Incidental Mutation 'R6852:Zfp560'
ID 535035
Institutional Source Beutler Lab
Gene Symbol Zfp560
Ensembl Gene ENSMUSG00000045519
Gene Name zinc finger protein 560
Synonyms 2310030G09Rik
MMRRC Submission 045023-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6852 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 20256432-20296473 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20259339 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 508 (C508R)
Ref Sequence ENSEMBL: ENSMUSP00000065620 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068079] [ENSMUST00000143992]
AlphaFold Q3URI6
Predicted Effect probably damaging
Transcript: ENSMUST00000068079
AA Change: C508R

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000065620
Gene: ENSMUSG00000045519
AA Change: C508R

DomainStartEndE-ValueType
KRAB 41 101 3.22e-27 SMART
low complexity region 147 158 N/A INTRINSIC
ZnF_C2H2 279 301 4.01e-5 SMART
ZnF_C2H2 307 329 9.58e-3 SMART
ZnF_C2H2 335 357 5.5e-3 SMART
ZnF_C2H2 363 385 9.58e-3 SMART
ZnF_C2H2 391 413 3.74e-5 SMART
ZnF_C2H2 419 441 2.43e-4 SMART
ZnF_C2H2 447 469 1.28e-3 SMART
ZnF_C2H2 475 497 1.06e-4 SMART
ZnF_C2H2 503 525 3.11e-2 SMART
ZnF_C2H2 531 553 8.47e-4 SMART
ZnF_C2H2 559 581 2.99e-4 SMART
ZnF_C2H2 587 609 4.24e-4 SMART
ZnF_C2H2 615 637 3.44e-4 SMART
ZnF_C2H2 643 665 1.26e-2 SMART
ZnF_C2H2 671 693 1.69e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000143992
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik C T 3: 137,770,930 (GRCm39) Q40* probably null Het
1700034E13Rik T C 18: 52,796,705 (GRCm39) V81A probably damaging Het
A630089N07Rik A G 16: 97,866,855 (GRCm39) I369T probably benign Het
Aatk T A 11: 119,901,294 (GRCm39) Q977L probably benign Het
Abca4 A T 3: 121,928,844 (GRCm39) Q144H probably damaging Het
Ampd3 T C 7: 110,401,753 (GRCm39) F416L probably benign Het
Anks1b A G 10: 90,096,516 (GRCm39) E425G probably damaging Het
Atm A G 9: 53,393,730 (GRCm39) S1737P possibly damaging Het
Bsph1 T A 7: 13,204,255 (GRCm39) probably null Het
Cabyr C T 18: 12,887,154 (GRCm39) P262S probably benign Het
Cdc14a G A 3: 116,122,325 (GRCm39) P214L possibly damaging Het
Cep128 C A 12: 91,333,116 (GRCm39) probably null Het
Cfh T A 1: 140,075,487 (GRCm39) R250S probably damaging Het
Ddx39a T C 8: 84,449,646 (GRCm39) I417T probably benign Het
Dgka T A 10: 128,558,408 (GRCm39) K548M probably damaging Het
Efr3a G A 15: 65,701,679 (GRCm39) V198I probably benign Het
Elapor1 T C 3: 108,389,654 (GRCm39) E203G probably damaging Het
Epg5 C T 18: 78,056,106 (GRCm39) T1760I probably damaging Het
Fat1 T C 8: 45,488,635 (GRCm39) V3472A possibly damaging Het
Fbxo48 T A 11: 16,903,402 (GRCm39) N9K probably benign Het
Fcgbpl1 T A 7: 27,846,560 (GRCm39) I1084N probably damaging Het
Fer1l6 A T 15: 58,466,727 (GRCm39) H833L probably damaging Het
Foxn1 G T 11: 78,251,786 (GRCm39) Q482K probably benign Het
Fstl5 A G 3: 76,615,162 (GRCm39) D741G probably damaging Het
Gmip C T 8: 70,270,641 (GRCm39) Q55* probably null Het
H2-T5 T C 17: 36,478,965 (GRCm39) N95D possibly damaging Het
Hapln2 G A 3: 87,929,958 (GRCm39) T306M possibly damaging Het
Kat6a T A 8: 23,428,676 (GRCm39) S1344T probably benign Het
Kctd1 C T 18: 15,119,401 (GRCm39) D705N possibly damaging Het
Lhx9 ACC ACCC 1: 138,769,544 (GRCm39) probably null Het
Micall2 G T 5: 139,701,548 (GRCm39) A482D possibly damaging Het
Mindy3 T A 2: 12,424,063 (GRCm39) M1L possibly damaging Het
Mtdh A G 15: 34,136,867 (GRCm39) E352G probably damaging Het
Muc5ac G A 7: 141,370,644 (GRCm39) V3219I probably benign Het
Myh4 A G 11: 67,143,794 (GRCm39) probably null Het
Ncor1 A G 11: 62,234,071 (GRCm39) I377T probably damaging Het
Oog4 C A 4: 143,165,679 (GRCm39) C156F possibly damaging Het
Or5m9 A T 2: 85,876,948 (GRCm39) I41F probably benign Het
Pcyt1a T C 16: 32,288,938 (GRCm39) S260P probably damaging Het
Phf3 A T 1: 30,843,711 (GRCm39) F1749L probably damaging Het
Prickle2 T C 6: 92,353,525 (GRCm39) D647G probably benign Het
Raver2 T C 4: 100,990,787 (GRCm39) S387P probably benign Het
Relch T C 1: 105,681,320 (GRCm39) L1184P probably damaging Het
Rgs19 A G 2: 181,330,941 (GRCm39) S231P possibly damaging Het
Rpl8 G T 15: 76,790,149 (GRCm39) R198L probably benign Het
Sacs T A 14: 61,416,737 (GRCm39) S77T possibly damaging Het
Samd14 G A 11: 94,912,280 (GRCm39) G219D probably damaging Het
Sec16a C T 2: 26,331,431 (GRCm39) V195M probably damaging Het
Sesn2 C T 4: 132,221,113 (GRCm39) V453I possibly damaging Het
Slc46a3 A T 5: 147,822,970 (GRCm39) C291S probably damaging Het
Smarcal1 A G 1: 72,630,332 (GRCm39) T129A possibly damaging Het
Sorl1 T A 9: 41,935,694 (GRCm39) R1041W possibly damaging Het
Sptlc3 T C 2: 139,408,506 (GRCm39) I207T probably benign Het
Srgap3 T C 6: 112,793,622 (GRCm39) D118G probably damaging Het
Tas2r117 T A 6: 132,779,892 (GRCm39) V10D probably benign Het
Tbcd A G 11: 121,500,206 (GRCm39) K1111E probably benign Het
Tor1aip1 A T 1: 155,911,566 (GRCm39) L139Q probably damaging Het
Trbv23 T C 6: 41,193,181 (GRCm39) V23A probably damaging Het
Ttll3 AAGTA AAGTATAGTA 6: 113,376,120 (GRCm39) probably null Het
Ttll3 GGCAAAG GGCAAAGCAAAG 6: 113,376,116 (GRCm39) probably null Het
Ttll3 CAAAGTAA CAAAGTAAAGTAA 6: 113,376,118 (GRCm39) probably null Het
Vmn1r42 T G 6: 89,821,769 (GRCm39) T267P possibly damaging Het
Vmn2r53 C A 7: 12,340,441 (GRCm39) V11F probably damaging Het
Vmn2r67 T C 7: 84,801,361 (GRCm39) M192V probably damaging Het
Vmn2r78 T C 7: 86,603,811 (GRCm39) V663A probably damaging Het
Zdhhc1 C T 8: 106,203,704 (GRCm39) G156S possibly damaging Het
Zfp318 AGAAG AGAAGAGGAAG 17: 46,723,464 (GRCm39) probably benign Het
Zfp318 GAAGAA GAAGAAAAAGAA 17: 46,723,459 (GRCm39) probably benign Het
Zfp318 AAGAAG AAGAAGTAGAAG 17: 46,723,460 (GRCm39) probably benign Het
Zfp654 G A 16: 64,606,961 (GRCm39) L414F probably damaging Het
Zfp872 A T 9: 22,111,355 (GRCm39) Y278F probably damaging Het
Zscan20 T C 4: 128,483,515 (GRCm39) S385G probably damaging Het
Other mutations in Zfp560
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00933:Zfp560 APN 9 20,260,104 (GRCm39) missense probably benign 0.00
IGL02400:Zfp560 APN 9 20,261,896 (GRCm39) missense possibly damaging 0.73
R0002:Zfp560 UTSW 9 20,258,813 (GRCm39) missense probably damaging 1.00
R0004:Zfp560 UTSW 9 20,259,263 (GRCm39) missense probably damaging 1.00
R0019:Zfp560 UTSW 9 20,259,656 (GRCm39) missense probably benign 0.23
R1401:Zfp560 UTSW 9 20,263,149 (GRCm39) missense possibly damaging 0.71
R1481:Zfp560 UTSW 9 20,260,086 (GRCm39) missense probably benign
R1521:Zfp560 UTSW 9 20,260,071 (GRCm39) splice site probably null
R1569:Zfp560 UTSW 9 20,260,011 (GRCm39) missense possibly damaging 0.83
R1579:Zfp560 UTSW 9 20,259,287 (GRCm39) missense possibly damaging 0.73
R1673:Zfp560 UTSW 9 20,258,949 (GRCm39) missense probably benign 0.37
R1694:Zfp560 UTSW 9 20,259,282 (GRCm39) nonsense probably null
R1796:Zfp560 UTSW 9 20,263,226 (GRCm39) missense possibly damaging 0.71
R2971:Zfp560 UTSW 9 20,260,240 (GRCm39) missense probably benign 0.00
R3416:Zfp560 UTSW 9 20,258,974 (GRCm39) nonsense probably null
R4182:Zfp560 UTSW 9 20,258,744 (GRCm39) missense probably benign 0.11
R4509:Zfp560 UTSW 9 20,260,019 (GRCm39) missense probably damaging 1.00
R4708:Zfp560 UTSW 9 20,263,214 (GRCm39) missense possibly damaging 0.85
R4735:Zfp560 UTSW 9 20,260,347 (GRCm39) missense probably benign 0.01
R4937:Zfp560 UTSW 9 20,259,263 (GRCm39) missense probably damaging 1.00
R5562:Zfp560 UTSW 9 20,261,883 (GRCm39) nonsense probably null
R6597:Zfp560 UTSW 9 20,259,297 (GRCm39) missense probably benign 0.00
R6863:Zfp560 UTSW 9 20,259,795 (GRCm39) missense probably damaging 0.99
R7267:Zfp560 UTSW 9 20,259,384 (GRCm39) missense probably damaging 0.96
R7619:Zfp560 UTSW 9 20,260,206 (GRCm39) missense probably benign 0.01
R7763:Zfp560 UTSW 9 20,258,619 (GRCm39) missense possibly damaging 0.96
R8220:Zfp560 UTSW 9 20,260,348 (GRCm39) missense probably benign 0.00
R8356:Zfp560 UTSW 9 20,260,231 (GRCm39) missense probably benign 0.25
R8858:Zfp560 UTSW 9 20,260,403 (GRCm39) missense probably benign 0.12
R8992:Zfp560 UTSW 9 20,260,895 (GRCm39) missense probably benign
Z1176:Zfp560 UTSW 9 20,259,000 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AACGACTGAAGGCTATTCCATCAC -3'
(R):5'- AAGTCTGTGGGAAGGCATTC -3'

Sequencing Primer
(F):5'- AGCGCACAGTGAATGCTTTC -3'
(R):5'- GGAAGGCATTCACATGTTCTTC -3'
Posted On 2018-09-12