Incidental Mutation 'R6924:Vmn2r65'
| ID |
539794 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r65
|
| Ensembl Gene |
ENSMUSG00000066372 |
| Gene Name |
vomeronasal 2, receptor 65 |
| Synonyms |
ENSMUSG00000070600 |
| MMRRC Submission |
045042-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R6924 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
84589377-84613217 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 84613198 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 7
(F7S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000036551
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044583]
|
| AlphaFold |
G3X931 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044583
AA Change: F7S
PolyPhen 2
Score 0.202 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000036551
Gene: ENSMUSG00000066372
AA Change: F7S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
435 |
5.6e-41 |
PFAM |
|
Pfam:NCD3G
|
501 |
553 |
1.3e-21 |
PFAM |
|
Pfam:7tm_3
|
584 |
821 |
2.3e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.8%
|
| Validation Efficiency |
98% (54/55) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 55 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700009N14Rik |
A |
C |
4: 39,450,884 (GRCm39) |
H30P |
probably damaging |
Het |
| Abhd6 |
A |
T |
14: 8,049,850 (GRCm38) |
H213L |
possibly damaging |
Het |
| Adam22 |
T |
A |
5: 8,417,322 (GRCm39) |
N40I |
possibly damaging |
Het |
| Ankrd42 |
A |
G |
7: 92,231,224 (GRCm39) |
|
probably benign |
Het |
| Arhgap40 |
C |
T |
2: 158,369,066 (GRCm39) |
R63C |
probably benign |
Het |
| Atf7ip |
T |
G |
6: 136,536,755 (GRCm39) |
|
probably null |
Het |
| Atg7 |
T |
C |
6: 114,686,172 (GRCm39) |
|
probably null |
Het |
| Car6 |
A |
C |
4: 150,273,713 (GRCm39) |
|
probably null |
Het |
| Carmil1 |
A |
T |
13: 24,259,667 (GRCm39) |
C302* |
probably null |
Het |
| Ccdc117 |
A |
T |
11: 5,484,255 (GRCm39) |
M195K |
probably benign |
Het |
| Cep95 |
T |
C |
11: 106,702,023 (GRCm39) |
M383T |
probably damaging |
Het |
| Col20a1 |
A |
G |
2: 180,638,643 (GRCm39) |
E419G |
probably damaging |
Het |
| Cyp2d9 |
C |
G |
15: 82,339,413 (GRCm39) |
R272G |
probably damaging |
Het |
| Dhx57 |
A |
T |
17: 80,546,244 (GRCm39) |
M1380K |
possibly damaging |
Het |
| Dnah14 |
A |
G |
1: 181,455,517 (GRCm39) |
S881G |
probably benign |
Het |
| Fcgbp |
T |
A |
7: 27,793,248 (GRCm39) |
I1084N |
probably benign |
Het |
| Fgf17 |
A |
T |
14: 70,878,981 (GRCm39) |
C21* |
probably null |
Het |
| Gemin4 |
A |
G |
11: 76,103,162 (GRCm39) |
L533P |
probably damaging |
Het |
| Gkn3 |
T |
C |
6: 87,365,784 (GRCm39) |
R12G |
probably benign |
Het |
| Gpr161 |
G |
T |
1: 165,149,188 (GRCm39) |
R519L |
possibly damaging |
Het |
| Grin2a |
A |
G |
16: 9,481,092 (GRCm39) |
V535A |
possibly damaging |
Het |
| Gys1 |
G |
A |
7: 45,093,059 (GRCm39) |
|
probably null |
Het |
| Hfm1 |
C |
T |
5: 106,998,276 (GRCm39) |
|
probably null |
Het |
| Hmcn2 |
T |
A |
2: 31,240,517 (GRCm39) |
|
probably null |
Het |
| Hnrnpul2 |
T |
C |
19: 8,808,873 (GRCm39) |
Y738H |
unknown |
Het |
| Hycc1 |
T |
C |
5: 24,191,133 (GRCm39) |
|
probably null |
Het |
| Igsf23 |
A |
G |
7: 19,675,684 (GRCm39) |
S141P |
possibly damaging |
Het |
| Lamc3 |
A |
C |
2: 31,828,081 (GRCm39) |
M1423L |
probably benign |
Het |
| Lcmt2 |
T |
C |
2: 120,970,484 (GRCm39) |
T200A |
probably benign |
Het |
| Lgr4 |
T |
C |
2: 109,842,784 (GRCm39) |
V899A |
probably damaging |
Het |
| Macf1 |
T |
A |
4: 123,421,145 (GRCm39) |
R36S |
possibly damaging |
Het |
| Mrgprb8 |
A |
G |
7: 48,038,871 (GRCm39) |
K181E |
possibly damaging |
Het |
| Muc2 |
G |
A |
7: 141,284,077 (GRCm39) |
V786M |
possibly damaging |
Het |
| Nacc2 |
T |
C |
2: 25,980,041 (GRCm39) |
T132A |
probably damaging |
Het |
| Nsmce2 |
T |
A |
15: 59,250,774 (GRCm39) |
I15K |
probably damaging |
Het |
| Or10p22 |
T |
G |
10: 128,825,960 (GRCm39) |
Y60D |
probably damaging |
Het |
| Or4k15c |
A |
G |
14: 50,321,307 (GRCm39) |
I277T |
possibly damaging |
Het |
| Otoa |
A |
T |
7: 120,730,724 (GRCm39) |
|
probably null |
Het |
| Otogl |
A |
G |
10: 107,644,502 (GRCm39) |
I1248T |
probably damaging |
Het |
| Ppp1r17 |
T |
A |
6: 56,003,007 (GRCm39) |
D32E |
probably damaging |
Het |
| Relt |
A |
C |
7: 100,496,468 (GRCm39) |
V427G |
probably damaging |
Het |
| Ric1 |
T |
A |
19: 29,546,788 (GRCm39) |
V256D |
probably damaging |
Het |
| Samhd1 |
T |
C |
2: 156,951,403 (GRCm39) |
T445A |
probably benign |
Het |
| Sepsecs |
T |
C |
5: 52,821,646 (GRCm39) |
I189V |
probably benign |
Het |
| Shroom3 |
T |
A |
5: 93,112,262 (GRCm39) |
D1793E |
probably damaging |
Het |
| Sim1 |
C |
T |
10: 50,784,635 (GRCm39) |
T137I |
probably benign |
Het |
| Stk17b |
A |
T |
1: 53,800,218 (GRCm39) |
D253E |
possibly damaging |
Het |
| Stmnd1 |
T |
C |
13: 46,452,969 (GRCm39) |
V215A |
probably benign |
Het |
| Tcl1 |
A |
G |
12: 105,185,015 (GRCm39) |
L65P |
probably damaging |
Het |
| Tiam2 |
A |
C |
17: 3,558,070 (GRCm39) |
K1231N |
probably damaging |
Het |
| Tm9sf3 |
T |
C |
19: 41,206,717 (GRCm39) |
Y476C |
probably damaging |
Het |
| Trim63 |
T |
C |
4: 134,048,572 (GRCm39) |
S194P |
probably damaging |
Het |
| Ugt1a10 |
T |
A |
1: 87,983,379 (GRCm39) |
I59N |
probably damaging |
Het |
| Zfp775 |
T |
A |
6: 48,596,589 (GRCm39) |
H154Q |
probably damaging |
Het |
| Zfp804b |
C |
T |
5: 6,819,902 (GRCm39) |
V1018I |
probably benign |
Het |
|
| Other mutations in Vmn2r65 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00942:Vmn2r65
|
APN |
7 |
84,592,761 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01104:Vmn2r65
|
APN |
7 |
84,589,996 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01154:Vmn2r65
|
APN |
7 |
84,592,729 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01453:Vmn2r65
|
APN |
7 |
84,589,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Vmn2r65
|
APN |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01748:Vmn2r65
|
APN |
7 |
84,589,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01997:Vmn2r65
|
APN |
7 |
84,589,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02527:Vmn2r65
|
APN |
7 |
84,595,724 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02617:Vmn2r65
|
APN |
7 |
84,589,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02676:Vmn2r65
|
APN |
7 |
84,589,381 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL03084:Vmn2r65
|
APN |
7 |
84,592,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
A4554:Vmn2r65
|
UTSW |
7 |
84,595,791 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4651001:Vmn2r65
|
UTSW |
7 |
84,595,461 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0322:Vmn2r65
|
UTSW |
7 |
84,595,756 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0453:Vmn2r65
|
UTSW |
7 |
84,595,442 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0862:Vmn2r65
|
UTSW |
7 |
84,592,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1392:Vmn2r65
|
UTSW |
7 |
84,596,624 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1508:Vmn2r65
|
UTSW |
7 |
84,589,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1687:Vmn2r65
|
UTSW |
7 |
84,590,026 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1876:Vmn2r65
|
UTSW |
7 |
84,595,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2136:Vmn2r65
|
UTSW |
7 |
84,592,781 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2259:Vmn2r65
|
UTSW |
7 |
84,590,119 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2338:Vmn2r65
|
UTSW |
7 |
84,590,051 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2880:Vmn2r65
|
UTSW |
7 |
84,613,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3410:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3411:Vmn2r65
|
UTSW |
7 |
84,595,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3770:Vmn2r65
|
UTSW |
7 |
84,589,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3800:Vmn2r65
|
UTSW |
7 |
84,589,738 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3850:Vmn2r65
|
UTSW |
7 |
84,595,859 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4105:Vmn2r65
|
UTSW |
7 |
84,595,691 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4568:Vmn2r65
|
UTSW |
7 |
84,596,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4677:Vmn2r65
|
UTSW |
7 |
84,613,082 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R4768:Vmn2r65
|
UTSW |
7 |
84,596,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4778:Vmn2r65
|
UTSW |
7 |
84,592,801 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5057:Vmn2r65
|
UTSW |
7 |
84,589,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5279:Vmn2r65
|
UTSW |
7 |
84,589,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5280:Vmn2r65
|
UTSW |
7 |
84,595,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5394:Vmn2r65
|
UTSW |
7 |
84,595,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5487:Vmn2r65
|
UTSW |
7 |
84,595,529 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5580:Vmn2r65
|
UTSW |
7 |
84,596,802 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5638:Vmn2r65
|
UTSW |
7 |
84,590,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5673:Vmn2r65
|
UTSW |
7 |
84,596,615 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5688:Vmn2r65
|
UTSW |
7 |
84,589,900 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5935:Vmn2r65
|
UTSW |
7 |
84,592,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6354:Vmn2r65
|
UTSW |
7 |
84,589,574 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6372:Vmn2r65
|
UTSW |
7 |
84,589,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7021:Vmn2r65
|
UTSW |
7 |
84,596,587 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7195:Vmn2r65
|
UTSW |
7 |
84,592,347 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7422:Vmn2r65
|
UTSW |
7 |
84,595,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7654:Vmn2r65
|
UTSW |
7 |
84,590,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7686:Vmn2r65
|
UTSW |
7 |
84,589,744 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7691:Vmn2r65
|
UTSW |
7 |
84,592,851 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,596,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7798:Vmn2r65
|
UTSW |
7 |
84,595,530 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8103:Vmn2r65
|
UTSW |
7 |
84,595,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8272:Vmn2r65
|
UTSW |
7 |
84,596,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8303:Vmn2r65
|
UTSW |
7 |
84,589,391 (GRCm39) |
nonsense |
probably null |
|
|
R8354:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8454:Vmn2r65
|
UTSW |
7 |
84,589,402 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8489:Vmn2r65
|
UTSW |
7 |
84,589,964 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8554:Vmn2r65
|
UTSW |
7 |
84,595,960 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8680:Vmn2r65
|
UTSW |
7 |
84,589,388 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8731:Vmn2r65
|
UTSW |
7 |
84,589,447 (GRCm39) |
nonsense |
probably null |
|
|
R8839:Vmn2r65
|
UTSW |
7 |
84,595,489 (GRCm39) |
nonsense |
probably null |
|
|
R8847:Vmn2r65
|
UTSW |
7 |
84,590,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8916:Vmn2r65
|
UTSW |
7 |
84,595,665 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9254:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Vmn2r65
|
UTSW |
7 |
84,596,650 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9392:Vmn2r65
|
UTSW |
7 |
84,589,718 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9563:Vmn2r65
|
UTSW |
7 |
84,589,880 (GRCm39) |
nonsense |
probably null |
|
|
R9686:Vmn2r65
|
UTSW |
7 |
84,590,084 (GRCm39) |
missense |
probably benign |
0.45 |
|
X0067:Vmn2r65
|
UTSW |
7 |
84,590,113 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1088:Vmn2r65
|
UTSW |
7 |
84,592,473 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Vmn2r65
|
UTSW |
7 |
84,590,234 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGGTCAACCTATCTTTATCCCTAG -3'
(R):5'- CATTCGAATAGAGAGCCCTGGG -3'
Sequencing Primer
(F):5'- GGCACTTACAAAATATCTGGATTTCC -3'
(R):5'- AGTGCTTAAGAATCCTCCAGAG -3'
|
| Posted On |
2018-11-06 |
Incidental Mutation