Incidental Mutation 'R6794:Cracdl'
ID 531649
Institutional Source Beutler Lab
Gene Symbol Cracdl
Ensembl Gene ENSMUSG00000026090
Gene Name capping protein inhibiting regulator of actin like
Synonyms 2010300C02Rik
MMRRC Submission 044907-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6794 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 37650758-37758905 bp(-) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) A to G at 37676936 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000123803 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160589] [ENSMUST00000162875]
AlphaFold E9Q3M9
Predicted Effect probably benign
Transcript: ENSMUST00000160589
Predicted Effect probably null
Transcript: ENSMUST00000162875
SMART Domains Protein: ENSMUSP00000123803
Gene: ENSMUSG00000026090

DomainStartEndE-ValueType
low complexity region 13 43 N/A INTRINSIC
Pfam:DUF4592 130 243 1.8e-33 PFAM
low complexity region 347 366 N/A INTRINSIC
internal_repeat_2 387 461 2.31e-5 PROSPERO
internal_repeat_3 404 474 3.67e-5 PROSPERO
internal_repeat_1 411 526 3.02e-34 PROSPERO
internal_repeat_2 485 559 2.31e-5 PROSPERO
internal_repeat_1 537 652 3.02e-34 PROSPERO
internal_repeat_3 570 698 3.67e-5 PROSPERO
low complexity region 705 718 N/A INTRINSIC
low complexity region 747 761 N/A INTRINSIC
low complexity region 787 803 N/A INTRINSIC
low complexity region 965 989 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.4%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agxt T C 1: 93,063,104 (GRCm39) V30A possibly damaging Het
Atf7 T C 15: 102,465,900 (GRCm39) K87E probably benign Het
Bltp3b T C 10: 89,641,624 (GRCm39) S932P probably benign Het
Btg4 A C 9: 51,030,651 (GRCm39) K250N possibly damaging Het
Cyc1 A G 15: 76,228,850 (GRCm39) Y132C probably damaging Het
Dcaf5 A T 12: 80,445,667 (GRCm39) D137E possibly damaging Het
Ddr2 C A 1: 169,809,667 (GRCm39) W770L probably damaging Het
Disc1 T C 8: 125,814,514 (GRCm39) V126A probably benign Het
Dock8 A G 19: 25,099,805 (GRCm39) N643D probably benign Het
Gabrg1 C T 5: 70,973,314 (GRCm39) R75H probably damaging Het
Gm14418 A T 2: 177,079,631 (GRCm39) H121Q probably damaging Het
H2-Ob T A 17: 34,460,162 (GRCm39) L20Q possibly damaging Het
Herpud1 T A 8: 95,121,398 (GRCm39) probably null Het
Ica1 T C 6: 8,653,659 (GRCm39) D326G probably benign Het
Jph3 T C 8: 122,512,124 (GRCm39) L704P probably benign Het
Kmt2e TGCCGCCGCCGCCGCCACCGCCGCCGCCGC TGCCGCCGCCGCCGCCGCCACCGCCGCCGCCGC 5: 23,704,474 (GRCm39) probably benign Het
Lnpep T G 17: 17,751,421 (GRCm39) N948T probably damaging Het
Mdn1 T A 4: 32,741,893 (GRCm39) V3888D probably damaging Het
Muc5ac T C 7: 141,363,289 (GRCm39) probably benign Het
Nfkb2 T C 19: 46,296,159 (GRCm39) probably null Het
Pik3r2 T C 8: 71,223,361 (GRCm39) H380R probably benign Het
Prim1 T C 10: 127,854,018 (GRCm39) S124P probably damaging Het
Prokr1 T C 6: 87,565,675 (GRCm39) T57A possibly damaging Het
Ptpn4 T C 1: 119,671,120 (GRCm39) T213A probably damaging Het
Sapcd2 A G 2: 25,266,379 (GRCm39) S389G probably damaging Het
Scn5a T C 9: 119,364,955 (GRCm39) Q421R probably damaging Het
Serac1 A G 17: 6,101,985 (GRCm39) Y430H probably damaging Het
Shf A G 2: 122,184,321 (GRCm39) L234P probably damaging Het
Slc22a29 G T 19: 8,138,887 (GRCm39) S525Y probably benign Het
Thbs1 A G 2: 117,950,519 (GRCm39) probably null Het
Tln2 T C 9: 67,193,840 (GRCm39) D666G probably benign Het
Ubqlnl C T 7: 103,797,992 (GRCm39) E502K probably benign Het
Vmn2r118 T A 17: 55,899,348 (GRCm39) H852L possibly damaging Het
Vmn2r72 A G 7: 85,387,204 (GRCm39) F787L probably damaging Het
Xpc G A 6: 91,483,839 (GRCm39) A169V probably benign Het
Ylpm1 A G 12: 85,043,655 (GRCm39) H131R unknown Het
Other mutations in Cracdl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01376:Cracdl APN 1 37,667,425 (GRCm39) missense probably damaging 0.99
IGL01413:Cracdl APN 1 37,651,387 (GRCm39) missense possibly damaging 0.85
IGL01812:Cracdl APN 1 37,664,446 (GRCm39) missense probably benign 0.06
IGL02183:Cracdl APN 1 37,664,459 (GRCm39) missense possibly damaging 0.93
IGL02498:Cracdl APN 1 37,662,926 (GRCm39) missense probably benign
IGL02713:Cracdl APN 1 37,663,218 (GRCm39) missense possibly damaging 0.72
IGL02736:Cracdl APN 1 37,676,954 (GRCm39) missense probably damaging 1.00
FR4449:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4449:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4548:Cracdl UTSW 1 37,664,183 (GRCm39) missense probably damaging 0.96
FR4548:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4548:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4737:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
FR4737:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4976:Cracdl UTSW 1 37,664,183 (GRCm39) missense probably damaging 0.96
FR4976:Cracdl UTSW 1 37,664,116 (GRCm39) missense probably benign 0.40
FR4976:Cracdl UTSW 1 37,664,117 (GRCm39) nonsense probably null
R0022:Cracdl UTSW 1 37,667,326 (GRCm39) missense probably damaging 1.00
R0022:Cracdl UTSW 1 37,667,326 (GRCm39) missense probably damaging 1.00
R0055:Cracdl UTSW 1 37,663,337 (GRCm39) missense probably benign 0.18
R0153:Cracdl UTSW 1 37,663,720 (GRCm39) missense probably benign
R0523:Cracdl UTSW 1 37,683,710 (GRCm39) start codon destroyed probably null 0.94
R0699:Cracdl UTSW 1 37,651,411 (GRCm39) missense possibly damaging 0.85
R0928:Cracdl UTSW 1 37,663,663 (GRCm39) missense possibly damaging 0.85
R1457:Cracdl UTSW 1 37,665,093 (GRCm39) nonsense probably null
R1759:Cracdl UTSW 1 37,664,791 (GRCm39) missense probably benign 0.00
R1888:Cracdl UTSW 1 37,663,364 (GRCm39) missense possibly damaging 0.53
R1888:Cracdl UTSW 1 37,663,364 (GRCm39) missense possibly damaging 0.53
R2289:Cracdl UTSW 1 37,651,342 (GRCm39) missense possibly damaging 0.53
R2421:Cracdl UTSW 1 37,652,556 (GRCm39) missense probably benign 0.33
R2422:Cracdl UTSW 1 37,652,556 (GRCm39) missense probably benign 0.33
R2509:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R2510:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R2511:Cracdl UTSW 1 37,664,381 (GRCm39) missense probably benign
R3893:Cracdl UTSW 1 37,670,539 (GRCm39) missense probably benign 0.00
R4351:Cracdl UTSW 1 37,663,993 (GRCm39) missense probably benign
R4454:Cracdl UTSW 1 37,663,834 (GRCm39) missense probably damaging 1.00
R4788:Cracdl UTSW 1 37,670,556 (GRCm39) missense probably damaging 1.00
R4798:Cracdl UTSW 1 37,664,046 (GRCm39) missense probably benign 0.12
R5599:Cracdl UTSW 1 37,652,424 (GRCm39) missense possibly damaging 0.53
R5920:Cracdl UTSW 1 37,677,062 (GRCm39) missense probably damaging 1.00
R6051:Cracdl UTSW 1 37,663,306 (GRCm39) missense probably damaging 0.98
R6106:Cracdl UTSW 1 37,652,493 (GRCm39) missense possibly damaging 0.53
R6828:Cracdl UTSW 1 37,663,898 (GRCm39) missense possibly damaging 0.53
R6930:Cracdl UTSW 1 37,664,026 (GRCm39) missense possibly damaging 0.73
R7044:Cracdl UTSW 1 37,651,361 (GRCm39) missense possibly damaging 0.85
R7069:Cracdl UTSW 1 37,670,982 (GRCm39) missense probably damaging 1.00
R7149:Cracdl UTSW 1 37,651,352 (GRCm39) nonsense probably null
R7296:Cracdl UTSW 1 37,653,699 (GRCm39) missense possibly damaging 0.53
R7698:Cracdl UTSW 1 37,664,452 (GRCm39) missense probably benign 0.12
R7714:Cracdl UTSW 1 37,663,858 (GRCm39) missense probably benign 0.33
R8071:Cracdl UTSW 1 37,663,010 (GRCm39) nonsense probably null
R8205:Cracdl UTSW 1 37,664,047 (GRCm39) missense probably benign 0.06
R8443:Cracdl UTSW 1 37,652,537 (GRCm39) missense probably benign 0.33
R8720:Cracdl UTSW 1 37,652,522 (GRCm39) missense possibly damaging 0.53
R8917:Cracdl UTSW 1 37,676,993 (GRCm39) missense probably damaging 0.99
R9056:Cracdl UTSW 1 37,663,553 (GRCm39) missense possibly damaging 0.91
R9158:Cracdl UTSW 1 37,670,442 (GRCm39) missense probably damaging 0.99
R9290:Cracdl UTSW 1 37,663,634 (GRCm39) missense probably damaging 0.97
R9483:Cracdl UTSW 1 37,670,496 (GRCm39) missense probably damaging 1.00
R9641:Cracdl UTSW 1 37,663,592 (GRCm39) missense possibly damaging 0.85
X0025:Cracdl UTSW 1 37,664,026 (GRCm39) missense probably benign 0.33
Predicted Primers PCR Primer
(F):5'- TCCCTGTGCTTGGAAAAGC -3'
(R):5'- AGTATTCTGAGCCCCTGGTTTC -3'

Sequencing Primer
(F):5'- CCCTGTGCTTGGAAAAGCTAATAGAC -3'
(R):5'- TTCTTCTTGTCATCTGAATAGGAAAG -3'
Posted On 2018-08-29