Incidental Mutation 'R7001:Prb1b'
ID 544540
Institutional Source Beutler Lab
Gene Symbol Prb1b
Ensembl Gene ENSMUSG00000107874
Gene Name proline-rich protein BstNI subfamily 1B
Synonyms MP5, Prpmp5
MMRRC Submission 045106-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R7001 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 132288553-132291706 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 132289527 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Glutamic Acid at position 99 (G99E)
Ref Sequence ENSEMBL: ENSMUSP00000047347 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048686]
AlphaFold E9PXN1
Predicted Effect unknown
Transcript: ENSMUST00000048686
AA Change: G99E
SMART Domains Protein: ENSMUSP00000047347
Gene: ENSMUSG00000107874
AA Change: G99E

DomainStartEndE-ValueType
Pfam:Pro-rich 1 136 2.2e-36 PFAM
Pfam:Pro-rich 84 169 6.1e-17 PFAM
Pfam:Pro-rich 131 182 2.5e-10 PFAM
Pfam:Pro-rich 171 228 4.7e-10 PFAM
Pfam:Pro-rich 222 290 1.1e-11 PFAM
Meta Mutation Damage Score 0.0991 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 100% (56/56)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C A 3: 137,771,272 (GRCm39) Q154K probably benign Het
Aldh6a1 T G 12: 84,488,662 (GRCm39) T75P probably damaging Het
Ank2 T A 3: 126,871,230 (GRCm39) H98L probably damaging Het
Ankib1 A G 5: 3,744,781 (GRCm39) F800S probably benign Het
Arhgap10 A T 8: 78,091,717 (GRCm39) M434K possibly damaging Het
Cap1 A T 4: 122,758,408 (GRCm39) F257L probably benign Het
Cdt1 T A 8: 123,299,249 (GRCm39) H510Q probably damaging Het
Clca3b A C 3: 144,533,733 (GRCm39) D547E possibly damaging Het
Col24a1 T C 3: 145,004,627 (GRCm39) V35A probably benign Het
Cyp2j13 A T 4: 95,945,112 (GRCm39) N305K probably damaging Het
D3Ertd751e T A 3: 41,712,844 (GRCm39) probably null Het
D6Ertd527e G A 6: 87,088,194 (GRCm39) G119D unknown Het
Ddc T C 11: 11,774,870 (GRCm39) probably null Het
Dnah12 A T 14: 26,601,681 (GRCm39) Y3713F probably damaging Het
Dock8 T A 19: 25,077,041 (GRCm39) S504T probably benign Het
Farp2 T C 1: 93,547,906 (GRCm39) F941L possibly damaging Het
Farp2 A G 1: 93,547,952 (GRCm39) N956S possibly damaging Het
Fbxo3 T A 2: 103,881,569 (GRCm39) H300Q probably damaging Het
Fcgrt T C 7: 44,751,466 (GRCm39) T131A probably benign Het
Fndc7 G A 3: 108,783,964 (GRCm39) A215V probably benign Het
Frem1 T C 4: 82,904,798 (GRCm39) E890G probably benign Het
Fsip2 C A 2: 82,817,269 (GRCm39) P4334H probably damaging Het
Gcdh C A 8: 85,617,540 (GRCm39) V227L probably benign Het
Gm8267 A C 14: 44,960,385 (GRCm39) M120R possibly damaging Het
Gpatch2l G A 12: 86,290,958 (GRCm39) R47H probably damaging Het
Lasp1 T G 11: 97,697,659 (GRCm39) H26Q probably damaging Het
Lrrcc1 T A 3: 14,605,155 (GRCm39) I297N probably damaging Het
Map1b A T 13: 99,567,101 (GRCm39) N1873K unknown Het
Map2 A G 1: 66,454,646 (GRCm39) I1179V probably benign Het
Mtss1 A C 15: 58,820,183 (GRCm39) probably benign Het
Mtus2 A G 5: 148,214,438 (GRCm39) E28G probably damaging Het
Muc6 G A 7: 141,217,320 (GRCm39) T2386I probably damaging Het
Myo3a G T 2: 22,337,188 (GRCm39) V362L probably benign Het
N6amt1 G A 16: 87,151,180 (GRCm39) V14M probably benign Het
Nav1 A T 1: 135,382,349 (GRCm39) probably null Het
Nol6 A G 4: 41,121,279 (GRCm39) S326P probably benign Het
Olr1 T A 6: 129,465,074 (GRCm39) E100V probably damaging Het
Or52ab4 A G 7: 102,987,428 (GRCm39) S56G possibly damaging Het
Or8k37 A T 2: 86,469,495 (GRCm39) S186T probably benign Het
Otop3 T C 11: 115,230,479 (GRCm39) Y119H probably damaging Het
Ryr2 A T 13: 11,809,491 (GRCm39) M778K probably damaging Het
Serpina3n G T 12: 104,375,184 (GRCm39) M85I probably benign Het
Serpine2 A G 1: 79,772,748 (GRCm39) F390L probably damaging Het
Sf3b1 A G 1: 55,040,205 (GRCm39) V591A probably damaging Het
Sf3b1 A G 1: 55,053,640 (GRCm39) probably null Het
Slc26a5 C T 5: 22,016,334 (GRCm39) V646I probably damaging Het
Slitrk3 T A 3: 72,957,942 (GRCm39) K277* probably null Het
Sv2c A G 13: 96,118,461 (GRCm39) S463P probably benign Het
Tbc1d4 G A 14: 101,696,185 (GRCm39) T858M probably benign Het
Tbx18 T A 9: 87,609,457 (GRCm39) I193F probably damaging Het
Tm6sf2 A C 8: 70,530,982 (GRCm39) D245A probably damaging Het
Unc119 T C 11: 78,239,380 (GRCm39) Y234H probably damaging Het
Wrn A T 8: 33,842,157 (GRCm39) S46T probably benign Het
Zfp729a A T 13: 67,768,468 (GRCm39) I587K probably benign Het
Zfp872 C A 9: 22,111,912 (GRCm39) H464N probably damaging Het
Other mutations in Prb1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01392:Prb1b APN 6 132,289,383 (GRCm39) missense unknown
IGL02259:Prb1b APN 6 132,289,637 (GRCm39) missense unknown
IGL02434:Prb1b APN 6 132,289,339 (GRCm39) missense unknown
IGL03238:Prb1b APN 6 132,289,308 (GRCm39) missense unknown
R0971:Prb1b UTSW 6 132,290,618 (GRCm39) missense unknown
R1900:Prb1b UTSW 6 132,291,661 (GRCm39) missense unknown
R3800:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R3951:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R3952:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R3981:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R4083:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R4348:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R4351:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R4352:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R4353:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R6190:Prb1b UTSW 6 132,289,692 (GRCm39) missense unknown
R9023:Prb1b UTSW 6 132,289,174 (GRCm39) frame shift probably null
R9028:Prb1b UTSW 6 132,289,618 (GRCm39) missense unknown
R9193:Prb1b UTSW 6 132,288,996 (GRCm39) missense unknown
R9256:Prb1b UTSW 6 132,288,972 (GRCm39) missense unknown
R9388:Prb1b UTSW 6 132,289,437 (GRCm39) missense unknown
R9644:Prb1b UTSW 6 132,289,218 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TTCATGGTTCCCAGGCCTAAG -3'
(R):5'- TTTACTTGAATAGAGATGGGAGAGC -3'

Sequencing Primer
(F):5'- TTCCCAGGCCTAAGGGGTC -3'
(R):5'- AGCCAAGGGTATGGTCATCATTTTC -3'
Posted On 2019-05-13