Incidental Mutation 'R6910:Dennd3'
ID 538990
Institutional Source Beutler Lab
Gene Symbol Dennd3
Ensembl Gene ENSMUSG00000036661
Gene Name DENN domain containing 3
Synonyms E030003N15Rik
MMRRC Submission 045002-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R6910 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 73384409-73444091 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73426965 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 781 (T781A)
Ref Sequence ENSEMBL: ENSMUSP00000134002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043414] [ENSMUST00000160267] [ENSMUST00000173292]
AlphaFold A2RT67
Predicted Effect probably benign
Transcript: ENSMUST00000043414
AA Change: T781A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000046774
Gene: ENSMUSG00000036661
AA Change: T781A

DomainStartEndE-ValueType
Blast:uDENN 12 161 3e-78 BLAST
DENN 187 373 1.54e-62 SMART
dDENN 436 499 6.81e-14 SMART
WD40 1015 1054 3.68e1 SMART
WD40 1057 1098 3.32e-5 SMART
WD40 1232 1272 1.1e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160267
SMART Domains Protein: ENSMUSP00000124538
Gene: ENSMUSG00000036661

DomainStartEndE-ValueType
Blast:WD40 51 90 2e-9 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000173292
AA Change: T781A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000134002
Gene: ENSMUSG00000036661
AA Change: T781A

DomainStartEndE-ValueType
Blast:uDENN 12 161 2e-78 BLAST
DENN 187 373 1.54e-62 SMART
dDENN 436 499 6.81e-14 SMART
WD40 1015 1054 3.68e1 SMART
WD40 1057 1098 3.32e-5 SMART
Meta Mutation Damage Score 0.0861 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cfap54 A G 10: 92,672,374 (GRCm39) S2899P probably benign Het
Chil5 A G 3: 105,926,977 (GRCm39) W82R probably damaging Het
Epha2 A G 4: 141,048,824 (GRCm39) D597G probably damaging Het
Gcn1 A G 5: 115,744,597 (GRCm39) T1598A probably benign Het
Glp2r A G 11: 67,621,497 (GRCm39) F162S probably benign Het
Gm17655 T A 5: 110,195,039 (GRCm39) R248* probably null Het
Gnptab G A 10: 88,267,258 (GRCm39) G450S probably damaging Het
Gpatch2l G A 12: 86,290,958 (GRCm39) R47H probably damaging Het
Hapln2 A G 3: 87,931,135 (GRCm39) Y127H probably damaging Het
Hdac4 G T 1: 91,909,875 (GRCm39) T463K probably damaging Het
Ift80 A C 3: 68,835,068 (GRCm39) S458A probably benign Het
Lama1 A G 17: 68,098,459 (GRCm39) D1846G possibly damaging Het
Map3k8 A G 18: 4,340,801 (GRCm39) I171T probably benign Het
Micu1 A G 10: 59,576,489 (GRCm39) E115G probably damaging Het
Mrpl39 A G 16: 84,532,080 (GRCm39) V9A unknown Het
Ncoa7 T G 10: 30,570,117 (GRCm39) I281L possibly damaging Het
Nms A G 1: 38,980,976 (GRCm39) E54G probably benign Het
Nrip1 G A 16: 76,091,305 (GRCm39) A84V probably damaging Het
Or10ak9 T A 4: 118,726,335 (GRCm39) M119K probably damaging Het
Or11g27 G A 14: 50,771,330 (GRCm39) V154M probably benign Het
Pcdhga10 T A 18: 37,881,285 (GRCm39) S349T probably damaging Het
R3hcc1 G A 14: 69,935,024 (GRCm39) P454L probably damaging Het
Rsrc1 C T 3: 66,901,982 (GRCm39) P44L unknown Het
Ryr3 T C 2: 112,788,520 (GRCm39) D170G probably damaging Het
Sanbr A G 11: 23,570,447 (GRCm39) V151A probably damaging Het
Scp2 C A 4: 107,962,283 (GRCm39) G81C probably damaging Het
Sez6 A G 11: 77,844,695 (GRCm39) T173A possibly damaging Het
Syne1 T C 10: 4,998,887 (GRCm39) H8142R probably benign Het
Tcof1 G C 18: 60,962,123 (GRCm39) A702G possibly damaging Het
Tnfrsf11a A G 1: 105,772,272 (GRCm39) T520A probably damaging Het
Tpm1 A G 9: 66,939,256 (GRCm39) S170P probably damaging Het
Try5 T C 6: 41,288,733 (GRCm39) D54G possibly damaging Het
Vmn2r-ps158 T C 7: 42,673,475 (GRCm39) F178L probably benign Het
Zan T C 5: 137,417,342 (GRCm39) E3041G unknown Het
Zfp1001 A T 2: 150,165,987 (GRCm39) Q56L probably benign Het
Zfp616 A T 11: 73,975,828 (GRCm39) H699L probably damaging Het
Other mutations in Dennd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Dennd3 APN 15 73,438,982 (GRCm39) missense probably benign 0.26
IGL00579:Dennd3 APN 15 73,412,691 (GRCm39) missense possibly damaging 0.63
IGL02101:Dennd3 APN 15 73,399,794 (GRCm39) missense possibly damaging 0.81
IGL02164:Dennd3 APN 15 73,416,297 (GRCm39) missense probably benign 0.26
IGL02389:Dennd3 APN 15 73,438,905 (GRCm39) missense probably damaging 1.00
IGL02604:Dennd3 APN 15 73,428,252 (GRCm39) missense probably damaging 1.00
IGL02697:Dennd3 APN 15 73,396,085 (GRCm39) missense possibly damaging 0.82
IGL02885:Dennd3 APN 15 73,440,545 (GRCm39) missense probably benign
IGL03356:Dennd3 APN 15 73,440,482 (GRCm39) missense probably benign 0.19
IGL03388:Dennd3 APN 15 73,416,208 (GRCm39) missense probably damaging 0.98
BB006:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
BB016:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
R0118:Dennd3 UTSW 15 73,436,925 (GRCm39) missense probably damaging 1.00
R0925:Dennd3 UTSW 15 73,405,284 (GRCm39) missense probably damaging 1.00
R1076:Dennd3 UTSW 15 73,412,582 (GRCm39) missense probably damaging 1.00
R1355:Dennd3 UTSW 15 73,412,703 (GRCm39) splice site probably benign
R1370:Dennd3 UTSW 15 73,412,703 (GRCm39) splice site probably benign
R1480:Dennd3 UTSW 15 73,404,695 (GRCm39) missense probably benign 0.20
R1727:Dennd3 UTSW 15 73,436,977 (GRCm39) missense possibly damaging 0.95
R1732:Dennd3 UTSW 15 73,409,267 (GRCm39) splice site probably benign
R1771:Dennd3 UTSW 15 73,426,950 (GRCm39) missense possibly damaging 0.71
R1776:Dennd3 UTSW 15 73,426,950 (GRCm39) missense possibly damaging 0.71
R1779:Dennd3 UTSW 15 73,394,357 (GRCm39) critical splice donor site probably null
R1838:Dennd3 UTSW 15 73,436,949 (GRCm39) missense probably damaging 1.00
R2146:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2146:Dennd3 UTSW 15 73,395,345 (GRCm39) missense probably damaging 1.00
R2147:Dennd3 UTSW 15 73,395,336 (GRCm39) missense probably damaging 1.00
R2148:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2149:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2150:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2174:Dennd3 UTSW 15 73,427,154 (GRCm39) missense probably damaging 1.00
R2295:Dennd3 UTSW 15 73,395,404 (GRCm39) critical splice donor site probably null
R2905:Dennd3 UTSW 15 73,429,495 (GRCm39) missense probably damaging 1.00
R3106:Dennd3 UTSW 15 73,436,973 (GRCm39) nonsense probably null
R3757:Dennd3 UTSW 15 73,394,083 (GRCm39) missense probably benign 0.00
R3785:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3786:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3787:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3847:Dennd3 UTSW 15 73,414,581 (GRCm39) missense possibly damaging 0.64
R4369:Dennd3 UTSW 15 73,412,658 (GRCm39) missense probably damaging 0.98
R4601:Dennd3 UTSW 15 73,439,009 (GRCm39) missense probably damaging 0.99
R4666:Dennd3 UTSW 15 73,442,709 (GRCm39) missense probably damaging 1.00
R4680:Dennd3 UTSW 15 73,405,225 (GRCm39) missense possibly damaging 0.82
R4708:Dennd3 UTSW 15 73,395,344 (GRCm39) missense probably damaging 1.00
R4789:Dennd3 UTSW 15 73,394,131 (GRCm39) missense probably damaging 1.00
R4920:Dennd3 UTSW 15 73,412,574 (GRCm39) missense probably benign 0.13
R5043:Dennd3 UTSW 15 73,399,785 (GRCm39) missense probably benign 0.00
R5074:Dennd3 UTSW 15 73,419,144 (GRCm39) missense probably damaging 1.00
R5410:Dennd3 UTSW 15 73,419,297 (GRCm39) missense probably benign 0.02
R5421:Dennd3 UTSW 15 73,438,964 (GRCm39) missense probably benign
R5560:Dennd3 UTSW 15 73,404,744 (GRCm39) missense probably damaging 1.00
R6008:Dennd3 UTSW 15 73,438,929 (GRCm39) missense possibly damaging 0.88
R6357:Dennd3 UTSW 15 73,428,321 (GRCm39) missense possibly damaging 0.49
R6563:Dennd3 UTSW 15 73,416,229 (GRCm39) missense probably damaging 0.98
R6687:Dennd3 UTSW 15 73,428,215 (GRCm39) missense possibly damaging 0.64
R6837:Dennd3 UTSW 15 73,429,542 (GRCm39) missense probably damaging 1.00
R7125:Dennd3 UTSW 15 73,405,140 (GRCm39) missense possibly damaging 0.50
R7297:Dennd3 UTSW 15 73,429,459 (GRCm39) missense probably damaging 1.00
R7524:Dennd3 UTSW 15 73,396,095 (GRCm39) nonsense probably null
R7580:Dennd3 UTSW 15 73,428,296 (GRCm39) missense possibly damaging 0.89
R7653:Dennd3 UTSW 15 73,434,275 (GRCm39) missense probably damaging 0.99
R7731:Dennd3 UTSW 15 73,434,216 (GRCm39) missense probably damaging 0.99
R7767:Dennd3 UTSW 15 73,394,079 (GRCm39) missense probably benign
R7806:Dennd3 UTSW 15 73,442,624 (GRCm39) missense possibly damaging 0.87
R7860:Dennd3 UTSW 15 73,412,657 (GRCm39) missense probably damaging 0.97
R7902:Dennd3 UTSW 15 73,439,964 (GRCm39) critical splice donor site probably benign
R7929:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
R8218:Dennd3 UTSW 15 73,384,622 (GRCm39) missense probably benign 0.31
R8436:Dennd3 UTSW 15 73,434,198 (GRCm39) missense probably damaging 1.00
R8444:Dennd3 UTSW 15 73,442,672 (GRCm39) missense probably benign 0.09
R8698:Dennd3 UTSW 15 73,394,154 (GRCm39) missense possibly damaging 0.52
R8967:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R9147:Dennd3 UTSW 15 73,429,463 (GRCm39) missense probably damaging 1.00
R9148:Dennd3 UTSW 15 73,429,463 (GRCm39) missense probably damaging 1.00
R9194:Dennd3 UTSW 15 73,419,153 (GRCm39) missense probably benign 0.04
R9449:Dennd3 UTSW 15 73,429,477 (GRCm39) missense probably damaging 1.00
R9501:Dennd3 UTSW 15 73,419,041 (GRCm39) missense probably benign 0.01
R9616:Dennd3 UTSW 15 73,440,563 (GRCm39) missense probably benign
R9730:Dennd3 UTSW 15 73,426,959 (GRCm39) missense probably damaging 1.00
RF006:Dennd3 UTSW 15 73,419,441 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATCTTCTGCCCCACAGCTG -3'
(R):5'- ATGTTCCTGAAGGTGGCAATC -3'

Sequencing Primer
(F):5'- TAGTGCCTGCCTAAAGTC -3'
(R):5'- TGGCAATCTCCACATAGCCGG -3'
Posted On 2018-11-06