A INTRINSIC
WH2 731 748 1.36e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000227045
Predicted Effect
Predicted Effect
Meta Mutation Damage Score 0.1007 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 100% (56/56)
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trap allele exhibit polycystic kidney in 50% of mice by 5 months of age. Mouse embryonic fibroblasts from mice homozygous for a different gene trap allele exhibit altered cell morphology and physiology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C A 3: 137,771,272 (GRCm39) Q154K probably benign Het
Aldh6a1 T G 12: 84,488,662 (GRCm39) T75P probably damaging Het
Ank2 T A 3: 126,871,230 (GRCm39) H98L probably damaging Het
Ankib1 A G 5: 3,744,781 (GRCm39) F800S probably benign Het
Arhgap10 A T 8: 78,091,717 (GRCm39) M434K possibly damaging Het
Cap1 A T 4: 122,758,408 (GRCm39) F257L probably benign Het
Cdt1 T A 8: 123,299,249 (GRCm39) H510Q probably damaging Het
Clca3b A C 3: 144,533,733 (GRCm39) D547E possibly damaging Het
Col24a1 T C 3: 145,004,627 (GRCm39) V35A probably benign Het
Cyp2j13 A T 4: 95,945,112 (GRCm39) N305K probably damaging Het
D3Ertd751e T A 3: 41,712,844 (GRCm39) probably null Het
D6Ertd527e G A 6: 87,088,194 (GRCm39) G119D unknown Het
Ddc T C 11: 11,774,870 (GRCm39) probably null Het
Dnah12 A T 14: 26,601,681 (GRCm39) Y3713F probably damaging Het
Dock8 T A 19: 25,077,041 (GRCm39) S504T probably benign Het
Farp2 T C 1: 93,547,906 (GRCm39) F941L possibly damaging Het
Farp2 A G 1: 93,547,952 (GRCm39) N956S possibly damaging Het
Fbxo3 T A 2: 103,881,569 (GRCm39) H300Q probably damaging Het
Fcgrt T C 7: 44,751,466 (GRCm39) T131A probably benign Het
Fndc7 G A 3: 108,783,964 (GRCm39) A215V probably benign Het
Frem1 T C 4: 82,904,798 (GRCm39) E890G probably benign Het
Fsip2 C A 2: 82,817,269 (GRCm39) P4334H probably damaging Het
Gcdh C A 8: 85,617,540 (GRCm39) V227L probably benign Het
Gm8267 A C 14: 44,960,385 (GRCm39) M120R possibly damaging Het
Gpatch2l G A 12: 86,290,958 (GRCm39) R47H probably damaging Het
Lasp1 T G 11: 97,697,659 (GRCm39) H26Q probably damaging Het
Lrrcc1 T A 3: 14,605,155 (GRCm39) I297N probably damaging Het
Map1b A T 13: 99,567,101 (GRCm39) N1873K unknown Het
Map2 A G 1: 66,454,646 (GRCm39) I1179V probably benign Het
Mtus2 A G 5: 148,214,438 (GRCm39) E28G probably damaging Het
Muc6 G A 7: 141,217,320 (GRCm39) T2386I probably damaging Het
Myo3a G T 2: 22,337,188 (GRCm39) V362L probably benign Het
N6amt1 G A 16: 87,151,180 (GRCm39) V14M probably benign Het
Nav1 A T 1: 135,382,349 (GRCm39) probably null Het
Nol6 A G 4: 41,121,279 (GRCm39) S326P probably benign Het
Olr1 T A 6: 129,465,074 (GRCm39) E100V probably damaging Het
Or52ab4 A G 7: 102,987,428 (GRCm39) S56G possibly damaging Het
Or8k37 A T 2: 86,469,495 (GRCm39) S186T probably benign Het
Otop3 T C 11: 115,230,479 (GRCm39) Y119H probably damaging Het
Prb1b C T 6: 132,289,527 (GRCm39) G99E unknown Het
Ryr2 A T 13: 11,809,491 (GRCm39) M778K probably damaging Het
Serpina3n G T 12: 104,375,184 (GRCm39) M85I probably benign Het
Serpine2 A G 1: 79,772,748 (GRCm39) F390L probably damaging Het
Sf3b1 A G 1: 55,040,205 (GRCm39) V591A probably damaging Het
Sf3b1 A G 1: 55,053,640 (GRCm39) probably null Het
Slc26a5 C T 5: 22,016,334 (GRCm39) V646I probably damaging Het
Slitrk3 T A 3: 72,957,942 (GRCm39) K277* probably null Het
Sv2c A G 13: 96,118,461 (GRCm39) S463P probably benign Het
Tbc1d4 G A 14: 101,696,185 (GRCm39) T858M probably benign Het
Tbx18 T A 9: 87,609,457 (GRCm39) I193F probably damaging Het
Tm6sf2 A C 8: 70,530,982 (GRCm39) D245A probably damaging Het
Unc119 T C 11: 78,239,380 (GRCm39) Y234H probably damaging Het
Wrn A T 8: 33,842,157 (GRCm39) S46T probably benign Het
Zfp729a A T 13: 67,768,468 (GRCm39) I587K probably benign Het
Zfp872 C A 9: 22,111,912 (GRCm39) H464N probably damaging Het
Other mutations in Mtss1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00555:Mtss1 APN 15 58,823,317 (GRCm39) critical splice donor site probably null
IGL00693:Mtss1 APN 15 58,815,973 (GRCm39) missense probably damaging 1.00
IGL00817:Mtss1 APN 15 58,815,481 (GRCm39) splice site probably null
IGL00923:Mtss1 APN 15 58,815,348 (GRCm39) missense possibly damaging 0.80
IGL01704:Mtss1 APN 15 58,926,932 (GRCm39) missense possibly damaging 0.91
IGL02257:Mtss1 APN 15 58,828,394 (GRCm39) missense probably damaging 1.00
IGL02632:Mtss1 APN 15 58,815,864 (GRCm39) missense probably damaging 0.99
IGL02829:Mtss1 APN 15 58,930,277 (GRCm39) splice site probably benign
IGL02838:Mtss1 APN 15 58,953,364 (GRCm39) missense probably benign 0.06
IGL02968:Mtss1 APN 15 58,828,364 (GRCm39) missense possibly damaging 0.77
IGL03012:Mtss1 APN 15 58,930,249 (GRCm39) missense probably damaging 0.97
IGL03022:Mtss1 APN 15 58,825,439 (GRCm39) missense probably damaging 1.00
R0193:Mtss1 UTSW 15 58,815,866 (GRCm39) missense probably damaging 0.99
R0498:Mtss1 UTSW 15 58,817,286 (GRCm39) missense probably damaging 1.00
R0510:Mtss1 UTSW 15 58,828,387 (GRCm39) missense probably benign 0.07
R0655:Mtss1 UTSW 15 58,953,351 (GRCm39) missense probably damaging 0.99
R1183:Mtss1 UTSW 15 58,842,897 (GRCm39) missense probably damaging 0.97
R1428:Mtss1 UTSW 15 58,819,239 (GRCm39) missense probably benign 0.04
R1503:Mtss1 UTSW 15 58,823,521 (GRCm39) missense probably damaging 1.00
R1597:Mtss1 UTSW 15 58,815,560 (GRCm39) missense probably damaging 1.00
R1795:Mtss1 UTSW 15 58,930,249 (GRCm39) missense possibly damaging 0.92
R3689:Mtss1 UTSW 15 58,825,385 (GRCm39) missense probably damaging 1.00
R4724:Mtss1 UTSW 15 58,953,367 (GRCm39) missense probably damaging 0.98
R4811:Mtss1 UTSW 15 58,815,922 (GRCm39) missense probably damaging 1.00
R4968:Mtss1 UTSW 15 58,815,767 (GRCm39) missense probably damaging 1.00
R5082:Mtss1 UTSW 15 58,842,868 (GRCm39) missense probably damaging 1.00
R5783:Mtss1 UTSW 15 58,815,373 (GRCm39) missense probably benign 0.05
R6253:Mtss1 UTSW 15 58,815,568 (GRCm39) missense probably benign 0.02
R6767:Mtss1 UTSW 15 58,825,430 (GRCm39) missense probably benign 0.00
R6890:Mtss1 UTSW 15 58,823,508 (GRCm39) missense probably damaging 1.00
R7502:Mtss1 UTSW 15 58,820,210 (GRCm39) missense probably damaging 0.96
R7722:Mtss1 UTSW 15 58,926,935 (GRCm39) missense probably damaging 1.00
R7867:Mtss1 UTSW 15 58,842,858 (GRCm39) missense possibly damaging 0.82
R7888:Mtss1 UTSW 15 58,844,373 (GRCm39) missense probably damaging 1.00
R8954:Mtss1 UTSW 15 58,826,986 (GRCm39) missense probably damaging 1.00
R9493:Mtss1 UTSW 15 58,926,869 (GRCm39) missense probably damaging 1.00
Z1177:Mtss1 UTSW 15 58,817,269 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAACACAGACCCTGTTCTGG -3'
(R):5'- AATGACTTCCGGTGACCTG -3'

Sequencing Primer
(F):5'- TTCTGGGGAGGAAGCCTTCAC -3'
(R):5'- ACTTCCGGTGACCTGTGGTTTG -3'
Posted On 2019-05-13