Incidental Mutation 'R6860:Ptprk'
| ID |
535450 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ptprk
|
| Ensembl Gene |
ENSMUSG00000019889 |
| Gene Name |
protein tyrosine phosphatase receptor type K |
| Synonyms |
RPTPkappa, PTPk |
| MMRRC Submission |
045025-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6860 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
27950816-28473393 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 28210480 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 167
(F167L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126279
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166468]
[ENSMUST00000218276]
[ENSMUST00000218359]
|
| AlphaFold |
P35822 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166468
AA Change: F167L
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000126279
Gene: ENSMUSG00000019889
AA Change: F167L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
MAM
|
30 |
193 |
1.61e-73 |
SMART |
|
IG
|
200 |
288 |
2.16e-8 |
SMART |
|
FN3
|
290 |
373 |
1.48e-4 |
SMART |
|
FN3
|
389 |
475 |
4.24e1 |
SMART |
|
FN3
|
491 |
579 |
3.32e-7 |
SMART |
|
transmembrane domain
|
753 |
774 |
N/A |
INTRINSIC |
|
PTPc
|
898 |
1161 |
3.56e-132 |
SMART |
|
PTPc
|
1190 |
1455 |
2.68e-86 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000218276
AA Change: F167L
PolyPhen 2
Score 0.892 (Sensitivity: 0.82; Specificity: 0.94)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000218359
AA Change: F167L
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| Meta Mutation Damage Score |
0.5107 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.3%
|
| Validation Efficiency |
100% (86/86) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933427D14Rik |
T |
C |
11: 72,080,412 (GRCm39) |
E418G |
probably damaging |
Het |
| 9930012K11Rik |
C |
A |
14: 70,395,071 (GRCm39) |
V28L |
possibly damaging |
Het |
| Abtb2 |
C |
T |
2: 103,539,770 (GRCm39) |
R712* |
probably null |
Het |
| Acvr1c |
C |
T |
2: 58,177,717 (GRCm39) |
G171S |
probably damaging |
Het |
| Ahctf1 |
G |
T |
1: 179,580,853 (GRCm39) |
A1783E |
probably benign |
Het |
| Anapc4 |
A |
T |
5: 53,006,170 (GRCm39) |
Q149L |
probably damaging |
Het |
| Ankrd27 |
T |
C |
7: 35,327,952 (GRCm39) |
V824A |
possibly damaging |
Het |
| Ankrd31 |
G |
C |
13: 96,968,094 (GRCm39) |
C577S |
probably benign |
Het |
| Apol7c |
T |
C |
15: 77,410,274 (GRCm39) |
N224S |
probably benign |
Het |
| Arl14 |
A |
T |
3: 69,130,029 (GRCm39) |
T59S |
probably benign |
Het |
| Astn1 |
T |
A |
1: 158,440,042 (GRCm39) |
I870K |
probably damaging |
Het |
| B4galt1 |
A |
T |
4: 40,807,796 (GRCm39) |
V335E |
probably benign |
Het |
| C2cd3 |
C |
T |
7: 100,039,448 (GRCm39) |
P216S |
probably benign |
Het |
| Cchcr1 |
C |
A |
17: 35,840,015 (GRCm39) |
N711K |
possibly damaging |
Het |
| Chd2 |
A |
G |
7: 73,147,558 (GRCm39) |
F467L |
possibly damaging |
Het |
| Cntn6 |
A |
T |
6: 104,838,907 (GRCm39) |
E987V |
possibly damaging |
Het |
| Col11a2 |
T |
A |
17: 34,272,572 (GRCm39) |
L286H |
probably damaging |
Het |
| Cwc22 |
C |
T |
2: 77,759,792 (GRCm39) |
R85Q |
possibly damaging |
Het |
| Cyp7a1 |
A |
C |
4: 6,272,587 (GRCm39) |
F209V |
probably damaging |
Het |
| Dmtn |
T |
C |
14: 70,852,322 (GRCm39) |
T189A |
possibly damaging |
Het |
| Dnhd1 |
C |
G |
7: 105,327,473 (GRCm39) |
N777K |
probably benign |
Het |
| Dusp16 |
A |
T |
6: 134,702,842 (GRCm39) |
C216* |
probably null |
Het |
| Fan1 |
T |
A |
7: 64,022,234 (GRCm39) |
N340Y |
probably damaging |
Het |
| Fbn1 |
T |
C |
2: 125,170,078 (GRCm39) |
N1993S |
probably damaging |
Het |
| Fbxw22 |
A |
G |
9: 109,213,030 (GRCm39) |
S306P |
probably benign |
Het |
| Ferd3l |
T |
C |
12: 33,978,651 (GRCm39) |
S55P |
probably benign |
Het |
| Fpr-rs3 |
A |
G |
17: 20,844,560 (GRCm39) |
S194P |
possibly damaging |
Het |
| Gm19965 |
G |
A |
1: 116,748,609 (GRCm39) |
D97N |
probably benign |
Het |
| Gtpbp2 |
A |
G |
17: 46,478,914 (GRCm39) |
|
probably benign |
Het |
| H3c7 |
G |
T |
13: 23,728,760 (GRCm39) |
V36L |
probably benign |
Het |
| Hcn3 |
A |
C |
3: 89,067,152 (GRCm39) |
I72S |
possibly damaging |
Het |
| Hk3 |
T |
A |
13: 55,162,278 (GRCm39) |
N109Y |
probably damaging |
Het |
| Iqub |
T |
C |
6: 24,505,737 (GRCm39) |
E57G |
possibly damaging |
Het |
| Kcnk3 |
T |
A |
5: 30,779,397 (GRCm39) |
M149K |
possibly damaging |
Het |
| Kcp |
C |
T |
6: 29,505,719 (GRCm39) |
G51D |
probably benign |
Het |
| Kif26a |
C |
A |
12: 112,113,263 (GRCm39) |
A53D |
probably damaging |
Het |
| Lifr |
T |
A |
15: 7,202,418 (GRCm39) |
I353K |
probably benign |
Het |
| Llph |
A |
T |
10: 120,067,189 (GRCm39) |
N102I |
probably damaging |
Het |
| Lmo3 |
C |
A |
6: 138,393,566 (GRCm39) |
R18L |
possibly damaging |
Het |
| Lrrc46 |
T |
C |
11: 96,926,371 (GRCm39) |
E175G |
probably benign |
Het |
| Ltk |
A |
T |
2: 119,585,075 (GRCm39) |
C128* |
probably null |
Het |
| Map1b |
T |
C |
13: 99,571,275 (GRCm39) |
E482G |
probably damaging |
Het |
| Mapk8ip2 |
T |
C |
15: 89,344,655 (GRCm39) |
V740A |
probably damaging |
Het |
| Miga2 |
T |
C |
2: 30,261,175 (GRCm39) |
W157R |
probably benign |
Het |
| Mlip |
A |
G |
9: 77,009,675 (GRCm39) |
*837Q |
probably null |
Het |
| Mroh2a |
G |
T |
1: 88,182,657 (GRCm39) |
R1195L |
possibly damaging |
Het |
| Myl1 |
T |
C |
1: 66,984,217 (GRCm39) |
|
probably benign |
Het |
| Or1l4 |
T |
C |
2: 37,092,189 (GRCm39) |
L312P |
possibly damaging |
Het |
| Or2a5 |
T |
C |
6: 42,873,750 (GRCm39) |
Y122H |
probably benign |
Het |
| Or51ab3 |
A |
G |
7: 103,201,075 (GRCm39) |
I28V |
probably benign |
Het |
| P3h3 |
A |
T |
6: 124,834,331 (GRCm39) |
V107D |
probably benign |
Het |
| Papolb |
A |
T |
5: 142,514,651 (GRCm39) |
S331T |
possibly damaging |
Het |
| Pars2 |
T |
G |
4: 106,511,700 (GRCm39) |
V494G |
probably benign |
Het |
| Pcdhb3 |
C |
A |
18: 37,434,763 (GRCm39) |
T243K |
probably benign |
Het |
| Pde9a |
T |
A |
17: 31,689,698 (GRCm39) |
M415K |
probably damaging |
Het |
| Ppp1r9b |
G |
A |
11: 94,882,974 (GRCm39) |
A201T |
probably benign |
Het |
| Prl |
A |
G |
13: 27,248,942 (GRCm39) |
N197S |
possibly damaging |
Het |
| Prl2c1 |
T |
A |
13: 28,035,724 (GRCm39) |
M32K |
probably benign |
Het |
| Prrt4 |
T |
C |
6: 29,170,737 (GRCm39) |
S572G |
possibly damaging |
Het |
| Psd |
T |
A |
19: 46,310,858 (GRCm39) |
D397V |
probably damaging |
Het |
| Psme2b |
A |
T |
11: 48,836,307 (GRCm39) |
Y213* |
probably null |
Het |
| Ptcd3 |
T |
A |
6: 71,874,094 (GRCm39) |
|
probably null |
Het |
| Rfx7 |
T |
C |
9: 72,524,226 (GRCm39) |
V472A |
probably damaging |
Het |
| Sanbr |
A |
G |
11: 23,575,100 (GRCm39) |
L58P |
probably damaging |
Het |
| Scnn1g |
T |
C |
7: 121,339,576 (GRCm39) |
L125S |
probably damaging |
Het |
| Sec16a |
T |
C |
2: 26,320,124 (GRCm39) |
Y1438C |
probably damaging |
Het |
| Serinc3 |
C |
T |
2: 163,476,366 (GRCm39) |
S155N |
probably benign |
Het |
| Slc3a2 |
A |
T |
19: 8,690,996 (GRCm39) |
V78E |
probably damaging |
Het |
| Slc44a4 |
T |
A |
17: 35,140,044 (GRCm39) |
L23Q |
probably damaging |
Het |
| Slco5a1 |
C |
T |
1: 12,951,420 (GRCm39) |
|
probably benign |
Het |
| Slit1 |
A |
G |
19: 41,605,154 (GRCm39) |
M899T |
probably benign |
Het |
| Sorl1 |
A |
G |
9: 41,933,688 (GRCm39) |
I1094T |
probably benign |
Het |
| Spag9 |
T |
A |
11: 93,972,196 (GRCm39) |
L258Q |
probably benign |
Het |
| Strip1 |
T |
C |
3: 107,526,252 (GRCm39) |
E488G |
possibly damaging |
Het |
| Stx18 |
G |
A |
5: 38,262,235 (GRCm39) |
D30N |
possibly damaging |
Het |
| Sync |
T |
C |
4: 129,181,583 (GRCm39) |
|
probably null |
Het |
| Syncrip |
A |
G |
9: 88,358,849 (GRCm39) |
V220A |
probably damaging |
Het |
| Tagln2 |
T |
C |
1: 172,333,476 (GRCm39) |
I110T |
probably benign |
Het |
| Taok1 |
T |
C |
11: 77,432,627 (GRCm39) |
T729A |
probably benign |
Het |
| Tgfbrap1 |
C |
T |
1: 43,106,759 (GRCm39) |
V75I |
possibly damaging |
Het |
| Tnfrsf21 |
A |
G |
17: 43,327,957 (GRCm39) |
T24A |
probably benign |
Het |
| Tnxb |
T |
A |
17: 34,932,131 (GRCm39) |
D2221E |
probably damaging |
Het |
| Triml1 |
A |
G |
8: 43,583,603 (GRCm39) |
S333P |
probably damaging |
Het |
| Trp53bp1 |
C |
A |
2: 121,029,594 (GRCm39) |
R1862L |
probably damaging |
Het |
| Tsc22d1 |
T |
G |
14: 76,655,732 (GRCm39) |
I737S |
possibly damaging |
Het |
| U2af2 |
A |
T |
7: 5,082,273 (GRCm39) |
K462N |
possibly damaging |
Het |
| Ubap2 |
A |
C |
4: 41,233,631 (GRCm39) |
N86K |
probably damaging |
Het |
| Uso1 |
A |
G |
5: 92,343,207 (GRCm39) |
K764E |
probably benign |
Het |
| Vmn1r192 |
T |
A |
13: 22,372,122 (GRCm39) |
M33L |
probably benign |
Het |
|
| Other mutations in Ptprk |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00310:Ptprk
|
APN |
10 |
28,212,506 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL00533:Ptprk
|
APN |
10 |
28,461,971 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01062:Ptprk
|
APN |
10 |
28,456,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01295:Ptprk
|
APN |
10 |
28,351,174 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01372:Ptprk
|
APN |
10 |
28,445,923 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01452:Ptprk
|
APN |
10 |
28,450,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01829:Ptprk
|
APN |
10 |
28,449,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01861:Ptprk
|
APN |
10 |
28,259,441 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01955:Ptprk
|
APN |
10 |
28,471,861 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02263:Ptprk
|
APN |
10 |
27,951,110 (GRCm39) |
missense |
unknown |
|
|
IGL02489:Ptprk
|
APN |
10 |
28,259,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Ptprk
|
APN |
10 |
28,451,614 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02713:Ptprk
|
APN |
10 |
28,468,807 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02943:Ptprk
|
APN |
10 |
28,351,172 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03240:Ptprk
|
APN |
10 |
28,368,957 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03373:Ptprk
|
APN |
10 |
28,442,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
LCD18:Ptprk
|
UTSW |
10 |
28,450,983 (GRCm39) |
intron |
probably benign |
|
|
PIT4366001:Ptprk
|
UTSW |
10 |
28,462,015 (GRCm39) |
missense |
probably benign |
|
|
R0010:Ptprk
|
UTSW |
10 |
28,461,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0021:Ptprk
|
UTSW |
10 |
28,468,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0021:Ptprk
|
UTSW |
10 |
28,468,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0035:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R0035:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R0053:Ptprk
|
UTSW |
10 |
28,351,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0063:Ptprk
|
UTSW |
10 |
28,139,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0063:Ptprk
|
UTSW |
10 |
28,139,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0244:Ptprk
|
UTSW |
10 |
28,082,221 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0281:Ptprk
|
UTSW |
10 |
28,449,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0387:Ptprk
|
UTSW |
10 |
28,230,625 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0480:Ptprk
|
UTSW |
10 |
28,461,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0480:Ptprk
|
UTSW |
10 |
28,461,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0585:Ptprk
|
UTSW |
10 |
28,451,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Ptprk
|
UTSW |
10 |
27,951,132 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0684:Ptprk
|
UTSW |
10 |
28,359,294 (GRCm39) |
splice site |
probably benign |
|
|
R1073:Ptprk
|
UTSW |
10 |
28,372,943 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1377:Ptprk
|
UTSW |
10 |
28,462,022 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1422:Ptprk
|
UTSW |
10 |
28,351,276 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1482:Ptprk
|
UTSW |
10 |
28,139,512 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Ptprk
|
UTSW |
10 |
28,461,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1576:Ptprk
|
UTSW |
10 |
28,427,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1618:Ptprk
|
UTSW |
10 |
28,369,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1654:Ptprk
|
UTSW |
10 |
28,259,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Ptprk
|
UTSW |
10 |
28,342,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Ptprk
|
UTSW |
10 |
28,230,688 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2033:Ptprk
|
UTSW |
10 |
28,468,763 (GRCm39) |
unclassified |
probably benign |
|
|
R2059:Ptprk
|
UTSW |
10 |
28,442,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2076:Ptprk
|
UTSW |
10 |
28,465,364 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2164:Ptprk
|
UTSW |
10 |
28,436,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2260:Ptprk
|
UTSW |
10 |
28,082,145 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2394:Ptprk
|
UTSW |
10 |
28,427,713 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2432:Ptprk
|
UTSW |
10 |
28,468,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2437:Ptprk
|
UTSW |
10 |
28,230,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2495:Ptprk
|
UTSW |
10 |
28,351,074 (GRCm39) |
splice site |
probably benign |
|
|
R3037:Ptprk
|
UTSW |
10 |
28,456,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3162:Ptprk
|
UTSW |
10 |
28,468,822 (GRCm39) |
missense |
probably benign |
|
|
R3162:Ptprk
|
UTSW |
10 |
28,468,822 (GRCm39) |
missense |
probably benign |
|
|
R3687:Ptprk
|
UTSW |
10 |
28,349,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Ptprk
|
UTSW |
10 |
28,259,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3892:Ptprk
|
UTSW |
10 |
28,139,617 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3963:Ptprk
|
UTSW |
10 |
28,427,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4077:Ptprk
|
UTSW |
10 |
28,139,508 (GRCm39) |
missense |
probably benign |
|
|
R4079:Ptprk
|
UTSW |
10 |
28,139,508 (GRCm39) |
missense |
probably benign |
|
|
R4112:Ptprk
|
UTSW |
10 |
28,351,284 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4255:Ptprk
|
UTSW |
10 |
28,082,241 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4523:Ptprk
|
UTSW |
10 |
28,342,048 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Ptprk
|
UTSW |
10 |
28,139,686 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4652:Ptprk
|
UTSW |
10 |
28,139,686 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4828:Ptprk
|
UTSW |
10 |
28,436,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Ptprk
|
UTSW |
10 |
28,456,480 (GRCm39) |
nonsense |
probably null |
|
|
R4883:Ptprk
|
UTSW |
10 |
28,464,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5004:Ptprk
|
UTSW |
10 |
28,462,059 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5013:Ptprk
|
UTSW |
10 |
28,427,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5092:Ptprk
|
UTSW |
10 |
28,468,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5126:Ptprk
|
UTSW |
10 |
28,451,640 (GRCm39) |
splice site |
probably null |
|
|
R5183:Ptprk
|
UTSW |
10 |
28,351,232 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5264:Ptprk
|
UTSW |
10 |
28,461,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Ptprk
|
UTSW |
10 |
28,468,050 (GRCm39) |
splice site |
probably null |
|
|
R5330:Ptprk
|
UTSW |
10 |
28,463,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5474:Ptprk
|
UTSW |
10 |
28,372,926 (GRCm39) |
nonsense |
probably null |
|
|
R5516:Ptprk
|
UTSW |
10 |
28,372,926 (GRCm39) |
nonsense |
probably null |
|
|
R5796:Ptprk
|
UTSW |
10 |
28,259,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5843:Ptprk
|
UTSW |
10 |
28,369,060 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5952:Ptprk
|
UTSW |
10 |
28,461,671 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6065:Ptprk
|
UTSW |
10 |
28,351,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6226:Ptprk
|
UTSW |
10 |
28,440,099 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6264:Ptprk
|
UTSW |
10 |
28,442,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6638:Ptprk
|
UTSW |
10 |
28,471,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6843:Ptprk
|
UTSW |
10 |
28,467,978 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6869:Ptprk
|
UTSW |
10 |
28,349,055 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7214:Ptprk
|
UTSW |
10 |
28,450,905 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7307:Ptprk
|
UTSW |
10 |
28,465,004 (GRCm39) |
nonsense |
probably null |
|
|
R7349:Ptprk
|
UTSW |
10 |
28,468,834 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7442:Ptprk
|
UTSW |
10 |
28,450,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7585:Ptprk
|
UTSW |
10 |
28,436,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7661:Ptprk
|
UTSW |
10 |
28,342,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7694:Ptprk
|
UTSW |
10 |
28,465,366 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7740:Ptprk
|
UTSW |
10 |
28,372,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Ptprk
|
UTSW |
10 |
28,468,853 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7831:Ptprk
|
UTSW |
10 |
28,444,404 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7836:Ptprk
|
UTSW |
10 |
28,449,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8049:Ptprk
|
UTSW |
10 |
28,259,565 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8235:Ptprk
|
UTSW |
10 |
28,465,037 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8274:Ptprk
|
UTSW |
10 |
28,456,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8286:Ptprk
|
UTSW |
10 |
28,444,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8372:Ptprk
|
UTSW |
10 |
28,230,688 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8727:Ptprk
|
UTSW |
10 |
28,442,541 (GRCm39) |
unclassified |
probably benign |
|
|
R8794:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R8842:Ptprk
|
UTSW |
10 |
28,442,497 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8861:Ptprk
|
UTSW |
10 |
28,446,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Ptprk
|
UTSW |
10 |
28,467,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8910:Ptprk
|
UTSW |
10 |
28,368,993 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8919:Ptprk
|
UTSW |
10 |
28,359,203 (GRCm39) |
nonsense |
probably null |
|
|
R8976:Ptprk
|
UTSW |
10 |
28,461,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8982:Ptprk
|
UTSW |
10 |
28,436,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9036:Ptprk
|
UTSW |
10 |
28,461,928 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9135:Ptprk
|
UTSW |
10 |
28,456,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9308:Ptprk
|
UTSW |
10 |
28,450,850 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9317:Ptprk
|
UTSW |
10 |
28,230,731 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9475:Ptprk
|
UTSW |
10 |
28,210,476 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9585:Ptprk
|
UTSW |
10 |
28,369,147 (GRCm39) |
nonsense |
probably null |
|
|
R9625:Ptprk
|
UTSW |
10 |
28,462,006 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9700:Ptprk
|
UTSW |
10 |
28,456,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9745:Ptprk
|
UTSW |
10 |
28,139,608 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
Z1177:Ptprk
|
UTSW |
10 |
28,369,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAATACTTGCTAGTACGTGCTTAAGC -3'
(R):5'- CAATGGCCAGGCAATAAACG -3'
Sequencing Primer
(F):5'- TTGGAACTTTGTGAACACAGCAG -3'
(R):5'- GATCAACAGCCTCTGCCAGTC -3'
|
| Posted On |
2018-09-12 |
Incidental Mutation