Incidental Mutation 'R6852:Vmn2r67'
| ID |
535026 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r67
|
| Ensembl Gene |
ENSMUSG00000095664 |
| Gene Name |
vomeronasal 2, receptor 67 |
| Synonyms |
EG620672 |
| MMRRC Submission |
045023-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.111)
|
| Stock # |
R6852 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
84785448-84805110 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 84801361 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 192
(M192V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126007
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168730]
|
| AlphaFold |
K7N6T2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168730
AA Change: M192V
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000126007
Gene: ENSMUSG00000095664
AA Change: M192V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
464 |
2.1e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
4.8e-19 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
1.4e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110002E22Rik |
C |
T |
3: 137,770,930 (GRCm39) |
Q40* |
probably null |
Het |
| 1700034E13Rik |
T |
C |
18: 52,796,705 (GRCm39) |
V81A |
probably damaging |
Het |
| A630089N07Rik |
A |
G |
16: 97,866,855 (GRCm39) |
I369T |
probably benign |
Het |
| Aatk |
T |
A |
11: 119,901,294 (GRCm39) |
Q977L |
probably benign |
Het |
| Abca4 |
A |
T |
3: 121,928,844 (GRCm39) |
Q144H |
probably damaging |
Het |
| Ampd3 |
T |
C |
7: 110,401,753 (GRCm39) |
F416L |
probably benign |
Het |
| Anks1b |
A |
G |
10: 90,096,516 (GRCm39) |
E425G |
probably damaging |
Het |
| Atm |
A |
G |
9: 53,393,730 (GRCm39) |
S1737P |
possibly damaging |
Het |
| Bsph1 |
T |
A |
7: 13,204,255 (GRCm39) |
|
probably null |
Het |
| Cabyr |
C |
T |
18: 12,887,154 (GRCm39) |
P262S |
probably benign |
Het |
| Cdc14a |
G |
A |
3: 116,122,325 (GRCm39) |
P214L |
possibly damaging |
Het |
| Cep128 |
C |
A |
12: 91,333,116 (GRCm39) |
|
probably null |
Het |
| Cfh |
T |
A |
1: 140,075,487 (GRCm39) |
R250S |
probably damaging |
Het |
| Ddx39a |
T |
C |
8: 84,449,646 (GRCm39) |
I417T |
probably benign |
Het |
| Dgka |
T |
A |
10: 128,558,408 (GRCm39) |
K548M |
probably damaging |
Het |
| Efr3a |
G |
A |
15: 65,701,679 (GRCm39) |
V198I |
probably benign |
Het |
| Elapor1 |
T |
C |
3: 108,389,654 (GRCm39) |
E203G |
probably damaging |
Het |
| Epg5 |
C |
T |
18: 78,056,106 (GRCm39) |
T1760I |
probably damaging |
Het |
| Fat1 |
T |
C |
8: 45,488,635 (GRCm39) |
V3472A |
possibly damaging |
Het |
| Fbxo48 |
T |
A |
11: 16,903,402 (GRCm39) |
N9K |
probably benign |
Het |
| Fcgbpl1 |
T |
A |
7: 27,846,560 (GRCm39) |
I1084N |
probably damaging |
Het |
| Fer1l6 |
A |
T |
15: 58,466,727 (GRCm39) |
H833L |
probably damaging |
Het |
| Foxn1 |
G |
T |
11: 78,251,786 (GRCm39) |
Q482K |
probably benign |
Het |
| Fstl5 |
A |
G |
3: 76,615,162 (GRCm39) |
D741G |
probably damaging |
Het |
| Gmip |
C |
T |
8: 70,270,641 (GRCm39) |
Q55* |
probably null |
Het |
| H2-T5 |
T |
C |
17: 36,478,965 (GRCm39) |
N95D |
possibly damaging |
Het |
| Hapln2 |
G |
A |
3: 87,929,958 (GRCm39) |
T306M |
possibly damaging |
Het |
| Kat6a |
T |
A |
8: 23,428,676 (GRCm39) |
S1344T |
probably benign |
Het |
| Kctd1 |
C |
T |
18: 15,119,401 (GRCm39) |
D705N |
possibly damaging |
Het |
| Lhx9 |
ACC |
ACCC |
1: 138,769,544 (GRCm39) |
|
probably null |
Het |
| Micall2 |
G |
T |
5: 139,701,548 (GRCm39) |
A482D |
possibly damaging |
Het |
| Mindy3 |
T |
A |
2: 12,424,063 (GRCm39) |
M1L |
possibly damaging |
Het |
| Mtdh |
A |
G |
15: 34,136,867 (GRCm39) |
E352G |
probably damaging |
Het |
| Muc5ac |
G |
A |
7: 141,370,644 (GRCm39) |
V3219I |
probably benign |
Het |
| Myh4 |
A |
G |
11: 67,143,794 (GRCm39) |
|
probably null |
Het |
| Ncor1 |
A |
G |
11: 62,234,071 (GRCm39) |
I377T |
probably damaging |
Het |
| Oog4 |
C |
A |
4: 143,165,679 (GRCm39) |
C156F |
possibly damaging |
Het |
| Or5m9 |
A |
T |
2: 85,876,948 (GRCm39) |
I41F |
probably benign |
Het |
| Pcyt1a |
T |
C |
16: 32,288,938 (GRCm39) |
S260P |
probably damaging |
Het |
| Phf3 |
A |
T |
1: 30,843,711 (GRCm39) |
F1749L |
probably damaging |
Het |
| Prickle2 |
T |
C |
6: 92,353,525 (GRCm39) |
D647G |
probably benign |
Het |
| Raver2 |
T |
C |
4: 100,990,787 (GRCm39) |
S387P |
probably benign |
Het |
| Relch |
T |
C |
1: 105,681,320 (GRCm39) |
L1184P |
probably damaging |
Het |
| Rgs19 |
A |
G |
2: 181,330,941 (GRCm39) |
S231P |
possibly damaging |
Het |
| Rpl8 |
G |
T |
15: 76,790,149 (GRCm39) |
R198L |
probably benign |
Het |
| Sacs |
T |
A |
14: 61,416,737 (GRCm39) |
S77T |
possibly damaging |
Het |
| Samd14 |
G |
A |
11: 94,912,280 (GRCm39) |
G219D |
probably damaging |
Het |
| Sec16a |
C |
T |
2: 26,331,431 (GRCm39) |
V195M |
probably damaging |
Het |
| Sesn2 |
C |
T |
4: 132,221,113 (GRCm39) |
V453I |
possibly damaging |
Het |
| Slc46a3 |
A |
T |
5: 147,822,970 (GRCm39) |
C291S |
probably damaging |
Het |
| Smarcal1 |
A |
G |
1: 72,630,332 (GRCm39) |
T129A |
possibly damaging |
Het |
| Sorl1 |
T |
A |
9: 41,935,694 (GRCm39) |
R1041W |
possibly damaging |
Het |
| Sptlc3 |
T |
C |
2: 139,408,506 (GRCm39) |
I207T |
probably benign |
Het |
| Srgap3 |
T |
C |
6: 112,793,622 (GRCm39) |
D118G |
probably damaging |
Het |
| Tas2r117 |
T |
A |
6: 132,779,892 (GRCm39) |
V10D |
probably benign |
Het |
| Tbcd |
A |
G |
11: 121,500,206 (GRCm39) |
K1111E |
probably benign |
Het |
| Tor1aip1 |
A |
T |
1: 155,911,566 (GRCm39) |
L139Q |
probably damaging |
Het |
| Trbv23 |
T |
C |
6: 41,193,181 (GRCm39) |
V23A |
probably damaging |
Het |
| Ttll3 |
AAGTA |
AAGTATAGTA |
6: 113,376,120 (GRCm39) |
|
probably null |
Het |
| Ttll3 |
GGCAAAG |
GGCAAAGCAAAG |
6: 113,376,116 (GRCm39) |
|
probably null |
Het |
| Ttll3 |
CAAAGTAA |
CAAAGTAAAGTAA |
6: 113,376,118 (GRCm39) |
|
probably null |
Het |
| Vmn1r42 |
T |
G |
6: 89,821,769 (GRCm39) |
T267P |
possibly damaging |
Het |
| Vmn2r53 |
C |
A |
7: 12,340,441 (GRCm39) |
V11F |
probably damaging |
Het |
| Vmn2r78 |
T |
C |
7: 86,603,811 (GRCm39) |
V663A |
probably damaging |
Het |
| Zdhhc1 |
C |
T |
8: 106,203,704 (GRCm39) |
G156S |
possibly damaging |
Het |
| Zfp318 |
AGAAG |
AGAAGAGGAAG |
17: 46,723,464 (GRCm39) |
|
probably benign |
Het |
| Zfp318 |
GAAGAA |
GAAGAAAAAGAA |
17: 46,723,459 (GRCm39) |
|
probably benign |
Het |
| Zfp318 |
AAGAAG |
AAGAAGTAGAAG |
17: 46,723,460 (GRCm39) |
|
probably benign |
Het |
| Zfp560 |
A |
G |
9: 20,259,339 (GRCm39) |
C508R |
probably damaging |
Het |
| Zfp654 |
G |
A |
16: 64,606,961 (GRCm39) |
L414F |
probably damaging |
Het |
| Zfp872 |
A |
T |
9: 22,111,355 (GRCm39) |
Y278F |
probably damaging |
Het |
| Zscan20 |
T |
C |
4: 128,483,515 (GRCm39) |
S385G |
probably damaging |
Het |
|
| Other mutations in Vmn2r67 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00096:Vmn2r67
|
APN |
7 |
84,801,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01346:Vmn2r67
|
APN |
7 |
84,786,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01373:Vmn2r67
|
APN |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01674:Vmn2r67
|
APN |
7 |
84,785,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01978:Vmn2r67
|
APN |
7 |
84,800,649 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02013:Vmn2r67
|
APN |
7 |
84,800,863 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02115:Vmn2r67
|
APN |
7 |
84,800,787 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02250:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02252:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02328:Vmn2r67
|
APN |
7 |
84,799,898 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02740:Vmn2r67
|
APN |
7 |
84,785,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Vmn2r67
|
APN |
7 |
84,785,951 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL03237:Vmn2r67
|
APN |
7 |
84,799,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Vmn2r67
|
UTSW |
7 |
84,799,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Vmn2r67
|
UTSW |
7 |
84,785,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1193:Vmn2r67
|
UTSW |
7 |
84,800,653 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1282:Vmn2r67
|
UTSW |
7 |
84,785,932 (GRCm39) |
missense |
probably benign |
|
|
R1416:Vmn2r67
|
UTSW |
7 |
84,800,824 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1429:Vmn2r67
|
UTSW |
7 |
84,802,031 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1970:Vmn2r67
|
UTSW |
7 |
84,801,013 (GRCm39) |
missense |
probably benign |
|
|
R2229:Vmn2r67
|
UTSW |
7 |
84,801,250 (GRCm39) |
missense |
probably benign |
0.21 |
|
R2246:Vmn2r67
|
UTSW |
7 |
84,785,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2262:Vmn2r67
|
UTSW |
7 |
84,786,182 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2398:Vmn2r67
|
UTSW |
7 |
84,785,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4249:Vmn2r67
|
UTSW |
7 |
84,799,722 (GRCm39) |
splice site |
probably null |
|
|
R4666:Vmn2r67
|
UTSW |
7 |
84,799,831 (GRCm39) |
missense |
probably benign |
|
|
R4669:Vmn2r67
|
UTSW |
7 |
84,799,732 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4966:Vmn2r67
|
UTSW |
7 |
84,785,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5264:Vmn2r67
|
UTSW |
7 |
84,801,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r67
|
UTSW |
7 |
84,786,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5327:Vmn2r67
|
UTSW |
7 |
84,785,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5401:Vmn2r67
|
UTSW |
7 |
84,785,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Vmn2r67
|
UTSW |
7 |
84,801,023 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5574:Vmn2r67
|
UTSW |
7 |
84,801,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5643:Vmn2r67
|
UTSW |
7 |
84,799,151 (GRCm39) |
nonsense |
probably null |
|
|
R5914:Vmn2r67
|
UTSW |
7 |
84,801,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Vmn2r67
|
UTSW |
7 |
84,799,768 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Vmn2r67
|
UTSW |
7 |
84,799,142 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6309:Vmn2r67
|
UTSW |
7 |
84,801,124 (GRCm39) |
missense |
probably benign |
|
|
R6442:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6665:Vmn2r67
|
UTSW |
7 |
84,785,900 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6701:Vmn2r67
|
UTSW |
7 |
84,802,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6848:Vmn2r67
|
UTSW |
7 |
84,801,840 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6991:Vmn2r67
|
UTSW |
7 |
84,804,953 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7143:Vmn2r67
|
UTSW |
7 |
84,801,846 (GRCm39) |
missense |
probably benign |
|
|
R7197:Vmn2r67
|
UTSW |
7 |
84,785,774 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7393:Vmn2r67
|
UTSW |
7 |
84,805,086 (GRCm39) |
missense |
probably null |
0.87 |
|
R7420:Vmn2r67
|
UTSW |
7 |
84,785,944 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7622:Vmn2r67
|
UTSW |
7 |
84,785,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7664:Vmn2r67
|
UTSW |
7 |
84,805,019 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7665:Vmn2r67
|
UTSW |
7 |
84,801,196 (GRCm39) |
nonsense |
probably null |
|
|
R7896:Vmn2r67
|
UTSW |
7 |
84,785,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7913:Vmn2r67
|
UTSW |
7 |
84,801,036 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8026:Vmn2r67
|
UTSW |
7 |
84,785,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8114:Vmn2r67
|
UTSW |
7 |
84,805,097 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8317:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8363:Vmn2r67
|
UTSW |
7 |
84,804,969 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8421:Vmn2r67
|
UTSW |
7 |
84,785,893 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8444:Vmn2r67
|
UTSW |
7 |
84,785,854 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8751:Vmn2r67
|
UTSW |
7 |
84,801,450 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8810:Vmn2r67
|
UTSW |
7 |
84,786,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8811:Vmn2r67
|
UTSW |
7 |
84,799,895 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9215:Vmn2r67
|
UTSW |
7 |
84,802,008 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r67
|
UTSW |
7 |
84,785,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9433:Vmn2r67
|
UTSW |
7 |
84,804,917 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9453:Vmn2r67
|
UTSW |
7 |
84,800,697 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9471:Vmn2r67
|
UTSW |
7 |
84,799,723 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9526:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9538:Vmn2r67
|
UTSW |
7 |
84,801,327 (GRCm39) |
missense |
|
|
|
R9544:Vmn2r67
|
UTSW |
7 |
84,786,317 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9574:Vmn2r67
|
UTSW |
7 |
84,786,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9599:Vmn2r67
|
UTSW |
7 |
84,804,941 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9768:Vmn2r67
|
UTSW |
7 |
84,802,037 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTTACGGGCCATGCTATG -3'
(R):5'- TAGAGAATCACAAGAGGTTCAACAC -3'
Sequencing Primer
(F):5'- TTACGGGCCATGCTATGCTCAG -3'
(R):5'- TCACAAGAGGTTCAACACAATTG -3'
|
| Posted On |
2018-09-12 |
Incidental Mutation