Incidental Mutation 'R6937:Vmn2r86'
ID |
540352 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r86
|
Ensembl Gene |
ENSMUSG00000092162 |
Gene Name |
vomeronasal 2, receptor 86 |
Synonyms |
EG625109 |
MMRRC Submission |
045051-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.068)
|
Stock # |
R6937 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
10 |
Chromosomal Location |
130282068-130291763 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 130284523 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 523
(I523F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126596
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170257]
|
AlphaFold |
G5E8Y4 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000170257
AA Change: I523F
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000126596 Gene: ENSMUSG00000092162 AA Change: I523F
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
425 |
1.1e-25 |
PFAM |
Pfam:NCD3G
|
508 |
562 |
2.4e-19 |
PFAM |
Pfam:7tm_3
|
595 |
829 |
6.4e-55 |
PFAM |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.1%
- 20x: 97.1%
|
Validation Efficiency |
98% (42/43) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 44 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ankrd52 |
T |
C |
10: 128,222,889 (GRCm39) |
V613A |
probably benign |
Het |
Cdh23 |
A |
T |
10: 60,322,893 (GRCm39) |
L337Q |
probably damaging |
Het |
Chrna6 |
A |
G |
8: 27,897,055 (GRCm39) |
L274P |
probably damaging |
Het |
Ciita |
G |
A |
16: 10,330,355 (GRCm39) |
|
probably null |
Het |
Csnka2ip |
A |
T |
16: 64,299,058 (GRCm39) |
|
probably benign |
Het |
Ddx60 |
G |
A |
8: 62,490,103 (GRCm39) |
D1691N |
probably damaging |
Het |
Dnah7b |
T |
C |
1: 46,234,280 (GRCm39) |
I1441T |
probably damaging |
Het |
Dock4 |
T |
C |
12: 40,884,634 (GRCm39) |
S1713P |
probably benign |
Het |
Ep400 |
T |
C |
5: 110,859,018 (GRCm39) |
|
probably benign |
Het |
Epn1 |
T |
C |
7: 5,092,943 (GRCm39) |
I85T |
probably damaging |
Het |
Eri2 |
T |
C |
7: 119,386,012 (GRCm39) |
K228E |
probably damaging |
Het |
Garem1 |
C |
T |
18: 21,280,827 (GRCm39) |
A510T |
probably benign |
Het |
Gfm2 |
T |
A |
13: 97,299,572 (GRCm39) |
|
probably null |
Het |
Hnrnpd |
T |
C |
5: 100,111,629 (GRCm39) |
T321A |
probably benign |
Het |
Htr2a |
A |
T |
14: 74,882,604 (GRCm39) |
I197F |
probably damaging |
Het |
Krtap2-4 |
T |
A |
11: 99,505,299 (GRCm39) |
|
probably benign |
Het |
Lcn3 |
C |
A |
2: 25,657,823 (GRCm39) |
Y179* |
probably null |
Het |
Mak |
A |
T |
13: 41,201,578 (GRCm39) |
M261K |
probably damaging |
Het |
Marchf7 |
A |
G |
2: 60,071,310 (GRCm39) |
T605A |
probably damaging |
Het |
Mcm4 |
A |
C |
16: 15,454,199 (GRCm39) |
F83V |
probably benign |
Het |
Myo18b |
T |
C |
5: 112,950,258 (GRCm39) |
N1546S |
probably benign |
Het |
Nckap1 |
T |
A |
2: 80,339,060 (GRCm39) |
K989N |
probably damaging |
Het |
Ndufaf5 |
A |
G |
2: 140,023,522 (GRCm39) |
D119G |
probably damaging |
Het |
Or7g28 |
A |
T |
9: 19,271,985 (GRCm39) |
V222D |
probably damaging |
Het |
Pcdh1 |
T |
C |
18: 38,336,528 (GRCm39) |
T36A |
possibly damaging |
Het |
Pitpna |
C |
T |
11: 75,494,557 (GRCm39) |
T100I |
possibly damaging |
Het |
Pmf1 |
A |
T |
3: 88,306,496 (GRCm39) |
L102Q |
probably damaging |
Het |
Rftn2 |
T |
C |
1: 55,233,508 (GRCm39) |
|
probably null |
Het |
Robo3 |
A |
G |
9: 37,341,176 (GRCm39) |
L10P |
probably benign |
Het |
Serpinb6a |
T |
C |
13: 34,102,801 (GRCm39) |
I241V |
possibly damaging |
Het |
St14 |
A |
T |
9: 31,040,956 (GRCm39) |
|
probably null |
Het |
Stat6 |
T |
C |
10: 127,494,571 (GRCm39) |
|
probably null |
Het |
Tdpoz6 |
T |
C |
3: 93,599,523 (GRCm39) |
N282S |
probably benign |
Het |
Tdpoz8 |
A |
G |
3: 92,981,417 (GRCm39) |
H145R |
probably benign |
Het |
Tenm4 |
G |
A |
7: 96,202,703 (GRCm39) |
R106H |
probably benign |
Het |
Tgfbrap1 |
A |
T |
1: 43,091,064 (GRCm39) |
V687E |
probably damaging |
Het |
Trim30d |
A |
T |
7: 104,132,634 (GRCm39) |
S68T |
probably damaging |
Het |
Ttn |
A |
G |
2: 76,663,253 (GRCm39) |
|
probably benign |
Het |
Ugt3a1 |
A |
T |
15: 9,292,158 (GRCm39) |
D97V |
probably benign |
Het |
Ugt8a |
G |
A |
3: 125,709,250 (GRCm39) |
|
probably benign |
Het |
Vmn1r184 |
A |
T |
7: 25,966,750 (GRCm39) |
K165N |
probably benign |
Het |
Wapl |
G |
A |
14: 34,444,311 (GRCm39) |
V588I |
probably benign |
Het |
Wdr7 |
C |
T |
18: 63,924,938 (GRCm39) |
P974S |
probably benign |
Het |
Zfp975 |
T |
C |
7: 42,314,480 (GRCm39) |
D31G |
possibly damaging |
Het |
|
Other mutations in Vmn2r86 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01295:Vmn2r86
|
APN |
10 |
130,288,895 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01328:Vmn2r86
|
APN |
10 |
130,288,365 (GRCm39) |
missense |
possibly damaging |
0.78 |
IGL01377:Vmn2r86
|
APN |
10 |
130,288,855 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01548:Vmn2r86
|
APN |
10 |
130,282,151 (GRCm39) |
missense |
probably benign |
0.22 |
IGL01804:Vmn2r86
|
APN |
10 |
130,288,858 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01921:Vmn2r86
|
APN |
10 |
130,291,610 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02406:Vmn2r86
|
APN |
10 |
130,284,508 (GRCm39) |
missense |
possibly damaging |
0.81 |
IGL02625:Vmn2r86
|
APN |
10 |
130,288,781 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02960:Vmn2r86
|
APN |
10 |
130,289,636 (GRCm39) |
missense |
possibly damaging |
0.74 |
IGL03104:Vmn2r86
|
APN |
10 |
130,282,501 (GRCm39) |
missense |
probably damaging |
1.00 |
R0408:Vmn2r86
|
UTSW |
10 |
130,282,723 (GRCm39) |
missense |
probably damaging |
1.00 |
R0437:Vmn2r86
|
UTSW |
10 |
130,282,412 (GRCm39) |
missense |
probably damaging |
1.00 |
R0577:Vmn2r86
|
UTSW |
10 |
130,288,444 (GRCm39) |
missense |
probably benign |
0.04 |
R0726:Vmn2r86
|
UTSW |
10 |
130,282,265 (GRCm39) |
missense |
probably damaging |
1.00 |
R0811:Vmn2r86
|
UTSW |
10 |
130,289,497 (GRCm39) |
missense |
probably benign |
0.00 |
R0812:Vmn2r86
|
UTSW |
10 |
130,289,497 (GRCm39) |
missense |
probably benign |
0.00 |
R1055:Vmn2r86
|
UTSW |
10 |
130,282,226 (GRCm39) |
missense |
probably damaging |
1.00 |
R1066:Vmn2r86
|
UTSW |
10 |
130,282,145 (GRCm39) |
missense |
probably benign |
0.01 |
R1199:Vmn2r86
|
UTSW |
10 |
130,284,443 (GRCm39) |
splice site |
probably benign |
|
R1332:Vmn2r86
|
UTSW |
10 |
130,282,739 (GRCm39) |
missense |
probably damaging |
1.00 |
R1568:Vmn2r86
|
UTSW |
10 |
130,289,010 (GRCm39) |
missense |
probably benign |
0.09 |
R1866:Vmn2r86
|
UTSW |
10 |
130,282,255 (GRCm39) |
missense |
probably damaging |
1.00 |
R1897:Vmn2r86
|
UTSW |
10 |
130,288,314 (GRCm39) |
missense |
probably damaging |
1.00 |
R2017:Vmn2r86
|
UTSW |
10 |
130,282,582 (GRCm39) |
missense |
probably benign |
0.39 |
R3162:Vmn2r86
|
UTSW |
10 |
130,291,673 (GRCm39) |
missense |
probably damaging |
0.99 |
R3162:Vmn2r86
|
UTSW |
10 |
130,291,673 (GRCm39) |
missense |
probably damaging |
0.99 |
R3858:Vmn2r86
|
UTSW |
10 |
130,291,594 (GRCm39) |
missense |
probably benign |
|
R4049:Vmn2r86
|
UTSW |
10 |
130,282,966 (GRCm39) |
missense |
probably damaging |
0.98 |
R4378:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4411:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4413:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4422:Vmn2r86
|
UTSW |
10 |
130,288,845 (GRCm39) |
missense |
possibly damaging |
0.87 |
R4738:Vmn2r86
|
UTSW |
10 |
130,282,939 (GRCm39) |
missense |
probably damaging |
0.99 |
R4767:Vmn2r86
|
UTSW |
10 |
130,291,606 (GRCm39) |
missense |
probably benign |
0.00 |
R4872:Vmn2r86
|
UTSW |
10 |
130,289,460 (GRCm39) |
missense |
probably damaging |
0.98 |
R4880:Vmn2r86
|
UTSW |
10 |
130,289,484 (GRCm39) |
missense |
probably benign |
0.33 |
R5092:Vmn2r86
|
UTSW |
10 |
130,282,456 (GRCm39) |
missense |
probably damaging |
1.00 |
R5421:Vmn2r86
|
UTSW |
10 |
130,282,805 (GRCm39) |
missense |
probably benign |
0.41 |
R6007:Vmn2r86
|
UTSW |
10 |
130,289,535 (GRCm39) |
missense |
probably damaging |
1.00 |
R6330:Vmn2r86
|
UTSW |
10 |
130,282,396 (GRCm39) |
missense |
probably benign |
0.05 |
R6355:Vmn2r86
|
UTSW |
10 |
130,291,763 (GRCm39) |
start codon destroyed |
probably damaging |
0.98 |
R6397:Vmn2r86
|
UTSW |
10 |
130,282,131 (GRCm39) |
nonsense |
probably null |
|
R6419:Vmn2r86
|
UTSW |
10 |
130,282,795 (GRCm39) |
missense |
probably damaging |
1.00 |
R6933:Vmn2r86
|
UTSW |
10 |
130,282,126 (GRCm39) |
missense |
probably damaging |
1.00 |
R6959:Vmn2r86
|
UTSW |
10 |
130,282,400 (GRCm39) |
missense |
probably damaging |
1.00 |
R7010:Vmn2r86
|
UTSW |
10 |
130,291,726 (GRCm39) |
missense |
probably benign |
|
R7549:Vmn2r86
|
UTSW |
10 |
130,282,697 (GRCm39) |
missense |
probably damaging |
1.00 |
R8179:Vmn2r86
|
UTSW |
10 |
130,288,953 (GRCm39) |
missense |
probably benign |
0.00 |
R8257:Vmn2r86
|
UTSW |
10 |
130,288,279 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8286:Vmn2r86
|
UTSW |
10 |
130,285,855 (GRCm39) |
missense |
probably benign |
0.03 |
R8479:Vmn2r86
|
UTSW |
10 |
130,282,735 (GRCm39) |
missense |
probably damaging |
1.00 |
R8805:Vmn2r86
|
UTSW |
10 |
130,282,396 (GRCm39) |
missense |
probably benign |
0.05 |
R8960:Vmn2r86
|
UTSW |
10 |
130,289,672 (GRCm39) |
missense |
probably benign |
0.27 |
R9021:Vmn2r86
|
UTSW |
10 |
130,282,934 (GRCm39) |
missense |
probably damaging |
1.00 |
R9120:Vmn2r86
|
UTSW |
10 |
130,289,677 (GRCm39) |
missense |
probably benign |
0.00 |
R9137:Vmn2r86
|
UTSW |
10 |
130,282,409 (GRCm39) |
missense |
probably damaging |
1.00 |
R9311:Vmn2r86
|
UTSW |
10 |
130,288,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R9312:Vmn2r86
|
UTSW |
10 |
130,288,406 (GRCm39) |
missense |
probably benign |
0.02 |
R9433:Vmn2r86
|
UTSW |
10 |
130,282,567 (GRCm39) |
missense |
possibly damaging |
0.88 |
R9696:Vmn2r86
|
UTSW |
10 |
130,285,702 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
Predicted Primers |
PCR Primer
(F):5'- TGCTGGGTCCAAAAGAAGTTG -3'
(R):5'- TCAGTGCATTGCAGGGTAATAC -3'
Sequencing Primer
(F):5'- TAAGCTCTGACACATGGAGGCTTTAG -3'
(R):5'- CTGGTTATCAGAGGACCATG -3'
|
Posted On |
2018-11-06 |