Incidental Mutation 'R6778:Ifitm6'
ID 531374
Institutional Source Beutler Lab
Gene Symbol Ifitm6
Ensembl Gene ENSMUSG00000059108
Gene Name interferon induced transmembrane protein 6
Synonyms fragilis5
MMRRC Submission 044894-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6778 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 140595725-140596805 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 140596056 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 59 (M59K)
Ref Sequence ENSEMBL: ENSMUSP00000147357 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081924] [ENSMUST00000209328] [ENSMUST00000211330]
AlphaFold A0A1B0GS75
Predicted Effect possibly damaging
Transcript: ENSMUST00000081924
AA Change: M59K

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000080594
Gene: ENSMUSG00000059108
AA Change: M59K

DomainStartEndE-ValueType
Pfam:CD225 10 91 2.3e-31 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000209328
AA Change: M59K

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000211330
AA Change: M79K

PolyPhen 2 Score 0.681 (Sensitivity: 0.86; Specificity: 0.92)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts14 T A 10: 61,061,231 (GRCm39) N403Y probably damaging Het
Akap6 A G 12: 53,072,599 (GRCm39) E989G probably damaging Het
Aoc2 A G 11: 101,216,187 (GRCm39) N90S probably damaging Het
Apol9a T C 15: 77,288,533 (GRCm39) Y278C probably benign Het
Casq2 T A 3: 102,035,247 (GRCm39) probably null Het
Ccdc7a T A 8: 129,547,601 (GRCm39) T1284S possibly damaging Het
Dlat A G 9: 50,562,157 (GRCm39) L289P probably damaging Het
Dnah8 C T 17: 30,854,640 (GRCm39) P101S probably benign Het
Dzip3 C A 16: 48,802,446 (GRCm39) A28S probably benign Het
Ffar4 A G 19: 38,102,112 (GRCm39) E249G possibly damaging Het
Fubp3 A T 2: 31,488,685 (GRCm39) K180N possibly damaging Het
Gm7489 T A 15: 53,749,348 (GRCm39) probably benign Het
Igkv4-80 A T 6: 68,993,545 (GRCm39) Y115* probably null Het
Igsf21 G T 4: 139,761,959 (GRCm39) R240S probably benign Het
Kank4 A T 4: 98,649,742 (GRCm39) N942K probably benign Het
Man2a1 C A 17: 65,021,630 (GRCm39) T35K possibly damaging Het
Mvk T A 5: 114,590,441 (GRCm39) D193E probably benign Het
Npas2 T A 1: 39,364,381 (GRCm39) M241K possibly damaging Het
Npsr1 T A 9: 24,165,914 (GRCm39) I100N possibly damaging Het
Olfml2b A G 1: 170,472,639 (GRCm39) D50G probably damaging Het
Or10d4c T A 9: 39,558,043 (GRCm39) V7E probably damaging Het
Pcnx1 A G 12: 81,965,645 (GRCm39) D604G probably damaging Het
Pitx2 C T 3: 129,012,392 (GRCm39) P254L probably damaging Het
Rdh10 T C 1: 16,176,408 (GRCm39) F56S probably damaging Het
Rin1 T C 19: 5,104,914 (GRCm39) L647P probably damaging Het
Sgk3 T A 1: 9,956,369 (GRCm39) probably null Het
Sgpp1 A G 12: 75,763,068 (GRCm39) I371T probably benign Het
Slc12a9 T C 5: 137,313,343 (GRCm39) Y872C possibly damaging Het
Spata31f3 T C 4: 42,868,522 (GRCm39) K367R possibly damaging Het
Syne1 A G 10: 5,052,406 (GRCm39) F7487L probably damaging Het
Tars1 T C 15: 11,389,785 (GRCm39) N375S probably benign Het
Tbc1d31 A G 15: 57,801,425 (GRCm39) Y320C probably damaging Het
Tbl1xr1 T A 3: 22,243,946 (GRCm39) F73L probably benign Het
Tmem145 G A 7: 25,010,801 (GRCm39) V378I probably benign Het
Tmprss11d T C 5: 86,457,209 (GRCm39) H150R probably benign Het
Tnc T G 4: 63,913,835 (GRCm39) I1326L probably benign Het
Trpc7 T C 13: 56,952,500 (GRCm39) Y502C probably damaging Het
Usp32 T C 11: 84,916,512 (GRCm39) I811V probably benign Het
Vmn1r71 C T 7: 10,482,143 (GRCm39) A182T probably benign Het
Wdr47 T A 3: 108,540,412 (GRCm39) N602K probably benign Het
Other mutations in Ifitm6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01469:Ifitm6 APN 7 140,596,725 (GRCm39) missense probably damaging 0.98
IGL03297:Ifitm6 APN 7 140,595,948 (GRCm39) missense probably damaging 1.00
PIT4802001:Ifitm6 UTSW 7 140,596,648 (GRCm39) missense probably damaging 1.00
R0076:Ifitm6 UTSW 7 140,595,920 (GRCm39) missense possibly damaging 0.53
R4007:Ifitm6 UTSW 7 140,596,627 (GRCm39) missense possibly damaging 0.86
R4418:Ifitm6 UTSW 7 140,595,984 (GRCm39) missense probably damaging 0.96
R5558:Ifitm6 UTSW 7 140,595,985 (GRCm39) missense probably benign 0.02
R8742:Ifitm6 UTSW 7 140,596,008 (GRCm39) missense probably benign 0.04
R8995:Ifitm6 UTSW 7 140,596,617 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGGAGTCCCACCCTTAGTATC -3'
(R):5'- GGTGAGCTGAGCATACAGTTC -3'

Sequencing Primer
(F):5'- GAGTCCCACCCTTAGTATCTAATAGG -3'
(R):5'- AGCTGAGCATACAGTTCTTGGGTC -3'
Posted On 2018-08-29