Incidental Mutation 'R6910:Or11g27'
ID 538988
Institutional Source Beutler Lab
Gene Symbol Or11g27
Ensembl Gene ENSMUSG00000094285
Gene Name olfactory receptor family 11 subfamily G member 27
Synonyms GA_x6K02T2PMLR-6243196-6244132, MOR106-8P, Olfr264, Olfr743, Olfr743-ps1, Olfr265, GA_x6K02T2N6FY-2320-2039, GA_x6K02T2N6FY-3870-3385, MOR106-14
MMRRC Submission 045002-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R6910 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 50770871-50771806 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 50771330 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 154 (V154M)
Ref Sequence ENSEMBL: ENSMUSP00000150946 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071294] [ENSMUST00000215793]
AlphaFold L7N1Y2
Predicted Effect probably benign
Transcript: ENSMUST00000071294
AA Change: V154M

PolyPhen 2 Score 0.312 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000071263
Gene: ENSMUSG00000094285
AA Change: V154M

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 1.6e-56 PFAM
Pfam:7tm_1 45 294 1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215793
AA Change: V154M

PolyPhen 2 Score 0.312 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cfap54 A G 10: 92,672,374 (GRCm39) S2899P probably benign Het
Chil5 A G 3: 105,926,977 (GRCm39) W82R probably damaging Het
Dennd3 A G 15: 73,426,965 (GRCm39) T781A probably benign Het
Epha2 A G 4: 141,048,824 (GRCm39) D597G probably damaging Het
Gcn1 A G 5: 115,744,597 (GRCm39) T1598A probably benign Het
Glp2r A G 11: 67,621,497 (GRCm39) F162S probably benign Het
Gm17655 T A 5: 110,195,039 (GRCm39) R248* probably null Het
Gnptab G A 10: 88,267,258 (GRCm39) G450S probably damaging Het
Gpatch2l G A 12: 86,290,958 (GRCm39) R47H probably damaging Het
Hapln2 A G 3: 87,931,135 (GRCm39) Y127H probably damaging Het
Hdac4 G T 1: 91,909,875 (GRCm39) T463K probably damaging Het
Ift80 A C 3: 68,835,068 (GRCm39) S458A probably benign Het
Lama1 A G 17: 68,098,459 (GRCm39) D1846G possibly damaging Het
Map3k8 A G 18: 4,340,801 (GRCm39) I171T probably benign Het
Micu1 A G 10: 59,576,489 (GRCm39) E115G probably damaging Het
Mrpl39 A G 16: 84,532,080 (GRCm39) V9A unknown Het
Ncoa7 T G 10: 30,570,117 (GRCm39) I281L possibly damaging Het
Nms A G 1: 38,980,976 (GRCm39) E54G probably benign Het
Nrip1 G A 16: 76,091,305 (GRCm39) A84V probably damaging Het
Or10ak9 T A 4: 118,726,335 (GRCm39) M119K probably damaging Het
Pcdhga10 T A 18: 37,881,285 (GRCm39) S349T probably damaging Het
R3hcc1 G A 14: 69,935,024 (GRCm39) P454L probably damaging Het
Rsrc1 C T 3: 66,901,982 (GRCm39) P44L unknown Het
Ryr3 T C 2: 112,788,520 (GRCm39) D170G probably damaging Het
Sanbr A G 11: 23,570,447 (GRCm39) V151A probably damaging Het
Scp2 C A 4: 107,962,283 (GRCm39) G81C probably damaging Het
Sez6 A G 11: 77,844,695 (GRCm39) T173A possibly damaging Het
Syne1 T C 10: 4,998,887 (GRCm39) H8142R probably benign Het
Tcof1 G C 18: 60,962,123 (GRCm39) A702G possibly damaging Het
Tnfrsf11a A G 1: 105,772,272 (GRCm39) T520A probably damaging Het
Tpm1 A G 9: 66,939,256 (GRCm39) S170P probably damaging Het
Try5 T C 6: 41,288,733 (GRCm39) D54G possibly damaging Het
Vmn2r-ps158 T C 7: 42,673,475 (GRCm39) F178L probably benign Het
Zan T C 5: 137,417,342 (GRCm39) E3041G unknown Het
Zfp1001 A T 2: 150,165,987 (GRCm39) Q56L probably benign Het
Zfp616 A T 11: 73,975,828 (GRCm39) H699L probably damaging Het
Other mutations in Or11g27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01128:Or11g27 APN 14 50,771,406 (GRCm39) missense probably damaging 1.00
IGL01551:Or11g27 APN 14 50,771,618 (GRCm39) missense probably benign
IGL02024:Or11g27 APN 14 50,771,307 (GRCm39) missense probably benign 0.00
IGL02867:Or11g27 APN 14 50,770,970 (GRCm39) missense probably benign
IGL02889:Or11g27 APN 14 50,770,970 (GRCm39) missense probably benign
IGL03195:Or11g27 APN 14 50,770,877 (GRCm39) missense probably benign
IGL03296:Or11g27 APN 14 50,771,402 (GRCm39) missense possibly damaging 0.90
R0049:Or11g27 UTSW 14 50,771,151 (GRCm39) missense probably damaging 1.00
R0049:Or11g27 UTSW 14 50,771,151 (GRCm39) missense probably damaging 1.00
R0102:Or11g27 UTSW 14 50,771,088 (GRCm39) missense probably damaging 1.00
R0556:Or11g27 UTSW 14 50,771,381 (GRCm39) missense probably benign 0.01
R0626:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0661:Or11g27 UTSW 14 50,771,552 (GRCm39) missense probably benign
R0759:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0761:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R0894:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1109:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1110:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1312:Or11g27 UTSW 14 50,771,652 (GRCm39) missense probably benign
R1446:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1470:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1470:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1502:Or11g27 UTSW 14 50,771,234 (GRCm39) missense possibly damaging 0.47
R1518:Or11g27 UTSW 14 50,771,622 (GRCm39) missense probably damaging 1.00
R1529:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1624:Or11g27 UTSW 14 50,771,100 (GRCm39) missense probably damaging 1.00
R1646:Or11g27 UTSW 14 50,771,040 (GRCm39) missense probably benign 0.01
R1687:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R1795:Or11g27 UTSW 14 50,771,159 (GRCm39) missense possibly damaging 0.78
R2011:Or11g27 UTSW 14 50,771,141 (GRCm39) missense probably damaging 1.00
R2120:Or11g27 UTSW 14 50,771,403 (GRCm39) missense probably damaging 1.00
R2697:Or11g27 UTSW 14 50,771,238 (GRCm39) missense probably damaging 1.00
R2857:Or11g27 UTSW 14 50,770,897 (GRCm39) missense probably benign 0.19
R2858:Or11g27 UTSW 14 50,770,897 (GRCm39) missense probably benign 0.19
R3906:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R4327:Or11g27 UTSW 14 50,770,971 (GRCm39) missense probably benign 0.05
R4355:Or11g27 UTSW 14 50,771,216 (GRCm39) missense possibly damaging 0.94
R4663:Or11g27 UTSW 14 50,771,061 (GRCm39) missense probably damaging 1.00
R5214:Or11g27 UTSW 14 50,771,804 (GRCm39) makesense probably null
R5964:Or11g27 UTSW 14 50,771,655 (GRCm39) missense probably damaging 0.99
R6148:Or11g27 UTSW 14 50,771,778 (GRCm39) missense probably benign 0.00
R6167:Or11g27 UTSW 14 50,771,612 (GRCm39) missense probably damaging 1.00
R6301:Or11g27 UTSW 14 50,771,711 (GRCm39) missense probably benign 0.02
R6616:Or11g27 UTSW 14 50,771,364 (GRCm39) missense probably benign 0.43
R7076:Or11g27 UTSW 14 50,771,278 (GRCm39) nonsense probably null
R7483:Or11g27 UTSW 14 50,771,472 (GRCm39) missense probably benign 0.06
R7574:Or11g27 UTSW 14 50,771,770 (GRCm39) missense probably benign 0.01
R7731:Or11g27 UTSW 14 50,771,141 (GRCm39) missense probably damaging 0.99
R8691:Or11g27 UTSW 14 50,770,910 (GRCm39) missense probably benign 0.01
R9072:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R9073:Or11g27 UTSW 14 50,771,211 (GRCm39) missense probably benign 0.03
R9321:Or11g27 UTSW 14 50,771,471 (GRCm39) missense probably benign 0.01
R9478:Or11g27 UTSW 14 50,771,051 (GRCm39) missense probably benign 0.01
R9557:Or11g27 UTSW 14 50,771,552 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GATCATTTCCTTCGCTGGATGC -3'
(R):5'- AGTCTGAACACAGTTCTTAGGAC -3'

Sequencing Primer
(F):5'- TTCGCTGGATGCTTCCTG -3'
(R):5'- GGACCAATATGTAAGATCCCATGATG -3'
Posted On 2018-11-06