Incidental Mutation 'R6986:Ticam1'
ID 543000
Institutional Source Beutler Lab
Gene Symbol Ticam1
Ensembl Gene ENSMUSG00000047123
Gene Name TIR domain containing adaptor molecule 1
Synonyms Trif, TICAM-1
MMRRC Submission 045093-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6986 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 56576462-56583767 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 56576900 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 732 (E732K)
Ref Sequence ENSEMBL: ENSMUSP00000055104 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058136]
AlphaFold Q80UF7
Predicted Effect probably benign
Transcript: ENSMUST00000058136
AA Change: E732K

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000055104
Gene: ENSMUSG00000047123
AA Change: E732K

DomainStartEndE-ValueType
PDB:4BSX|D 5 153 3e-52 PDB
low complexity region 345 384 N/A INTRINSIC
SCOP:d1fyva_ 386 491 8e-3 SMART
PDB:2M1X|A 391 547 1e-74 PDB
Pfam:RHIM 610 698 4.7e-13 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 98.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
PHENOTYPE: Homozygous null mice are viable but exhibit abnormalities of the innate immune system. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy9 T C 16: 4,129,441 (GRCm39) N482D probably damaging Het
Agbl3 A G 6: 34,816,387 (GRCm39) K766E probably benign Het
Aldh3a1 T A 11: 61,105,077 (GRCm39) I154N probably damaging Het
Cdca2 C T 14: 67,932,446 (GRCm39) V486I probably benign Het
Celf3 G C 3: 94,395,024 (GRCm39) A313P possibly damaging Het
Cgrrf1 T C 14: 47,069,586 (GRCm39) probably benign Het
Chd7 T A 4: 8,859,285 (GRCm39) N2458K possibly damaging Het
Chrna5 T A 9: 54,913,741 (GRCm39) M429K possibly damaging Het
Cux2 A T 5: 122,006,642 (GRCm39) L876Q possibly damaging Het
Cyb5rl T A 4: 106,928,073 (GRCm39) S3T probably benign Het
Ehd4 A T 2: 119,927,571 (GRCm39) M321K probably damaging Het
Ell2 C A 13: 75,910,006 (GRCm39) L119M probably damaging Het
Endod1 T C 9: 14,268,606 (GRCm39) E293G probably damaging Het
Fat3 G A 9: 15,932,631 (GRCm39) T1434I probably damaging Het
Flrt2 T A 12: 95,747,459 (GRCm39) I599N probably damaging Het
Gm6370 T A 5: 146,430,398 (GRCm39) probably null Het
Gm7247 T C 14: 51,602,832 (GRCm39) M56T possibly damaging Het
H3c8 A G 13: 23,719,603 (GRCm39) probably benign Het
Herc2 G A 7: 55,756,201 (GRCm39) R747H possibly damaging Het
Ints8 T C 4: 11,204,474 (GRCm39) Y994C probably damaging Het
Irf1 A G 11: 53,664,966 (GRCm39) T165A probably damaging Het
Lgr6 G T 1: 134,921,694 (GRCm39) Q217K possibly damaging Het
Lrrc36 T C 8: 106,185,079 (GRCm39) S619P probably damaging Het
Morn4 T C 19: 42,066,453 (GRCm39) N45D possibly damaging Het
Mtarc2 T C 1: 184,573,460 (GRCm39) H53R probably benign Het
Mtmr3 T C 11: 4,439,692 (GRCm39) T583A probably damaging Het
Ncdn A G 4: 126,641,022 (GRCm39) Y493H probably damaging Het
Nckap1 T A 2: 80,350,911 (GRCm39) Y726F probably benign Het
Optc T A 1: 133,825,702 (GRCm39) M275L probably benign Het
Or2w25 A G 11: 59,504,924 (GRCm39) K378R possibly damaging Het
Or6c69c G A 10: 129,911,199 (GRCm39) V307M possibly damaging Het
Perm1 A T 4: 156,302,976 (GRCm39) K507* probably null Het
Pgbd5 C T 8: 125,111,212 (GRCm39) E160K possibly damaging Het
Polr2k C A 15: 36,175,181 (GRCm39) P14T probably benign Het
Ppp2r3d A T 9: 124,439,080 (GRCm38) Y112* probably null Het
Pramel14 T A 4: 143,719,888 (GRCm39) D159V probably damaging Het
Rnase9 T C 14: 51,276,537 (GRCm39) N147S probably benign Het
Rnls C T 19: 33,359,781 (GRCm39) G11D probably damaging Het
Sbf2 T C 7: 109,929,822 (GRCm39) T333A probably damaging Het
Scn3a A T 2: 65,338,962 (GRCm39) N572K probably damaging Het
Serinc3 A G 2: 163,469,891 (GRCm39) L319P probably benign Het
Setbp1 T C 18: 78,901,054 (GRCm39) D871G probably damaging Het
Sf3b2 T C 19: 5,329,923 (GRCm39) T661A probably benign Het
Sgsm2 T A 11: 74,782,867 (GRCm39) R30W probably damaging Het
Sh3tc1 A G 5: 35,881,288 (GRCm39) S52P probably benign Het
Smox C T 2: 131,364,031 (GRCm39) A45V possibly damaging Het
Snrpa A T 7: 26,892,389 (GRCm39) M57K probably damaging Het
Spata31f3 A G 4: 42,868,696 (GRCm39) V309A possibly damaging Het
Srbd1 A T 17: 86,292,650 (GRCm39) I973N probably damaging Het
Srp72 T A 5: 77,142,723 (GRCm39) S428T probably benign Het
Ss18l2 A G 9: 121,541,671 (GRCm39) Y50C probably damaging Het
St14 A G 9: 31,007,845 (GRCm39) L578P probably damaging Het
Tmc1 T C 19: 20,801,647 (GRCm39) N460D probably benign Het
Tnni3k C T 3: 154,667,501 (GRCm39) G280R probably damaging Het
Trgv6 G T 13: 19,374,814 (GRCm39) G40W possibly damaging Het
Trpc3 A G 3: 36,709,165 (GRCm39) probably null Het
Tshr C T 12: 91,500,731 (GRCm39) A152V probably damaging Het
Tuft1 G A 3: 94,521,461 (GRCm39) P358S probably damaging Het
Vmn2r120 A T 17: 57,816,340 (GRCm39) S672T probably damaging Het
Vmn2r83 G T 10: 79,316,093 (GRCm39) E496D probably benign Het
Vmn2r91 A G 17: 18,356,271 (GRCm39) N646S probably benign Het
Zfp9 A G 6: 118,441,426 (GRCm39) V412A possibly damaging Het
Zmynd8 G T 2: 165,675,335 (GRCm39) H273N probably damaging Het
Other mutations in Ticam1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02160:Ticam1 APN 17 56,577,560 (GRCm39) missense possibly damaging 0.80
IGL02164:Ticam1 APN 17 56,577,019 (GRCm39) missense unknown
Lps2 UTSW 17 56,576,969 (GRCm39) frame shift probably null
Pangu UTSW 17 56,276,693 (GRCm38) critical splice donor site probably benign
Yue UTSW 17 56,578,339 (GRCm39) missense probably benign 0.06
R0930:Ticam1 UTSW 17 56,578,687 (GRCm39) missense probably damaging 1.00
R0930:Ticam1 UTSW 17 56,577,226 (GRCm39) missense unknown
R1509:Ticam1 UTSW 17 56,578,113 (GRCm39) missense probably benign 0.43
R1837:Ticam1 UTSW 17 56,577,799 (GRCm39) missense possibly damaging 0.87
R1863:Ticam1 UTSW 17 56,578,436 (GRCm39) missense probably damaging 1.00
R1867:Ticam1 UTSW 17 56,578,718 (GRCm39) missense probably benign 0.01
R1872:Ticam1 UTSW 17 56,578,897 (GRCm39) missense probably benign 0.00
R1893:Ticam1 UTSW 17 56,578,894 (GRCm39) missense probably benign 0.36
R1980:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R1981:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R1982:Ticam1 UTSW 17 56,578,555 (GRCm39) missense probably damaging 0.99
R2263:Ticam1 UTSW 17 56,578,888 (GRCm39) missense possibly damaging 0.95
R2513:Ticam1 UTSW 17 56,578,612 (GRCm39) missense possibly damaging 0.61
R4294:Ticam1 UTSW 17 56,578,339 (GRCm39) missense probably benign 0.06
R4888:Ticam1 UTSW 17 56,578,642 (GRCm39) missense probably damaging 0.98
R4982:Ticam1 UTSW 17 56,579,020 (GRCm39) missense probably benign 0.10
R5396:Ticam1 UTSW 17 56,578,117 (GRCm39) missense probably benign 0.02
R5604:Ticam1 UTSW 17 56,578,756 (GRCm39) missense probably benign 0.13
R5641:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5647:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5648:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5657:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5770:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5771:Ticam1 UTSW 17 56,577,629 (GRCm39) frame shift probably null
R5964:Ticam1 UTSW 17 56,578,703 (GRCm39) missense probably damaging 0.99
R5974:Ticam1 UTSW 17 56,578,178 (GRCm39) missense probably benign
R6217:Ticam1 UTSW 17 56,577,730 (GRCm39) missense probably damaging 1.00
R6983:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6984:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6985:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6987:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6988:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R6989:Ticam1 UTSW 17 56,576,900 (GRCm39) missense probably benign 0.00
R7029:Ticam1 UTSW 17 56,578,154 (GRCm39) missense possibly damaging 0.51
R7684:Ticam1 UTSW 17 56,576,984 (GRCm39) missense unknown
R7755:Ticam1 UTSW 17 56,577,182 (GRCm39) missense unknown
R7885:Ticam1 UTSW 17 56,578,067 (GRCm39) missense probably benign 0.04
R8021:Ticam1 UTSW 17 56,577,089 (GRCm39) missense unknown
R8414:Ticam1 UTSW 17 56,578,340 (GRCm39) missense probably benign 0.00
R8822:Ticam1 UTSW 17 56,578,444 (GRCm39) missense probably damaging 1.00
R9442:Ticam1 UTSW 17 56,577,428 (GRCm39) missense probably benign 0.00
R9521:Ticam1 UTSW 17 56,578,388 (GRCm39) missense probably benign 0.07
V8831:Ticam1 UTSW 17 56,576,969 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- GGTCTCAAGCTGGGTCCAAC -3'
(R):5'- TCCTCAGGGTGGTACTCCAG -3'

Sequencing Primer
(F):5'- TGGGTCCAACTAATAGCCACTGTG -3'
(R):5'- CAGGGTGGTACTCCAGTTTTCC -3'
Posted On 2018-11-28