Incidental Mutation 'R6910:Ncoa7'
ID 538979
Institutional Source Beutler Lab
Gene Symbol Ncoa7
Ensembl Gene ENSMUSG00000039697
Gene Name nuclear receptor coactivator 7
Synonyms 9030406N13Rik
MMRRC Submission 045002-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6910 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 30521578-30683401 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 30570117 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 281 (I281L)
Ref Sequence ENSEMBL: ENSMUSP00000149957 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068567] [ENSMUST00000213836] [ENSMUST00000215725] [ENSMUST00000215740] [ENSMUST00000215926]
AlphaFold Q6DFV7
Predicted Effect possibly damaging
Transcript: ENSMUST00000068567
AA Change: I281L

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000066741
Gene: ENSMUSG00000039697
AA Change: I281L

DomainStartEndE-ValueType
coiled coil region 1 32 N/A INTRINSIC
LysM 118 161 2.24e-7 SMART
low complexity region 165 176 N/A INTRINSIC
TLDc 781 943 2.86e-64 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000213836
AA Change: I281L

PolyPhen 2 Score 0.891 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000215725
Predicted Effect possibly damaging
Transcript: ENSMUST00000215740
AA Change: I281L

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215926
AA Change: I243L

PolyPhen 2 Score 0.781 (Sensitivity: 0.85; Specificity: 0.93)
Predicted Effect probably benign
Transcript: ENSMUST00000217398
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (37/37)
Allele List at MGI

All alleles(108) : Gene trapped(108)

Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cfap54 A G 10: 92,672,374 (GRCm39) S2899P probably benign Het
Chil5 A G 3: 105,926,977 (GRCm39) W82R probably damaging Het
Dennd3 A G 15: 73,426,965 (GRCm39) T781A probably benign Het
Epha2 A G 4: 141,048,824 (GRCm39) D597G probably damaging Het
Gcn1 A G 5: 115,744,597 (GRCm39) T1598A probably benign Het
Glp2r A G 11: 67,621,497 (GRCm39) F162S probably benign Het
Gm17655 T A 5: 110,195,039 (GRCm39) R248* probably null Het
Gnptab G A 10: 88,267,258 (GRCm39) G450S probably damaging Het
Gpatch2l G A 12: 86,290,958 (GRCm39) R47H probably damaging Het
Hapln2 A G 3: 87,931,135 (GRCm39) Y127H probably damaging Het
Hdac4 G T 1: 91,909,875 (GRCm39) T463K probably damaging Het
Ift80 A C 3: 68,835,068 (GRCm39) S458A probably benign Het
Lama1 A G 17: 68,098,459 (GRCm39) D1846G possibly damaging Het
Map3k8 A G 18: 4,340,801 (GRCm39) I171T probably benign Het
Micu1 A G 10: 59,576,489 (GRCm39) E115G probably damaging Het
Mrpl39 A G 16: 84,532,080 (GRCm39) V9A unknown Het
Nms A G 1: 38,980,976 (GRCm39) E54G probably benign Het
Nrip1 G A 16: 76,091,305 (GRCm39) A84V probably damaging Het
Or10ak9 T A 4: 118,726,335 (GRCm39) M119K probably damaging Het
Or11g27 G A 14: 50,771,330 (GRCm39) V154M probably benign Het
Pcdhga10 T A 18: 37,881,285 (GRCm39) S349T probably damaging Het
R3hcc1 G A 14: 69,935,024 (GRCm39) P454L probably damaging Het
Rsrc1 C T 3: 66,901,982 (GRCm39) P44L unknown Het
Ryr3 T C 2: 112,788,520 (GRCm39) D170G probably damaging Het
Sanbr A G 11: 23,570,447 (GRCm39) V151A probably damaging Het
Scp2 C A 4: 107,962,283 (GRCm39) G81C probably damaging Het
Sez6 A G 11: 77,844,695 (GRCm39) T173A possibly damaging Het
Syne1 T C 10: 4,998,887 (GRCm39) H8142R probably benign Het
Tcof1 G C 18: 60,962,123 (GRCm39) A702G possibly damaging Het
Tnfrsf11a A G 1: 105,772,272 (GRCm39) T520A probably damaging Het
Tpm1 A G 9: 66,939,256 (GRCm39) S170P probably damaging Het
Try5 T C 6: 41,288,733 (GRCm39) D54G possibly damaging Het
Vmn2r-ps158 T C 7: 42,673,475 (GRCm39) F178L probably benign Het
Zan T C 5: 137,417,342 (GRCm39) E3041G unknown Het
Zfp1001 A T 2: 150,165,987 (GRCm39) Q56L probably benign Het
Zfp616 A T 11: 73,975,828 (GRCm39) H699L probably damaging Het
Other mutations in Ncoa7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01406:Ncoa7 APN 10 30,566,836 (GRCm39) missense probably damaging 1.00
IGL01716:Ncoa7 APN 10 30,538,330 (GRCm39) missense probably damaging 0.96
IGL02114:Ncoa7 APN 10 30,538,360 (GRCm39) missense probably damaging 1.00
IGL02170:Ncoa7 APN 10 30,565,849 (GRCm39) missense possibly damaging 0.94
IGL02436:Ncoa7 APN 10 30,570,143 (GRCm39) missense probably damaging 1.00
IGL02499:Ncoa7 APN 10 30,566,885 (GRCm39) missense probably benign 0.04
IGL02533:Ncoa7 APN 10 30,598,781 (GRCm39) missense probably damaging 1.00
IGL02533:Ncoa7 APN 10 30,566,895 (GRCm39) missense possibly damaging 0.87
IGL02590:Ncoa7 APN 10 30,570,159 (GRCm39) missense probably damaging 1.00
IGL02657:Ncoa7 APN 10 30,528,972 (GRCm39) missense probably damaging 1.00
IGL03065:Ncoa7 APN 10 30,523,993 (GRCm39) missense probably damaging 1.00
IGL03088:Ncoa7 APN 10 30,574,121 (GRCm39) splice site probably null
IGL03090:Ncoa7 APN 10 30,538,396 (GRCm39) missense probably damaging 0.96
IGL03196:Ncoa7 APN 10 30,523,510 (GRCm39) utr 3 prime probably benign
D6062:Ncoa7 UTSW 10 30,598,651 (GRCm39) missense probably damaging 1.00
R0058:Ncoa7 UTSW 10 30,523,537 (GRCm39) missense probably damaging 1.00
R0058:Ncoa7 UTSW 10 30,523,537 (GRCm39) missense probably damaging 1.00
R0578:Ncoa7 UTSW 10 30,577,913 (GRCm39) critical splice donor site probably null
R0729:Ncoa7 UTSW 10 30,567,575 (GRCm39) missense probably benign 0.00
R1538:Ncoa7 UTSW 10 30,570,207 (GRCm39) missense probably damaging 0.99
R1539:Ncoa7 UTSW 10 30,647,725 (GRCm39) missense probably damaging 1.00
R1574:Ncoa7 UTSW 10 30,570,097 (GRCm39) missense probably damaging 1.00
R1574:Ncoa7 UTSW 10 30,570,097 (GRCm39) missense probably damaging 1.00
R1624:Ncoa7 UTSW 10 30,580,655 (GRCm39) missense possibly damaging 0.87
R1639:Ncoa7 UTSW 10 30,577,988 (GRCm39) missense probably damaging 1.00
R1655:Ncoa7 UTSW 10 30,574,241 (GRCm39) critical splice acceptor site probably null
R1876:Ncoa7 UTSW 10 30,574,122 (GRCm39) intron probably benign
R1885:Ncoa7 UTSW 10 30,524,448 (GRCm39) missense possibly damaging 0.81
R1886:Ncoa7 UTSW 10 30,524,448 (GRCm39) missense possibly damaging 0.81
R1887:Ncoa7 UTSW 10 30,524,448 (GRCm39) missense possibly damaging 0.81
R1909:Ncoa7 UTSW 10 30,565,796 (GRCm39) missense probably damaging 1.00
R1938:Ncoa7 UTSW 10 30,574,166 (GRCm39) missense probably benign 0.02
R1965:Ncoa7 UTSW 10 30,530,426 (GRCm39) nonsense probably null
R1978:Ncoa7 UTSW 10 30,567,295 (GRCm39) missense probably benign
R2303:Ncoa7 UTSW 10 30,530,431 (GRCm39) missense probably damaging 1.00
R3777:Ncoa7 UTSW 10 30,565,752 (GRCm39) missense probably damaging 1.00
R3778:Ncoa7 UTSW 10 30,565,752 (GRCm39) missense probably damaging 1.00
R4026:Ncoa7 UTSW 10 30,598,720 (GRCm39) missense probably benign 0.02
R4230:Ncoa7 UTSW 10 30,574,253 (GRCm39) splice site probably null
R4667:Ncoa7 UTSW 10 30,566,786 (GRCm39) missense probably damaging 1.00
R4786:Ncoa7 UTSW 10 30,531,638 (GRCm39) missense probably benign 0.28
R4809:Ncoa7 UTSW 10 30,647,758 (GRCm39) missense possibly damaging 0.92
R4820:Ncoa7 UTSW 10 30,524,472 (GRCm39) missense probably damaging 1.00
R4839:Ncoa7 UTSW 10 30,598,655 (GRCm39) missense possibly damaging 0.93
R4861:Ncoa7 UTSW 10 30,580,608 (GRCm39) missense probably benign
R4861:Ncoa7 UTSW 10 30,580,608 (GRCm39) missense probably benign
R5271:Ncoa7 UTSW 10 30,598,725 (GRCm39) missense probably benign 0.02
R5384:Ncoa7 UTSW 10 30,598,813 (GRCm39) missense probably benign 0.00
R5418:Ncoa7 UTSW 10 30,524,035 (GRCm39) missense probably damaging 1.00
R5964:Ncoa7 UTSW 10 30,580,632 (GRCm39) missense probably damaging 1.00
R6257:Ncoa7 UTSW 10 30,570,173 (GRCm39) missense probably damaging 1.00
R6683:Ncoa7 UTSW 10 30,647,717 (GRCm39) missense probably damaging 0.99
R6813:Ncoa7 UTSW 10 30,572,188 (GRCm39) missense probably damaging 1.00
R7123:Ncoa7 UTSW 10 30,530,435 (GRCm39) missense probably benign 0.28
R7327:Ncoa7 UTSW 10 30,565,796 (GRCm39) missense probably damaging 1.00
R7412:Ncoa7 UTSW 10 30,598,847 (GRCm39) missense possibly damaging 0.94
R7638:Ncoa7 UTSW 10 30,598,794 (GRCm39) missense probably benign 0.35
R7653:Ncoa7 UTSW 10 30,570,239 (GRCm39) missense probably damaging 1.00
R7848:Ncoa7 UTSW 10 30,524,414 (GRCm39) missense possibly damaging 0.82
R7861:Ncoa7 UTSW 10 30,567,056 (GRCm39) missense probably benign 0.38
R8125:Ncoa7 UTSW 10 30,570,087 (GRCm39) missense possibly damaging 0.80
R8198:Ncoa7 UTSW 10 30,580,664 (GRCm39) missense probably benign 0.00
R8240:Ncoa7 UTSW 10 30,567,725 (GRCm39) missense probably benign 0.45
R8353:Ncoa7 UTSW 10 30,570,155 (GRCm39) missense probably damaging 1.00
R8509:Ncoa7 UTSW 10 30,572,048 (GRCm39) missense probably benign 0.00
R8861:Ncoa7 UTSW 10 30,567,364 (GRCm39) missense probably benign 0.02
R9040:Ncoa7 UTSW 10 30,530,389 (GRCm39) missense probably benign 0.00
R9136:Ncoa7 UTSW 10 30,567,628 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GACGCCAGGTAGATCTTAAATAGC -3'
(R):5'- ACATGGAAGGTTCTGTGATGGC -3'

Sequencing Primer
(F):5'- TTTCAATTTCACAACACAAAATCTCC -3'
(R):5'- AAGGTTCTGTGATGGCTGAGGAATAC -3'
Posted On 2018-11-06